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Q86UL3

- GPAT4_HUMAN

UniProt

Q86UL3 - GPAT4_HUMAN

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Protein

Glycerol-3-phosphate acyltransferase 4

Gene
AGPAT6, GPAT4, UNQ551/PRO1108
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.1 Publication

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.

Enzyme regulationi

Inhibited by N-ethylmaleimide (NEM).1 Publication

Pathwayi

GO - Molecular functioni

  1. glycerol-3-phosphate O-acyltransferase activity Source: UniProtKB

GO - Biological processi

  1. acyl-CoA metabolic process Source: UniProtKB
  2. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
  3. cellular lipid metabolic process Source: Reactome
  4. diacylglycerol metabolic process Source: Ensembl
  5. fatty acid metabolic process Source: Ensembl
  6. glandular epithelial cell maturation Source: Ensembl
  7. glycerophospholipid biosynthetic process Source: Reactome
  8. lactation Source: UniProtKB
  9. lipid biosynthetic process Source: UniProtKB
  10. phosphatidic acid biosynthetic process Source: Reactome
  11. phosphatidylcholine biosynthetic process Source: UniProtKB
  12. phospholipid metabolic process Source: Reactome
  13. regulation of multicellular organism growth Source: Ensembl
  14. small molecule metabolic process Source: Reactome
  15. triglyceride biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_1190. Triglyceride Biosynthesis.
REACT_120906. Synthesis of PA.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferase 4 (EC:2.3.1.15)
Short name:
GPAT4
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 6
Short name:
1-AGP acyltransferase 6
Short name:
1-AGPAT 6
Acyl-CoA:glycerol-3-phosphate acyltransferase 4
Lysophosphatidic acid acyltransferase zeta
Short name:
LPAAT-zeta
Gene namesi
Name:AGPAT6
Synonyms:GPAT4
ORF Names:UNQ551/PRO1108
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:20880. AGPAT6.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei156 – 17621Helical; Reviewed predictionAdd
BLAST
Transmembranei180 – 20021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 Reviewed predictionAdd
BLAST
Chaini38 – 456419Glycerol-3-phosphate acyltransferase 4PRO_0000024703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi247 – 2471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi327 – 3271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi328 – 3281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi362 – 3621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ86UL3.
PaxDbiQ86UL3.
PRIDEiQ86UL3.

PTM databases

PhosphoSiteiQ86UL3.

Expressioni

Tissue specificityi

Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.2 Publications

Gene expression databases

ArrayExpressiQ86UL3.
BgeeiQ86UL3.
CleanExiHS_AGPAT6.
GenevestigatoriQ86UL3.

Organism-specific databases

HPAiHPA016471.

Interactioni

Protein-protein interaction databases

BioGridi126493. 3 interactions.
IntActiQ86UL3. 2 interactions.
MINTiMINT-2878746.
STRINGi9606.ENSP00000380184.

Structurei

3D structure databases

ProteinModelPortaliQ86UL3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi248 – 2536HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0204.
HOGENOMiHOG000265725.
InParanoidiQ86UL3.
KOiK13506.
OMAiITYHDRK.
OrthoDBiEOG70GMFG.
PhylomeDBiQ86UL3.
TreeFamiTF315039.

Family and domain databases

InterProiIPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UL3-1 [UniParc]FASTAAdd to Basket

« Hide

MFLLLPFDSL IVNLLGISLT VLFTLLLVFI IVPAIFGVSF GIRKLYMKSL    50
LKIFAWATLR MERGAKEKNH QLYKPYTNGI IAKDPTSLEE EIKEIRRSGS 100
SKALDNTPEF ELSDIFYFCR KGMETIMDDE VTKRFSAEEL ESWNLLSRTN 150
YNFQYISLRL TVLWGLGVLI RYCFLLPLRI ALAFTGISLL VVGTTVVGYL 200
PNGRFKEFMS KHVHLMCYRI CVRALTAIIT YHDRENRPRN GGICVANHTS 250
PIDVIILASD GYYAMVGQVH GGLMGVIQRA MVKACPHVWF ERSEVKDRHL 300
VAKRLTEHVQ DKSKLPILIF PEGTCINNTS VMMFKKGSFE IGATVYPVAI 350
KYDPQFGDAF WNSSKYGMVT YLLRMMTSWA IVCSVWYLPP MTREADEDAV 400
QFANRVKSAI ARQGGLVDLL WDGGLKREKV KDTFKEEQQK LYSKMIVGNH 450
KDRSRS 456
Length:456
Mass (Da):52,071
Last modified:June 1, 2003 - v1
Checksum:i5B9DEB2912E989E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF406612 mRNA. Translation: AAP21893.1.
AY358670 mRNA. Translation: AAQ89033.1.
BC051377 mRNA. Translation: AAH51377.2.
BC061884 mRNA. Translation: AAH61884.1.
CCDSiCCDS6117.1.
RefSeqiNP_848934.1. NM_178819.3.
UniGeneiHs.355753.

Genome annotation databases

EnsembliENST00000396987; ENSP00000380184; ENSG00000158669.
GeneIDi137964.
KEGGihsa:137964.
UCSCiuc003xnz.2. human.

Polymorphism databases

DMDMi68052729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF406612 mRNA. Translation: AAP21893.1 .
AY358670 mRNA. Translation: AAQ89033.1 .
BC051377 mRNA. Translation: AAH51377.2 .
BC061884 mRNA. Translation: AAH61884.1 .
CCDSi CCDS6117.1.
RefSeqi NP_848934.1. NM_178819.3.
UniGenei Hs.355753.

3D structure databases

ProteinModelPortali Q86UL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126493. 3 interactions.
IntActi Q86UL3. 2 interactions.
MINTi MINT-2878746.
STRINGi 9606.ENSP00000380184.

PTM databases

PhosphoSitei Q86UL3.

Polymorphism databases

DMDMi 68052729.

Proteomic databases

MaxQBi Q86UL3.
PaxDbi Q86UL3.
PRIDEi Q86UL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396987 ; ENSP00000380184 ; ENSG00000158669 .
GeneIDi 137964.
KEGGi hsa:137964.
UCSCi uc003xnz.2. human.

Organism-specific databases

CTDi 137964.
GeneCardsi GC08P041435.
HGNCi HGNC:20880. AGPAT6.
HPAi HPA016471.
MIMi 608143. gene.
neXtProti NX_Q86UL3.
PharmGKBi PA142672637.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0204.
HOGENOMi HOG000265725.
InParanoidi Q86UL3.
KOi K13506.
OMAi ITYHDRK.
OrthoDBi EOG70GMFG.
PhylomeDBi Q86UL3.
TreeFami TF315039.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00612 .
Reactomei REACT_1190. Triglyceride Biosynthesis.
REACT_120906. Synthesis of PA.

Miscellaneous databases

ChiTaRSi AGPAT6. human.
GenomeRNAii 137964.
NextBioi 83709.
PROi Q86UL3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86UL3.
Bgeei Q86UL3.
CleanExi HS_AGPAT6.
Genevestigatori Q86UL3.

Family and domain databases

InterProi IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view ]
Pfami PF01553. Acyltransferase. 1 hit.
[Graphical view ]
SMARTi SM00563. PlsC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family."
    Li D., Yu L., Wu H., Shan Y., Guo J., Dang Y., Wei Y., Zhao S.
    J. Hum. Genet. 48:438-442(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiGPAT4_HUMAN
AccessioniPrimary (citable) accession number: Q86UL3
Secondary accession number(s): Q86V89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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