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Q86UN7

- Q86UN7_HUMAN

UniProt

Q86UN7 - Q86UN7_HUMAN

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Protein
Submitted name: Calcium sensing receptor
Gene
CASR
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotations, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium sensing receptorImported
Gene namesi
Name:CASRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotations, Membrane

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG052876.

Family and domain databases

InterProiIPR000337. GPCR_3.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PROSITEiPS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q86UN7-1 [UniParc]FASTAAdd to Basket

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DASACNKCPD DFWSNENHTS CIAKEIEFLS WTEPFGIALT LFAVLGIFLT    50
AFVLGVFIKF RNTPIVKATN RELSYLLLFS LLCCFSSSLF FIGEPQDWTC 100
RLRQPAFGIS FVLCISCILV KTNRVLLVFE AKIPTSFHRK WWGLNLQFLL 150
VFLCTFMQIV ICVIWLYTAP PSSYRNQELE DEIIFITCHK GSLMALGFLI 200
GYTCLLAAIC FFFAFKSRKL PENFNEAKFI TFSMLIFFIV WISFIPAYAS 250
TYGKFVSAVE VIAILAASFG LLACIFFNKI YIILFKPSRN TIEEVRCSTA 300
AHAFKVAARA TLRRSNVSRK RSSSLGGSTG STPSSSISSK SNSEDPFPQP 350
ERQKQQQPLA LTQQEQQQQP LTLPQQQRSQ QQPRCKQKVI FGSGTVTFSL 400
SFDEPQKNAM AHRNSTHQNS LEAQKSSDTL TRHQPLLPLQ CGETDLDLTV 450
QETGLQGPVG GDQRPEVEDP EELSPALVVS SSQSFVISGG GSTVTENVVN 500
S 501
Length:501
Mass (Da):55,928
Last modified:June 1, 2003 - v1
Checksum:i414AF350779182C3
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY259116 Genomic DNA. Translation: AAP20759.1.
UniGeneiHs.435615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY259116 Genomic DNA. Translation: AAP20759.1 .
UniGenei Hs.435615.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052876.

Family and domain databases

InterProi IPR000337. GPCR_3.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PROSITEi PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel mutation (E767K) in the second extracellular loop of the calcium sensing receptor in a family with autosomal dominant hypocalcemia."
    Uckun-Kitapci A., Underwood L.E., Zhang J., Moats-Staats B.
    Am. J. Med. Genet. A 132:125-129(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ86UN7_HUMAN
AccessioniPrimary (citable) accession number: Q86UN7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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