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Q86UE6

- LRRT1_HUMAN

UniProt

Q86UE6 - LRRT1_HUMAN

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Protein
Leucine-rich repeat transmembrane neuronal protein 1
Gene
LRRTM1, UNQ675/PRO1309
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level By similarity.

GO - Biological processi

  1. exploration behavior Source: Ensembl
  2. locomotory behavior Source: Ensembl
  3. protein localization to synapse Source: Ensembl
  4. synapse organization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene namesi
Name:LRRTM1
ORF Names:UNQ675/PRO1309
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:19408. LRRTM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 427393Extracellular Reviewed prediction
Add
BLAST
Transmembranei428 – 44821Helical; Reviewed prediction
Add
BLAST
Topological domaini449 – 52274Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB
  4. excitatory synapse Source: Ensembl
  5. growth cone Source: UniProtKB
  6. integral component of membrane Source: UniProtKB-KW
  7. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 522488Leucine-rich repeat transmembrane neuronal protein 1
PRO_0000018350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi380 – 3801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86UE6.
PRIDEiQ86UE6.

PTM databases

PhosphoSiteiQ86UE6.

Expressioni

Tissue specificityi

Predominantly expressed in forebrain regions including thalamus and cerebral cortex.2 Publications

Gene expression databases

ArrayExpressiQ86UE6.
BgeeiQ86UE6.
CleanExiHS_LRRTM1.
GenevestigatoriQ86UE6.

Interactioni

Protein-protein interaction databases

IntActiQ86UE6. 1 interaction.
MINTiMINT-7027295.
STRINGi9606.ENSP00000295057.

Structurei

3D structure databases

ProteinModelPortaliQ86UE6.
SMRiQ86UE6. Positions 49-382.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 6329LRRNT
Add
BLAST
Repeati64 – 8724LRR 1
Add
BLAST
Repeati89 – 11123LRR 2
Add
BLAST
Repeati112 – 13524LRR 3
Add
BLAST
Repeati137 – 15923LRR 4
Add
BLAST
Repeati161 – 18323LRR 5
Add
BLAST
Repeati184 – 20724LRR 6
Add
BLAST
Repeati209 – 23123LRR 7
Add
BLAST
Repeati233 – 25523LRR 8
Add
BLAST
Repeati256 – 27823LRR 9
Add
BLAST
Repeati279 – 30224LRR 10
Add
BLAST
Domaini314 – 36552LRRCT
Add
BLAST

Sequence similaritiesi

Belongs to the LRRTM family.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ86UE6.
KOiK16665.
OMAiTLHMRSN.
OrthoDBiEOG7TBC1Q.
PhylomeDBiQ86UE6.
TreeFamiTF332659.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UE6-1 [UniParc]FASTAAdd to Basket

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MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL    50
YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH 100
ICSVQGDAFQ KLRRVKELTL SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ 150
ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL 200
ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL RRNKVAIVVS 250
SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL 300
NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG 350
EDVLDAVYAF HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG 400
QHDGTFEPAT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW 450
KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA 500
LVIINEYGSC TCHQQPAREC EV 522
Length:522
Mass (Da):58,641
Last modified:March 6, 2007 - v2
Checksum:i730004673B14245C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti330 – 3301N → S.3 Publications
Corresponds to variant rs6733871 [ dbSNP | Ensembl ].
VAR_022681

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti503 – 5031I → T in AAO67545. 1 Publication
Sequence conflicti503 – 5031I → T in BAB71240. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182024 mRNA. Translation: AAO67545.1.
AK056644 mRNA. Translation: BAB71240.1.
AK290512 mRNA. Translation: BAF83201.1.
AY358310 mRNA. Translation: AAQ88677.1.
CH471053 Genomic DNA. Translation: EAW99566.1.
CH471053 Genomic DNA. Translation: EAW99567.1.
BC045113 mRNA. Translation: AAH45113.1.
CCDSiCCDS1966.1.
RefSeqiNP_849161.2. NM_178839.4.
UniGeneiHs.591580.

Genome annotation databases

EnsembliENST00000295057; ENSP00000295057; ENSG00000162951.
ENST00000409148; ENSP00000386646; ENSG00000162951.
ENST00000417012; ENSP00000393562; ENSG00000162951.
ENST00000433224; ENSP00000414523; ENSG00000162951.
GeneIDi347730.
KEGGihsa:347730.
UCSCiuc002sok.1. human.

Polymorphism databases

DMDMi146330009.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182024 mRNA. Translation: AAO67545.1 .
AK056644 mRNA. Translation: BAB71240.1 .
AK290512 mRNA. Translation: BAF83201.1 .
AY358310 mRNA. Translation: AAQ88677.1 .
CH471053 Genomic DNA. Translation: EAW99566.1 .
CH471053 Genomic DNA. Translation: EAW99567.1 .
BC045113 mRNA. Translation: AAH45113.1 .
CCDSi CCDS1966.1.
RefSeqi NP_849161.2. NM_178839.4.
UniGenei Hs.591580.

3D structure databases

ProteinModelPortali Q86UE6.
SMRi Q86UE6. Positions 49-382.
ModBasei Search...

Protein-protein interaction databases

IntActi Q86UE6. 1 interaction.
MINTi MINT-7027295.
STRINGi 9606.ENSP00000295057.

PTM databases

PhosphoSitei Q86UE6.

Polymorphism databases

DMDMi 146330009.

Proteomic databases

PaxDbi Q86UE6.
PRIDEi Q86UE6.

Protocols and materials databases

DNASUi 347730.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295057 ; ENSP00000295057 ; ENSG00000162951 .
ENST00000409148 ; ENSP00000386646 ; ENSG00000162951 .
ENST00000417012 ; ENSP00000393562 ; ENSG00000162951 .
ENST00000433224 ; ENSP00000414523 ; ENSG00000162951 .
GeneIDi 347730.
KEGGi hsa:347730.
UCSCi uc002sok.1. human.

Organism-specific databases

CTDi 347730.
GeneCardsi GC02M080427.
H-InvDB HIX0002207.
HGNCi HGNC:19408. LRRTM1.
MIMi 610867. gene.
neXtProti NX_Q86UE6.
PharmGKBi PA134887293.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOGENOMi HOG000290681.
HOVERGENi HBG052362.
InParanoidi Q86UE6.
KOi K16665.
OMAi TLHMRSN.
OrthoDBi EOG7TBC1Q.
PhylomeDBi Q86UE6.
TreeFami TF332659.

Miscellaneous databases

GeneWikii LRRTM1.
GenomeRNAii 347730.
NextBioi 99250.
PROi Q86UE6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86UE6.
Bgeei Q86UE6.
CleanExi HS_LRRTM1.
Genevestigatori Q86UE6.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
    Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
    Tissue: Brain.
  6. Cited for: TISSUE SPECIFICITY, IMPRINTING.

Entry informationi

Entry nameiLRRT1_HUMAN
AccessioniPrimary (citable) accession number: Q86UE6
Secondary accession number(s): A8K397, D6W5K1, Q96DN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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