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Protein

Solute carrier organic anion transporter family member 6A1

Gene

SLCO6A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32472-MONOMER.

Protein family/group databases

TCDBi2.A.60.1.17. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 6A1
Alternative name(s):
Cancer/testis antigen 48
Short name:
CT48
Gonad-specific transporter
Short name:
GST
Organic anion-transporting polypeptide 6A1
Organic anion-transporting polypeptide I
Short name:
OATP-I
Solute carrier family 21 member 19
Gene namesi
Name:SLCO6A1
Synonyms:OATP6A1, SLC21A19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23613. SLCO6A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 126Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini127 – 145ExtracellularSequence analysisAdd BLAST19
Transmembranei146 – 166Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini167 – 171CytoplasmicSequence analysis5
Transmembranei172 – 196Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini197 – 223ExtracellularSequence analysisAdd BLAST27
Transmembranei224 – 254Helical; Name=4Sequence analysisAdd BLAST31
Topological domaini255 – 274CytoplasmicSequence analysisAdd BLAST20
Transmembranei275 – 295Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini296 – 311ExtracellularSequence analysisAdd BLAST16
Transmembranei312 – 336Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini337 – 378CytoplasmicSequence analysisAdd BLAST42
Transmembranei379 – 400Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini401 – 420ExtracellularSequence analysisAdd BLAST20
Transmembranei421 – 444Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini445 – 448CytoplasmicSequence analysis4
Transmembranei449 – 472Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini473 – 581ExtracellularSequence analysisAdd BLAST109
Transmembranei582 – 604Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini605 – 613CytoplasmicSequence analysis9
Transmembranei614 – 639Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini640 – 673ExtracellularSequence analysisAdd BLAST34
Transmembranei674 – 691Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini692 – 719CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi133482.
OpenTargetsiENSG00000205359.
PharmGKBiPA134949852.

Polymorphism and mutation databases

BioMutaiSLCO6A1.
DMDMi160185610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076421 – 719Solute carrier organic anion transporter family member 6A1Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi502 ↔ 528PROSITE-ProRule annotation
Disulfide bondi506 ↔ 517PROSITE-ProRule annotation
Disulfide bondi508 ↔ 532PROSITE-ProRule annotation
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1
Glycosylationi661N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86UG4.
PRIDEiQ86UG4.

PTM databases

iPTMnetiQ86UG4.
PhosphoSitePlusiQ86UG4.

Expressioni

Tissue specificityi

Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors.2 Publications

Gene expression databases

BgeeiENSG00000205359.
CleanExiHS_SLCO6A1.
ExpressionAtlasiQ86UG4. baseline and differential.
GenevisibleiQ86UG4. HS.

Organism-specific databases

HPAiHPA054126.

Interactioni

Protein-protein interaction databases

BioGridi126359. 12 interactors.
STRINGi9606.ENSP00000369135.

Structurei

3D structure databases

ProteinModelPortaliQ86UG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini496 – 551Kazal-likePROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 118Cys-richAdd BLAST30

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ86UG4.
KOiK14357.
OMAiALMRFIM.
OrthoDBiEOG091G02FX.
PhylomeDBiQ86UG4.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVGVARHSG SQDEVSRGVE PLEAARAQPA KDRRAKGTPK SSKPGKKHRY
60 70 80 90 100
LRLLPEALIR FGGFRKRKKA KSSVSKKPGE VDDSLEQPCG LGCLVSTCCE
110 120 130 140 150
CCNNIRCFMI FYCILLICQG VVFGLIDVSI GDFQKEYQLK TIEKLALEKS
160 170 180 190 200
YDISSGLVAI FIAFYGDRKK VIWFVASSFL IGLGSLLCAF PSINEENKQS
210 220 230 240 250
KVGIEDICEE IKVVSGCQSS GISFQSKYLS FFILGQTVQG IAGMPLYILG
260 270 280 290 300
ITFIDENVAT HSAGIYLGIA ECTSMIGYAL GYVLGAPLVK VPENTTSATN
310 320 330 340 350
TTVNNGSPEW LWTWWINFLF AAVVAWCTLI PLSCFPNNMP GSTRIKARKR
360 370 380 390 400
KQLHFFDSRL KDLKLGTNIK DLCAALWILM KNPVLICLAL SKATEYLVII
410 420 430 440 450
GASEFLPIYL ENQFILTPTV ATTLAGLVLI PGGALGQLLG GVIVSTLEMS
460 470 480 490 500
CKALMRFIMV TSVISLILLV FIIFVRCNPV QFAGINEDYD GTGKLGNLTA
510 520 530 540 550
PCNEKCRCSS SIYSSICGRD DIEYFSPCFA GCTYSKAQNQ KKMYYNCSCI
560 570 580 590 600
KEGLITADAE GDFIDARPGK CDAKCYKLPL FIAFIFSTLI FSGFSGVPIV
610 620 630 640 650
LAMTRVVPDK LRSLALGVSY VILRIFGTIP GPSIFKMSGE TSCILRDVNK
660 670 680 690 700
CGHTGRCWIY NKTKMAFLLV GICFLCKLCT IIFTTIAFFI YKRRLNENTD
710
FPDVTVKNPK VKKKEETDL
Length:719
Mass (Da):79,232
Last modified:October 23, 2007 - v2
Checksum:i56EFD346A8F0569B
GO
Isoform 2 (identifier: Q86UG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-267: Missing.

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):72,576
Checksum:i9F9946EB3C04FAAC
GO
Isoform 3 (identifier: Q86UG4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-267: Missing.
     301-491: Missing.

Note: No experimental confirmation available.
Show »
Length:466
Mass (Da):51,398
Checksum:iF8E2638DFECD13E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23E → D in BAD18590 (PubMed:14702039).Curated1
Sequence conflicti77 – 79KPG → NRE in AAP33048 (Ref. 1) Curated3
Sequence conflicti300N → K in BAD18590 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03662227A → V.Corresponds to variant rs13190449dbSNPEnsembl.1
Natural variantiVAR_036623381K → R.Corresponds to variant rs17150488dbSNPEnsembl.1
Natural variantiVAR_053680527P → A.Corresponds to variant rs10073333dbSNPEnsembl.1
Natural variantiVAR_036624654T → R.1 PublicationCorresponds to variant rs10055840dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028753206 – 267Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST62
Alternative sequenceiVSP_028754301 – 491Missing in isoform 3. 1 PublicationAdd BLAST191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273897 mRNA. Translation: AAP33048.1.
AF505657 mRNA. Translation: AAP30851.1.
AK131445 mRNA. Translation: BAD18590.1.
AC094108 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49095.1.
BC034976 mRNA. Translation: AAH34976.1.
CCDSiCCDS34206.1. [Q86UG4-1]
CCDS75282.1. [Q86UG4-2]
CCDS78042.1. [Q86UG4-3]
RefSeqiNP_001275931.1. NM_001289002.1. [Q86UG4-1]
NP_001275933.1. NM_001289004.1. [Q86UG4-2]
NP_001294943.1. NM_001308014.1.
NP_775759.3. NM_173488.4. [Q86UG4-1]
XP_005271931.1. XM_005271874.3. [Q86UG4-1]
UniGeneiHs.388874.

Genome annotation databases

EnsembliENST00000379807; ENSP00000369135; ENSG00000205359. [Q86UG4-1]
ENST00000389019; ENSP00000373671; ENSG00000205359. [Q86UG4-2]
ENST00000506729; ENSP00000421339; ENSG00000205359. [Q86UG4-1]
GeneIDi133482.
KEGGihsa:133482.
UCSCiuc003knn.5. human. [Q86UG4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273897 mRNA. Translation: AAP33048.1.
AF505657 mRNA. Translation: AAP30851.1.
AK131445 mRNA. Translation: BAD18590.1.
AC094108 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49095.1.
BC034976 mRNA. Translation: AAH34976.1.
CCDSiCCDS34206.1. [Q86UG4-1]
CCDS75282.1. [Q86UG4-2]
CCDS78042.1. [Q86UG4-3]
RefSeqiNP_001275931.1. NM_001289002.1. [Q86UG4-1]
NP_001275933.1. NM_001289004.1. [Q86UG4-2]
NP_001294943.1. NM_001308014.1.
NP_775759.3. NM_173488.4. [Q86UG4-1]
XP_005271931.1. XM_005271874.3. [Q86UG4-1]
UniGeneiHs.388874.

3D structure databases

ProteinModelPortaliQ86UG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126359. 12 interactors.
STRINGi9606.ENSP00000369135.

Protein family/group databases

TCDBi2.A.60.1.17. the organo anion transporter (oat) family.

PTM databases

iPTMnetiQ86UG4.
PhosphoSitePlusiQ86UG4.

Polymorphism and mutation databases

BioMutaiSLCO6A1.
DMDMi160185610.

Proteomic databases

PaxDbiQ86UG4.
PRIDEiQ86UG4.

Protocols and materials databases

DNASUi133482.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379807; ENSP00000369135; ENSG00000205359. [Q86UG4-1]
ENST00000389019; ENSP00000373671; ENSG00000205359. [Q86UG4-2]
ENST00000506729; ENSP00000421339; ENSG00000205359. [Q86UG4-1]
GeneIDi133482.
KEGGihsa:133482.
UCSCiuc003knn.5. human. [Q86UG4-1]

Organism-specific databases

CTDi133482.
DisGeNETi133482.
GeneCardsiSLCO6A1.
H-InvDBHIX0024807.
HGNCiHGNC:23613. SLCO6A1.
HPAiHPA054126.
MIMi613365. gene.
neXtProtiNX_Q86UG4.
OpenTargetsiENSG00000205359.
PharmGKBiPA134949852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ86UG4.
KOiK14357.
OMAiALMRFIM.
OrthoDBiEOG091G02FX.
PhylomeDBiQ86UG4.
TreeFamiTF317540.

Enzyme and pathway databases

BioCyciZFISH:G66-32472-MONOMER.

Miscellaneous databases

GenomeRNAii133482.
PROiQ86UG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205359.
CleanExiHS_SLCO6A1.
ExpressionAtlasiQ86UG4. baseline and differential.
GenevisibleiQ86UG4. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO6A1_HUMAN
AccessioniPrimary (citable) accession number: Q86UG4
Secondary accession number(s): A6NHC1
, Q6ZMY5, Q86UV2, Q8IYU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.