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Q86UE6

- LRRT1_HUMAN

UniProt

Q86UE6 - LRRT1_HUMAN

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Protein

Leucine-rich repeat transmembrane neuronal protein 1

Gene

LRRTM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.By similarity

GO - Biological processi

  1. exploration behavior Source: Ensembl
  2. locomotory behavior Source: Ensembl
  3. long-term synaptic potentiation Source: Ensembl
  4. negative regulation of receptor internalization Source: Ensembl
  5. protein localization to synapse Source: Ensembl
  6. synapse organization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene namesi
Name:LRRTM1
ORF Names:UNQ675/PRO1309
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:19408. LRRTM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 427393ExtracellularSequence AnalysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST
Topological domaini449 – 52274CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB
  4. excitatory synapse Source: Ensembl
  5. growth cone Source: UniProtKB
  6. integral component of membrane Source: UniProtKB-KW
  7. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 522488Leucine-rich repeat transmembrane neuronal protein 1PRO_0000018350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86UE6.
PRIDEiQ86UE6.

PTM databases

PhosphoSiteiQ86UE6.

Expressioni

Tissue specificityi

Predominantly expressed in forebrain regions including thalamus and cerebral cortex.2 Publications

Gene expression databases

BgeeiQ86UE6.
CleanExiHS_LRRTM1.
ExpressionAtlasiQ86UE6. baseline and differential.
GenevestigatoriQ86UE6.

Interactioni

Protein-protein interaction databases

IntActiQ86UE6. 1 interaction.
MINTiMINT-7027295.
STRINGi9606.ENSP00000295057.

Structurei

3D structure databases

ProteinModelPortaliQ86UE6.
SMRiQ86UE6. Positions 56-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 6329LRRNTAdd
BLAST
Repeati64 – 8724LRR 1Add
BLAST
Repeati89 – 11123LRR 2Add
BLAST
Repeati112 – 13524LRR 3Add
BLAST
Repeati137 – 15923LRR 4Add
BLAST
Repeati161 – 18323LRR 5Add
BLAST
Repeati184 – 20724LRR 6Add
BLAST
Repeati209 – 23123LRR 7Add
BLAST
Repeati233 – 25523LRR 8Add
BLAST
Repeati256 – 27823LRR 9Add
BLAST
Repeati279 – 30224LRR 10Add
BLAST
Domaini314 – 36552LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the LRRTM family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ86UE6.
KOiK16665.
OMAiTLHMRSN.
OrthoDBiEOG7TBC1Q.
PhylomeDBiQ86UE6.
TreeFamiTF332659.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86UE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL
60 70 80 90 100
YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH
110 120 130 140 150
ICSVQGDAFQ KLRRVKELTL SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ
160 170 180 190 200
ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL
210 220 230 240 250
ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL RRNKVAIVVS
260 270 280 290 300
SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL
310 320 330 340 350
NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG
360 370 380 390 400
EDVLDAVYAF HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG
410 420 430 440 450
QHDGTFEPAT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW
460 470 480 490 500
KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA
510 520
LVIINEYGSC TCHQQPAREC EV
Length:522
Mass (Da):58,641
Last modified:March 6, 2007 - v2
Checksum:i730004673B14245C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti503 – 5031I → T in AAO67545. (PubMed:12676565)Curated
Sequence conflicti503 – 5031I → T in BAB71240. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti330 – 3301N → S.3 Publications
Corresponds to variant rs6733871 [ dbSNP | Ensembl ].
VAR_022681

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182024 mRNA. Translation: AAO67545.1.
AK056644 mRNA. Translation: BAB71240.1.
AK290512 mRNA. Translation: BAF83201.1.
AY358310 mRNA. Translation: AAQ88677.1.
CH471053 Genomic DNA. Translation: EAW99566.1.
CH471053 Genomic DNA. Translation: EAW99567.1.
BC045113 mRNA. Translation: AAH45113.1.
CCDSiCCDS1966.1.
RefSeqiNP_849161.2. NM_178839.4.
UniGeneiHs.591580.

Genome annotation databases

EnsembliENST00000295057; ENSP00000295057; ENSG00000162951.
ENST00000409148; ENSP00000386646; ENSG00000162951.
ENST00000417012; ENSP00000393562; ENSG00000162951.
ENST00000433224; ENSP00000414523; ENSG00000162951.
GeneIDi347730.
KEGGihsa:347730.
UCSCiuc002sok.1. human.

Polymorphism databases

DMDMi146330009.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182024 mRNA. Translation: AAO67545.1 .
AK056644 mRNA. Translation: BAB71240.1 .
AK290512 mRNA. Translation: BAF83201.1 .
AY358310 mRNA. Translation: AAQ88677.1 .
CH471053 Genomic DNA. Translation: EAW99566.1 .
CH471053 Genomic DNA. Translation: EAW99567.1 .
BC045113 mRNA. Translation: AAH45113.1 .
CCDSi CCDS1966.1.
RefSeqi NP_849161.2. NM_178839.4.
UniGenei Hs.591580.

3D structure databases

ProteinModelPortali Q86UE6.
SMRi Q86UE6. Positions 56-382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q86UE6. 1 interaction.
MINTi MINT-7027295.
STRINGi 9606.ENSP00000295057.

PTM databases

PhosphoSitei Q86UE6.

Polymorphism databases

DMDMi 146330009.

Proteomic databases

PaxDbi Q86UE6.
PRIDEi Q86UE6.

Protocols and materials databases

DNASUi 347730.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295057 ; ENSP00000295057 ; ENSG00000162951 .
ENST00000409148 ; ENSP00000386646 ; ENSG00000162951 .
ENST00000417012 ; ENSP00000393562 ; ENSG00000162951 .
ENST00000433224 ; ENSP00000414523 ; ENSG00000162951 .
GeneIDi 347730.
KEGGi hsa:347730.
UCSCi uc002sok.1. human.

Organism-specific databases

CTDi 347730.
GeneCardsi GC02M080427.
H-InvDB HIX0002207.
HGNCi HGNC:19408. LRRTM1.
MIMi 610867. gene.
neXtProti NX_Q86UE6.
PharmGKBi PA134887293.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000290681.
HOVERGENi HBG052362.
InParanoidi Q86UE6.
KOi K16665.
OMAi TLHMRSN.
OrthoDBi EOG7TBC1Q.
PhylomeDBi Q86UE6.
TreeFami TF332659.

Miscellaneous databases

GeneWikii LRRTM1.
GenomeRNAii 347730.
NextBioi 99250.
PROi Q86UE6.
SOURCEi Search...

Gene expression databases

Bgeei Q86UE6.
CleanExi HS_LRRTM1.
ExpressionAtlasi Q86UE6. baseline and differential.
Genevestigatori Q86UE6.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
    Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
    Tissue: Brain.
  6. Cited for: TISSUE SPECIFICITY, IMPRINTING.

Entry informationi

Entry nameiLRRT1_HUMAN
AccessioniPrimary (citable) accession number: Q86UE6
Secondary accession number(s): A8K397, D6W5K1, Q96DN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 6, 2007
Last modified: November 26, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3