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Q86UP2

- KTN1_HUMAN

UniProt

Q86UP2 - KTN1_HUMAN

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Protein
Kinectin
Gene
KTN1, CG1, KIAA0004
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. microtubule-based movement Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kinectin
Alternative name(s):
CG-1 antigen
Kinesin receptor
Gene namesi
Name:KTN1
Synonyms:CG1, KIAA0004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:6467. KTN1.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type II membrane protein
Note: Vesicle membrane protein anchored to the endoplasmic reticulum.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Cytoplasmic Reviewed prediction
Transmembranei7 – 2923Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini30 – 13571328Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: HPA
  2. endoplasmic reticulum membrane Source: ProtInc
  3. integral component of membrane Source: ProtInc
  4. integral component of plasma membrane Source: ProtInc
  5. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13571357Kinectin
PRO_0000084337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751Phosphoserine3 Publications
Modified residuei153 – 1531Phosphothreonine4 Publications
Modified residuei156 – 1561Phosphoserine1 Publication
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Cross-linki309 – 309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi772 – 7721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi904 – 9041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1055 – 10551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1088 – 10881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1263 – 12631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1329 – 13291N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ86UP2.
PaxDbiQ86UP2.
PRIDEiQ86UP2.

PTM databases

PhosphoSiteiQ86UP2.

Expressioni

Tissue specificityi

High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Gene expression databases

ArrayExpressiQ86UP2.
BgeeiQ86UP2.
CleanExiHS_KTN1.
GenevestigatoriQ86UP2.

Organism-specific databases

HPAiCAB015331.
HPA003178.
HPA017876.

Interactioni

Subunit structurei

Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms By similarity.

Protein-protein interaction databases

BioGridi110092. 22 interactions.
DIPiDIP-27585N.
IntActiQ86UP2. 10 interactions.
MINTiMINT-1149569.
STRINGi9606.ENSP00000348562.

Structurei

3D structure databases

ProteinModelPortaliQ86UP2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili330 – 13561027 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the kinectin family.

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149793.
HOGENOMiHOG000113267.
HOVERGENiHBG007851.
InParanoidiQ86UP2.
KOiK17975.
OMAiKMQQSVY.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ86UP2.
TreeFamiTF333579.

Family and domain databases

InterProiIPR024854. Kinectin.
[Graphical view]
PANTHERiPTHR18864. PTHR18864. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT     50
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV 100
PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK 150
QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET 200
KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE 250
VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 300
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA 350
TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE 400
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK 450
LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV 500
QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL 550
MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 600
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE 650
VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF 700
KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL 750
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK 800
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL 850
EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL 900
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK 950
ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV 1000
ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML 1050
QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK 1100
KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL 1150
QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE 1200
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR 1250
QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA 1300
AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK 1350
EHYQVLE 1357
Length:1,357
Mass (Da):156,275
Last modified:June 1, 2003 - v1
Checksum:i971FCDF8AA8FC88E
GO
Isoform 2 (identifier: Q86UP2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1059: Missing.
     1232-1259: Missing.

Show »
Length:1,300
Mass (Da):149,611
Checksum:i5AE4CEBC926D079E
GO
Isoform 3 (identifier: Q86UP2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-854: Missing.
     1232-1259: Missing.

Show »
Length:1,306
Mass (Da):150,353
Checksum:iB972F3DD3C7B6960
GO
Isoform 4 (identifier: Q86UP2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1232-1259: Missing.

Show »
Length:1,329
Mass (Da):152,988
Checksum:i591E551B1658AB77
GO

Sequence cautioni

The sequence AAH50555.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAA02794.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261P → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035931
Natural varianti282 – 2821V → M.
Corresponds to variant rs2274073 [ dbSNP | Ensembl ].
VAR_016206
Natural varianti1316 – 13161T → P in a breast cancer sample; somatic mutation. 1 Publication
VAR_035932

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei832 – 85423Missing in isoform 3.
VSP_043207Add
BLAST
Alternative sequencei1031 – 105929Missing in isoform 2.
VSP_007981Add
BLAST
Alternative sequencei1232 – 125928Missing in isoform 2, isoform 3 and isoform 4.
VSP_007982Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151S → P in BAA02794. 1 Publication
Sequence conflicti210 – 2101Missing in CAA80271. 1 Publication
Sequence conflicti373 – 3731I → M in CAA80271. 1 Publication
Sequence conflicti939 – 9391E → G in CAA80271. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22551 mRNA. Translation: CAA80271.1.
L25616 mRNA. Translation: AAB65853.1.
AY264265 mRNA. Translation: AAP20418.1.
D13629 mRNA. Translation: BAA02794.2. Different initiation.
AK302797 mRNA. Translation: BAG64000.1.
AL138499 Genomic DNA. No translation available.
AL355773 Genomic DNA. No translation available.
BC050555 mRNA. Translation: AAH50555.1. Sequence problems.
BC112337 mRNA. Translation: AAI12338.1.
BC117132 mRNA. Translation: AAI17133.1.
BC143720 mRNA. Translation: AAI43721.1.
AY536375 mRNA. Translation: AAT66048.1.
CCDSiCCDS41957.1. [Q86UP2-1]
CCDS41958.1. [Q86UP2-2]
CCDS41959.1. [Q86UP2-3]
PIRiI53799.
S32763.
RefSeqiNP_001072989.1. NM_001079521.1. [Q86UP2-1]
NP_001072990.1. NM_001079522.1. [Q86UP2-3]
NP_001257943.1. NM_001271014.1. [Q86UP2-4]
NP_004977.2. NM_004986.3. [Q86UP2-2]
XP_006720201.1. XM_006720138.1. [Q86UP2-1]
XP_006720202.1. XM_006720139.1. [Q86UP2-4]
UniGeneiHs.509414.

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777. [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777. [Q86UP2-1]
ENST00000395311; ENSP00000378722; ENSG00000126777. [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777. [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777. [Q86UP2-3]
ENST00000416613; ENSP00000388807; ENSG00000126777. [Q86UP2-1]
ENST00000438792; ENSP00000391964; ENSG00000126777. [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777. [Q86UP2-1]
GeneIDi3895.
KEGGihsa:3895.
UCSCiuc001xcb.3. human. [Q86UP2-1]
uc001xcd.3. human. [Q86UP2-3]
uc001xce.3. human. [Q86UP2-2]

Polymorphism databases

DMDMi34098465.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22551 mRNA. Translation: CAA80271.1 .
L25616 mRNA. Translation: AAB65853.1 .
AY264265 mRNA. Translation: AAP20418.1 .
D13629 mRNA. Translation: BAA02794.2 . Different initiation.
AK302797 mRNA. Translation: BAG64000.1 .
AL138499 Genomic DNA. No translation available.
AL355773 Genomic DNA. No translation available.
BC050555 mRNA. Translation: AAH50555.1 . Sequence problems.
BC112337 mRNA. Translation: AAI12338.1 .
BC117132 mRNA. Translation: AAI17133.1 .
BC143720 mRNA. Translation: AAI43721.1 .
AY536375 mRNA. Translation: AAT66048.1 .
CCDSi CCDS41957.1. [Q86UP2-1 ]
CCDS41958.1. [Q86UP2-2 ]
CCDS41959.1. [Q86UP2-3 ]
PIRi I53799.
S32763.
RefSeqi NP_001072989.1. NM_001079521.1. [Q86UP2-1 ]
NP_001072990.1. NM_001079522.1. [Q86UP2-3 ]
NP_001257943.1. NM_001271014.1. [Q86UP2-4 ]
NP_004977.2. NM_004986.3. [Q86UP2-2 ]
XP_006720201.1. XM_006720138.1. [Q86UP2-1 ]
XP_006720202.1. XM_006720139.1. [Q86UP2-4 ]
UniGenei Hs.509414.

3D structure databases

ProteinModelPortali Q86UP2.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110092. 22 interactions.
DIPi DIP-27585N.
IntActi Q86UP2. 10 interactions.
MINTi MINT-1149569.
STRINGi 9606.ENSP00000348562.

PTM databases

PhosphoSitei Q86UP2.

Polymorphism databases

DMDMi 34098465.

Proteomic databases

MaxQBi Q86UP2.
PaxDbi Q86UP2.
PRIDEi Q86UP2.

Protocols and materials databases

DNASUi 3895.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395308 ; ENSP00000378719 ; ENSG00000126777 . [Q86UP2-3 ]
ENST00000395309 ; ENSP00000378720 ; ENSG00000126777 . [Q86UP2-1 ]
ENST00000395311 ; ENSP00000378722 ; ENSG00000126777 . [Q86UP2-3 ]
ENST00000395314 ; ENSP00000378725 ; ENSG00000126777 . [Q86UP2-1 ]
ENST00000413890 ; ENSP00000394992 ; ENSG00000126777 . [Q86UP2-3 ]
ENST00000416613 ; ENSP00000388807 ; ENSG00000126777 . [Q86UP2-1 ]
ENST00000438792 ; ENSP00000391964 ; ENSG00000126777 . [Q86UP2-2 ]
ENST00000459737 ; ENSP00000432149 ; ENSG00000126777 . [Q86UP2-1 ]
GeneIDi 3895.
KEGGi hsa:3895.
UCSCi uc001xcb.3. human. [Q86UP2-1 ]
uc001xcd.3. human. [Q86UP2-3 ]
uc001xce.3. human. [Q86UP2-2 ]

Organism-specific databases

CTDi 3895.
GeneCardsi GC14P056046.
HGNCi HGNC:6467. KTN1.
HPAi CAB015331.
HPA003178.
HPA017876.
MIMi 600381. gene.
neXtProti NX_Q86UP2.
PharmGKBi PA30256.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149793.
HOGENOMi HOG000113267.
HOVERGENi HBG007851.
InParanoidi Q86UP2.
KOi K17975.
OMAi KMQQSVY.
OrthoDBi EOG7ZWD1D.
PhylomeDBi Q86UP2.
TreeFami TF333579.

Miscellaneous databases

ChiTaRSi KTN1. human.
GeneWikii KTN1.
GenomeRNAii 3895.
NextBioi 15287.
PROi Q86UP2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86UP2.
Bgeei Q86UP2.
CleanExi HS_KTN1.
Genevestigatori Q86UP2.

Family and domain databases

InterProi IPR024854. Kinectin.
[Graphical view ]
PANTHERi PTHR18864. PTHR18864. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of human kinectin."
    Fuetterer A., Kruppa G., Kraemer B., Lemke H., Kroenke M.
    Mol. Biol. Cell 6:161-170(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphoid tissue.
  2. "Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats."
    Print C.G., Leung E., Harrison J.E.B., Watson J.D., Krissansen G.W.
    Gene 144:221-228(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Peripheral blood lymphocyte.
  3. "Identification of a variant of Homo sapiens kinectin mRNA."
    Wang H.-C., Chen W.-F., Su Y.-R.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  6. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-870 (ISOFORMS 1/2).
    Tissue: Cerebellum and Lung.
  8. "Integrin clustering induces kinectin accumulation."
    Tran H., Pankov R., Tran S.D., Hampton B., Burgess W.H., Yamada K.M.
    J. Cell Sci. 115:2031-2040(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 191-195; 395-405; 545-554; 747-761 AND 811-823.
  9. "SEREX-defined rhabdomyosarcoma antigens."
    Behrends U., Gotz C., Mautner J.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 538-1357.
    Tissue: Embryonic rhabdomyosarcoma.
  10. "The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22."
    Print C.G., Morris C.M., Spurr N.K., Rooke L., Krissansen G.W.
    Immunogenetics 43:227-229(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL LOCATION.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-309.
    Tissue: Mammary cancer.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; THR-153 AND SER-156, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-226 AND PRO-1316.

Entry informationi

Entry nameiKTN1_HUMAN
AccessioniPrimary (citable) accession number: Q86UP2
Secondary accession number(s): B4DZ88
, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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