Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinectin

Gene

KTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. microtubule-based movement Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kinectin
Alternative name(s):
CG-1 antigen
Kinesin receptor
Gene namesi
Name:KTN1
Synonyms:CG1, KIAA0004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:6467. KTN1.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type II membrane protein
Note: Vesicle membrane protein anchored to the endoplasmic reticulum.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Transmembranei7 – 2923Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini30 – 13571328LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: HPA
  2. endoplasmic reticulum membrane Source: ProtInc
  3. integral component of membrane Source: ProtInc
  4. integral component of plasma membrane Source: ProtInc
  5. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13571357KinectinPRO_0000084337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751Phosphoserine3 Publications
Modified residuei153 – 1531Phosphothreonine4 Publications
Modified residuei156 – 1561Phosphoserine1 Publication
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Cross-linki309 – 309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi772 – 7721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi904 – 9041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1055 – 10551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1088 – 10881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1263 – 12631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1329 – 13291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ86UP2.
PaxDbiQ86UP2.
PRIDEiQ86UP2.

PTM databases

PhosphoSiteiQ86UP2.

Expressioni

Tissue specificityi

High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Gene expression databases

BgeeiQ86UP2.
CleanExiHS_KTN1.
ExpressionAtlasiQ86UP2. baseline and differential.
GenevestigatoriQ86UP2.

Organism-specific databases

HPAiCAB015331.
HPA003178.
HPA017876.

Interactioni

Subunit structurei

Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.By similarity

Protein-protein interaction databases

BioGridi110092. 35 interactions.
DIPiDIP-27585N.
IntActiQ86UP2. 12 interactions.
MINTiMINT-1149569.
STRINGi9606.ENSP00000348562.

Structurei

3D structure databases

ProteinModelPortaliQ86UP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili330 – 13561027Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the kinectin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149793.
GeneTreeiENSGT00530000063895.
HOGENOMiHOG000113267.
HOVERGENiHBG007851.
InParanoidiQ86UP2.
KOiK17975.
OMAiKEHNVFQ.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ86UP2.
TreeFamiTF333579.

Family and domain databases

InterProiIPR024854. Kinectin.
[Graphical view]
PANTHERiPTHR18864. PTHR18864. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT
60 70 80 90 100
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV
110 120 130 140 150
PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK
160 170 180 190 200
QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET
210 220 230 240 250
KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE
260 270 280 290 300
VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE
310 320 330 340 350
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA
360 370 380 390 400
TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE
410 420 430 440 450
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK
460 470 480 490 500
LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV
510 520 530 540 550
QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL
560 570 580 590 600
MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV
610 620 630 640 650
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE
660 670 680 690 700
VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF
710 720 730 740 750
KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL
760 770 780 790 800
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK
810 820 830 840 850
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL
860 870 880 890 900
EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL
910 920 930 940 950
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK
960 970 980 990 1000
ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV
1010 1020 1030 1040 1050
ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML
1060 1070 1080 1090 1100
QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK
1110 1120 1130 1140 1150
KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL
1160 1170 1180 1190 1200
QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE
1210 1220 1230 1240 1250
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR
1260 1270 1280 1290 1300
QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA
1310 1320 1330 1340 1350
AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK

EHYQVLE
Length:1,357
Mass (Da):156,275
Last modified:June 1, 2003 - v1
Checksum:i971FCDF8AA8FC88E
GO
Isoform 2 (identifier: Q86UP2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1059: Missing.
     1232-1259: Missing.

Show »
Length:1,300
Mass (Da):149,611
Checksum:i5AE4CEBC926D079E
GO
Isoform 3 (identifier: Q86UP2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-854: Missing.
     1232-1259: Missing.

Show »
Length:1,306
Mass (Da):150,353
Checksum:iB972F3DD3C7B6960
GO
Isoform 4 (identifier: Q86UP2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1232-1259: Missing.

Show »
Length:1,329
Mass (Da):152,988
Checksum:i591E551B1658AB77
GO

Sequence cautioni

The sequence AAH50555.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA02794.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151S → P in BAA02794. (PubMed:7584026)Curated
Sequence conflicti210 – 2101Missing in CAA80271. (PubMed:7787243)Curated
Sequence conflicti373 – 3731I → M in CAA80271. (PubMed:7787243)Curated
Sequence conflicti939 – 9391E → G in CAA80271. (PubMed:7787243)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261P → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035931
Natural varianti282 – 2821V → M.
Corresponds to variant rs2274073 [ dbSNP | Ensembl ].
VAR_016206
Natural varianti1316 – 13161T → P in a breast cancer sample; somatic mutation. 1 Publication
VAR_035932

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei832 – 85423Missing in isoform 3. 1 PublicationVSP_043207Add
BLAST
Alternative sequencei1031 – 105929Missing in isoform 2. 2 PublicationsVSP_007981Add
BLAST
Alternative sequencei1232 – 125928Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_007982Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22551 mRNA. Translation: CAA80271.1.
L25616 mRNA. Translation: AAB65853.1.
AY264265 mRNA. Translation: AAP20418.1.
D13629 mRNA. Translation: BAA02794.2. Different initiation.
AK302797 mRNA. Translation: BAG64000.1.
AL138499 Genomic DNA. No translation available.
AL355773 Genomic DNA. No translation available.
BC050555 mRNA. Translation: AAH50555.1. Sequence problems.
BC112337 mRNA. Translation: AAI12338.1.
BC117132 mRNA. Translation: AAI17133.1.
BC143720 mRNA. Translation: AAI43721.1.
AY536375 mRNA. Translation: AAT66048.1.
CCDSiCCDS41957.1. [Q86UP2-1]
CCDS41958.1. [Q86UP2-2]
CCDS41959.1. [Q86UP2-3]
PIRiI53799.
S32763.
RefSeqiNP_001072989.1. NM_001079521.1. [Q86UP2-1]
NP_001072990.1. NM_001079522.1. [Q86UP2-3]
NP_001257943.1. NM_001271014.1. [Q86UP2-4]
NP_004977.2. NM_004986.3. [Q86UP2-2]
XP_006720201.1. XM_006720138.1. [Q86UP2-1]
XP_006720202.1. XM_006720139.1. [Q86UP2-4]
UniGeneiHs.509414.

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777. [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777. [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777. [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777. [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777. [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777. [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777. [Q86UP2-1]
GeneIDi3895.
KEGGihsa:3895.
UCSCiuc001xcb.3. human. [Q86UP2-1]
uc001xcd.3. human. [Q86UP2-3]
uc001xce.3. human. [Q86UP2-2]
uc010trb.2. human.

Polymorphism databases

DMDMi34098465.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22551 mRNA. Translation: CAA80271.1.
L25616 mRNA. Translation: AAB65853.1.
AY264265 mRNA. Translation: AAP20418.1.
D13629 mRNA. Translation: BAA02794.2. Different initiation.
AK302797 mRNA. Translation: BAG64000.1.
AL138499 Genomic DNA. No translation available.
AL355773 Genomic DNA. No translation available.
BC050555 mRNA. Translation: AAH50555.1. Sequence problems.
BC112337 mRNA. Translation: AAI12338.1.
BC117132 mRNA. Translation: AAI17133.1.
BC143720 mRNA. Translation: AAI43721.1.
AY536375 mRNA. Translation: AAT66048.1.
CCDSiCCDS41957.1. [Q86UP2-1]
CCDS41958.1. [Q86UP2-2]
CCDS41959.1. [Q86UP2-3]
PIRiI53799.
S32763.
RefSeqiNP_001072989.1. NM_001079521.1. [Q86UP2-1]
NP_001072990.1. NM_001079522.1. [Q86UP2-3]
NP_001257943.1. NM_001271014.1. [Q86UP2-4]
NP_004977.2. NM_004986.3. [Q86UP2-2]
XP_006720201.1. XM_006720138.1. [Q86UP2-1]
XP_006720202.1. XM_006720139.1. [Q86UP2-4]
UniGeneiHs.509414.

3D structure databases

ProteinModelPortaliQ86UP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110092. 35 interactions.
DIPiDIP-27585N.
IntActiQ86UP2. 12 interactions.
MINTiMINT-1149569.
STRINGi9606.ENSP00000348562.

PTM databases

PhosphoSiteiQ86UP2.

Polymorphism databases

DMDMi34098465.

Proteomic databases

MaxQBiQ86UP2.
PaxDbiQ86UP2.
PRIDEiQ86UP2.

Protocols and materials databases

DNASUi3895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777. [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777. [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777. [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777. [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777. [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777. [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777. [Q86UP2-1]
GeneIDi3895.
KEGGihsa:3895.
UCSCiuc001xcb.3. human. [Q86UP2-1]
uc001xcd.3. human. [Q86UP2-3]
uc001xce.3. human. [Q86UP2-2]
uc010trb.2. human.

Organism-specific databases

CTDi3895.
GeneCardsiGC14P056046.
HGNCiHGNC:6467. KTN1.
HPAiCAB015331.
HPA003178.
HPA017876.
MIMi600381. gene.
neXtProtiNX_Q86UP2.
PharmGKBiPA30256.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149793.
GeneTreeiENSGT00530000063895.
HOGENOMiHOG000113267.
HOVERGENiHBG007851.
InParanoidiQ86UP2.
KOiK17975.
OMAiKEHNVFQ.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ86UP2.
TreeFamiTF333579.

Miscellaneous databases

ChiTaRSiKTN1. human.
GeneWikiiKTN1.
GenomeRNAii3895.
NextBioi15287.
PROiQ86UP2.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UP2.
CleanExiHS_KTN1.
ExpressionAtlasiQ86UP2. baseline and differential.
GenevestigatoriQ86UP2.

Family and domain databases

InterProiIPR024854. Kinectin.
[Graphical view]
PANTHERiPTHR18864. PTHR18864. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of human kinectin."
    Fuetterer A., Kruppa G., Kraemer B., Lemke H., Kroenke M.
    Mol. Biol. Cell 6:161-170(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphoid tissue.
  2. "Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats."
    Print C.G., Leung E., Harrison J.E.B., Watson J.D., Krissansen G.W.
    Gene 144:221-228(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Peripheral blood lymphocyte.
  3. "Identification of a variant of Homo sapiens kinectin mRNA."
    Wang H.-C., Chen W.-F., Su Y.-R.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  6. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-870 (ISOFORMS 1/2).
    Tissue: Cerebellum and Lung.
  8. "Integrin clustering induces kinectin accumulation."
    Tran H., Pankov R., Tran S.D., Hampton B., Burgess W.H., Yamada K.M.
    J. Cell Sci. 115:2031-2040(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 191-195; 395-405; 545-554; 747-761 AND 811-823.
  9. "SEREX-defined rhabdomyosarcoma antigens."
    Behrends U., Gotz C., Mautner J.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 538-1357.
    Tissue: Embryonic rhabdomyosarcoma.
  10. "The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22."
    Print C.G., Morris C.M., Spurr N.K., Rooke L., Krissansen G.W.
    Immunogenetics 43:227-229(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL LOCATION.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-309.
    Tissue: Mammary cancer.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; THR-153 AND SER-156, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-226 AND PRO-1316.

Entry informationi

Entry nameiKTN1_HUMAN
AccessioniPrimary (citable) accession number: Q86UP2
Secondary accession number(s): B4DZ88
, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.