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Q86UN7

- Q86UN7_HUMAN

UniProt

Q86UN7 - Q86UN7_HUMAN

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Protein
Submitted name:

Calcium sensing receptor

Gene

CASR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium sensing receptorImported
Gene namesi
Name:CASRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG052876.

Family and domain databases

InterProiIPR000337. GPCR_3.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PROSITEiPS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q86UN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DASACNKCPD DFWSNENHTS CIAKEIEFLS WTEPFGIALT LFAVLGIFLT
60 70 80 90 100
AFVLGVFIKF RNTPIVKATN RELSYLLLFS LLCCFSSSLF FIGEPQDWTC
110 120 130 140 150
RLRQPAFGIS FVLCISCILV KTNRVLLVFE AKIPTSFHRK WWGLNLQFLL
160 170 180 190 200
VFLCTFMQIV ICVIWLYTAP PSSYRNQELE DEIIFITCHK GSLMALGFLI
210 220 230 240 250
GYTCLLAAIC FFFAFKSRKL PENFNEAKFI TFSMLIFFIV WISFIPAYAS
260 270 280 290 300
TYGKFVSAVE VIAILAASFG LLACIFFNKI YIILFKPSRN TIEEVRCSTA
310 320 330 340 350
AHAFKVAARA TLRRSNVSRK RSSSLGGSTG STPSSSISSK SNSEDPFPQP
360 370 380 390 400
ERQKQQQPLA LTQQEQQQQP LTLPQQQRSQ QQPRCKQKVI FGSGTVTFSL
410 420 430 440 450
SFDEPQKNAM AHRNSTHQNS LEAQKSSDTL TRHQPLLPLQ CGETDLDLTV
460 470 480 490 500
QETGLQGPVG GDQRPEVEDP EELSPALVVS SSQSFVISGG GSTVTENVVN

S
Length:501
Mass (Da):55,928
Last modified:June 1, 2003 - v1
Checksum:i414AF350779182C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY259116 Genomic DNA. Translation: AAP20759.1.
UniGeneiHs.435615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY259116 Genomic DNA. Translation: AAP20759.1 .
UniGenei Hs.435615.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052876.

Family and domain databases

InterProi IPR000337. GPCR_3.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PROSITEi PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel mutation (E767K) in the second extracellular loop of the calcium sensing receptor in a family with autosomal dominant hypocalcemia."
    Uckun-Kitapci A., Underwood L.E., Zhang J., Moats-Staats B.
    Am. J. Med. Genet. A 132:125-129(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ86UN7_HUMAN
AccessioniPrimary (citable) accession number: Q86UN7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.