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Q86UN2 (R4RL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name=NgR3
Gene names
Name:RTN4RL1
Synonyms:NGRH2, NGRL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Ref.1

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor. Note: Localized to the surface of neurons, including axons. Ref.2

Tissue specificity

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. Ref.1 Ref.2

Sequence similarities

Belongs to the Nogo receptor family.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 420396Reticulon-4 receptor-like 1
PRO_0000046042
Propeptide421 – 44121Removed in mature form Potential
PRO_0000046043

Regions

Domain25 – 5430LRRNT
Repeat55 – 7622LRR 1
Repeat77 – 9822LRR 2
Repeat101 – 12323LRR 3
Repeat126 – 14722LRR 4
Repeat150 – 17122LRR 5
Repeat174 – 19522LRR 6
Repeat198 – 21922LRR 7
Repeat222 – 24322LRR 8
Domain255 – 30652LRRCT

Amino acid modifications

Lipidation4201GPI-anchor amidated serine Potential

Experimental info

Sequence conflict221G → S in CAD39071. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q86UN2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 745272014C5304D3

FASTA44149,065
        10         20         30         40         50         60 
MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE GIPVDSERVF 

        70         80         90        100        110        120 
LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV HLEELDLGDN RQLRTLAPET 

       130        140        150        160        170        180 
FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL 

       190        200        210        220        230        240 
HGNKLWSLGP GTFRGLVNLD RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC 

       250        260        270        280        290        300 
LAPLGALEFL RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED 

       310        320        330        340        350        360 
FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR KPGKNCTNPR 

       370        380        390        400        410        420 
NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR KGKCARRTPI RAPSGVQQAS 

       430        440 
SASSLGASLL AWTLGLAVTL R 

« Hide

References

« Hide 'large scale' references
[1]"Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-441.
Tissue: Brain.
[6]"Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY250219 mRNA. Translation: AAP82836.1.
AF532859 mRNA. Translation: AAP21836.1.
CH471108 Genomic DNA. Translation: EAW90570.1.
BC128608 mRNA. Translation: AAI28609.1.
AL834409 mRNA. Translation: CAD39071.1.
BK001305 mRNA. Translation: DAA01388.1.
RefSeqNP_848663.1. NM_178568.2.
UniGeneHs.22917.

3D structure databases

ProteinModelPortalQ86UN2.
SMRQ86UN2. Positions 24-328.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000330631.

Polymorphism databases

DMDM74714017.

Proteomic databases

PaxDbQ86UN2.
PRIDEQ86UN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331238; ENSP00000330631; ENSG00000185924.
GeneID146760.
KEGGhsa:146760.
UCSCuc002ftp.3. human.

Organism-specific databases

CTD146760.
GeneCardsGC17M001786.
HGNCHGNC:21329. RTN4RL1.
HPAHPA044428.
MIM610461. gene.
neXtProtNX_Q86UN2.
PharmGKBPA134973992.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000116109.
HOVERGENHBG063707.
InParanoidQ86UN2.
KOK16660.
OMANCTSHRN.
OrthoDBEOG7CZK5N.
PhylomeDBQ86UN2.
TreeFamTF330080.

Gene expression databases

BgeeQ86UN2.
CleanExHS_RTN4RL1.
GenevestigatorQ86UN2.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
SMARTSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi146760.
NextBio85443.
PROQ86UN2.
SOURCESearch...

Entry information

Entry nameR4RL1_HUMAN
AccessionPrimary (citable) accession number: Q86UN2
Secondary accession number(s): A1A5E3, Q8ND46
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM