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Q86UN3

- R4RL2_HUMAN

UniProt

Q86UN3 - R4RL2_HUMAN

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Protein

Reticulon-4 receptor-like 2

Gene

RTN4RL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.1 Publication

GO - Molecular functioni

  1. receptor activity Source: UniProtKB

GO - Biological processi

  1. axon regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name:
NgR2
Gene namesi
Name:RTN4RL2Imported
Synonyms:NGRH1Imported, NGRL3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:23053. RTN4RL2.

Subcellular locationi

Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication
Note: Localized to the surface of neurons, including axons.

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
  2. cell surface Source: DFLAT
  3. external side of plasma membrane Source: Ensembl
  4. extracellular vesicular exosome Source: UniProtKB
  5. membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964131.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646Sequence AnalysisAdd
BLAST
Chaini47 – 390344Reticulon-4 receptor-like 2PRO_0000046048Add
BLAST
Propeptidei391 – 42030Removed in mature formSequence AnalysisPRO_0000046049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Lipidationi390 – 3901GPI-anchor amidated cysteineSequence Analysis

Post-translational modificationi

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ86UN3.
PaxDbiQ86UN3.
PRIDEiQ86UN3.

PTM databases

PhosphoSiteiQ86UN3.

Expressioni

Tissue specificityi

Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.2 Publications

Gene expression databases

BgeeiQ86UN3.
CleanExiHS_RTN4RL2.
ExpressionAtlasiQ86UN3. baseline and differential.
GenevestigatoriQ86UN3.

Organism-specific databases

HPAiCAB024870.

Interactioni

Protein-protein interaction databases

BioGridi131566. 3 interactions.
IntActiQ86UN3. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86UN3.
SMRiQ86UN3. Positions 29-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 6014LRRNTAdd
BLAST
Repeati61 – 8222LRR 1Add
BLAST
Repeati83 – 10422LRR 2Add
BLAST
Repeati107 – 12923LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati180 – 20122LRR 6Add
BLAST
Repeati204 – 22522LRR 7Add
BLAST
Repeati228 – 24922LRR 8Add
BLAST
Domaini261 – 31252LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ86UN3.
KOiK16661.
OMAiQDDIFSD.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ86UN3.
TreeFamiTF330080.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86UN3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPGLRRLLQ APASACLLLM LLALPLAAPS CPMLCTCYSS PPTVSCQANN
60 70 80 90 100
FSSVPLSLPP STQRLFLQNN LIRTLRPGTF GSNLLTLWLF SNNLSTIYPG
110 120 130 140 150
TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI
160 170 180 190 200
FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR
210 220 230 240 250
GLGSLDRLLL HGNRLQGVHR AAFRGLSRLT ILYLFNNSLA SLPGEALADL
260 270 280 290 300
PSLEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR
310 320 330 340 350
ALREADFQAC PPAAPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD
360 370 380 390 400
LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQMCPGAAC QAPPDSRGPA
410 420
LSAGLPSPLL CLLLLVPHHL
Length:420
Mass (Da):46,106
Last modified:June 1, 2003 - v1
Checksum:i09B9E875BC88A0E8
GO
Isoform 2 (identifier: Q86UN3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-193: DDLFADLANLSHLFLHGNRLRL → GPLPKGLCSCFSHPPSSLPTSR
     194-420: Missing.

Show »
Length:193
Mass (Da):21,373
Checksum:i432225844C809EAD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781G → S in AAP82838. (PubMed:14664809)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei172 – 19322DDLFA…NRLRL → GPLPKGLCSCFSHPPSSLPT SR in isoform 2. 1 PublicationVSP_047767Add
BLAST
Alternative sequencei194 – 420227Missing in isoform 2. 1 PublicationVSP_047768Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532858 mRNA. Translation: AAP21835.1.
AY250221 mRNA. Translation: AAP82838.1.
DQ864979 mRNA. Translation: ABI23432.1.
AP002893 Genomic DNA. No translation available.
BC113673 mRNA. Translation: AAI13674.1.
BC117276 mRNA. Translation: AAI17277.1.
BK001302 mRNA. Translation: DAA01385.1.
CCDSiCCDS7957.1. [Q86UN3-1]
RefSeqiNP_848665.1. NM_178570.2. [Q86UN3-1]
UniGeneiHs.502618.
Hs.603388.

Genome annotation databases

EnsembliENST00000335099; ENSP00000335397; ENSG00000186907. [Q86UN3-1]
ENST00000395120; ENSP00000378552; ENSG00000186907. [Q86UN3-2]
GeneIDi349667.
KEGGihsa:349667.
UCSCiuc010rjt.2. human. [Q86UN3-1]

Polymorphism databases

DMDMi74759401.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532858 mRNA. Translation: AAP21835.1 .
AY250221 mRNA. Translation: AAP82838.1 .
DQ864979 mRNA. Translation: ABI23432.1 .
AP002893 Genomic DNA. No translation available.
BC113673 mRNA. Translation: AAI13674.1 .
BC117276 mRNA. Translation: AAI17277.1 .
BK001302 mRNA. Translation: DAA01385.1 .
CCDSi CCDS7957.1. [Q86UN3-1 ]
RefSeqi NP_848665.1. NM_178570.2. [Q86UN3-1 ]
UniGenei Hs.502618.
Hs.603388.

3D structure databases

ProteinModelPortali Q86UN3.
SMRi Q86UN3. Positions 29-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131566. 3 interactions.
IntActi Q86UN3. 3 interactions.

PTM databases

PhosphoSitei Q86UN3.

Polymorphism databases

DMDMi 74759401.

Proteomic databases

MaxQBi Q86UN3.
PaxDbi Q86UN3.
PRIDEi Q86UN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335099 ; ENSP00000335397 ; ENSG00000186907 . [Q86UN3-1 ]
ENST00000395120 ; ENSP00000378552 ; ENSG00000186907 . [Q86UN3-2 ]
GeneIDi 349667.
KEGGi hsa:349667.
UCSCi uc010rjt.2. human. [Q86UN3-1 ]

Organism-specific databases

CTDi 349667.
GeneCardsi GC11P057228.
HGNCi HGNC:23053. RTN4RL2.
HPAi CAB024870.
MIMi 610462. gene.
neXtProti NX_Q86UN3.
PharmGKBi PA134964131.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000116109.
HOVERGENi HBG063707.
InParanoidi Q86UN3.
KOi K16661.
OMAi QDDIFSD.
OrthoDBi EOG7CZK5N.
PhylomeDBi Q86UN3.
TreeFami TF330080.

Miscellaneous databases

GenomeRNAii 349667.
NextBioi 99528.
PROi Q86UN3.
SOURCEi Search...

Gene expression databases

Bgeei Q86UN3.
CleanExi HS_RTN4RL2.
ExpressionAtlasi Q86UN3. baseline and differential.
Genevestigatori Q86UN3.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
    Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
    J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  2. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
    Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Splice variant of human RTN4RL2 (Nogo-66 receptor homolog NgR2)."
    Rader C., Hofer T., Giger R.J.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
    Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
    EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases."
    Walmsley A.R., Mir A.K., Frentzel S.
    Biochem. Biophys. Res. Commun. 327:112-116(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiR4RL2_HUMAN
AccessioniPrimary (citable) accession number: Q86UN3
Secondary accession number(s): Q0GGW3, Q17RL9, Q6X813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3