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Protein

Reticulon-4 receptor-like 1

Gene

RTN4RL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.1 Publication

GO - Molecular functioni

  • receptor activity Source: UniProtKB

GO - Biological processi

  • axon regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name:
NgR3
Gene namesi
Name:RTN4RL1Imported
Synonyms:NGRH2Imported, NGRL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:21329. RTN4RL1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • cell surface Source: DFLAT
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973992.

Polymorphism and mutation databases

BioMutaiRTN4RL1.
DMDMi74714017.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 420396Reticulon-4 receptor-like 1PRO_0000046042Add
BLAST
Propeptidei421 – 44121Removed in mature formSequence AnalysisPRO_0000046043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi420 – 4201GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ86UN2.
PRIDEiQ86UN2.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.2 Publications

Gene expression databases

BgeeiQ86UN2.
CleanExiHS_RTN4RL1.
GenevisibleiQ86UN2. HS.

Organism-specific databases

HPAiHPA044428.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10258951,EBI-10172290
KRTAP10-8P604103EBI-10258951,EBI-10171774
NOTCH2NLQ7Z3S93EBI-10258951,EBI-945833

Protein-protein interaction databases

BioGridi127008. 5 interactions.
IntActiQ86UN2. 3 interactions.
STRINGi9606.ENSP00000330631.

Structurei

3D structure databases

ProteinModelPortaliQ86UN2.
SMRiQ86UN2. Positions 25-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5430LRRNTAdd
BLAST
Repeati55 – 7622LRR 1Add
BLAST
Repeati77 – 9822LRR 2Add
BLAST
Repeati101 – 12323LRR 3Add
BLAST
Repeati126 – 14722LRR 4Add
BLAST
Repeati150 – 17122LRR 5Add
BLAST
Repeati174 – 19522LRR 6Add
BLAST
Repeati198 – 21922LRR 7Add
BLAST
Repeati222 – 24322LRR 8Add
BLAST
Domaini255 – 30652LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00790000122991.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ86UN2.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ86UN2.
TreeFamiTF330080.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE
60 70 80 90 100
GIPVDSERVF LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV
110 120 130 140 150
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS
160 170 180 190 200
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGP GTFRGLVNLD
210 220 230 240 250
RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC LAPLGALEFL
260 270 280 290 300
RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED
310 320 330 340 350
FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR
360 370 380 390 400
KPGKNCTNPR NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR
410 420 430 440
KGKCARRTPI RAPSGVQQAS SASSLGASLL AWTLGLAVTL R
Length:441
Mass (Da):49,065
Last modified:June 1, 2003 - v1
Checksum:i745272014C5304D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221G → S in CAD39071 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250219 mRNA. Translation: AAP82836.1.
AF532859 mRNA. Translation: AAP21836.1.
CH471108 Genomic DNA. Translation: EAW90570.1.
BC128608 mRNA. Translation: AAI28609.1.
AL834409 mRNA. Translation: CAD39071.1.
BK001305 mRNA. Translation: DAA01388.1.
CCDSiCCDS45569.1.
RefSeqiNP_848663.1. NM_178568.3.
UniGeneiHs.22917.

Genome annotation databases

EnsembliENST00000331238; ENSP00000330631; ENSG00000185924.
GeneIDi146760.
KEGGihsa:146760.
UCSCiuc002ftp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250219 mRNA. Translation: AAP82836.1.
AF532859 mRNA. Translation: AAP21836.1.
CH471108 Genomic DNA. Translation: EAW90570.1.
BC128608 mRNA. Translation: AAI28609.1.
AL834409 mRNA. Translation: CAD39071.1.
BK001305 mRNA. Translation: DAA01388.1.
CCDSiCCDS45569.1.
RefSeqiNP_848663.1. NM_178568.3.
UniGeneiHs.22917.

3D structure databases

ProteinModelPortaliQ86UN2.
SMRiQ86UN2. Positions 25-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127008. 5 interactions.
IntActiQ86UN2. 3 interactions.
STRINGi9606.ENSP00000330631.

Polymorphism and mutation databases

BioMutaiRTN4RL1.
DMDMi74714017.

Proteomic databases

PaxDbiQ86UN2.
PRIDEiQ86UN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331238; ENSP00000330631; ENSG00000185924.
GeneIDi146760.
KEGGihsa:146760.
UCSCiuc002ftp.3. human.

Organism-specific databases

CTDi146760.
GeneCardsiGC17M001786.
HGNCiHGNC:21329. RTN4RL1.
HPAiHPA044428.
MIMi610461. gene.
neXtProtiNX_Q86UN2.
PharmGKBiPA134973992.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00790000122991.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ86UN2.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ86UN2.
TreeFamiTF330080.

Miscellaneous databases

GenomeRNAii146760.
NextBioi85443.
PROiQ86UN2.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UN2.
CleanExiHS_RTN4RL1.
GenevisibleiQ86UN2. HS.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.
    Mol. Cell. Neurosci. 24:581-594(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  2. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
    Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
    J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-441.
    Tissue: Brain.
  6. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."
    Barton W.A., Liu B.P., Tzvetkova D., Jeffrey P.D., Fournier A.E., Sah D., Cate R., Strittmatter S.M., Nikolov D.B.
    EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiR4RL1_HUMAN
AccessioniPrimary (citable) accession number: Q86UN2
Secondary accession number(s): A1A5E3, Q8ND46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.