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Q86UN3

- R4RL2_HUMAN

UniProt

Q86UN3 - R4RL2_HUMAN

Protein

Reticulon-4 receptor-like 2

Gene

RTN4RL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.1 Publication

    GO - Molecular functioni

    1. receptor activity Source: UniProtKB

    GO - Biological processi

    1. axon regeneration Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulon-4 receptor-like 2
    Alternative name(s):
    Nogo receptor-like 3
    Nogo-66 receptor homolog 1
    Nogo-66 receptor-related protein 2
    Short name:
    NgR2
    Gene namesi
    Name:RTN4RL2Imported
    Synonyms:NGRH1Imported, NGRL3Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23053. RTN4RL2.

    Subcellular locationi

    Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication
    Note: Localized to the surface of neurons, including axons.

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: UniProtKB
    2. cell surface Source: DFLAT
    3. external side of plasma membrane Source: Ensembl
    4. extracellular vesicular exosome Source: UniProt
    5. membrane raft Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134964131.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4646Sequence AnalysisAdd
    BLAST
    Chaini47 – 390344Reticulon-4 receptor-like 2PRO_0000046048Add
    BLAST
    Propeptidei391 – 42030Removed in mature formSequence AnalysisPRO_0000046049Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Lipidationi390 – 3901GPI-anchor amidated cysteineSequence Analysis

    Post-translational modificationi

    Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiQ86UN3.
    PaxDbiQ86UN3.
    PRIDEiQ86UN3.

    PTM databases

    PhosphoSiteiQ86UN3.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.2 Publications

    Gene expression databases

    ArrayExpressiQ86UN3.
    BgeeiQ86UN3.
    CleanExiHS_RTN4RL2.
    GenevestigatoriQ86UN3.

    Organism-specific databases

    HPAiCAB024870.

    Interactioni

    Protein-protein interaction databases

    BioGridi131566. 2 interactions.
    IntActiQ86UN3. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UN3.
    SMRiQ86UN3. Positions 31-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 6014LRRNTAdd
    BLAST
    Repeati61 – 8222LRR 1Add
    BLAST
    Repeati83 – 10422LRR 2Add
    BLAST
    Repeati107 – 12923LRR 3Add
    BLAST
    Repeati132 – 15322LRR 4Add
    BLAST
    Repeati156 – 17722LRR 5Add
    BLAST
    Repeati180 – 20122LRR 6Add
    BLAST
    Repeati204 – 22522LRR 7Add
    BLAST
    Repeati228 – 24922LRR 8Add
    BLAST
    Domaini261 – 31252LRRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nogo receptor family.Curated
    Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116109.
    HOVERGENiHBG063707.
    InParanoidiQ86UN3.
    KOiK16661.
    OMAiQDDIFSD.
    OrthoDBiEOG7CZK5N.
    PhylomeDBiQ86UN3.
    TreeFamiTF330080.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UN3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPGLRRLLQ APASACLLLM LLALPLAAPS CPMLCTCYSS PPTVSCQANN    50
    FSSVPLSLPP STQRLFLQNN LIRTLRPGTF GSNLLTLWLF SNNLSTIYPG 100
    TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI 150
    FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR 200
    GLGSLDRLLL HGNRLQGVHR AAFRGLSRLT ILYLFNNSLA SLPGEALADL 250
    PSLEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR 300
    ALREADFQAC PPAAPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD 350
    LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQMCPGAAC QAPPDSRGPA 400
    LSAGLPSPLL CLLLLVPHHL 420
    Length:420
    Mass (Da):46,106
    Last modified:June 1, 2003 - v1
    Checksum:i09B9E875BC88A0E8
    GO
    Isoform 2 (identifier: Q86UN3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         172-193: DDLFADLANLSHLFLHGNRLRL → GPLPKGLCSCFSHPPSSLPTSR
         194-420: Missing.

    Show »
    Length:193
    Mass (Da):21,373
    Checksum:i432225844C809EAD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781G → S in AAP82838. (PubMed:14664809)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei172 – 19322DDLFA…NRLRL → GPLPKGLCSCFSHPPSSLPT SR in isoform 2. 1 PublicationVSP_047767Add
    BLAST
    Alternative sequencei194 – 420227Missing in isoform 2. 1 PublicationVSP_047768Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532858 mRNA. Translation: AAP21835.1.
    AY250221 mRNA. Translation: AAP82838.1.
    DQ864979 mRNA. Translation: ABI23432.1.
    AP002893 Genomic DNA. No translation available.
    BC113673 mRNA. Translation: AAI13674.1.
    BC117276 mRNA. Translation: AAI17277.1.
    BK001302 mRNA. Translation: DAA01385.1.
    CCDSiCCDS7957.1. [Q86UN3-1]
    RefSeqiNP_848665.1. NM_178570.2. [Q86UN3-1]
    UniGeneiHs.502618.
    Hs.603388.

    Genome annotation databases

    EnsembliENST00000335099; ENSP00000335397; ENSG00000186907. [Q86UN3-1]
    ENST00000395120; ENSP00000378552; ENSG00000186907. [Q86UN3-2]
    GeneIDi349667.
    KEGGihsa:349667.
    UCSCiuc010rjt.2. human. [Q86UN3-1]

    Polymorphism databases

    DMDMi74759401.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532858 mRNA. Translation: AAP21835.1 .
    AY250221 mRNA. Translation: AAP82838.1 .
    DQ864979 mRNA. Translation: ABI23432.1 .
    AP002893 Genomic DNA. No translation available.
    BC113673 mRNA. Translation: AAI13674.1 .
    BC117276 mRNA. Translation: AAI17277.1 .
    BK001302 mRNA. Translation: DAA01385.1 .
    CCDSi CCDS7957.1. [Q86UN3-1 ]
    RefSeqi NP_848665.1. NM_178570.2. [Q86UN3-1 ]
    UniGenei Hs.502618.
    Hs.603388.

    3D structure databases

    ProteinModelPortali Q86UN3.
    SMRi Q86UN3. Positions 31-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131566. 2 interactions.
    IntActi Q86UN3. 3 interactions.

    PTM databases

    PhosphoSitei Q86UN3.

    Polymorphism databases

    DMDMi 74759401.

    Proteomic databases

    MaxQBi Q86UN3.
    PaxDbi Q86UN3.
    PRIDEi Q86UN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335099 ; ENSP00000335397 ; ENSG00000186907 . [Q86UN3-1 ]
    ENST00000395120 ; ENSP00000378552 ; ENSG00000186907 . [Q86UN3-2 ]
    GeneIDi 349667.
    KEGGi hsa:349667.
    UCSCi uc010rjt.2. human. [Q86UN3-1 ]

    Organism-specific databases

    CTDi 349667.
    GeneCardsi GC11P057228.
    HGNCi HGNC:23053. RTN4RL2.
    HPAi CAB024870.
    MIMi 610462. gene.
    neXtProti NX_Q86UN3.
    PharmGKBi PA134964131.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116109.
    HOVERGENi HBG063707.
    InParanoidi Q86UN3.
    KOi K16661.
    OMAi QDDIFSD.
    OrthoDBi EOG7CZK5N.
    PhylomeDBi Q86UN3.
    TreeFami TF330080.

    Miscellaneous databases

    GenomeRNAii 349667.
    NextBioi 99528.
    PROi Q86UN3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UN3.
    Bgeei Q86UN3.
    CleanExi HS_RTN4RL2.
    Genevestigatori Q86UN3.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
      Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
      J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain1 Publication.
    2. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
      Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
      Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "Splice variant of human RTN4RL2 (Nogo-66 receptor homolog NgR2)."
      Rader C., Hofer T., Giger R.J.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
      Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
      EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases."
      Walmsley A.R., Mir A.K., Frentzel S.
      Biochem. Biophys. Res. Commun. 327:112-116(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiR4RL2_HUMAN
    AccessioniPrimary (citable) accession number: Q86UN3
    Secondary accession number(s): Q0GGW3, Q17RL9, Q6X813
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3