Q86UN2 (R4RL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Reticulon-4 receptor-like 1

Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name=NgR3

Gene names

Name:	RTN4RL1
Synonyms:	NGRH2, NGRL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Ref.1
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor. Note: Localized to the surface of neurons, including axons. Ref.2
Tissue specificity	Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. Ref.1 Ref.2
Sequence similarities	Belongs to the Nogo receptor family. Contains 8 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Leucine-rich repeat Repeat Signal
Molecular function	Receptor
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon regeneration Traceable author statement Ref.1. Source: UniProtKB
Cellular_component	anchored to plasma membrane Inferred from direct assay Ref.2. Source: UniProtKB cell surface Inferred from direct assay PubMed 20463223. Source: DFLAT external side of plasma membrane Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara
Molecular_function	receptor activity Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 420	396	Reticulon-4 receptor-like 1		PRO_0000046042
	Propeptide	421 – 441	21	Removed in mature form Potential		PRO_0000046043
Regions
	Domain	25 – 54	30	LRRNT
	Repeat	55 – 76	22	LRR 1
	Repeat	77 – 98	22	LRR 2
	Repeat	101 – 123	23	LRR 3
	Repeat	126 – 147	22	LRR 4
	Repeat	150 – 171	22	LRR 5
	Repeat	174 – 195	22	LRR 6
	Repeat	198 – 219	22	LRR 7
	Repeat	222 – 243	22	LRR 8
	Domain	255 – 306	52	LRRCT
Amino acid modifications
	Lipidation	420	1	GPI-anchor amidated serine Potential
Experimental info
	Sequence conflict	22	1	G → S in CAD39071. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q86UN2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 745272014C5304D3	FASTA	441	49,065
	10 20 30 40 50 60 MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE GIPVDSERVF 70 80 90 100 110 120 LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV HLEELDLGDN RQLRTLAPET 130 140 150 160 170 180 FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL 190 200 210 220 230 240 HGNKLWSLGP GTFRGLVNLD RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC 250 260 270 280 290 300 LAPLGALEFL RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED 310 320 330 340 350 360 FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR KPGKNCTNPR 370 380 390 400 410 420 NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR KGKCARRTPI RAPSGVQQAS 430 440 SASSLGASLL AWTLGLAVTL R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems." Lauren J., Airaksinen M.S., Saarma M., Timmusk T. Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor." Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S. J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-441. Tissue: Brain.
[6]	"Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins." Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B. EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY250219 mRNA. Translation: AAP82836.1. AF532859 mRNA. Translation: AAP21836.1. CH471108 Genomic DNA. Translation: EAW90570.1. BC128608 mRNA. Translation: AAI28609.1. AL834409 mRNA. Translation: CAD39071.1. BK001305 mRNA. Translation: DAA01388.1.
IPI	IPI00328745.
RefSeq	NP_848663.1. NM_178568.2.
UniGene	Hs.22917.
3D structure databases
ProteinModelPortal	Q86UN2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000330631.
Polymorphism databases
DMDM	74714017.
Proteomic databases
PaxDb	Q86UN2.
PRIDE	Q86UN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331238; ENSP00000330631; ENSG00000185924.
GeneID	146760.
KEGG	hsa:146760.
UCSC	uc002ftp.3. human.
Organism-specific databases
CTD	146760.
GeneCards	GC17M001786.
HGNC	HGNC:21329. RTN4RL1.
HPA	HPA044428.
MIM	610461. gene.
neXtProt	NX_Q86UN2.
PharmGKB	PA134973992.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOGENOM	HOG000116109.
HOVERGEN	HBG063707.
InParanoid	Q86UN2.
KO	K16660.
OMA	NCTSHRN.
OrthoDB	EOG4FXR7G.
Gene expression databases
Bgee	Q86UN2.
CleanEx	HS_RTN4RL1.
Genevestigator	Q86UN2.
GermOnline	ENSG00000185924. Homo sapiens.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
SMART	SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	146760.
NextBio	85443.
SOURCE	Search...

Entry information

Entry name

R4RL1_HUMAN

Accession

Primary (citable) accession number: Q86UN2
Secondary accession number(s): A1A5E3, Q8ND46

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.