Q86UG4 (SO6A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier organic anion transporter family member 6A1

Alternative name(s):
Cancer/testis antigen 48
Short name=CT48
Gonad-specific transporter
Short name=GST
Organic anion-transporting polypeptide 6A1
Organic anion-transporting polypeptide I
Short name=OATP-I
Solute carrier family 21 member 19

Gene names

Name:	SLCO6A1
Synonyms:	OATP6A1, SLC21A19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors. Ref.2 Ref.7
Sequence similarities	Belongs to the organo anion transporter (TC 2.A.60) family. [View classification] Contains 1 Kazal-like domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86UG4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86UG4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     206-267: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86UG4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     206-267: Missing.
     301-491: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 719	719	Solute carrier organic anion transporter family member 6A1		PRO_0000307642
Regions
	Topological domain	1 – 106	106	Cytoplasmic Potential
	Transmembrane	107 – 126	20	Helical; Name=1; Potential
	Topological domain	127 – 145	19	Extracellular Potential
	Transmembrane	146 – 166	21	Helical; Name=2; Potential
	Topological domain	167 – 171	5	Cytoplasmic Potential
	Transmembrane	172 – 196	25	Helical; Name=3; Potential
	Topological domain	197 – 223	27	Extracellular Potential
	Transmembrane	224 – 254	31	Helical; Name=4; Potential
	Topological domain	255 – 274	20	Cytoplasmic Potential
	Transmembrane	275 – 295	21	Helical; Name=5; Potential
	Topological domain	296 – 311	16	Extracellular Potential
	Transmembrane	312 – 336	25	Helical; Name=6; Potential
	Topological domain	337 – 378	42	Cytoplasmic Potential
	Transmembrane	379 – 400	22	Helical; Name=7; Potential
	Topological domain	401 – 420	20	Extracellular Potential
	Transmembrane	421 – 444	24	Helical; Name=8; Potential
	Topological domain	445 – 448	4	Cytoplasmic Potential
	Transmembrane	449 – 472	24	Helical; Name=9; Potential
	Topological domain	473 – 581	109	Extracellular Potential
	Transmembrane	582 – 604	23	Helical; Name=10; Potential
	Topological domain	605 – 613	9	Cytoplasmic Potential
	Transmembrane	614 – 639	26	Helical; Name=11; Potential
	Topological domain	640 – 673	34	Extracellular Potential
	Transmembrane	674 – 691	18	Helical; Name=12; Potential
	Topological domain	692 – 719	28	Cytoplasmic Potential
	Domain	496 – 551	56	Kazal-like
	Compositional bias	89 – 118	30	Cys-rich
Amino acid modifications
	Glycosylation	300	1	N-linked (GlcNAc...) Potential
	Glycosylation	497	1	N-linked (GlcNAc...) Potential
	Glycosylation	546	1	N-linked (GlcNAc...) Potential
	Glycosylation	661	1	N-linked (GlcNAc...) Potential
	Disulfide bond	502 ↔ 528		By similarity
	Disulfide bond	506 ↔ 517		By similarity
	Disulfide bond	508 ↔ 532		By similarity
Natural variations
	Alternative sequence	206 – 267	62	Missing in isoform 2 and isoform 3.		VSP_028753
	Alternative sequence	301 – 491	191	Missing in isoform 3.		VSP_028754
	Natural variant	27	1	A → V. Corresponds to variant rs13190449 [ dbSNP | Ensembl ].		VAR_036622
	Natural variant	381	1	K → R. Corresponds to variant rs17150488 [ dbSNP | Ensembl ].		VAR_036623
	Natural variant	527	1	P → A. Corresponds to variant rs10073333 [ dbSNP | Ensembl ].		VAR_053680
	Natural variant	654	1	T → R. Ref.3 Corresponds to variant rs10055840 [ dbSNP | Ensembl ].		VAR_036624
Experimental info
	Sequence conflict	23	1	E → D in BAD18590. Ref.3
	Sequence conflict	77 – 79	3	KPG → NRE in AAP33048. Ref.1
	Sequence conflict	300	1	N → K in BAD18590. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 56EFD346A8F0569B	FASTA	719	79,232
	10 20 30 40 50 60 MFVGVARHSG SQDEVSRGVE PLEAARAQPA KDRRAKGTPK SSKPGKKHRY LRLLPEALIR 70 80 90 100 110 120 FGGFRKRKKA KSSVSKKPGE VDDSLEQPCG LGCLVSTCCE CCNNIRCFMI FYCILLICQG 130 140 150 160 170 180 VVFGLIDVSI GDFQKEYQLK TIEKLALEKS YDISSGLVAI FIAFYGDRKK VIWFVASSFL 190 200 210 220 230 240 IGLGSLLCAF PSINEENKQS KVGIEDICEE IKVVSGCQSS GISFQSKYLS FFILGQTVQG 250 260 270 280 290 300 IAGMPLYILG ITFIDENVAT HSAGIYLGIA ECTSMIGYAL GYVLGAPLVK VPENTTSATN 310 320 330 340 350 360 TTVNNGSPEW LWTWWINFLF AAVVAWCTLI PLSCFPNNMP GSTRIKARKR KQLHFFDSRL 370 380 390 400 410 420 KDLKLGTNIK DLCAALWILM KNPVLICLAL SKATEYLVII GASEFLPIYL ENQFILTPTV 430 440 450 460 470 480 ATTLAGLVLI PGGALGQLLG GVIVSTLEMS CKALMRFIMV TSVISLILLV FIIFVRCNPV 490 500 510 520 530 540 QFAGINEDYD GTGKLGNLTA PCNEKCRCSS SIYSSICGRD DIEYFSPCFA GCTYSKAQNQ 550 560 570 580 590 600 KKMYYNCSCI KEGLITADAE GDFIDARPGK CDAKCYKLPL FIAFIFSTLI FSGFSGVPIV 610 620 630 640 650 660 LAMTRVVPDK LRSLALGVSY VILRIFGTIP GPSIFKMSGE TSCILRDVNK CGHTGRCWIY 670 680 690 700 710 NKTKMAFLLV GICFLCKLCT IIFTTIAFFI YKRRLNENTD FPDVTVKNPK VKKKEETDL
	Isoform 2 [UniParc]. Checksum: 9F9946EB3C04FAAC	FASTA	657	72,576
	10 20 30 40 50 60 MFVGVARHSG SQDEVSRGVE PLEAARAQPA KDRRAKGTPK SSKPGKKHRY LRLLPEALIR 70 80 90 100 110 120 FGGFRKRKKA KSSVSKKPGE VDDSLEQPCG LGCLVSTCCE CCNNIRCFMI FYCILLICQG 130 140 150 160 170 180 VVFGLIDVSI GDFQKEYQLK TIEKLALEKS YDISSGLVAI FIAFYGDRKK VIWFVASSFL 190 200 210 220 230 240 IGLGSLLCAF PSINEENKQS KVGIEGIAEC TSMIGYALGY VLGAPLVKVP ENTTSATNTT 250 260 270 280 290 300 VNNGSPEWLW TWWINFLFAA VVAWCTLIPL SCFPNNMPGS TRIKARKRKQ LHFFDSRLKD 310 320 330 340 350 360 LKLGTNIKDL CAALWILMKN PVLICLALSK ATEYLVIIGA SEFLPIYLEN QFILTPTVAT 370 380 390 400 410 420 TLAGLVLIPG GALGQLLGGV IVSTLEMSCK ALMRFIMVTS VISLILLVFI IFVRCNPVQF 430 440 450 460 470 480 AGINEDYDGT GKLGNLTAPC NEKCRCSSSI YSSICGRDDI EYFSPCFAGC TYSKAQNQKK 490 500 510 520 530 540 MYYNCSCIKE GLITADAEGD FIDARPGKCD AKCYKLPLFI AFIFSTLIFS GFSGVPIVLA 550 560 570 580 590 600 MTRVVPDKLR SLALGVSYVI LRIFGTIPGP SIFKMSGETS CILRDVNKCG HTGRCWIYNK 610 620 630 640 650 TKMAFLLVGI CFLCKLCTII FTTIAFFIYK RRLNENTDFP DVTVKNPKVK KKEETDL
	Isoform 3 [UniParc]. Checksum: F8E2638DFECD13E4	FASTA	466	51,398
	10 20 30 40 50 60 MFVGVARHSG SQDEVSRGVE PLEAARAQPA KDRRAKGTPK SSKPGKKHRY LRLLPEALIR 70 80 90 100 110 120 FGGFRKRKKA KSSVSKKPGE VDDSLEQPCG LGCLVSTCCE CCNNIRCFMI FYCILLICQG 130 140 150 160 170 180 VVFGLIDVSI GDFQKEYQLK TIEKLALEKS YDISSGLVAI FIAFYGDRKK VIWFVASSFL 190 200 210 220 230 240 IGLGSLLCAF PSINEENKQS KVGIEGIAEC TSMIGYALGY VLGAPLVKVP ENTTSATNTG 250 260 270 280 290 300 KLGNLTAPCN EKCRCSSSIY SSICGRDDIE YFSPCFAGCT YSKAQNQKKM YYNCSCIKEG 310 320 330 340 350 360 LITADAEGDF IDARPGKCDA KCYKLPLFIA FIFSTLIFSG FSGVPIVLAM TRVVPDKLRS 370 380 390 400 410 420 LALGVSYVIL RIFGTIPGPS IFKMSGETSC ILRDVNKCGH TGRCWIYNKT KMAFLLVGIC 430 440 450 460 FLCKLCTIIF TTIAFFIYKR RLNENTDFPD VTVKNPKVKK KEETDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of two novel OATP genes on human 5q21.1." Fu-Zhang W. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification and characterization of novel rat and human gonad-specific organic anion transporters." Suzuki T., Onogawa T., Asano N., Mizutamari H., Mikkaichi T., Tanemoto M., Abe M., Satoh F., Unno M., Nunoki K., Suzuki M., Hishinuma T., Goto J., Shimosegawa T., Matsuno S., Ito S., Abe T. Mol. Endocrinol. 17:1203-1215(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-654. Tissue: Testis.
[4]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[7]	"Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer." Lee S.-Y., Williamson B., Caballero O.L., Chen Y.-T., Scanlan M.J., Ritter G., Jongeneel C.V., Simpson A.J.G., Old L.J. Cancer Immun. 4:13-13(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY273897 mRNA. Translation: AAP33048.1. AF505657 mRNA. Translation: AAP30851.1. AK131445 mRNA. Translation: BAD18590.1. AC094108 Genomic DNA. No translation available. CH471086 Genomic DNA. Translation: EAW49095.1. BC034976 mRNA. Translation: AAH34976.1.
IPI	IPI00328811. IPI00442213. IPI00743263.
RefSeq	NP_775759.3. NM_173488.3.
UniGene	Hs.388874.
3D structure databases
ProteinModelPortal	Q86UG4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369135.
PTM databases
PhosphoSite	Q86UG4.
Polymorphism databases
DMDM	160185610.
Proteomic databases
PaxDb	Q86UG4.
PRIDE	Q86UG4.
Protocols and materials databases
DNASU	133482.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379807; ENSP00000369135; ENSG00000205359. ENST00000389019; ENSP00000373671; ENSG00000205359. ENST00000506729; ENSP00000421339; ENSG00000205359.
GeneID	133482.
KEGG	hsa:133482.
UCSC	uc003knn.3. human. uc003knq.3. human.
Organism-specific databases
CTD	133482.
GeneCards	GC05M101735.
H-InvDB	HIX0024807.
HGNC	HGNC:23613. SLCO6A1.
HPA	HPA054126.
MIM	613365. gene.
neXtProt	NX_Q86UG4.
PharmGKB	PA134949852.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG257460.
HOGENOM	HOG000231270.
HOVERGEN	HBG100565.
InParanoid	Q86UG4.
KO	K14357.
OMA	TLIPLSC.
OrthoDB	EOG4WH8K9.
Gene expression databases
ArrayExpress	Q86UG4.
Bgee	Q86UG4.
CleanEx	HS_SLCO6A1.
Genevestigator	Q86UG4.
Family and domain databases
InterPro	IPR002350. Kazal_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004156. OA_transporter. [Graphical view]
PANTHER	PTHR11388. PTHR11388. 1 hit.
Pfam	PF07648. Kazal_2. 1 hit. PF03137. OATP. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00805. oat. 1 hit.
PROSITE	PS51465. KAZAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	133482.
NextBio	83218.
SOURCE	Search...

Entry information

Entry name

SO6A1_HUMAN

Accession

Primary (citable) accession number: Q86UG4
Secondary accession number(s): A6NHC1 , Q6ZMY5, Q86UV2, Q8IYU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.