Q86UF2 (CTGE6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cTAGE family member 6
Short name=Protein cTAGE-6

Gene names

Name:	CTAGE6
Synonyms:	CTAGE6P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	777 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the cTAGE family.
Sequence caution	The sequence BC043153 differs from that shown. Reason: Frameshift at position 63.

Ontologies

Keywords
Cellular component	Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 777	777	cTAGE family member 6		PRO_0000384149
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Coiled coil	118 – 269	152	Potential
	Coiled coil	339 – 498	160	Potential
	Compositional bias	691 – 775	85	Pro-rich
Experimental info
	Sequence conflict	237	1	E → Q in AAI01324. Ref.2
	Sequence conflict	237	1	E → Q in AAI01325. Ref.2
	Sequence conflict	296	1	E → K in AAI01324. Ref.2
	Sequence conflict	311	1	L → P in AAI01324. Ref.2
	Sequence conflict	348	1	T → S in AAI01325. Ref.2
	Sequence conflict	364	1	E → A in AAI01325. Ref.2
	Sequence conflict	412	1	E → G in BC043153. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q86UF2 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: CD26899AC51E30C0	FASTA	777	87,900
	10 20 30 40 50 60 MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW 70 80 90 100 110 120 RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA 130 140 150 160 170 180 AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE 190 200 210 220 230 240 SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGEVSE 250 260 270 280 290 300 LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ 310 320 330 340 350 360 WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ 370 380 390 400 410 420 TQQESLQSEN IYFESENQKL QQKLKIMTEF YQEDEMKLYR KLTVEENYRI EEEEKLSKVE 430 440 450 460 470 480 EKLSRATEQL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR 490 500 510 520 530 540 KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHAP NGPAPLGQRS SETRAFLSPQ 550 560 570 580 590 600 TLLEDPLGLS PVLPEGGGRG PRGPGNPLDH QITNERGEPS CDRLTDPHRA PSDTGSLSSP 610 620 630 640 650 660 VEQDCKMMFP PPGQSYPDSA LPPQREDRFY SNSERLSGSA EPRSFKMTSL DKMDGSMPSE 670 680 690 700 710 720 MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP 730 740 750 760 770 FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYFHPRPG FYPNPAF

References

[1]

"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC106862 mRNA. No translation available. BC043153 mRNA. No translation available. BC101323 mRNA. Translation: AAI01324.1. BC101324 mRNA. Translation: AAI01325.1.
IPI	IPI00845515.
RefSeq	NP_848656.2. NM_178561.4.
UniGene	Hs.676333.
3D structure databases
ProteinModelPortal	Q86UF2.
ModBase	Search...
PTM databases
PhosphoSite	Q86UF2.
Polymorphism databases
DMDM	259016213.
Proteomic databases
PaxDb	Q86UF2.
PRIDE	Q86UF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	340307.
KEGG	hsa:340307.
UCSC	uc003wdk.4. human.
Organism-specific databases
CTD	340307.
GeneCards	GC07M143454.
HGNC	HGNC:28644. CTAGE6.
HPA	HPA000387. HPA000922.
neXtProt	NX_Q86UF2.
PharmGKB	PA165617921.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG133684.
HOGENOM	HOG000112043.
HOVERGEN	HBG051216.
OrthoDB	EOG4WSWC5.
Gene expression databases
CleanEx	HS_CTAGE6.
Genevestigator	Q86UF2.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	340307.
NextBio	97811.

Entry information

Entry name

CTGE6_HUMAN

Accession

Primary (citable) accession number: Q86UF2
Secondary accession number(s): A4FU29, Q3ZCM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	September 22, 2009
Last modified:	May 29, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.