Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

A-kinase anchor protein 14

Gene

AKAP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Enzyme and pathway databases

BioCyciZFISH:G66-30646-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 14
Short name:
AKAP-14
Alternative name(s):
A-kinase anchor protein 28 kDa
Short name:
AKAP 28
Protein kinase A-anchoring protein 14
Short name:
PRKA14
Gene namesi
Name:AKAP14
Synonyms:AKAP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24061. AKAP14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43L → P: Abolishes RII-binding; when associated with P-47. 1 Publication1
Mutagenesisi47V → P: Abolishes RII-binding; when associated with P-43. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000186471.
PharmGKBiPA134914893.

Polymorphism and mutation databases

BioMutaiAKAP14.
DMDMi46395790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645211 – 197A-kinase anchor protein 14Add BLAST197

Proteomic databases

PaxDbiQ86UN6.
PRIDEiQ86UN6.

PTM databases

iPTMnetiQ86UN6.
PhosphoSitePlusiQ86UN6.

Expressioni

Tissue specificityi

Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.1 Publication

Gene expression databases

BgeeiENSG00000186471.
CleanExiHS_AKAP14.
GenevisibleiQ86UN6. HS.

Organism-specific databases

HPAiHPA060999.

Interactioni

Subunit structurei

Binds to type II regulatory subunits (RII).1 Publication

Protein-protein interaction databases

BioGridi127707. 11 interactors.
IntActiQ86UN6. 4 interactors.
STRINGi9606.ENSP00000360485.

Structurei

3D structure databases

ProteinModelPortaliQ86UN6.
SMRiQ86UN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 52RII-bindingAdd BLAST18

Phylogenomic databases

eggNOGiENOG410IXR2. Eukaryota.
ENOG4111RMU. LUCA.
GeneTreeiENSGT00390000003444.
HOGENOMiHOG000293385.
HOVERGENiHBG050473.
InParanoidiQ86UN6.
KOiK16530.
OMAiRWSIPTR.
OrthoDBiEOG091G0L2E.
PhylomeDBiQ86UN6.
TreeFamiTF329057.

Family and domain databases

InterProiIPR025663. AKAP_28.
[Graphical view]
PfamiPF14469. AKAP28. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UN6-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY
60 70 80 90 100
AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSKCV SKKCWAHGVE
110 120 130 140 150
FVERKDLIHS FLYIYYVHWS ISTADLPVAR ISAGTYFTMK VSKTKPPDAP
160 170 180 190
IVVSYVGDHQ ALVHRPGMVR FRENWQKNLT DAKYSFMESF PFLFNRV
Length:197
Mass (Da):22,815
Last modified:June 1, 2003 - v1
Checksum:i3A76B9C3036EAEB9
GO
Isoform 2 (identifier: Q86UN6-2) [UniParc]FASTAAdd to basket
Also known as: Isoform B

The sequence of this isoform differs from the canonical sequence as follows:
     88-147: Missing.

Show »
Length:137
Mass (Da):15,898
Checksum:i572CCE6742C45A32
GO
Isoform 3 (identifier: Q86UN6-3) [UniParc]FASTAAdd to basket
Also known as: Isoform C

The sequence of this isoform differs from the canonical sequence as follows:
     88-89: KC → VS
     90-197: Missing.

Show »
Length:89
Mass (Da):10,187
Checksum:i2C5E377D247E3277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q86UN6-2)
Sequence conflicti87S → SP in AAP20826 (PubMed:12475942).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00990988 – 147Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_00991088 – 89KC → VS in isoform 3. 1 Publication2
Alternative sequenceiVSP_00991190 – 197Missing in isoform 3. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514780 mRNA. Translation: AAP20825.1.
AF514781 mRNA. Translation: AAP20826.1.
AF514782 mRNA. Translation: AAP20827.1.
AC002477 Genomic DNA. No translation available.
BC066357 mRNA. Translation: AAH66357.1.
CCDSiCCDS14591.1. [Q86UN6-1]
CCDS35376.1. [Q86UN6-2]
CCDS35377.1. [Q86UN6-3]
RefSeqiNP_001008534.1. NM_001008534.1. [Q86UN6-2]
NP_001008535.1. NM_001008535.1. [Q86UN6-3]
NP_848928.1. NM_178813.5. [Q86UN6-1]
UniGeneiHs.592245.

Genome annotation databases

EnsembliENST00000334356; ENSP00000334680; ENSG00000186471. [Q86UN6-2]
ENST00000371422; ENSP00000360476; ENSG00000186471. [Q86UN6-3]
ENST00000371425; ENSP00000360479; ENSG00000186471. [Q86UN6-2]
ENST00000371431; ENSP00000360485; ENSG00000186471. [Q86UN6-1]
GeneIDi158798.
KEGGihsa:158798.
UCSCiuc004ese.4. human. [Q86UN6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514780 mRNA. Translation: AAP20825.1.
AF514781 mRNA. Translation: AAP20826.1.
AF514782 mRNA. Translation: AAP20827.1.
AC002477 Genomic DNA. No translation available.
BC066357 mRNA. Translation: AAH66357.1.
CCDSiCCDS14591.1. [Q86UN6-1]
CCDS35376.1. [Q86UN6-2]
CCDS35377.1. [Q86UN6-3]
RefSeqiNP_001008534.1. NM_001008534.1. [Q86UN6-2]
NP_001008535.1. NM_001008535.1. [Q86UN6-3]
NP_848928.1. NM_178813.5. [Q86UN6-1]
UniGeneiHs.592245.

3D structure databases

ProteinModelPortaliQ86UN6.
SMRiQ86UN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127707. 11 interactors.
IntActiQ86UN6. 4 interactors.
STRINGi9606.ENSP00000360485.

PTM databases

iPTMnetiQ86UN6.
PhosphoSitePlusiQ86UN6.

Polymorphism and mutation databases

BioMutaiAKAP14.
DMDMi46395790.

Proteomic databases

PaxDbiQ86UN6.
PRIDEiQ86UN6.

Protocols and materials databases

DNASUi158798.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334356; ENSP00000334680; ENSG00000186471. [Q86UN6-2]
ENST00000371422; ENSP00000360476; ENSG00000186471. [Q86UN6-3]
ENST00000371425; ENSP00000360479; ENSG00000186471. [Q86UN6-2]
ENST00000371431; ENSP00000360485; ENSG00000186471. [Q86UN6-1]
GeneIDi158798.
KEGGihsa:158798.
UCSCiuc004ese.4. human. [Q86UN6-1]

Organism-specific databases

CTDi158798.
GeneCardsiAKAP14.
HGNCiHGNC:24061. AKAP14.
HPAiHPA060999.
MIMi300462. gene.
neXtProtiNX_Q86UN6.
OpenTargetsiENSG00000186471.
PharmGKBiPA134914893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXR2. Eukaryota.
ENOG4111RMU. LUCA.
GeneTreeiENSGT00390000003444.
HOGENOMiHOG000293385.
HOVERGENiHBG050473.
InParanoidiQ86UN6.
KOiK16530.
OMAiRWSIPTR.
OrthoDBiEOG091G0L2E.
PhylomeDBiQ86UN6.
TreeFamiTF329057.

Enzyme and pathway databases

BioCyciZFISH:G66-30646-MONOMER.

Miscellaneous databases

GenomeRNAii158798.
PROiQ86UN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186471.
CleanExiHS_AKAP14.
GenevisibleiQ86UN6. HS.

Family and domain databases

InterProiIPR025663. AKAP_28.
[Graphical view]
PfamiPF14469. AKAP28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKA28_HUMAN
AccessioniPrimary (citable) accession number: Q86UN6
Secondary accession number(s): A6NNZ0, Q86UN4, Q86UN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.