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Protein

Reticulon-4 receptor-like 2

Gene

RTN4RL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).By similarity1 Publication

GO - Molecular functioni

  • protein kinase inhibitor activity Source: GO_Central
  • receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-163125. Post-translational modification: synthesis of GPI-anchored proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 11 Publication
Nogo-66 receptor-related protein 2
Short name:
NgR2
Gene namesi
Name:RTN4RL2Imported
Synonyms:NGRH11 PublicationImported, NGRL3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23053. RTN4RL2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • axon Source: UniProtKB
  • cell surface Source: DFLAT
  • cytoplasm Source: GO_Central
  • dendrite Source: UniProtKB-SubCell
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • membrane raft Source: UniProtKB
  • neuron projection Source: UniProtKB
  • perikaryon Source: UniProtKB
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186907.
PharmGKBiPA134964131.

Polymorphism and mutation databases

DMDMi74759401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_000004604847 – 390Reticulon-4 receptor-like 2Add BLAST344
PropeptideiPRO_0000046049391 – 420Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi390GPI-anchor amidated cysteineSequence analysis1

Post-translational modificationi

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.1 Publication
N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ86UN3.
MaxQBiQ86UN3.
PaxDbiQ86UN3.
PeptideAtlasiQ86UN3.
PRIDEiQ86UN3.

PTM databases

iPTMnetiQ86UN3.
PhosphoSitePlusiQ86UN3.

Expressioni

Tissue specificityi

Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.2 Publications

Gene expression databases

BgeeiENSG00000186907.
CleanExiHS_RTN4RL2.
ExpressionAtlasiQ86UN3. baseline and differential.
GenevisibleiQ86UN3. HS.

Interactioni

Subunit structurei

Interaction with MAG is controversial, and may be indirect (Probable). Does not interact with MAG, OMG and RTN4 (PubMed:12839991). Interacts with MAG (By similarity).By similarityCurated1 Publication

Protein-protein interaction databases

BioGridi131566. 6 interactors.
IntActiQ86UN3. 3 interactors.
STRINGi9606.ENSP00000335397.

Structurei

3D structure databases

ProteinModelPortaliQ86UN3.
SMRiQ86UN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 60LRRNTAdd BLAST14
Repeati61 – 82LRR 1Add BLAST22
Repeati83 – 104LRR 2Add BLAST22
Repeati107 – 129LRR 3Add BLAST23
Repeati132 – 153LRR 4Add BLAST22
Repeati156 – 177LRR 5Add BLAST22
Repeati180 – 201LRR 6Add BLAST22
Repeati204 – 225LRR 7Add BLAST22
Repeati228 – 249LRR 8Add BLAST22
Domaini261 – 312LRRCTAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni315 – 327Important for interaction with MAGBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000203132.
HOVERGENiHBG063707.
InParanoidiQ86UN3.
KOiK16661.
OMAiPTEDDYW.
OrthoDBiEOG091G08II.
PhylomeDBiQ86UN3.
TreeFamiTF330080.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
SMARTiView protein in SMART
SM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPGLRRLLQ APASACLLLM LLALPLAAPS CPMLCTCYSS PPTVSCQANN
60 70 80 90 100
FSSVPLSLPP STQRLFLQNN LIRTLRPGTF GSNLLTLWLF SNNLSTIYPG
110 120 130 140 150
TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI
160 170 180 190 200
FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR
210 220 230 240 250
GLGSLDRLLL HGNRLQGVHR AAFRGLSRLT ILYLFNNSLA SLPGEALADL
260 270 280 290 300
PSLEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR
310 320 330 340 350
ALREADFQAC PPAAPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD
360 370 380 390 400
LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQMCPGAAC QAPPDSRGPA
410 420
LSAGLPSPLL CLLLLVPHHL
Length:420
Mass (Da):46,106
Last modified:June 1, 2003 - v1
Checksum:i09B9E875BC88A0E8
GO
Isoform 2 (identifier: Q86UN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-193: DDLFADLANLSHLFLHGNRLRL → GPLPKGLCSCFSHPPSSLPTSR
     194-420: Missing.

Show »
Length:193
Mass (Da):21,373
Checksum:i432225844C809EAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78G → S in AAP82838 (PubMed:14664809).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047767172 – 193DDLFA…NRLRL → GPLPKGLCSCFSHPPSSLPT SR in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_047768194 – 420Missing in isoform 2. 1 PublicationAdd BLAST227

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532858 mRNA. Translation: AAP21835.1.
AY250221 mRNA. Translation: AAP82838.1.
DQ864979 mRNA. Translation: ABI23432.1.
AP002893 Genomic DNA. No translation available.
BC113673 mRNA. Translation: AAI13674.1.
BC117276 mRNA. Translation: AAI17277.1.
BK001302 mRNA. Translation: DAA01385.1.
CCDSiCCDS7957.1. [Q86UN3-1]
RefSeqiNP_848665.1. NM_178570.2. [Q86UN3-1]
UniGeneiHs.502618.
Hs.603388.

Genome annotation databases

EnsembliENST00000335099; ENSP00000335397; ENSG00000186907. [Q86UN3-1]
ENST00000395120; ENSP00000378552; ENSG00000186907. [Q86UN3-2]
GeneIDi349667.
KEGGihsa:349667.
UCSCiuc010rjt.4. human. [Q86UN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiR4RL2_HUMAN
AccessioniPrimary (citable) accession number: Q86UN3
Secondary accession number(s): Q0GGW3, Q17RL9, Q6X813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families