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Protein

Reticulon-4 receptor-like 1

Gene

RTN4RL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-163125. Post-translational modification: synthesis of GPI-anchored proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 21 Publication
Nogo-66 receptor-related protein 3
Short name:
NgR3
Gene namesi
Name:RTN4RL1Imported
Synonyms:NGRH21 PublicationImported, NGRL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000185924.6.
HGNCiHGNC:21329. RTN4RL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185924.
PharmGKBiPA134973992.

Polymorphism and mutation databases

BioMutaiRTN4RL1.
DMDMi74714017.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004604225 – 420Reticulon-4 receptor-like 1Add BLAST396
PropeptideiPRO_0000046043421 – 441Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi420GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ86UN2.
PeptideAtlasiQ86UN2.
PRIDEiQ86UN2.

PTM databases

iPTMnetiQ86UN2.
PhosphoSitePlusiQ86UN2.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.2 Publications

Gene expression databases

BgeeiENSG00000185924.
CleanExiHS_RTN4RL1.
GenevisibleiQ86UN2. HS.

Organism-specific databases

HPAiHPA044428.

Interactioni

Subunit structurei

Identified in a complex that contains RTN4R, RTN4RL1 and NGFR; the interaction depends on the presence of chondroitin sulfate proteoglycans. Does not interact with MAG, OMG and RTN4.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127008. 5 interactors.
IntActiQ86UN2. 4 interactors.
STRINGi9606.ENSP00000330631.

Structurei

3D structure databases

ProteinModelPortaliQ86UN2.
SMRiQ86UN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 54LRRNTAdd BLAST30
Repeati55 – 76LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 123LRR 3Add BLAST23
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati222 – 243LRR 8Add BLAST22
Domaini255 – 306LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00900000140818.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ86UN2.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG091G08II.
PhylomeDBiQ86UN2.
TreeFamiTF330080.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
SMARTiView protein in SMART
SM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 6 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE
60 70 80 90 100
GIPVDSERVF LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV
110 120 130 140 150
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS
160 170 180 190 200
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGP GTFRGLVNLD
210 220 230 240 250
RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC LAPLGALEFL
260 270 280 290 300
RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED
310 320 330 340 350
FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR
360 370 380 390 400
KPGKNCTNPR NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR
410 420 430 440
KGKCARRTPI RAPSGVQQAS SASSLGASLL AWTLGLAVTL R
Length:441
Mass (Da):49,065
Last modified:June 1, 2003 - v1
Checksum:i745272014C5304D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22G → S in CAD39071 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250219 mRNA. Translation: AAP82836.1.
AF532859 mRNA. Translation: AAP21836.1.
CH471108 Genomic DNA. Translation: EAW90570.1.
BC128608 mRNA. Translation: AAI28609.1.
AL834409 mRNA. Translation: CAD39071.1.
BK001305 mRNA. Translation: DAA01388.1.
CCDSiCCDS45569.1.
RefSeqiNP_848663.1. NM_178568.3.
UniGeneiHs.22917.

Genome annotation databases

EnsembliENST00000331238; ENSP00000330631; ENSG00000185924.
GeneIDi146760.
KEGGihsa:146760.
UCSCiuc002ftp.4. human.

Similar proteinsi

Entry informationi

Entry nameiR4RL1_HUMAN
AccessioniPrimary (citable) accession number: Q86UN2
Secondary accession number(s): A1A5E3, Q8ND46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families