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Protein

Zinc finger homeobox protein 4

Gene

ZFHX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri613 – 63624C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri644 – 66724C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri699 – 72325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri767 – 78923C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri917 – 94125C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri973 – 99523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1021 – 104525C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1172 – 119524C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1201 – 122424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1352 – 137423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1380 – 140324C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1496 – 152227C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1548 – 157225C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1901 – 192424C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2084 – 214360Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2181 – 224060Homeobox 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2267 – 229125C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2448 – 247023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2560 – 261960Homeobox 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2630 – 265324C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
DNA bindingi2884 – 294360Homeobox 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2962 – 298625C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3354 – 337825C2H2-type 19; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3398 – 342225C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger homeobox protein 4
Alternative name(s):
Zinc finger homeodomain protein 4
Short name:
ZFH-4
Gene namesi
Name:ZFHX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30939. ZFHX4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ZFHX4 is found in one patient with ptosis. Translocation t(1;8)(p34.3;q21.12).

Organism-specific databases

MalaCardsiZFHX4.
PharmGKBiPA134986366.

Polymorphism and mutation databases

BioMutaiZFHX4.
DMDMi74762449.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 35673567Zinc finger homeobox protein 4PRO_0000278465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei2663 – 26631PhosphoserineCombined sources
Cross-linki3154 – 3154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86UP3.
MaxQBiQ86UP3.
PaxDbiQ86UP3.
PRIDEiQ86UP3.

PTM databases

iPTMnetiQ86UP3.
PhosphoSiteiQ86UP3.

Expressioni

Tissue specificityi

Expressed in brain, skeletal muscle and liver. Very low expression in stomach.

Gene expression databases

BgeeiQ86UP3.
CleanExiHS_ZFHX4.
ExpressionAtlasiQ86UP3. baseline and differential.
GenevisibleiQ86UP3. HS.

Organism-specific databases

HPAiHPA023837.

Interactioni

Protein-protein interaction databases

BioGridi122877. 10 interactions.
IntActiQ86UP3. 4 interactions.
STRINGi9606.ENSP00000430497.

Structurei

3D structure databases

ProteinModelPortaliQ86UP3.
SMRiQ86UP3. Positions 2082-2146, 2186-2239, 2555-2617, 2957-3003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3265 – 329430Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi523 – 5264Poly-Ser
Compositional biasi1644 – 1793150Gln-richAdd
BLAST
Compositional biasi1949 – 2048100Pro-richAdd
BLAST
Compositional biasi2345 – 242985Pro-richAdd
BLAST
Compositional biasi3050 – 312475Pro-richAdd
BLAST
Compositional biasi3454 – 353380Ser-richAdd
BLAST

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 4 homeobox DNA-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri613 – 63624C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri644 – 66724C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri699 – 72325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri767 – 78923C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri917 – 94125C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri973 – 99523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1021 – 104525C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1172 – 119524C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1201 – 122424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1352 – 137423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1380 – 140324C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1496 – 152227C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1548 – 157225C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1901 – 192424C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2267 – 229125C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2448 – 247023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2630 – 265324C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2962 – 298625C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3354 – 337825C2H2-type 19; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3398 – 342225C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1146. Eukaryota.
ENOG410XYHC. LUCA.
GeneTreeiENSGT00530000063717.
HOGENOMiHOG000155777.
HOVERGENiHBG050606.
InParanoidiQ86UP3.
KOiK09380.
OMAiLEHYKSD.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ86UP3.
TreeFamiTF323288.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METCDSPPIS RQENGQSTSK LCGTTQLDNE VPEKVAGMEP DRENSSTDDN
60 70 80 90 100
LKTDERKSEA LLGFSVENAA ATQVTSAKEI PCNECATSFP SLQKYMEHHC
110 120 130 140 150
PNARLPVLKD DNESEISELE DSDVENLTGE IVYQPDGSAY IIEDSKESGQ
160 170 180 190 200
NAQTGANSKL FSTAMFLDSL ASAGEKSDQS ASAPMSFYPQ IINTFHIASS
210 220 230 240 250
LGKPFTADQA FPNTSALAGV GPVLHSFRVY DLRHKREKDY LTSDGSAKNS
260 270 280 290 300
CVSKDVPNNV DLSKFDGCVS DGKRKPVLMC FLCKLSFGYI RSFVTHAVHD
310 320 330 340 350
HRMTLNDEEQ KLLSNKCVSA IIQGIGKDKE PLISFLEPKK STSVYPHFST
360 370 380 390 400
TNLIGPDPTF RGLWSAFHVE NGDSLPAGFA FLKGSASTSS SAEQPLGITQ
410 420 430 440 450
MPKAEVNLGG LSSLVVNTPI TSVSLSHSSS ESSKMSESKD QENNCERPKE
460 470 480 490 500
SNVLHPNGEC PVKSEPTEPG DEDEEDAYSN ELDDEEVLGE LTDSIGNKDF
510 520 530 540 550
PLLNQSISPL SSSVLKFIEK GTSSSSATVS DDTEKKKQTA AVRASGSVAS
560 570 580 590 600
NYGISGKDFA DASASKDSAT AAHPSEIARG DEDSSATPHQ HGFTPSTPGT
610 620 630 640 650
PGPGGDGSPG SGIECPKCDT VLGSSRSLGG HMTMMHSRNS CKTLKCPKCN
660 670 680 690 700
WHYKYQQTLE AHMKEKHPEP GGSCVYCKTG QPHPRLARGE SYTCGYKPFR
710 720 730 740 750
CEVCNYSTTT KGNLSIHMQS DKHLNNVQNL QNGNGEQVFG HSAPAPNTSL
760 770 780 790 800
SGCGTPSPSK PKQKPTWRCE VCDYETNVAR NLRIHMTSEK HMHNMMLLQQ
810 820 830 840 850
NMKQIQHNLH LGLAPAEAEL YQYYLAQNIG LTGMKLENPA DPQLMINPFQ
860 870 880 890 900
LDPATAAALA PGLGELSPYI SDPALKLFQC AVCNKFTSDS LEALSVHVSS
910 920 930 940 950
ERSLPEEEWR AVIGDIYQCK LCNYNTQLKA NFQLHCKTDK HMQKYQLVAH
960 970 980 990 1000
IKEGGKSNEW RLKCIAIGNP VHLKCNACDY YTNSVDKLRL HTTNHRHEAA
1010 1020 1030 1040 1050
LKLYKHLQKQ EGAVNPESCY YYCAVCDYTT KVKLNLVQHV RSVKHQQTEG
1060 1070 1080 1090 1100
LRKLQLHQQG LAPEEDNLSE IFFVKDCPPN ELETASLGAR TCDDDLTEQH
1110 1120 1130 1140 1150
EEAEGAIKPT AVAEDDEKDT SERDNSEGKN SNKDSVSVAG GTQPLLLAKE
1160 1170 1180 1190 1200
EDVATKRSKP TEDNKFCHEQ FYQCPYCNYN SRDQSRIQMH VLSQHSVQPV
1210 1220 1230 1240 1250
ICCPLCQDVL SNKMHLQLHL THLHSVSPDC VEKLLMTVPV PDVMMPNSML
1260 1270 1280 1290 1300
LPAAASEKSE RDTPAAVTAE GSGKYSGESP MDDKSMAGLE DSKANVEVKN
1310 1320 1330 1340 1350
EEQKPTKEPL EVSEWNKNSS KDVKIPDTLQ DQLNEQQKRQ PLSVSDRHVY
1360 1370 1380 1390 1400
KYRCNHCSLA FKTMQKLQIH SQYHAIRAAT MCNLCQRSFR TFQALKKHLE
1410 1420 1430 1440 1450
AGHPELSEAE LQQLYASLPV NGELWAESET MSQDDHGLEQ EMEREYEVDH
1460 1470 1480 1490 1500
EGKASPVGSD SSSIPDDMGS EPKRTLPFRK GPNFTMEKFL DPSRPYKCTV
1510 1520 1530 1540 1550
CKESFTQKNI LLVHYNSVSH LHKLKKVLQE ASSPVPQETN SNTDNKPYKC
1560 1570 1580 1590 1600
SICNVAYSQS STLEIHMRSV LHQTKARAAK LEPSGHVAGG HSIAANVNSP
1610 1620 1630 1640 1650
GQGMLDSMSL AAVNSKDTHL DAKELNKKQT PDLISAQPAH HPPQSPAQIQ
1660 1670 1680 1690 1700
MQLQHELQQQ AAFFQPQFLN PAFLPHFPMT PEALLQFQQP QFLFPFYIPG
1710 1720 1730 1740 1750
TEFSLGPDLG LPGSATFGMP GMTGMAGSLL EDLKQQIQTQ HHVGQTQLQI
1760 1770 1780 1790 1800
LQQQAQQYQA TQPQLQPQKQ QQQPPPPQQQ QQQQASKLLK QEQSNIVSAD
1810 1820 1830 1840 1850
CQIMKDVPSY KEAEDISEKP EKPKQEFISE GEGLKEGKDT KKQKSLEPSI
1860 1870 1880 1890 1900
PPPRIASGAR GNAAKALLEN FGFELVIQYN ENRQKVQKKG KSGEGENTDK
1910 1920 1930 1940 1950
LECGTCGKLF SNVLILKSHQ EHVHGQFFPY AALEKFARQY REAYDKLYPI
1960 1970 1980 1990 2000
SPSSPETPPP PPPPPPLPPA PPQPSSMGPV KIPNTVSTPL QAPPPTPPPP
2010 2020 2030 2040 2050
PPPPPPPPPP PPPPPPSAPP QVQLPVSLDL PLFPSIMMQP VQHPALPPQL
2060 2070 2080 2090 2100
ALQLPQMDAL SADLTQLCQQ QLGLDPNFLR HSQFKRPRTR ITDDQLKILR
2110 2120 2130 2140 2150
AYFDINNSPS EEQIQEMAEK SGLSQKVIKH WFRNTLFKER QRNKDSPYNF
2160 2170 2180 2190 2200
SNPPITVLED IRIDPQPTSL EHYKSDASFS KRSSRTRFTD YQLRVLQDFF
2210 2220 2230 2240 2250
DTNAYPKDDE IEQLSTVLNL PTRVIVVWFQ NARQKARKSY ENQAETKDNE
2260 2270 2280 2290 2300
KRELTNERYI RTSNMQYQCK KCNVVFPRIF DLITHQKKQC YKDEDDDAQD
2310 2320 2330 2340 2350
ESQTEDSMDA TDQVVYKHCT VSGQTDAAKN AAAPAASSGS GTSTPLIPSP
2360 2370 2380 2390 2400
KPEPEKTSPK PEYPAEKPKQ SDPSPPSQGT KPALPLASTS SDPPQASTAQ
2410 2420 2430 2440 2450
PQPQPQPPKQ PQLIGRPPSA SQTPVPSSPL QISMTSLQNS LPPQLLQYQC
2460 2470 2480 2490 2500
DQCTVAFPTL ELWQEHQHMH FLAAQNQFLH SPFLERPMDM PYMIFDPNNP
2510 2520 2530 2540 2550
LMTGQLLGSS LTQMPPQASS SHTTAPTTVA ASLKRKLDDK EDNNCSEKEG
2560 2570 2580 2590 2600
GNSGEDQHRD KRLRTTITPE QLEILYEKYL LDSNPTRKML DHIAREVGLK
2610 2620 2630 2640 2650
KRVVQVWFQN TRARERKGQF RAVGPAQSHK RCPFCRALFK AKSALESHIR
2660 2670 2680 2690 2700
SRHWNEGKQA GYSLPPSPLI STEDGGESPQ KYIYFDYPSL PLTKIDLSSE
2710 2720 2730 2740 2750
NELASTVSTP VSKTAELSPK NLLSPSSFKA ECSEDVENLN APPAEAGYDQ
2760 2770 2780 2790 2800
NKTDFDETSS INTAISDATT GDEGNTEMES TTGSSGDVKP ALSPKEPKTL
2810 2820 2830 2840 2850
DTLPKPATTP TTEVCDDKFL FSLTSPSIHF NDKDGDHDQS FYITDDPDDN
2860 2870 2880 2890 2900
ADRSETSSIA DPSSPNPFGS SNPFKSKSND RPGHKRFRTQ MSNLQLKVLK
2910 2920 2930 2940 2950
ACFSDYRTPT MQECEMLGNE IGLPKRVVQV WFQNARAKEK KFKINIGKPF
2960 2970 2980 2990 3000
MINQGGTEGT KPECTLCGVK YSARLSIRDH IFSKQHISKV RETVGSQLDR
3010 3020 3030 3040 3050
EKDYLAPTTV RQLMAQQELD RIKKASDVLG LTVQQPGMMD SSSLHGISLP
3060 3070 3080 3090 3100
TAYPGLPGLP PVLLPGMNGP SSLPGFPQNS NISAGMLGFP TSATSSPALS
3110 3120 3130 3140 3150
LSSAPTKPLL QTPPPPPPPP PPPPSSSLSG QQTEQQNKES EKKQTKPNKV
3160 3170 3180 3190 3200
KKIKEEELEA TKPEKHPKKE EKISSALSVL GKVVGETHVD PIQLQALQNA
3210 3220 3230 3240 3250
IAGDPASFIG GQFLPYFIPG FASYFTPQLP GTVQGGYFPP VCGMESLFPY
3260 3270 3280 3290 3300
GPTMPQTLAG LSPGALLQQY QQYQQNLQES LQKQQKQQQE QQQKPVQAKT
3310 3320 3330 3340 3350
SKVESDQPQN SNDASETKED KSTATESTKE EPQLESKSAD FSDTYVVPFV
3360 3370 3380 3390 3400
KYEFICRKCQ MMFTDEDAAV NHQKSFCYFG QPLIDPQETV LRVPVSKYQC
3410 3420 3430 3440 3450
LACDVAISGN EALSQHLQSS LHKEKTIKQA MRNAKEHVRL LPHSVCSPNP
3460 3470 3480 3490 3500
NTTSTSQSAA SSNNTYPHLS CFSMKSWPNI LFQASARRAA SPPSSPPSLS
3510 3520 3530 3540 3550
LPSTVTSSLC STSGVQTSLP TESCSDESDS ELSQKLEDLD NSLEVKAKPA
3560
SGLDGNFNSI RMDMFSV
Length:3,567
Mass (Da):393,730
Last modified:June 1, 2003 - v1
Checksum:i99DE9E581F477EFB
GO
Isoform 2 (identifier: Q86UP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-863: L → LVNNELPPEIRLASGQLMGDDLSLLTA
     1100-1100: H → QLRSTSEEQS
     1135-1135: S → SGIITPEKELK
     2000-2016: Missing.
     3082-3083: IS → TLTPPG

Note: No experimental confirmation available.
Show »
Length:3,599
Mass (Da):397,313
Checksum:i42CF89E269BF1E23
GO
Isoform 3 (identifier: Q86UP3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1049: HLQKQEGAVN...VRSVKHQQTE → VSSDIHFRWH...KTSKGRGHSF
     1050-3567: Missing.

Note: No experimental confirmation available.
Show »
Length:1,049
Mass (Da):114,782
Checksum:i42132524E5905573
GO
Isoform 4 (identifier: Q86UP3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3082-3083: IS → TLTPPG

Show »
Length:3,571
Mass (Da):394,096
Checksum:i69B36792C706F29D
GO
Isoform 5 (identifier: Q86UP3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-863: L → LVNNELPPEIRLASGQLMGDDLSLLTA
     1100-1100: H → QLRSTSEEQS
     1135-1135: S → SGIITPEKELK
     3082-3083: IS → TLTPPG

Show »
Length:3,616
Mass (Da):398,964
Checksum:i8FFA9FD9E8F1F38A
GO

Sequence cautioni

The sequence AK131408 differs from that shown. Reason: Frameshift at position 338. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321P → L in AK131408 (PubMed:14702039).Curated
Sequence conflicti406 – 4061V → A in AK131408 (PubMed:14702039).Curated
Sequence conflicti937 – 9371K → E in AK131408 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2036 – 20361I → V.
Corresponds to variant rs16919452 [ dbSNP | Ensembl ].
VAR_057375
Natural varianti3033 – 30331V → G.
Corresponds to variant rs16939380 [ dbSNP | Ensembl ].
VAR_057376

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei863 – 8631L → LVNNELPPEIRLASGQLMGD DLSLLTA in isoform 2 and isoform 5. 1 PublicationVSP_023298
Alternative sequencei1006 – 104944HLQKQ…HQQTE → VSSDIHFRWHRVEKGINSFR AWSTSLQLKEKKREKTSKGR GHSF in isoform 3. 1 PublicationVSP_023299Add
BLAST
Alternative sequencei1050 – 35672518Missing in isoform 3. 1 PublicationVSP_023300Add
BLAST
Alternative sequencei1100 – 11001H → QLRSTSEEQS in isoform 2 and isoform 5. 1 PublicationVSP_023301
Alternative sequencei1135 – 11351S → SGIITPEKELK in isoform 2 and isoform 5. 1 PublicationVSP_023302
Alternative sequencei2000 – 201617Missing in isoform 2. 1 PublicationVSP_023303Add
BLAST
Alternative sequencei3082 – 30832IS → TLTPPG in isoform 2, isoform 4 and isoform 5. 1 PublicationVSP_023304

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083343 mRNA. Translation: BAE96598.1.
AY260762 mRNA. Translation: AAP20225.1.
AK131408 mRNA. No translation available.
AC011716 Genomic DNA. No translation available.
AC023200 Genomic DNA. No translation available.
AC087110 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87051.1.
CCDSiCCDS47878.2. [Q86UP3-5]
RefSeqiNP_078997.4. NM_024721.4. [Q86UP3-5]
XP_011515894.1. XM_011517592.1. [Q86UP3-5]
XP_011515895.1. XM_011517593.1. [Q86UP3-5]
XP_011515896.1. XM_011517594.1. [Q86UP3-5]
XP_011515897.1. XM_011517595.1. [Q86UP3-5]
UniGeneiHs.458973.

Genome annotation databases

EnsembliENST00000521891; ENSP00000430497; ENSG00000091656. [Q86UP3-5]
GeneIDi79776.
KEGGihsa:79776.
UCSCiuc003yau.3. human. [Q86UP3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083343 mRNA. Translation: BAE96598.1.
AY260762 mRNA. Translation: AAP20225.1.
AK131408 mRNA. No translation available.
AC011716 Genomic DNA. No translation available.
AC023200 Genomic DNA. No translation available.
AC087110 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87051.1.
CCDSiCCDS47878.2. [Q86UP3-5]
RefSeqiNP_078997.4. NM_024721.4. [Q86UP3-5]
XP_011515894.1. XM_011517592.1. [Q86UP3-5]
XP_011515895.1. XM_011517593.1. [Q86UP3-5]
XP_011515896.1. XM_011517594.1. [Q86UP3-5]
XP_011515897.1. XM_011517595.1. [Q86UP3-5]
UniGeneiHs.458973.

3D structure databases

ProteinModelPortaliQ86UP3.
SMRiQ86UP3. Positions 2082-2146, 2186-2239, 2555-2617, 2957-3003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122877. 10 interactions.
IntActiQ86UP3. 4 interactions.
STRINGi9606.ENSP00000430497.

PTM databases

iPTMnetiQ86UP3.
PhosphoSiteiQ86UP3.

Polymorphism and mutation databases

BioMutaiZFHX4.
DMDMi74762449.

Proteomic databases

EPDiQ86UP3.
MaxQBiQ86UP3.
PaxDbiQ86UP3.
PRIDEiQ86UP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521891; ENSP00000430497; ENSG00000091656. [Q86UP3-5]
GeneIDi79776.
KEGGihsa:79776.
UCSCiuc003yau.3. human. [Q86UP3-1]

Organism-specific databases

CTDi79776.
GeneCardsiZFHX4.
HGNCiHGNC:30939. ZFHX4.
HPAiHPA023837.
MalaCardsiZFHX4.
MIMi606940. gene.
neXtProtiNX_Q86UP3.
PharmGKBiPA134986366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1146. Eukaryota.
ENOG410XYHC. LUCA.
GeneTreeiENSGT00530000063717.
HOGENOMiHOG000155777.
HOVERGENiHBG050606.
InParanoidiQ86UP3.
KOiK09380.
OMAiLEHYKSD.
OrthoDBiEOG7FR7FH.
PhylomeDBiQ86UP3.
TreeFamiTF323288.

Miscellaneous databases

ChiTaRSiZFHX4. human.
GenomeRNAii79776.
PROiQ86UP3.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UP3.
CleanExiHS_ZFHX4.
ExpressionAtlasiQ86UP3. baseline and differential.
GenevisibleiQ86UP3. HS.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A homeodomain-zinc finger protein, ZFHX4, is expressed in neuronal differentiation manner and suppressed in muscle differentiation manner."
    Hemmi K., Ma D., Miura Y., Kawaguchi M., Sasahara M., Hashimoto-Tamaoki T., Tamaoki T., Sakata N., Tsuchiya K.
    Biol. Pharm. Bull. 29:1830-1835(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  2. Shan Y.X., Huang C.Q., Dang Y.J., Yu L.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Mesangial cell.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation."
    McMullan T.W., Crolla J.A., Gregory S.G., Carter N.P., Cooper R.A., Howell G.R., Robinson D.O.
    Hum. Genet. 110:244-250(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-3154, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZFHX4_HUMAN
AccessioniPrimary (citable) accession number: Q86UP3
Secondary accession number(s): G3V138, Q18PS0, Q6ZN20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.