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Protein

Reticulon-4 receptor-like 1

Gene

RTN4RL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.1 Publication

GO - Molecular functioni

  • protein kinase inhibitor activity Source: GO_Central
  • receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:G66-30724-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name:
NgR3
Gene namesi
Name:RTN4RL1Imported
Synonyms:NGRH2Imported, NGRL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:21329. RTN4RL1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • cell surface Source: DFLAT
  • cytoplasm Source: GO_Central
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185924.
PharmGKBiPA134973992.

Polymorphism and mutation databases

BioMutaiRTN4RL1.
DMDMi74714017.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004604225 – 420Reticulon-4 receptor-like 1Add BLAST396
PropeptideiPRO_0000046043421 – 441Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi420GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ86UN2.
PeptideAtlasiQ86UN2.
PRIDEiQ86UN2.

PTM databases

iPTMnetiQ86UN2.
PhosphoSitePlusiQ86UN2.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.2 Publications

Gene expression databases

BgeeiENSG00000185924.
CleanExiHS_RTN4RL1.
GenevisibleiQ86UN2. HS.

Organism-specific databases

HPAiHPA044428.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10258951,EBI-10172290
KRTAP10-8P604103EBI-10258951,EBI-10171774
NOTCH2NLQ7Z3S95EBI-10258951,EBI-945833

Protein-protein interaction databases

BioGridi127008. 5 interactors.
IntActiQ86UN2. 4 interactors.
STRINGi9606.ENSP00000330631.

Structurei

3D structure databases

ProteinModelPortaliQ86UN2.
SMRiQ86UN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 54LRRNTAdd BLAST30
Repeati55 – 76LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 123LRR 3Add BLAST23
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati222 – 243LRR 8Add BLAST22
Domaini255 – 306LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ86UN2.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG091G08II.
PhylomeDBiQ86UN2.
TreeFamiTF330080.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE
60 70 80 90 100
GIPVDSERVF LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV
110 120 130 140 150
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS
160 170 180 190 200
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGP GTFRGLVNLD
210 220 230 240 250
RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC LAPLGALEFL
260 270 280 290 300
RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED
310 320 330 340 350
FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR
360 370 380 390 400
KPGKNCTNPR NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR
410 420 430 440
KGKCARRTPI RAPSGVQQAS SASSLGASLL AWTLGLAVTL R
Length:441
Mass (Da):49,065
Last modified:June 1, 2003 - v1
Checksum:i745272014C5304D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22G → S in CAD39071 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250219 mRNA. Translation: AAP82836.1.
AF532859 mRNA. Translation: AAP21836.1.
CH471108 Genomic DNA. Translation: EAW90570.1.
BC128608 mRNA. Translation: AAI28609.1.
AL834409 mRNA. Translation: CAD39071.1.
BK001305 mRNA. Translation: DAA01388.1.
CCDSiCCDS45569.1.
RefSeqiNP_848663.1. NM_178568.3.
UniGeneiHs.22917.

Genome annotation databases

EnsembliENST00000331238; ENSP00000330631; ENSG00000185924.
GeneIDi146760.
KEGGihsa:146760.
UCSCiuc002ftp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250219 mRNA. Translation: AAP82836.1.
AF532859 mRNA. Translation: AAP21836.1.
CH471108 Genomic DNA. Translation: EAW90570.1.
BC128608 mRNA. Translation: AAI28609.1.
AL834409 mRNA. Translation: CAD39071.1.
BK001305 mRNA. Translation: DAA01388.1.
CCDSiCCDS45569.1.
RefSeqiNP_848663.1. NM_178568.3.
UniGeneiHs.22917.

3D structure databases

ProteinModelPortaliQ86UN2.
SMRiQ86UN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127008. 5 interactors.
IntActiQ86UN2. 4 interactors.
STRINGi9606.ENSP00000330631.

PTM databases

iPTMnetiQ86UN2.
PhosphoSitePlusiQ86UN2.

Polymorphism and mutation databases

BioMutaiRTN4RL1.
DMDMi74714017.

Proteomic databases

PaxDbiQ86UN2.
PeptideAtlasiQ86UN2.
PRIDEiQ86UN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331238; ENSP00000330631; ENSG00000185924.
GeneIDi146760.
KEGGihsa:146760.
UCSCiuc002ftp.4. human.

Organism-specific databases

CTDi146760.
GeneCardsiRTN4RL1.
HGNCiHGNC:21329. RTN4RL1.
HPAiHPA044428.
MIMi610461. gene.
neXtProtiNX_Q86UN2.
OpenTargetsiENSG00000185924.
PharmGKBiPA134973992.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ86UN2.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG091G08II.
PhylomeDBiQ86UN2.
TreeFamiTF330080.

Enzyme and pathway databases

BioCyciZFISH:G66-30724-MONOMER.

Miscellaneous databases

GenomeRNAii146760.
PROiQ86UN2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185924.
CleanExiHS_RTN4RL1.
GenevisibleiQ86UN2. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiR4RL1_HUMAN
AccessioniPrimary (citable) accession number: Q86UN2
Secondary accession number(s): A1A5E3, Q8ND46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.