Q86UP2 (KTN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinectin

Alternative name(s):
CG-1 antigen
Kinesin receptor

Gene names

Name:	KTN1
Synonyms:	CG1, KIAA0004

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1357 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Subunit structure	Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note: Vesicle membrane protein anchored to the endoplasmic reticulum.
Tissue specificity	High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.
Sequence similarities	Belongs to the kinectin family.
Sequence caution	The sequence AAH50555.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA02794.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Signal-anchor Transmembrane Transmembrane helix
PTM	Glycoprotein Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Non-traceable author statement Ref.1. Source: ProtInc
Cellular_component	endoplasmic reticulum membrane Traceable author statement Ref.1. Source: ProtInc integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q86UP2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86UP2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1059: Missing.
     1232-1259: Missing.

Isoform 3 (identifier: Q86UP2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     832-854: Missing.
     1232-1259: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1357	1357	Kinectin		PRO_0000084337
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 29	23	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	30 – 1357	1328	Lumenal Potential
	Coiled coil	330 – 1356	1027	Potential
Amino acid modifications
	Modified residue	75	1	Phosphoserine Ref.11 Ref.12 Ref.14
	Modified residue	153	1	Phosphothreonine Ref.9 Ref.11 Ref.12 Ref.14
	Modified residue	156	1	Phosphoserine Ref.11
	Glycosylation	172	1	N-linked (GlcNAc...) Potential
	Glycosylation	435	1	N-linked (GlcNAc...) Potential
	Glycosylation	772	1	N-linked (GlcNAc...) Potential
	Glycosylation	904	1	N-linked (GlcNAc...) Potential
	Glycosylation	1055	1	N-linked (GlcNAc...) Potential
	Glycosylation	1088	1	N-linked (GlcNAc...) Potential
	Glycosylation	1263	1	N-linked (GlcNAc...) Potential
	Glycosylation	1329	1	N-linked (GlcNAc...) Potential
	Cross-link	309		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.10
Natural variations
	Alternative sequence	832 – 854	23	Missing in isoform 3.		VSP_043207
	Alternative sequence	1031 – 1059	29	Missing in isoform 2.		VSP_007981
	Alternative sequence	1232 – 1259	28	Missing in isoform 2 and isoform 3.		VSP_007982
	Natural variant	226	1	P → R in a breast cancer sample; somatic mutation. Ref.15		VAR_035931
	Natural variant	282	1	V → M. Corresponds to variant rs2274073 [ dbSNP | Ensembl ].		VAR_016206
	Natural variant	1316	1	T → P in a breast cancer sample; somatic mutation. Ref.15		VAR_035932
Experimental info
	Sequence conflict	15	1	S → P in BAA02794. Ref.4
	Sequence conflict	210	1	Missing in CAA80271. Ref.1
	Sequence conflict	373	1	I → M in CAA80271. Ref.1
	Sequence conflict	939	1	E → G in CAA80271. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 971FCDF8AA8FC88E	FASTA	1,357	156,275
	10 20 30 40 50 60 MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK 70 80 90 100 110 120 KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK 130 140 150 160 170 180 QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK 190 200 210 220 230 240 VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA 250 260 270 280 290 300 DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 310 320 330 340 350 360 ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ 370 380 390 400 410 420 EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA 430 440 450 460 470 480 HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE 490 500 510 520 530 540 QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL 550 560 570 580 590 600 VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 610 620 630 640 650 660 LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE 670 680 690 700 710 720 QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL 730 740 750 760 770 780 VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ 790 800 810 820 830 840 DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA 850 860 870 880 890 900 LKEEIGNVQL EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL 910 920 930 940 950 960 QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK ERESDLSSKT 970 980 990 1000 1010 1020 QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV ISEREKEISG LWNELDSLKD 1030 1040 1050 1060 1070 1080 AVEHQRKKNN DLREKNWEAM EALASTEKML QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF 1090 1100 1110 1120 1130 1140 PKVSVPSNLS YGEWLHGFEK KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK 1150 1160 1170 1180 1190 1200 SVLAETEGIL QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE 1210 1220 1230 1240 1250 1260 NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR QNEELNLLKA 1270 1280 1290 1300 1310 1320 QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA AGDTTVIENS DVSPETESSE 1330 1340 1350 KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK EHYQVLE
	Isoform 2 [UniParc]. Checksum: 5AE4CEBC926D079E	FASTA	1,300	149,611
	10 20 30 40 50 60 MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK 70 80 90 100 110 120 KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK 130 140 150 160 170 180 QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK 190 200 210 220 230 240 VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA 250 260 270 280 290 300 DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 310 320 330 340 350 360 ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ 370 380 390 400 410 420 EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA 430 440 450 460 470 480 HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE 490 500 510 520 530 540 QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL 550 560 570 580 590 600 VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 610 620 630 640 650 660 LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE 670 680 690 700 710 720 QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL 730 740 750 760 770 780 VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ 790 800 810 820 830 840 DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA 850 860 870 880 890 900 LKEEIGNVQL EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL 910 920 930 940 950 960 QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK ERESDLSSKT 970 980 990 1000 1010 1020 QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV ISEREKEISG LWNELDSLKD 1030 1040 1050 1060 1070 1080 AVEHQRKKNN ERQQQVEAVE LEAKEVLKKL FPKVSVPSNL SYGEWLHGFE KKAKECMAGT 1090 1100 1110 1120 1130 1140 SGSEEVKVLE HKLKEADEMH TLLQLECEKY KSVLAETEGI LQKLQRSVEQ EENKWKVKVD 1150 1160 1170 1180 1190 1200 ESHKTIKQMQ SSFTSSEQEL ERLRSENKDI ENLRREREHL EMELEKAEME RSTYVTEVRE 1210 1220 1230 1240 1250 1260 LKAQLNETLT KLRTEQNERQ KVAGDLHKAQ QSLELIQSKI VKAAGDTTVI ENSDVSPETE 1270 1280 1290 1300 SSEKETMSVS LNQTVTQLQQ LLQAVNQQLT KEKEHYQVLE
	Isoform 3 [UniParc]. Checksum: B972F3DD3C7B6960	FASTA	1,306	150,353
	10 20 30 40 50 60 MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK 70 80 90 100 110 120 KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK 130 140 150 160 170 180 QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK 190 200 210 220 230 240 VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA 250 260 270 280 290 300 DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 310 320 330 340 350 360 ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ 370 380 390 400 410 420 EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA 430 440 450 460 470 480 HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE 490 500 510 520 530 540 QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL 550 560 570 580 590 600 VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 610 620 630 640 650 660 LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE 670 680 690 700 710 720 QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL 730 740 750 760 770 780 VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ 790 800 810 820 830 840 DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQLSITSKVQ 850 860 870 880 890 900 ELQNLLKGKE EQMNTMKAVL EEKEKDLANT GKWLQDLQEE NESLKAHVQE VAQHNLKEAS 910 920 930 940 950 960 SASQFEELEI VLKEKENELK RLEAMLKERE SDLSSKTQLL QDVQDENKLF KSQIEQLKQQ 970 980 990 1000 1010 1020 NYQQASSFPP HEELLKVISE REKEISGLWN ELDSLKDAVE HQRKKNNDLR EKNWEAMEAL 1030 1040 1050 1060 1070 1080 ASTEKMLQDK VNKTSKERQQ QVEAVELEAK EVLKKLFPKV SVPSNLSYGE WLHGFEKKAK 1090 1100 1110 1120 1130 1140 ECMAGTSGSE EVKVLEHKLK EADEMHTLLQ LECEKYKSVL AETEGILQKL QRSVEQEENK 1150 1160 1170 1180 1190 1200 WKVKVDESHK TIKQMQSSFT SSEQELERLR SENKDIENLR REREHLEMEL EKAEMERSTY 1210 1220 1230 1240 1250 1260 VTEVRELKAQ LNETLTKLRT EQNERQKVAG DLHKAQQSLE LIQSKIVKAA GDTTVIENSD 1270 1280 1290 1300 VSPETESSEK ETMSVSLNQT VTQLQQLLQA VNQQLTKEKE HYQVLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of human kinectin." Fuetterer A., Kruppa G., Kraemer B., Lemke H., Kroenke M. Mol. Biol. Cell 6:161-170(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Lymphoid tissue.
[2]	"Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats." Print C.G., Leung E., Harrison J.E.B., Watson J.D., Krissansen G.W. Gene 144:221-228(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Peripheral blood lymphocyte.
[3]	"Identification of a variant of Homo sapiens kinectin mRNA." Wang H.-C., Chen W.-F., Su Y.-R. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-870 (ISOFORMS 1/2). Tissue: Lung.
[7]	"Integrin clustering induces kinectin accumulation." Tran H., Pankov R., Tran S.D., Hampton B., Burgess W.H., Yamada K.M. J. Cell Sci. 115:2031-2040(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 191-195; 395-405; 545-554; 747-761 AND 811-823.
[8]	"The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22." Print C.G., Morris C.M., Spurr N.K., Rooke L., Krissansen G.W. Immunogenetics 43:227-229(1996) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL LOCATION.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-309, MASS SPECTROMETRY. Tissue: Mammary cancer.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; THR-153 AND SER-156, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, MASS SPECTROMETRY.
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-226 AND PRO-1316.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z22551 mRNA. Translation: CAA80271.1. L25616 mRNA. Translation: AAB65853.1. AY264265 mRNA. Translation: AAP20418.1. D13629 mRNA. Translation: BAA02794.2. Different initiation. AL138499 Genomic DNA. No translation available. AL355773 Genomic DNA. No translation available. BC050555 mRNA. Translation: AAH50555.1. Sequence problems. BC112337 mRNA. Translation: AAI12338.1. BC117132 mRNA. Translation: AAI17133.1.
IPI	IPI00328753. IPI00337736.
PIR	I53799. S32763.
RefSeq	NP_001072989.1. NM_001079521.1. NP_001072990.1. NM_001079522.1. NP_004977.2. NM_004986.3.
UniGene	Hs.509414.
3D structure databases
ProteinModelPortal	Q86UP2.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27585N.
IntAct	Q86UP2. 6 interactions.
MINT	MINT-1149569.
STRING	9606.ENSP00000348562.
PTM databases
PhosphoSite	Q86UP2.
Polymorphism databases
DMDM	34098465.
Proteomic databases
PaxDb	Q86UP2.
PRIDE	Q86UP2.
Protocols and materials databases
DNASU	3895.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395308; ENSP00000378719; ENSG00000126777. ENST00000395309; ENSP00000378720; ENSG00000126777. ENST00000395311; ENSP00000378722; ENSG00000126777. ENST00000395314; ENSP00000378725; ENSG00000126777. ENST00000413890; ENSP00000394992; ENSG00000126777. ENST00000416613; ENSP00000388807; ENSG00000126777. ENST00000438792; ENSP00000391964; ENSG00000126777. ENST00000459737; ENSP00000432149; ENSG00000126777.
GeneID	3895.
KEGG	hsa:3895.
UCSC	uc001xcb.3. human. uc001xcd.3. human. uc001xce.3. human.
Organism-specific databases
CTD	3895.
GeneCards	GC14P056046.
HGNC	HGNC:6467. KTN1.
HPA	CAB015331. HPA003178. HPA017876.
MIM	600381. gene.
neXtProt	NX_Q86UP2.
PharmGKB	PA30256.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149793.
HOGENOM	HOG000113267.
HOVERGEN	HBG007851.
InParanoid	Q86UP2.
OMA	IPLMDNA.
PhylomeDB	Q86UP2.
Gene expression databases
ArrayExpress	Q86UP2.
Bgee	Q86UP2.
CleanEx	HS_KTN1.
Genevestigator	Q86UP2.
GermOnline	ENSG00000126777. Homo sapiens.
Family and domain databases
InterPro	IPR024854. Kinectin. [Graphical view]
PANTHER	PTHR18864. PTHR18864. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	KTN1. human.
GenomeRNAi	3895.
NextBio	15287.
SOURCE	Search...

Entry information

Entry name

KTN1_HUMAN

Accession

Primary (citable) accession number: Q86UP2
Secondary accession number(s): Q13999 , Q14707, Q15387, Q17RZ5, Q86W57

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.