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Q86UN7

- Q86UN7_HUMAN

UniProt

Q86UN7 - Q86UN7_HUMAN

Protein
Submitted name:

Calcium sensing receptor

Gene

CASR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptorSAAS annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Calcium sensing receptorImported
    Gene namesi
    Name:CASRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG052876.

    Family and domain databases

    InterProiIPR000337. GPCR_3.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PROSITEiPS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q86UN7-1 [UniParc]FASTAAdd to Basket

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    DASACNKCPD DFWSNENHTS CIAKEIEFLS WTEPFGIALT LFAVLGIFLT    50
    AFVLGVFIKF RNTPIVKATN RELSYLLLFS LLCCFSSSLF FIGEPQDWTC 100
    RLRQPAFGIS FVLCISCILV KTNRVLLVFE AKIPTSFHRK WWGLNLQFLL 150
    VFLCTFMQIV ICVIWLYTAP PSSYRNQELE DEIIFITCHK GSLMALGFLI 200
    GYTCLLAAIC FFFAFKSRKL PENFNEAKFI TFSMLIFFIV WISFIPAYAS 250
    TYGKFVSAVE VIAILAASFG LLACIFFNKI YIILFKPSRN TIEEVRCSTA 300
    AHAFKVAARA TLRRSNVSRK RSSSLGGSTG STPSSSISSK SNSEDPFPQP 350
    ERQKQQQPLA LTQQEQQQQP LTLPQQQRSQ QQPRCKQKVI FGSGTVTFSL 400
    SFDEPQKNAM AHRNSTHQNS LEAQKSSDTL TRHQPLLPLQ CGETDLDLTV 450
    QETGLQGPVG GDQRPEVEDP EELSPALVVS SSQSFVISGG GSTVTENVVN 500
    S 501
    Length:501
    Mass (Da):55,928
    Last modified:June 1, 2003 - v1
    Checksum:i414AF350779182C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY259116 Genomic DNA. Translation: AAP20759.1.
    UniGeneiHs.435615.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY259116 Genomic DNA. Translation: AAP20759.1 .
    UniGenei Hs.435615.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG052876.

    Family and domain databases

    InterProi IPR000337. GPCR_3.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PROSITEi PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel mutation (E767K) in the second extracellular loop of the calcium sensing receptor in a family with autosomal dominant hypocalcemia."
      Uckun-Kitapci A., Underwood L.E., Zhang J., Moats-Staats B.
      Am. J. Med. Genet. A 132:125-129(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ86UN7_HUMAN
    AccessioniPrimary (citable) accession number: Q86UN7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.