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Q86UE6 (LRRT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat transmembrane neuronal protein 1
Gene names
Name:LRRTM1
ORF Names:UNQ675/PRO1309
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Predominantly expressed in forebrain regions including thalamus and cerebral cortex. Ref.1 Ref.6

Miscellaneous

This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia.

Sequence similarities

Belongs to the LRRTM family.

Contains 10 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 522488Leucine-rich repeat transmembrane neuronal protein 1
PRO_0000018350

Regions

Topological domain35 – 427393Extracellular Potential
Transmembrane428 – 44821Helical; Potential
Topological domain449 – 52274Cytoplasmic Potential
Domain35 – 6329LRRNT
Repeat64 – 8724LRR 1
Repeat89 – 11123LRR 2
Repeat112 – 13524LRR 3
Repeat137 – 15923LRR 4
Repeat161 – 18323LRR 5
Repeat184 – 20724LRR 6
Repeat209 – 23123LRR 7
Repeat233 – 25523LRR 8
Repeat256 – 27823LRR 9
Repeat279 – 30224LRR 10
Domain314 – 36552LRRCT

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation3801N-linked (GlcNAc...) Potential

Natural variations

Natural variant3301N → S. Ref.2 Ref.3 Ref.5
Corresponds to variant rs6733871 [ dbSNP | Ensembl ].
VAR_022681

Experimental info

Sequence conflict5031I → T in AAO67545. Ref.1
Sequence conflict5031I → T in BAB71240. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q86UE6 [UniParc].

Last modified March 6, 2007. Version 2.
Checksum: 730004673B14245C

FASTA52258,641
        10         20         30         40         50         60 
MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA 

        70         80         90        100        110        120 
PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL 

       130        140        150        160        170        180 
SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI 

       190        200        210        220        230        240 
FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL 

       250        260        270        280        290        300 
RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL 

       310        320        330        340        350        360 
NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG EDVLDAVYAF 

       370        380        390        400        410        420 
HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG QHDGTFEPAT VALPGGEHAE 

       430        440        450        460        470        480 
NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM 

       490        500        510        520 
AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
Tissue: Brain.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-330.
Tissue: Brain.
[6]"LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia."
Francks C., Maegawa S., Lauren J., Abrahams B.S., Velayos-Baeza A., Medland S.E., Colella S., Groszer M., McAuley E.Z., Caffrey T.M., Timmusk T., Pruunsild P., Koppel I., Lind P.A., Matsumoto-Itaba N., Nicod J., Xiong L., Joober R. expand/collapse author list , Enard W., Krinsky B., Nanba E., Richardson A.J., Riley B.P., Martin N.G., Strittmatter S.M., Moeller H.J., Rujescu D., St Clair D., Muglia P., Roos J.L., Fisher S.E., Wade-Martins R., Rouleau G.A., Stein J.F., Karayiorgou M., Geschwind D.H., Ragoussis J., Kendler K.S., Airaksinen M.S., Oshimura M., DeLisi L.E., Monaco A.P.
Mol. Psychiatry 12:1129-1139(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, IMPRINTING.
+Additional computationally mapped references.

Web resources

Protein Spotlight

The hands to say it - Issue 91 of February 2008

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY182024 mRNA. Translation: AAO67545.1.
AK056644 mRNA. Translation: BAB71240.1.
AK290512 mRNA. Translation: BAF83201.1.
AY358310 mRNA. Translation: AAQ88677.1.
CH471053 Genomic DNA. Translation: EAW99566.1.
CH471053 Genomic DNA. Translation: EAW99567.1.
BC045113 mRNA. Translation: AAH45113.1.
CCDSCCDS1966.1.
RefSeqNP_849161.2. NM_178839.4.
UniGeneHs.591580.

3D structure databases

ProteinModelPortalQ86UE6.
SMRQ86UE6. Positions 49-382.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ86UE6. 1 interaction.
MINTMINT-7027295.
STRING9606.ENSP00000295057.

PTM databases

PhosphoSiteQ86UE6.

Polymorphism databases

DMDM146330009.

Proteomic databases

PaxDbQ86UE6.
PRIDEQ86UE6.

Protocols and materials databases

DNASU347730.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295057; ENSP00000295057; ENSG00000162951.
ENST00000409148; ENSP00000386646; ENSG00000162951.
ENST00000417012; ENSP00000393562; ENSG00000162951.
ENST00000433224; ENSP00000414523; ENSG00000162951.
GeneID347730.
KEGGhsa:347730.
UCSCuc002sok.1. human.

Organism-specific databases

CTD347730.
GeneCardsGC02M080427.
H-InvDBHIX0002207.
HGNCHGNC:19408. LRRTM1.
MIM610867. gene.
neXtProtNX_Q86UE6.
PharmGKBPA134887293.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000290681.
HOVERGENHBG052362.
InParanoidQ86UE6.
KOK16665.
OMATLHMRSN.
OrthoDBEOG7TBC1Q.
PhylomeDBQ86UE6.
TreeFamTF332659.

Gene expression databases

ArrayExpressQ86UE6.
BgeeQ86UE6.
CleanExHS_LRRTM1.
GenevestigatorQ86UE6.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLRRTM1.
GenomeRNAi347730.
NextBio99250.
PROQ86UE6.
SOURCESearch...

Entry information

Entry nameLRRT1_HUMAN
AccessionPrimary (citable) accession number: Q86UE6
Secondary accession number(s): A8K397, D6W5K1, Q96DN1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM