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Protein

Reticulon-4 receptor-like 2

Gene

RTN4RL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.1 Publication

GO - Molecular functioni

  • receptor activity Source: UniProtKB

GO - Biological processi

  • axon regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name:
NgR2
Gene namesi
Name:RTN4RL2Imported
Synonyms:NGRH1Imported, NGRL3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23053. RTN4RL2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • cell surface Source: DFLAT
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964131.

Polymorphism and mutation databases

DMDMi74759401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646Sequence AnalysisAdd
BLAST
Chaini47 – 390344Reticulon-4 receptor-like 2PRO_0000046048Add
BLAST
Propeptidei391 – 42030Removed in mature formSequence AnalysisPRO_0000046049Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Lipidationi390 – 3901GPI-anchor amidated cysteineSequence Analysis

Post-translational modificationi

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ86UN3.
PaxDbiQ86UN3.
PRIDEiQ86UN3.

PTM databases

PhosphoSiteiQ86UN3.

Expressioni

Tissue specificityi

Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.2 Publications

Gene expression databases

BgeeiQ86UN3.
CleanExiHS_RTN4RL2.
ExpressionAtlasiQ86UN3. baseline and differential.
GenevisibleiQ86UN3. HS.

Organism-specific databases

HPAiCAB024870.

Interactioni

Protein-protein interaction databases

BioGridi131566. 3 interactions.
IntActiQ86UN3. 3 interactions.
STRINGi9606.ENSP00000335397.

Structurei

3D structure databases

ProteinModelPortaliQ86UN3.
SMRiQ86UN3. Positions 29-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 6014LRRNTAdd
BLAST
Repeati61 – 8222LRR 1Add
BLAST
Repeati83 – 10422LRR 2Add
BLAST
Repeati107 – 12923LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati180 – 20122LRR 6Add
BLAST
Repeati204 – 22522LRR 7Add
BLAST
Repeati228 – 24922LRR 8Add
BLAST
Domaini261 – 31252LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000203132.
HOVERGENiHBG063707.
InParanoidiQ86UN3.
KOiK16661.
OMAiHRCKLAT.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ86UN3.
TreeFamiTF330080.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPGLRRLLQ APASACLLLM LLALPLAAPS CPMLCTCYSS PPTVSCQANN
60 70 80 90 100
FSSVPLSLPP STQRLFLQNN LIRTLRPGTF GSNLLTLWLF SNNLSTIYPG
110 120 130 140 150
TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI
160 170 180 190 200
FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR
210 220 230 240 250
GLGSLDRLLL HGNRLQGVHR AAFRGLSRLT ILYLFNNSLA SLPGEALADL
260 270 280 290 300
PSLEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR
310 320 330 340 350
ALREADFQAC PPAAPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD
360 370 380 390 400
LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQMCPGAAC QAPPDSRGPA
410 420
LSAGLPSPLL CLLLLVPHHL
Length:420
Mass (Da):46,106
Last modified:June 1, 2003 - v1
Checksum:i09B9E875BC88A0E8
GO
Isoform 2 (identifier: Q86UN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-193: DDLFADLANLSHLFLHGNRLRL → GPLPKGLCSCFSHPPSSLPTSR
     194-420: Missing.

Show »
Length:193
Mass (Da):21,373
Checksum:i432225844C809EAD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781G → S in AAP82838 (PubMed:14664809).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei172 – 19322DDLFA…NRLRL → GPLPKGLCSCFSHPPSSLPT SR in isoform 2. 1 PublicationVSP_047767Add
BLAST
Alternative sequencei194 – 420227Missing in isoform 2. 1 PublicationVSP_047768Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532858 mRNA. Translation: AAP21835.1.
AY250221 mRNA. Translation: AAP82838.1.
DQ864979 mRNA. Translation: ABI23432.1.
AP002893 Genomic DNA. No translation available.
BC113673 mRNA. Translation: AAI13674.1.
BC117276 mRNA. Translation: AAI17277.1.
BK001302 mRNA. Translation: DAA01385.1.
CCDSiCCDS7957.1. [Q86UN3-1]
RefSeqiNP_848665.1. NM_178570.2. [Q86UN3-1]
UniGeneiHs.502618.
Hs.603388.

Genome annotation databases

EnsembliENST00000335099; ENSP00000335397; ENSG00000186907.
ENST00000395120; ENSP00000378552; ENSG00000186907. [Q86UN3-2]
GeneIDi349667.
KEGGihsa:349667.
UCSCiuc010rjt.2. human. [Q86UN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532858 mRNA. Translation: AAP21835.1.
AY250221 mRNA. Translation: AAP82838.1.
DQ864979 mRNA. Translation: ABI23432.1.
AP002893 Genomic DNA. No translation available.
BC113673 mRNA. Translation: AAI13674.1.
BC117276 mRNA. Translation: AAI17277.1.
BK001302 mRNA. Translation: DAA01385.1.
CCDSiCCDS7957.1. [Q86UN3-1]
RefSeqiNP_848665.1. NM_178570.2. [Q86UN3-1]
UniGeneiHs.502618.
Hs.603388.

3D structure databases

ProteinModelPortaliQ86UN3.
SMRiQ86UN3. Positions 29-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131566. 3 interactions.
IntActiQ86UN3. 3 interactions.
STRINGi9606.ENSP00000335397.

PTM databases

PhosphoSiteiQ86UN3.

Polymorphism and mutation databases

DMDMi74759401.

Proteomic databases

MaxQBiQ86UN3.
PaxDbiQ86UN3.
PRIDEiQ86UN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335099; ENSP00000335397; ENSG00000186907.
ENST00000395120; ENSP00000378552; ENSG00000186907. [Q86UN3-2]
GeneIDi349667.
KEGGihsa:349667.
UCSCiuc010rjt.2. human. [Q86UN3-1]

Organism-specific databases

CTDi349667.
GeneCardsiGC11P057228.
HGNCiHGNC:23053. RTN4RL2.
HPAiCAB024870.
MIMi610462. gene.
neXtProtiNX_Q86UN3.
PharmGKBiPA134964131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000203132.
HOVERGENiHBG063707.
InParanoidiQ86UN3.
KOiK16661.
OMAiHRCKLAT.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ86UN3.
TreeFamiTF330080.

Miscellaneous databases

GenomeRNAii349667.
NextBioi99528.
PROiQ86UN3.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UN3.
CleanExiHS_RTN4RL2.
ExpressionAtlasiQ86UN3. baseline and differential.
GenevisibleiQ86UN3. HS.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
    Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
    J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  2. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
    Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Splice variant of human RTN4RL2 (Nogo-66 receptor homolog NgR2)."
    Rader C., Hofer T., Giger R.J.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
    Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
    EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases."
    Walmsley A.R., Mir A.K., Frentzel S.
    Biochem. Biophys. Res. Commun. 327:112-116(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiR4RL2_HUMAN
AccessioniPrimary (citable) accession number: Q86UN3
Secondary accession number(s): Q0GGW3, Q17RL9, Q6X813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.