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Q86UN6

- AKA28_HUMAN

UniProt

Q86UN6 - AKA28_HUMAN

Protein

A-kinase anchor protein 14

Gene

AKAP14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

    GO - Biological processi

    1. spermatogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A-kinase anchor protein 14
    Short name:
    AKAP-14
    Alternative name(s):
    A-kinase anchor protein 28 kDa
    Short name:
    AKAP 28
    Protein kinase A-anchoring protein 14
    Short name:
    PRKA14
    Gene namesi
    Name:AKAP14
    Synonyms:AKAP28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:24061. AKAP14.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi43 – 431L → P: Abolishes RII-binding; when associated with P-47. 1 Publication
    Mutagenesisi47 – 471V → P: Abolishes RII-binding; when associated with P-43. 1 Publication

    Organism-specific databases

    PharmGKBiPA134914893.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197A-kinase anchor protein 14PRO_0000064521Add
    BLAST

    Proteomic databases

    PaxDbiQ86UN6.
    PRIDEiQ86UN6.

    PTM databases

    PhosphoSiteiQ86UN6.

    Expressioni

    Tissue specificityi

    Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.1 Publication

    Gene expression databases

    ArrayExpressiQ86UN6.
    BgeeiQ86UN6.
    CleanExiHS_AKAP14.
    GenevestigatoriQ86UN6.

    Organism-specific databases

    HPAiHPA060999.

    Interactioni

    Subunit structurei

    Binds to type II regulatory subunits (RII).1 Publication

    Protein-protein interaction databases

    BioGridi127707. 1 interaction.
    IntActiQ86UN6. 1 interaction.
    STRINGi9606.ENSP00000360485.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 5218RII-bindingAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG85614.
    HOGENOMiHOG000293385.
    HOVERGENiHBG050473.
    InParanoidiQ86UN6.
    KOiK16530.
    OMAiRWSIPTR.
    OrthoDBiEOG73FQNR.
    PhylomeDBiQ86UN6.
    TreeFamiTF329057.

    Family and domain databases

    InterProiIPR025663. AKAP_28.
    [Graphical view]
    PfamiPF14469. AKAP28. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UN6-1) [UniParc]FASTAAdd to Basket

    Also known as: Isoform A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY    50
    AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSKCV SKKCWAHGVE 100
    FVERKDLIHS FLYIYYVHWS ISTADLPVAR ISAGTYFTMK VSKTKPPDAP 150
    IVVSYVGDHQ ALVHRPGMVR FRENWQKNLT DAKYSFMESF PFLFNRV 197
    Length:197
    Mass (Da):22,815
    Last modified:June 1, 2003 - v1
    Checksum:i3A76B9C3036EAEB9
    GO
    Isoform 2 (identifier: Q86UN6-2) [UniParc]FASTAAdd to Basket

    Also known as: Isoform B

    The sequence of this isoform differs from the canonical sequence as follows:
         88-147: Missing.

    Show »
    Length:137
    Mass (Da):15,898
    Checksum:i572CCE6742C45A32
    GO
    Isoform 3 (identifier: Q86UN6-3) [UniParc]FASTAAdd to Basket

    Also known as: Isoform C

    The sequence of this isoform differs from the canonical sequence as follows:
         88-89: KC → VS
         90-197: Missing.

    Show »
    Length:89
    Mass (Da):10,187
    Checksum:i2C5E377D247E3277
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 2 (identifier: Q86UN6-2)
    Sequence conflicti87 – 871S → SP in AAP20826. (PubMed:12475942)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei88 – 14760Missing in isoform 2. 1 PublicationVSP_009909Add
    BLAST
    Alternative sequencei88 – 892KC → VS in isoform 3. 1 PublicationVSP_009910
    Alternative sequencei90 – 197108Missing in isoform 3. 1 PublicationVSP_009911Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF514780 mRNA. Translation: AAP20825.1.
    AF514781 mRNA. Translation: AAP20826.1.
    AF514782 mRNA. Translation: AAP20827.1.
    AC002477 Genomic DNA. No translation available.
    BC066357 mRNA. Translation: AAH66357.1.
    CCDSiCCDS14591.1. [Q86UN6-1]
    CCDS35377.1. [Q86UN6-3]
    RefSeqiNP_001008534.1. NM_001008534.1.
    NP_001008535.1. NM_001008535.1. [Q86UN6-3]
    NP_848928.1. NM_178813.5. [Q86UN6-1]
    UniGeneiHs.592245.

    Genome annotation databases

    EnsembliENST00000334356; ENSP00000334680; ENSG00000186471. [Q86UN6-2]
    ENST00000371422; ENSP00000360476; ENSG00000186471. [Q86UN6-3]
    ENST00000371425; ENSP00000360479; ENSG00000186471. [Q86UN6-2]
    ENST00000371431; ENSP00000360485; ENSG00000186471. [Q86UN6-1]
    GeneIDi158798.
    KEGGihsa:158798.
    UCSCiuc004esd.3. human. [Q86UN6-3]
    uc004ese.3. human. [Q86UN6-1]

    Polymorphism databases

    DMDMi46395790.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF514780 mRNA. Translation: AAP20825.1 .
    AF514781 mRNA. Translation: AAP20826.1 .
    AF514782 mRNA. Translation: AAP20827.1 .
    AC002477 Genomic DNA. No translation available.
    BC066357 mRNA. Translation: AAH66357.1 .
    CCDSi CCDS14591.1. [Q86UN6-1 ]
    CCDS35377.1. [Q86UN6-3 ]
    RefSeqi NP_001008534.1. NM_001008534.1.
    NP_001008535.1. NM_001008535.1. [Q86UN6-3 ]
    NP_848928.1. NM_178813.5. [Q86UN6-1 ]
    UniGenei Hs.592245.

    3D structure databases

    ProteinModelPortali Q86UN6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127707. 1 interaction.
    IntActi Q86UN6. 1 interaction.
    STRINGi 9606.ENSP00000360485.

    PTM databases

    PhosphoSitei Q86UN6.

    Polymorphism databases

    DMDMi 46395790.

    Proteomic databases

    PaxDbi Q86UN6.
    PRIDEi Q86UN6.

    Protocols and materials databases

    DNASUi 158798.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334356 ; ENSP00000334680 ; ENSG00000186471 . [Q86UN6-2 ]
    ENST00000371422 ; ENSP00000360476 ; ENSG00000186471 . [Q86UN6-3 ]
    ENST00000371425 ; ENSP00000360479 ; ENSG00000186471 . [Q86UN6-2 ]
    ENST00000371431 ; ENSP00000360485 ; ENSG00000186471 . [Q86UN6-1 ]
    GeneIDi 158798.
    KEGGi hsa:158798.
    UCSCi uc004esd.3. human. [Q86UN6-3 ]
    uc004ese.3. human. [Q86UN6-1 ]

    Organism-specific databases

    CTDi 158798.
    GeneCardsi GC0XP119029.
    HGNCi HGNC:24061. AKAP14.
    HPAi HPA060999.
    MIMi 300462. gene.
    neXtProti NX_Q86UN6.
    PharmGKBi PA134914893.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85614.
    HOGENOMi HOG000293385.
    HOVERGENi HBG050473.
    InParanoidi Q86UN6.
    KOi K16530.
    OMAi RWSIPTR.
    OrthoDBi EOG73FQNR.
    PhylomeDBi Q86UN6.
    TreeFami TF329057.

    Miscellaneous databases

    GenomeRNAii 158798.
    NextBioi 87803.
    PROi Q86UN6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UN6.
    Bgeei Q86UN6.
    CleanExi HS_AKAP14.
    Genevestigatori Q86UN6.

    Family and domain databases

    InterProi IPR025663. AKAP_28.
    [Graphical view ]
    Pfami PF14469. AKAP28. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of an A-kinase anchoring protein in human ciliary axonemes."
      Kultgen P.L., Byrd S.K., Ostrowski L.E., Milgram S.L.
      Mol. Biol. Cell 13:4156-4166(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBUNIT, TISSUE SPECIFICITY, MUTAGENESIS OF LEU-43 AND VAL-47.
      Tissue: Lung epithelium.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiAKA28_HUMAN
    AccessioniPrimary (citable) accession number: Q86UN6
    Secondary accession number(s): A6NNZ0, Q86UN4, Q86UN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3