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Q86UE6

- LRRT1_HUMAN

UniProt

Q86UE6 - LRRT1_HUMAN

Protein

Leucine-rich repeat transmembrane neuronal protein 1

Gene

LRRTM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.By similarity

    GO - Biological processi

    1. exploration behavior Source: Ensembl
    2. locomotory behavior Source: Ensembl
    3. protein localization to synapse Source: Ensembl
    4. synapse organization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat transmembrane neuronal protein 1
    Gene namesi
    Name:LRRTM1
    ORF Names:UNQ675/PRO1309
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:19408. LRRTM1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. endoplasmic reticulum Source: UniProtKB
    4. excitatory synapse Source: Ensembl
    5. growth cone Source: UniProtKB
    6. integral component of membrane Source: UniProtKB-KW
    7. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134887293.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 522488Leucine-rich repeat transmembrane neuronal protein 1PRO_0000018350Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ86UE6.
    PRIDEiQ86UE6.

    PTM databases

    PhosphoSiteiQ86UE6.

    Expressioni

    Tissue specificityi

    Predominantly expressed in forebrain regions including thalamus and cerebral cortex.2 Publications

    Gene expression databases

    ArrayExpressiQ86UE6.
    BgeeiQ86UE6.
    CleanExiHS_LRRTM1.
    GenevestigatoriQ86UE6.

    Interactioni

    Protein-protein interaction databases

    IntActiQ86UE6. 1 interaction.
    MINTiMINT-7027295.
    STRINGi9606.ENSP00000295057.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UE6.
    SMRiQ86UE6. Positions 49-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 427393ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini449 – 52274CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 6329LRRNTAdd
    BLAST
    Repeati64 – 8724LRR 1Add
    BLAST
    Repeati89 – 11123LRR 2Add
    BLAST
    Repeati112 – 13524LRR 3Add
    BLAST
    Repeati137 – 15923LRR 4Add
    BLAST
    Repeati161 – 18323LRR 5Add
    BLAST
    Repeati184 – 20724LRR 6Add
    BLAST
    Repeati209 – 23123LRR 7Add
    BLAST
    Repeati233 – 25523LRR 8Add
    BLAST
    Repeati256 – 27823LRR 9Add
    BLAST
    Repeati279 – 30224LRR 10Add
    BLAST
    Domaini314 – 36552LRRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LRRTM family.Curated
    Contains 10 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000290681.
    HOVERGENiHBG052362.
    InParanoidiQ86UE6.
    KOiK16665.
    OMAiTLHMRSN.
    OrthoDBiEOG7TBC1Q.
    PhylomeDBiQ86UE6.
    TreeFamiTF332659.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 3 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86UE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL    50
    YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH 100
    ICSVQGDAFQ KLRRVKELTL SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ 150
    ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL 200
    ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL RRNKVAIVVS 250
    SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL 300
    NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG 350
    EDVLDAVYAF HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG 400
    QHDGTFEPAT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW 450
    KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA 500
    LVIINEYGSC TCHQQPAREC EV 522
    Length:522
    Mass (Da):58,641
    Last modified:March 6, 2007 - v2
    Checksum:i730004673B14245C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti503 – 5031I → T in AAO67545. (PubMed:12676565)Curated
    Sequence conflicti503 – 5031I → T in BAB71240. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti330 – 3301N → S.3 Publications
    Corresponds to variant rs6733871 [ dbSNP | Ensembl ].
    VAR_022681

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY182024 mRNA. Translation: AAO67545.1.
    AK056644 mRNA. Translation: BAB71240.1.
    AK290512 mRNA. Translation: BAF83201.1.
    AY358310 mRNA. Translation: AAQ88677.1.
    CH471053 Genomic DNA. Translation: EAW99566.1.
    CH471053 Genomic DNA. Translation: EAW99567.1.
    BC045113 mRNA. Translation: AAH45113.1.
    CCDSiCCDS1966.1.
    RefSeqiNP_849161.2. NM_178839.4.
    UniGeneiHs.591580.

    Genome annotation databases

    EnsembliENST00000295057; ENSP00000295057; ENSG00000162951.
    ENST00000409148; ENSP00000386646; ENSG00000162951.
    ENST00000417012; ENSP00000393562; ENSG00000162951.
    ENST00000433224; ENSP00000414523; ENSG00000162951.
    GeneIDi347730.
    KEGGihsa:347730.
    UCSCiuc002sok.1. human.

    Polymorphism databases

    DMDMi146330009.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The hands to say it - Issue 91 of February 2008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY182024 mRNA. Translation: AAO67545.1 .
    AK056644 mRNA. Translation: BAB71240.1 .
    AK290512 mRNA. Translation: BAF83201.1 .
    AY358310 mRNA. Translation: AAQ88677.1 .
    CH471053 Genomic DNA. Translation: EAW99566.1 .
    CH471053 Genomic DNA. Translation: EAW99567.1 .
    BC045113 mRNA. Translation: AAH45113.1 .
    CCDSi CCDS1966.1.
    RefSeqi NP_849161.2. NM_178839.4.
    UniGenei Hs.591580.

    3D structure databases

    ProteinModelPortali Q86UE6.
    SMRi Q86UE6. Positions 49-382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q86UE6. 1 interaction.
    MINTi MINT-7027295.
    STRINGi 9606.ENSP00000295057.

    PTM databases

    PhosphoSitei Q86UE6.

    Polymorphism databases

    DMDMi 146330009.

    Proteomic databases

    PaxDbi Q86UE6.
    PRIDEi Q86UE6.

    Protocols and materials databases

    DNASUi 347730.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295057 ; ENSP00000295057 ; ENSG00000162951 .
    ENST00000409148 ; ENSP00000386646 ; ENSG00000162951 .
    ENST00000417012 ; ENSP00000393562 ; ENSG00000162951 .
    ENST00000433224 ; ENSP00000414523 ; ENSG00000162951 .
    GeneIDi 347730.
    KEGGi hsa:347730.
    UCSCi uc002sok.1. human.

    Organism-specific databases

    CTDi 347730.
    GeneCardsi GC02M080427.
    H-InvDB HIX0002207.
    HGNCi HGNC:19408. LRRTM1.
    MIMi 610867. gene.
    neXtProti NX_Q86UE6.
    PharmGKBi PA134887293.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000290681.
    HOVERGENi HBG052362.
    InParanoidi Q86UE6.
    KOi K16665.
    OMAi TLHMRSN.
    OrthoDBi EOG7TBC1Q.
    PhylomeDBi Q86UE6.
    TreeFami TF332659.

    Miscellaneous databases

    GeneWikii LRRTM1.
    GenomeRNAii 347730.
    NextBioi 99250.
    PROi Q86UE6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UE6.
    Bgeei Q86UE6.
    CleanExi HS_LRRTM1.
    Genevestigatori Q86UE6.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 3 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
      Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
      Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
      Tissue: Brain.
    6. Cited for: TISSUE SPECIFICITY, IMPRINTING.

    Entry informationi

    Entry nameiLRRT1_HUMAN
    AccessioniPrimary (citable) accession number: Q86UE6
    Secondary accession number(s): A8K397, D6W5K1, Q96DN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3