Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-24

Gene

CDH24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.1 Publication

GO - Molecular functioni

  • alpha-catenin binding Source: UniProtKB
  • beta-catenin binding Source: UniProtKB
  • calcium ion binding Source: MGI
  • delta-catenin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-24
Gene namesi
Name:CDH24
Synonyms:CDH11L
ORF Names:UNQ2834/PRO34009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:14265. CDH24.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 641597ExtracellularSequence analysisAdd
BLAST
Transmembranei642 – 66221HelicalSequence analysisAdd
BLAST
Topological domaini663 – 819157CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26297.

Polymorphism and mutation databases

BioMutaiCDH24.
DMDMi38257450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei21 – 4424Sequence analysisPRO_0000003827Add
BLAST
Chaini45 – 819775Cadherin-24PRO_0000003828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence analysis
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence analysis
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ86UP0.
PRIDEiQ86UP0.

2D gel databases

UCD-2DPAGEQ86UP0.

PTM databases

iPTMnetiQ86UP0.
PhosphoSiteiQ86UP0.

Expressioni

Gene expression databases

BgeeiQ86UP0.
CleanExiHS_CDH24.
ExpressionAtlasiQ86UP0. baseline and differential.
GenevisibleiQ86UP0. HS.

Interactioni

Subunit structurei

Associates with alpha-, beta- and delta-catenins.

GO - Molecular functioni

  • alpha-catenin binding Source: UniProtKB
  • beta-catenin binding Source: UniProtKB
  • delta-catenin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122158. 4 interactions.
IntActiQ86UP0. 1 interaction.
STRINGi9606.ENSP00000267383.

Structurei

3D structure databases

ProteinModelPortaliQ86UP0.
SMRiQ86UP0. Positions 45-615, 719-813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 150105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 259109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini260 – 374115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini375 – 517143Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini517 – 630114Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ86UP0.
KOiK06814.
OMAiRVWHNLT.
OrthoDBiEOG7M3HZN.
PhylomeDBiQ86UP0.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UP0-1) [UniParc]FASTAAdd to basket

Also known as: Long form

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWGLVRLLLA WLGGWGCMGR LAAPARAWAG SREHPGPALL RTRRSWVWNQ
60 70 80 90 100
FFVIEEYAGP EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN
110 120 130 140 150
IHVTKSLDRE EKAQYVLLAQ AVDRASNRPL EPPSEFIIKV QDINDNPPIF
160 170 180 190 200
PLGPYHATVP EMSNVGTSVI QVTAHDADDP SYGNSAKLVY TVLDGLPFFS
210 220 230 240 250
VDPQTGVVRT AIPNMDRETQ EEFLVVIQAK DMGGHMGGLS GSTTVTVTLS
260 270 280 290 300
DVNDNPPKFP QSLYQFSVVE TAGPGTLVGR LRAQDPDLGD NALMAYSILD
310 320 330 340 350
GEGSEAFSIS TDLQGRDGLL TVRKPLDFES QRSYSFRVEA TNTLIDPAYL
360 370 380 390 400
RRGPFKDVAS VRVAVQDAPE PPAFTQAAYH LTVPENKAPG TLVGQISAAD
410 420 430 440 450
LDSPASPIRY SILPHSDPER CFSIQPEEGT IHTAAPLDRE ARAWHNLTVL
460 470 480 490 500
ATELGWSWGP ERGWVPLLVA EWSAPAAPPQ RSPVGSAVGI PQDSSAQASR
510 520 530 540 550
VQVAIQTLDE NDNAPQLAEP YDTFVCDSAA PGQLIQVIRA LDRDEVGNSS
560 570 580 590 600
HVSFQGPLGP DANFTVQDNR DGSASLLLPS RPAPPRHAPY LVPIELWDWG
610 620 630 640 650
QPALSSTATV TVSVCRCQPD GSVASCWPEA HLSAAGLSTG ALLAIITCVG
660 670 680 690 700
ALLALVVLFV ALRRQKQEAL MVLEEEDVRE NIITYDDEGG GEEDTEAFDI
710 720 730 740 750
TALQNPDGAA PPAPGPPARR DVLPRARVSR QPRPPGPADV AQLLALRLRE
760 770 780 790 800
ADEDPGVPPY DSVQVYGYEG RGSSCGSLSS LGSGSEAGGA PGPAEPLDDW
810
GPLFRTLAEL YGAKEPPAP
Length:819
Mass (Da):87,752
Last modified:June 1, 2003 - v1
Checksum:i9083034F18BA7E4A
GO
Isoform 2 (identifier: Q86UP0-2) [UniParc]FASTAAdd to basket

Also known as: Short form

The sequence of this isoform differs from the canonical sequence as follows:
     455-492: Missing.

Show »
Length:781
Mass (Da):83,776
Checksum:iEE1730E67347CF76
GO
Isoform 3 (identifier: Q86UP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.
     428-492: EGTIHTAAPL...PVGSAVGIPQ → MNIVCTWYCS...WRVCFGVLPS

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):41,746
Checksum:i7E4C2075B1DD0710
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 427427Missing in isoform 3. 1 PublicationVSP_008718Add
BLAST
Alternative sequencei428 – 49265EGTIH…VGIPQ → MNIVCTWYCSIHSATLFSTC TLHAYFMCFLCMLYASCGIH AHAPHMLRVNCVVCVWRVCF GVLPS in isoform 3. 1 PublicationVSP_008719Add
BLAST
Alternative sequencei455 – 49238Missing in isoform 2. 2 PublicationsVSP_008717Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260900 mRNA. Translation: AAP20590.1.
AY260901 mRNA. Translation: AAP20591.1.
AY358199 mRNA. Translation: AAQ88566.1.
AL137477 mRNA. Translation: CAB70758.1.
CH471078 Genomic DNA. Translation: EAW66190.1.
CH471078 Genomic DNA. Translation: EAW66192.1.
CCDSiCCDS9585.1. [Q86UP0-1]
CCDS9586.1. [Q86UP0-2]
PIRiT46418.
RefSeqiNP_071923.2. NM_022478.3. [Q86UP0-1]
NP_659422.2. NM_144985.3. [Q86UP0-2]
UniGeneiHs.155912.

Genome annotation databases

EnsembliENST00000267383; ENSP00000267383; ENSG00000139880. [Q86UP0-1]
ENST00000397359; ENSP00000380517; ENSG00000139880. [Q86UP0-1]
ENST00000487137; ENSP00000434821; ENSG00000139880. [Q86UP0-2]
ENST00000554034; ENSP00000452493; ENSG00000139880. [Q86UP0-2]
GeneIDi64403.
KEGGihsa:64403.
UCSCiuc001wil.4. human. [Q86UP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260900 mRNA. Translation: AAP20590.1.
AY260901 mRNA. Translation: AAP20591.1.
AY358199 mRNA. Translation: AAQ88566.1.
AL137477 mRNA. Translation: CAB70758.1.
CH471078 Genomic DNA. Translation: EAW66190.1.
CH471078 Genomic DNA. Translation: EAW66192.1.
CCDSiCCDS9585.1. [Q86UP0-1]
CCDS9586.1. [Q86UP0-2]
PIRiT46418.
RefSeqiNP_071923.2. NM_022478.3. [Q86UP0-1]
NP_659422.2. NM_144985.3. [Q86UP0-2]
UniGeneiHs.155912.

3D structure databases

ProteinModelPortaliQ86UP0.
SMRiQ86UP0. Positions 45-615, 719-813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122158. 4 interactions.
IntActiQ86UP0. 1 interaction.
STRINGi9606.ENSP00000267383.

PTM databases

iPTMnetiQ86UP0.
PhosphoSiteiQ86UP0.

Polymorphism and mutation databases

BioMutaiCDH24.
DMDMi38257450.

2D gel databases

UCD-2DPAGEQ86UP0.

Proteomic databases

PaxDbiQ86UP0.
PRIDEiQ86UP0.

Protocols and materials databases

DNASUi64403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267383; ENSP00000267383; ENSG00000139880. [Q86UP0-1]
ENST00000397359; ENSP00000380517; ENSG00000139880. [Q86UP0-1]
ENST00000487137; ENSP00000434821; ENSG00000139880. [Q86UP0-2]
ENST00000554034; ENSP00000452493; ENSG00000139880. [Q86UP0-2]
GeneIDi64403.
KEGGihsa:64403.
UCSCiuc001wil.4. human. [Q86UP0-1]

Organism-specific databases

CTDi64403.
GeneCardsiCDH24.
HGNCiHGNC:14265. CDH24.
neXtProtiNX_Q86UP0.
PharmGKBiPA26297.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ86UP0.
KOiK06814.
OMAiRVWHNLT.
OrthoDBiEOG7M3HZN.
PhylomeDBiQ86UP0.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Miscellaneous databases

GenomeRNAii64403.
NextBioi66352.
PROiQ86UP0.

Gene expression databases

BgeeiQ86UP0.
CleanExiHS_CDH24.
ExpressionAtlasiQ86UP0. baseline and differential.
GenevisibleiQ86UP0. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cadherin-24, a novel alternatively spliced type II cadherin."
    Katafiasz B.J., Nieman M.T., Wheelock M.J., Johnson K.R.
    J. Biol. Chem. 278:27513-27519(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INTERACTION WITH CATENINS.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCAD24_HUMAN
AccessioniPrimary (citable) accession number: Q86UP0
Secondary accession number(s): D3DS44, Q86UP1, Q9NT84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: March 16, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.