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Q86UP2

- KTN1_HUMAN

UniProt

Q86UP2 - KTN1_HUMAN

Protein

Kinectin

Gene

KTN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. microtubule-based movement Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinectin
    Alternative name(s):
    CG-1 antigen
    Kinesin receptor
    Gene namesi
    Name:KTN1
    Synonyms:CG1, KIAA0004
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6467. KTN1.

    Subcellular locationi

    Endoplasmic reticulum membrane; Single-pass type II membrane protein
    Note: Vesicle membrane protein anchored to the endoplasmic reticulum.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HPA
    2. endoplasmic reticulum membrane Source: ProtInc
    3. integral component of membrane Source: ProtInc
    4. integral component of plasma membrane Source: ProtInc
    5. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30256.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13571357KinectinPRO_0000084337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei75 – 751Phosphoserine3 Publications
    Modified residuei153 – 1531Phosphothreonine4 Publications
    Modified residuei156 – 1561Phosphoserine1 Publication
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Cross-linki309 – 309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi772 – 7721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi904 – 9041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1055 – 10551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1088 – 10881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1263 – 12631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1329 – 13291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ86UP2.
    PaxDbiQ86UP2.
    PRIDEiQ86UP2.

    PTM databases

    PhosphoSiteiQ86UP2.

    Expressioni

    Tissue specificityi

    High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

    Gene expression databases

    ArrayExpressiQ86UP2.
    BgeeiQ86UP2.
    CleanExiHS_KTN1.
    GenevestigatoriQ86UP2.

    Organism-specific databases

    HPAiCAB015331.
    HPA003178.
    HPA017876.

    Interactioni

    Subunit structurei

    Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.By similarity

    Protein-protein interaction databases

    BioGridi110092. 22 interactions.
    DIPiDIP-27585N.
    IntActiQ86UP2. 12 interactions.
    MINTiMINT-1149569.
    STRINGi9606.ENSP00000348562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UP2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini30 – 13571328LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili330 – 13561027Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the kinectin family.Curated

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149793.
    HOGENOMiHOG000113267.
    HOVERGENiHBG007851.
    InParanoidiQ86UP2.
    KOiK17975.
    OMAiKMQQSVY.
    OrthoDBiEOG7ZWD1D.
    PhylomeDBiQ86UP2.
    TreeFamiTF333579.

    Family and domain databases

    InterProiIPR024854. Kinectin.
    [Graphical view]
    PANTHERiPTHR18864. PTHR18864. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT     50
    KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV 100
    PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK 150
    QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET 200
    KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE 250
    VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 300
    ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA 350
    TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE 400
    TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK 450
    LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV 500
    QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL 550
    MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 600
    LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE 650
    VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF 700
    KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL 750
    LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK 800
    KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL 850
    EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL 900
    QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK 950
    ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV 1000
    ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML 1050
    QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK 1100
    KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL 1150
    QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE 1200
    NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR 1250
    QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA 1300
    AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK 1350
    EHYQVLE 1357
    Length:1,357
    Mass (Da):156,275
    Last modified:June 1, 2003 - v1
    Checksum:i971FCDF8AA8FC88E
    GO
    Isoform 2 (identifier: Q86UP2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1031-1059: Missing.
         1232-1259: Missing.

    Show »
    Length:1,300
    Mass (Da):149,611
    Checksum:i5AE4CEBC926D079E
    GO
    Isoform 3 (identifier: Q86UP2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         832-854: Missing.
         1232-1259: Missing.

    Show »
    Length:1,306
    Mass (Da):150,353
    Checksum:iB972F3DD3C7B6960
    GO
    Isoform 4 (identifier: Q86UP2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1232-1259: Missing.

    Show »
    Length:1,329
    Mass (Da):152,988
    Checksum:i591E551B1658AB77
    GO

    Sequence cautioni

    The sequence AAH50555.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA02794.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151S → P in BAA02794. (PubMed:7584026)Curated
    Sequence conflicti210 – 2101Missing in CAA80271. (PubMed:7787243)Curated
    Sequence conflicti373 – 3731I → M in CAA80271. (PubMed:7787243)Curated
    Sequence conflicti939 – 9391E → G in CAA80271. (PubMed:7787243)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti226 – 2261P → R in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035931
    Natural varianti282 – 2821V → M.
    Corresponds to variant rs2274073 [ dbSNP | Ensembl ].
    VAR_016206
    Natural varianti1316 – 13161T → P in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035932

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei832 – 85423Missing in isoform 3. 1 PublicationVSP_043207Add
    BLAST
    Alternative sequencei1031 – 105929Missing in isoform 2. 2 PublicationsVSP_007981Add
    BLAST
    Alternative sequencei1232 – 125928Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_007982Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22551 mRNA. Translation: CAA80271.1.
    L25616 mRNA. Translation: AAB65853.1.
    AY264265 mRNA. Translation: AAP20418.1.
    D13629 mRNA. Translation: BAA02794.2. Different initiation.
    AK302797 mRNA. Translation: BAG64000.1.
    AL138499 Genomic DNA. No translation available.
    AL355773 Genomic DNA. No translation available.
    BC050555 mRNA. Translation: AAH50555.1. Sequence problems.
    BC112337 mRNA. Translation: AAI12338.1.
    BC117132 mRNA. Translation: AAI17133.1.
    BC143720 mRNA. Translation: AAI43721.1.
    AY536375 mRNA. Translation: AAT66048.1.
    CCDSiCCDS41957.1. [Q86UP2-1]
    CCDS41958.1. [Q86UP2-2]
    CCDS41959.1. [Q86UP2-3]
    PIRiI53799.
    S32763.
    RefSeqiNP_001072989.1. NM_001079521.1. [Q86UP2-1]
    NP_001072990.1. NM_001079522.1. [Q86UP2-3]
    NP_001257943.1. NM_001271014.1. [Q86UP2-4]
    NP_004977.2. NM_004986.3. [Q86UP2-2]
    XP_006720201.1. XM_006720138.1. [Q86UP2-1]
    XP_006720202.1. XM_006720139.1. [Q86UP2-4]
    UniGeneiHs.509414.

    Genome annotation databases

    EnsembliENST00000395308; ENSP00000378719; ENSG00000126777. [Q86UP2-3]
    ENST00000395309; ENSP00000378720; ENSG00000126777. [Q86UP2-1]
    ENST00000395311; ENSP00000378722; ENSG00000126777. [Q86UP2-3]
    ENST00000395314; ENSP00000378725; ENSG00000126777. [Q86UP2-1]
    ENST00000413890; ENSP00000394992; ENSG00000126777. [Q86UP2-3]
    ENST00000438792; ENSP00000391964; ENSG00000126777. [Q86UP2-2]
    ENST00000459737; ENSP00000432149; ENSG00000126777. [Q86UP2-1]
    GeneIDi3895.
    KEGGihsa:3895.
    UCSCiuc001xcb.3. human. [Q86UP2-1]
    uc001xcd.3. human. [Q86UP2-3]
    uc001xce.3. human. [Q86UP2-2]

    Polymorphism databases

    DMDMi34098465.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22551 mRNA. Translation: CAA80271.1 .
    L25616 mRNA. Translation: AAB65853.1 .
    AY264265 mRNA. Translation: AAP20418.1 .
    D13629 mRNA. Translation: BAA02794.2 . Different initiation.
    AK302797 mRNA. Translation: BAG64000.1 .
    AL138499 Genomic DNA. No translation available.
    AL355773 Genomic DNA. No translation available.
    BC050555 mRNA. Translation: AAH50555.1 . Sequence problems.
    BC112337 mRNA. Translation: AAI12338.1 .
    BC117132 mRNA. Translation: AAI17133.1 .
    BC143720 mRNA. Translation: AAI43721.1 .
    AY536375 mRNA. Translation: AAT66048.1 .
    CCDSi CCDS41957.1. [Q86UP2-1 ]
    CCDS41958.1. [Q86UP2-2 ]
    CCDS41959.1. [Q86UP2-3 ]
    PIRi I53799.
    S32763.
    RefSeqi NP_001072989.1. NM_001079521.1. [Q86UP2-1 ]
    NP_001072990.1. NM_001079522.1. [Q86UP2-3 ]
    NP_001257943.1. NM_001271014.1. [Q86UP2-4 ]
    NP_004977.2. NM_004986.3. [Q86UP2-2 ]
    XP_006720201.1. XM_006720138.1. [Q86UP2-1 ]
    XP_006720202.1. XM_006720139.1. [Q86UP2-4 ]
    UniGenei Hs.509414.

    3D structure databases

    ProteinModelPortali Q86UP2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110092. 22 interactions.
    DIPi DIP-27585N.
    IntActi Q86UP2. 12 interactions.
    MINTi MINT-1149569.
    STRINGi 9606.ENSP00000348562.

    PTM databases

    PhosphoSitei Q86UP2.

    Polymorphism databases

    DMDMi 34098465.

    Proteomic databases

    MaxQBi Q86UP2.
    PaxDbi Q86UP2.
    PRIDEi Q86UP2.

    Protocols and materials databases

    DNASUi 3895.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395308 ; ENSP00000378719 ; ENSG00000126777 . [Q86UP2-3 ]
    ENST00000395309 ; ENSP00000378720 ; ENSG00000126777 . [Q86UP2-1 ]
    ENST00000395311 ; ENSP00000378722 ; ENSG00000126777 . [Q86UP2-3 ]
    ENST00000395314 ; ENSP00000378725 ; ENSG00000126777 . [Q86UP2-1 ]
    ENST00000413890 ; ENSP00000394992 ; ENSG00000126777 . [Q86UP2-3 ]
    ENST00000438792 ; ENSP00000391964 ; ENSG00000126777 . [Q86UP2-2 ]
    ENST00000459737 ; ENSP00000432149 ; ENSG00000126777 . [Q86UP2-1 ]
    GeneIDi 3895.
    KEGGi hsa:3895.
    UCSCi uc001xcb.3. human. [Q86UP2-1 ]
    uc001xcd.3. human. [Q86UP2-3 ]
    uc001xce.3. human. [Q86UP2-2 ]

    Organism-specific databases

    CTDi 3895.
    GeneCardsi GC14P056046.
    HGNCi HGNC:6467. KTN1.
    HPAi CAB015331.
    HPA003178.
    HPA017876.
    MIMi 600381. gene.
    neXtProti NX_Q86UP2.
    PharmGKBi PA30256.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149793.
    HOGENOMi HOG000113267.
    HOVERGENi HBG007851.
    InParanoidi Q86UP2.
    KOi K17975.
    OMAi KMQQSVY.
    OrthoDBi EOG7ZWD1D.
    PhylomeDBi Q86UP2.
    TreeFami TF333579.

    Miscellaneous databases

    ChiTaRSi KTN1. human.
    GeneWikii KTN1.
    GenomeRNAii 3895.
    NextBioi 15287.
    PROi Q86UP2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UP2.
    Bgeei Q86UP2.
    CleanExi HS_KTN1.
    Genevestigatori Q86UP2.

    Family and domain databases

    InterProi IPR024854. Kinectin.
    [Graphical view ]
    PANTHERi PTHR18864. PTHR18864. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of human kinectin."
      Fuetterer A., Kruppa G., Kraemer B., Lemke H., Kroenke M.
      Mol. Biol. Cell 6:161-170(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lymphoid tissue.
    2. "Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats."
      Print C.G., Leung E., Harrison J.E.B., Watson J.D., Krissansen G.W.
      Gene 144:221-228(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Peripheral blood lymphocyte.
    3. "Identification of a variant of Homo sapiens kinectin mRNA."
      Wang H.-C., Chen W.-F., Su Y.-R.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone marrow.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    6. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-870 (ISOFORMS 1/2).
      Tissue: Cerebellum and Lung.
    8. "Integrin clustering induces kinectin accumulation."
      Tran H., Pankov R., Tran S.D., Hampton B., Burgess W.H., Yamada K.M.
      J. Cell Sci. 115:2031-2040(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 191-195; 395-405; 545-554; 747-761 AND 811-823.
    9. "SEREX-defined rhabdomyosarcoma antigens."
      Behrends U., Gotz C., Mautner J.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 538-1357.
      Tissue: Embryonic rhabdomyosarcoma.
    10. "The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22."
      Print C.G., Morris C.M., Spurr N.K., Rooke L., Krissansen G.W.
      Immunogenetics 43:227-229(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL LOCATION.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-309.
      Tissue: Mammary cancer.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; THR-153 AND SER-156, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-226 AND PRO-1316.

    Entry informationi

    Entry nameiKTN1_HUMAN
    AccessioniPrimary (citable) accession number: Q86UP2
    Secondary accession number(s): B4DZ88
    , Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3