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Q86UN3 (R4RL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name=NgR2
Gene names
Name:RTN4RL2
Synonyms:NGRH1, NGRL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Ref.2

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor. Note: Localized to the surface of neurons, including axons. Ref.1

Tissue specificity

Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid. Ref.1 Ref.2

Post-translational modification

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.

Sequence similarities

Belongs to the Nogo receptor family.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86UN3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86UN3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     172-193: DDLFADLANLSHLFLHGNRLRL → GPLPKGLCSCFSHPPSSLPTSR
     194-420: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4646 Potential
Chain47 – 390344Reticulon-4 receptor-like 2
PRO_0000046048
Propeptide391 – 42030Removed in mature form Potential
PRO_0000046049

Regions

Domain47 – 6014LRRNT
Repeat61 – 8222LRR 1
Repeat83 – 10422LRR 2
Repeat107 – 12923LRR 3
Repeat132 – 15322LRR 4
Repeat156 – 17722LRR 5
Repeat180 – 20122LRR 6
Repeat204 – 22522LRR 7
Repeat228 – 24922LRR 8
Domain261 – 31252LRRCT

Amino acid modifications

Lipidation3901GPI-anchor amidated cysteine Potential
Glycosylation501N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence172 – 19322DDLFA…NRLRL → GPLPKGLCSCFSHPPSSLPT SR in isoform 2.
VSP_047767
Alternative sequence194 – 420227Missing in isoform 2.
VSP_047768

Experimental info

Sequence conflict781G → S in AAP82838. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 09B9E875BC88A0E8

FASTA42046,106
        10         20         30         40         50         60 
MLPGLRRLLQ APASACLLLM LLALPLAAPS CPMLCTCYSS PPTVSCQANN FSSVPLSLPP 

        70         80         90        100        110        120 
STQRLFLQNN LIRTLRPGTF GSNLLTLWLF SNNLSTIYPG TFRHLQALEE LDLGDNRHLR 

       130        140        150        160        170        180 
SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI FRGLVSLQYL YLQENSLLHL QDDLFADLAN 

       190        200        210        220        230        240 
LSHLFLHGNR LRLLTEHVFR GLGSLDRLLL HGNRLQGVHR AAFRGLSRLT ILYLFNNSLA 

       250        260        270        280        290        300 
SLPGEALADL PSLEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR 

       310        320        330        340        350        360 
ALREADFQAC PPAAPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD LPAEDSRGRQ 

       370        380        390        400        410        420 
GGDAPTEDDY WGGYGGEDQR GEQMCPGAAC QAPPDSRGPA LSAGLPSPLL CLLLLVPHHL 

« Hide

Isoform 2 [UniParc].

Checksum: 432225844C809EAD
Show »

FASTA19321,373

References

« Hide 'large scale' references
[1]"Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]"Splice variant of human RTN4RL2 (Nogo-66 receptor homolog NgR2)."
Rader C., Hofer T., Giger R.J.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases."
Walmsley A.R., Mir A.K., Frentzel S.
Biochem. Biophys. Res. Commun. 327:112-116(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF532858 mRNA. Translation: AAP21835.1.
AY250221 mRNA. Translation: AAP82838.1.
DQ864979 mRNA. Translation: ABI23432.1.
AP002893 Genomic DNA. No translation available.
BC113673 mRNA. Translation: AAI13674.1.
BC117276 mRNA. Translation: AAI17277.1.
BK001302 mRNA. Translation: DAA01385.1.
CCDSCCDS7957.1. [Q86UN3-1]
RefSeqNP_848665.1. NM_178570.2. [Q86UN3-1]
UniGeneHs.502618.
Hs.603388.

3D structure databases

ProteinModelPortalQ86UN3.
SMRQ86UN3. Positions 31-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131566. 2 interactions.
IntActQ86UN3. 2 interactions.

PTM databases

PhosphoSiteQ86UN3.

Polymorphism databases

DMDM74759401.

Proteomic databases

MaxQBQ86UN3.
PaxDbQ86UN3.
PRIDEQ86UN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335099; ENSP00000335397; ENSG00000186907. [Q86UN3-1]
ENST00000395120; ENSP00000378552; ENSG00000186907. [Q86UN3-2]
GeneID349667.
KEGGhsa:349667.
UCSCuc010rjt.2. human. [Q86UN3-1]

Organism-specific databases

CTD349667.
GeneCardsGC11P057228.
HGNCHGNC:23053. RTN4RL2.
HPACAB024870.
MIM610462. gene.
neXtProtNX_Q86UN3.
PharmGKBPA134964131.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000116109.
HOVERGENHBG063707.
InParanoidQ86UN3.
KOK16661.
OMAQDDIFSD.
OrthoDBEOG7CZK5N.
PhylomeDBQ86UN3.
TreeFamTF330080.

Gene expression databases

ArrayExpressQ86UN3.
BgeeQ86UN3.
CleanExHS_RTN4RL2.
GenevestigatorQ86UN3.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi349667.
NextBio99528.
PROQ86UN3.
SOURCESearch...

Entry information

Entry nameR4RL2_HUMAN
AccessionPrimary (citable) accession number: Q86UN3
Secondary accession number(s): Q0GGW3, Q17RL9, Q6X813
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM