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Protein

cTAGE family member 6

Gene

CTAGE6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-30668-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
cTAGE family member 6
Short name:
Protein cTAGE-6
Gene namesi
Name:CTAGE6
Synonyms:CTAGE6P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:28644. CTAGE6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000271321.
PharmGKBiPA165617921.

Polymorphism and mutation databases

BioMutaiCTAGE6.
DMDMi259016213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003841491 – 777cTAGE family member 6Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei299PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UF2.
MaxQBiQ86UF2.
PaxDbiQ86UF2.
PeptideAtlasiQ86UF2.
PRIDEiQ86UF2.

PTM databases

iPTMnetiQ86UF2.
PhosphoSitePlusiQ86UF2.

Expressioni

Gene expression databases

BgeeiENSG00000271321.
CleanExiHS_CTAGE6.
GenevisibleiQ86UF2. HS.

Organism-specific databases

HPAiHPA000387.
HPA000922.

Interactioni

Protein-protein interaction databases

BioGridi131033. 2 interactors.
STRINGi9606.ENSP00000417289.

Structurei

3D structure databases

ProteinModelPortaliQ86UF2.
SMRiQ86UF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 269Sequence analysisAdd BLAST152
Coiled coili339 – 498Sequence analysisAdd BLAST160

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi691 – 775Pro-richAdd BLAST85

Sequence similaritiesi

Belongs to the cTAGE family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063635.
HOGENOMiHOG000112043.
HOVERGENiHBG051216.
InParanoidiQ86UF2.
OrthoDBiEOG091G0PEA.

Sequencei

Sequence statusi: Complete.

Q86UF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI
60 70 80 90 100
GFFVVLLFLW RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ
110 120 130 140 150
KEYEGYEVES SLEDASFEKA AAEEARSLEA TCEKLNRSNS ELEDEILCLE
160 170 180 190 200
KDLKEEKSKH SQQDELMADI SKSIQSLEDE SKSLKSQIAE AKIICKTFKM
210 220 230 240 250
SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGEVSE LNKQKITFED
260 270 280 290 300
SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
310 320 330 340 350
WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE
360 370 380 390 400
ELTEHIKNLQ TQQESLQSEN IYFESENQKL QQKLKIMTEF YQEDEMKLYR
410 420 430 440 450
KLTVEENYRI EEEEKLSKVE EKLSRATEQL ETYRKLAKDL EEELERTVHF
460 470 480 490 500
YQKQVISYEK RGHDNWLAAR TAERNLSDLR KENAHNKQKL TETELKFELL
510 520 530 540 550
EKDPNALDVS NTAFGREHAP NGPAPLGQRS SETRAFLSPQ TLLEDPLGLS
560 570 580 590 600
PVLPEGGGRG PRGPGNPLDH QITNERGEPS CDRLTDPHRA PSDTGSLSSP
610 620 630 640 650
VEQDCKMMFP PPGQSYPDSA LPPQREDRFY SNSERLSGSA EPRSFKMTSL
660 670 680 690 700
DKMDGSMPSE MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP
710 720 730 740 750
VRGPLFPVDT RGPFMRRGPP FPPPPPGTMF GASRGYFPPR DFPGPPHAPF
760 770
AMRNIYPPRG LPPYFHPRPG FYPNPAF
Length:777
Mass (Da):87,900
Last modified:September 22, 2009 - v2
Checksum:iCD26899AC51E30C0
GO

Sequence cautioni

The sequence BC043153 differs from that shown. Reason: Frameshift at position 63.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237E → Q in AAI01324 (PubMed:15489334).Curated1
Sequence conflicti237E → Q in AAI01325 (PubMed:15489334).Curated1
Sequence conflicti296E → K in AAI01324 (PubMed:15489334).Curated1
Sequence conflicti311L → P in AAI01324 (PubMed:15489334).Curated1
Sequence conflicti348T → S in AAI01325 (PubMed:15489334).Curated1
Sequence conflicti364E → A in AAI01325 (PubMed:15489334).Curated1
Sequence conflicti412E → G in BC043153 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106862 mRNA. No translation available.
BC043153 mRNA. No translation available.
BC101323 mRNA. Translation: AAI01324.1.
BC101324 mRNA. Translation: AAI01325.1.
CCDSiCCDS64790.1.
RefSeqiNP_848656.2. NM_178561.4.
UniGeneiHs.676333.

Genome annotation databases

EnsembliENST00000470691; ENSP00000474388; ENSG00000271321.
GeneIDi340307.
KEGGihsa:340307.
UCSCiuc003wdk.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106862 mRNA. No translation available.
BC043153 mRNA. No translation available.
BC101323 mRNA. Translation: AAI01324.1.
BC101324 mRNA. Translation: AAI01325.1.
CCDSiCCDS64790.1.
RefSeqiNP_848656.2. NM_178561.4.
UniGeneiHs.676333.

3D structure databases

ProteinModelPortaliQ86UF2.
SMRiQ86UF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131033. 2 interactors.
STRINGi9606.ENSP00000417289.

PTM databases

iPTMnetiQ86UF2.
PhosphoSitePlusiQ86UF2.

Polymorphism and mutation databases

BioMutaiCTAGE6.
DMDMi259016213.

Proteomic databases

EPDiQ86UF2.
MaxQBiQ86UF2.
PaxDbiQ86UF2.
PeptideAtlasiQ86UF2.
PRIDEiQ86UF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470691; ENSP00000474388; ENSG00000271321.
GeneIDi340307.
KEGGihsa:340307.
UCSCiuc003wdk.5. human.

Organism-specific databases

CTDi340307.
GeneCardsiCTAGE6.
HGNCiHGNC:28644. CTAGE6.
HPAiHPA000387.
HPA000922.
neXtProtiNX_Q86UF2.
OpenTargetsiENSG00000271321.
PharmGKBiPA165617921.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063635.
HOGENOMiHOG000112043.
HOVERGENiHBG051216.
InParanoidiQ86UF2.
OrthoDBiEOG091G0PEA.

Enzyme and pathway databases

BioCyciZFISH:G66-30668-MONOMER.

Miscellaneous databases

GenomeRNAii340307.
PROiQ86UF2.

Gene expression databases

BgeeiENSG00000271321.
CleanExiHS_CTAGE6.
GenevisibleiQ86UF2. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCTGE6_HUMAN
AccessioniPrimary (citable) accession number: Q86UF2
Secondary accession number(s): A4FU29, Q3ZCM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.