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Q86UN2

- R4RL1_HUMAN

UniProt

Q86UN2 - R4RL1_HUMAN

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Protein

Reticulon-4 receptor-like 1

Gene

RTN4RL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.1 Publication

GO - Molecular functioni

  1. receptor activity Source: UniProtKB

GO - Biological processi

  1. axon regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name:
NgR3
Gene namesi
Name:RTN4RL1Imported
Synonyms:NGRH2Imported, NGRL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:21329. RTN4RL1.

Subcellular locationi

Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication
Note: Localized to the surface of neurons, including axons.

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
  2. cell surface Source: DFLAT
  3. external side of plasma membrane Source: Ensembl
  4. extracellular vesicular exosome Source: UniProtKB
  5. membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 420396Reticulon-4 receptor-like 1PRO_0000046042Add
BLAST
Propeptidei421 – 44121Removed in mature formSequence AnalysisPRO_0000046043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi420 – 4201GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ86UN2.
PRIDEiQ86UN2.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.2 Publications

Gene expression databases

BgeeiQ86UN2.
CleanExiHS_RTN4RL1.
GenevestigatoriQ86UN2.

Organism-specific databases

HPAiHPA044428.

Interactioni

Protein-protein interaction databases

BioGridi127008. 1 interaction.
STRINGi9606.ENSP00000330631.

Structurei

3D structure databases

ProteinModelPortaliQ86UN2.
SMRiQ86UN2. Positions 25-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5430LRRNTAdd
BLAST
Repeati55 – 7622LRR 1Add
BLAST
Repeati77 – 9822LRR 2Add
BLAST
Repeati101 – 12323LRR 3Add
BLAST
Repeati126 – 14722LRR 4Add
BLAST
Repeati150 – 17122LRR 5Add
BLAST
Repeati174 – 19522LRR 6Add
BLAST
Repeati198 – 21922LRR 7Add
BLAST
Repeati222 – 24322LRR 8Add
BLAST
Domaini255 – 30652LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ86UN2.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ86UN2.
TreeFamiTF330080.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UN2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE
60 70 80 90 100
GIPVDSERVF LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV
110 120 130 140 150
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS
160 170 180 190 200
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGP GTFRGLVNLD
210 220 230 240 250
RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC LAPLGALEFL
260 270 280 290 300
RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED
310 320 330 340 350
FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR
360 370 380 390 400
KPGKNCTNPR NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR
410 420 430 440
KGKCARRTPI RAPSGVQQAS SASSLGASLL AWTLGLAVTL R
Length:441
Mass (Da):49,065
Last modified:June 1, 2003 - v1
Checksum:i745272014C5304D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221G → S in CAD39071. (PubMed:17974005)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250219 mRNA. Translation: AAP82836.1.
AF532859 mRNA. Translation: AAP21836.1.
CH471108 Genomic DNA. Translation: EAW90570.1.
BC128608 mRNA. Translation: AAI28609.1.
AL834409 mRNA. Translation: CAD39071.1.
BK001305 mRNA. Translation: DAA01388.1.
CCDSiCCDS45569.1.
RefSeqiNP_848663.1. NM_178568.2.
UniGeneiHs.22917.

Genome annotation databases

EnsembliENST00000331238; ENSP00000330631; ENSG00000185924.
GeneIDi146760.
KEGGihsa:146760.
UCSCiuc002ftp.3. human.

Polymorphism databases

DMDMi74714017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250219 mRNA. Translation: AAP82836.1 .
AF532859 mRNA. Translation: AAP21836.1 .
CH471108 Genomic DNA. Translation: EAW90570.1 .
BC128608 mRNA. Translation: AAI28609.1 .
AL834409 mRNA. Translation: CAD39071.1 .
BK001305 mRNA. Translation: DAA01388.1 .
CCDSi CCDS45569.1.
RefSeqi NP_848663.1. NM_178568.2.
UniGenei Hs.22917.

3D structure databases

ProteinModelPortali Q86UN2.
SMRi Q86UN2. Positions 25-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127008. 1 interaction.
STRINGi 9606.ENSP00000330631.

Polymorphism databases

DMDMi 74714017.

Proteomic databases

PaxDbi Q86UN2.
PRIDEi Q86UN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331238 ; ENSP00000330631 ; ENSG00000185924 .
GeneIDi 146760.
KEGGi hsa:146760.
UCSCi uc002ftp.3. human.

Organism-specific databases

CTDi 146760.
GeneCardsi GC17M001786.
HGNCi HGNC:21329. RTN4RL1.
HPAi HPA044428.
MIMi 610461. gene.
neXtProti NX_Q86UN2.
PharmGKBi PA134973992.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000116109.
HOVERGENi HBG063707.
InParanoidi Q86UN2.
KOi K16660.
OMAi NCTSHRN.
OrthoDBi EOG7CZK5N.
PhylomeDBi Q86UN2.
TreeFami TF330080.

Miscellaneous databases

GenomeRNAii 146760.
NextBioi 85443.
PROi Q86UN2.
SOURCEi Search...

Gene expression databases

Bgeei Q86UN2.
CleanExi HS_RTN4RL1.
Genevestigatori Q86UN2.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
    Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  2. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
    Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
    J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-441.
    Tissue: Brain.
  6. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
    Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
    EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiR4RL1_HUMAN
AccessioniPrimary (citable) accession number: Q86UN2
Secondary accession number(s): A1A5E3, Q8ND46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3