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Q86UE4

- LYRIC_HUMAN

UniProt

Q86UE4 - LYRIC_HUMAN

Protein

Protein LYRIC

Gene

MTDH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.4 Publications

    GO - Molecular functioni

    1. double-stranded RNA binding Source: MGI
    2. NF-kappaB binding Source: UniProtKB
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. RNA polymerase II transcription factor binding Source: UniProtKB
    6. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    2. negative regulation of apoptotic process Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. positive regulation of angiogenesis Source: UniProtKB
    5. positive regulation of autophagy Source: UniProtKB
    6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    7. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    8. positive regulation of protein kinase B signaling Source: UniProtKB
    9. tight junction assembly Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein LYRIC
    Alternative name(s):
    3D3/LYRIC
    Astrocyte elevated gene-1 protein
    Short name:
    AEG-1
    Lysine-rich CEACAM1 co-isolated protein
    Metadherin
    Metastasis adhesion protein
    Gene namesi
    Name:MTDH
    Synonyms:AEG1, LYRIC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:29608. MTDH.

    Subcellular locationi

    Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane By similarity; Single-pass membrane protein By similarity. Cell junctiontight junction By similarity. Nucleusnucleolus By similarity. Cytoplasmperinuclear region
    Note: In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain By similarity. TNF-alpha causes translocation from the cytoplasm to the nucleus.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. endoplasmic reticulum Source: UniProtKB
    4. endoplasmic reticulum membrane Source: UniProtKB
    5. integral component of membrane Source: UniProtKB-KW
    6. intercellular canaliculus Source: UniProtKB
    7. nuclear body Source: UniProtKB
    8. nuclear membrane Source: UniProtKB-SubCell
    9. nucleolus Source: HPA
    10. nucleus Source: UniProtKB
    11. perinuclear region of cytoplasm Source: UniProtKB
    12. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671307.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Protein LYRICPRO_0000084533Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei143 – 1431Phosphothreonine2 Publications
    Modified residuei264 – 2641N6-acetyllysineBy similarity
    Modified residuei298 – 2981Phosphoserine5 Publications
    Modified residuei306 – 3061Phosphoserine1 Publication
    Modified residuei308 – 3081Phosphoserine2 Publications
    Modified residuei311 – 3111Phosphoserine1 Publication
    Modified residuei344 – 3441Phosphoserine1 Publication
    Modified residuei369 – 3691Phosphoserine1 Publication
    Modified residuei415 – 4151Phosphoserine1 Publication
    Modified residuei426 – 4261Phosphoserine5 Publications
    Modified residuei458 – 4581Phosphothreonine1 Publication
    Modified residuei568 – 5681Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ86UE4.
    PaxDbiQ86UE4.
    PeptideAtlasiQ86UE4.
    PRIDEiQ86UE4.

    PTM databases

    PhosphoSiteiQ86UE4.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.1 Publication

    Inductioni

    By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.2 Publications

    Gene expression databases

    ArrayExpressiQ86UE4.
    BgeeiQ86UE4.
    CleanExiHS_MTDH.
    GenevestigatoriQ86UE4.

    Organism-specific databases

    HPAiHPA010932.
    HPA015104.

    Interactioni

    Subunit structurei

    Interacts with BCCIP, CREBBP/CBP and RELA/p65.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CREBBPQ927932EBI-1046588,EBI-81215

    Protein-protein interaction databases

    BioGridi124913. 16 interactions.
    IntActiQ86UE4. 8 interactions.
    STRINGi9606.ENSP00000338235.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848LumenalSequence AnalysisAdd
    BLAST
    Topological domaini70 – 582513CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7171Activation of NF-kappa-BAdd
    BLAST
    Regioni72 – 16998Interaction with BCCIPAdd
    BLAST
    Regioni101 – 205105Interaction with RELAAdd
    BLAST
    Regioni381 – 44363Lung-homing for mammary tumorsBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 679Poly-Leu
    Compositional biasi441 – 45111Poly-LysAdd
    BLAST
    Compositional biasi573 – 5775Poly-Lys

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45896.
    HOGENOMiHOG000113417.
    HOVERGENiHBG052379.
    InParanoidiQ86UE4.
    OMAiGWNEKSV.
    OrthoDBiEOG7XWPPV.
    PhylomeDBiQ86UE4.
    TreeFamiTF331350.

    Sequencei

    Sequence statusi: Complete.

    Q86UE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARSWQDEL AQQAEEGSAR LREMLSVGLG FLRTELGLDL GLEPKRYPGW    50
    VILVGTGALG LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAAVPAAAP 100
    DDLALLKNLR SEEQKKKNRK KLSEKPKPNG RTVEVAEGEA VRTPQSVTAK 150
    QPPEIDKKNE KSKKNKKKSK SDAKAVQNSS RHDGKEVDEG AWETKISHRE 200
    KRQQRKRDKV LTDSGSLDST IPGIENTITV TTEQLTTASF PVGSKKNKGD 250
    SHLNVQVSNF KSGKGDSTLQ VSSGLNENLT VNGGGWNEKS VKLSSQISAG 300
    EEKWNSVSPA SAGKRKTEPS AWSQDTGDAN TNGKDWGRSW SDRSIFSGIG 350
    STAEPVSQST TSDYQWDVSR NQPYIDDEWS GLNGLSSADP NSDWNAPAEE 400
    WGNWVDEERA SLLKSQEPIP DDQKVSDDDK EKGEGALPTG KSKKKKKKKK 450
    KQGEDNSTAQ DTEELEKEIR EDLPVNTSKT RPKQEKAFSL KTISTSDPAE 500
    VLVKNSQPIK TLPPATSTEP SVILSKSDSD KSSSQVPPIL QETDKSKSNT 550
    KQNSVPPSQT KSETSWESPK QIKKKKKARR ET 582
    Length:582
    Mass (Da):63,837
    Last modified:December 21, 2004 - v2
    Checksum:i2460D6218FD3A4C4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781A → S in AAH09324. (PubMed:15489334)Curated
    Sequence conflicti78 – 781A → S in AAH45642. (PubMed:15489334)Curated
    Sequence conflicti145 – 1451Q → H in AAX84832. 1 PublicationCurated
    Sequence conflicti543 – 5431T → A in AAX84832. 1 PublicationCurated
    Sequence conflicti581 – 5811E → D in AAX84832. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti317 – 3171T → A.1 Publication
    Corresponds to variant rs17854374 [ dbSNP | Ensembl ].
    VAR_054661

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF501310 mRNA. Translation: AAP30791.1.
    AY082966 mRNA. Translation: AAL92861.1.
    AF411226 mRNA. Translation: AAO65771.1.
    AY974040 mRNA. Translation: AAX84832.1.
    BC009324 mRNA. Translation: AAH09324.1.
    BC014977 mRNA. Translation: AAH14977.1.
    BC045642 mRNA. Translation: AAH45642.1.
    AK000745 mRNA. No translation available.
    CCDSiCCDS6274.1.
    RefSeqiNP_848927.2. NM_178812.3.
    UniGeneiHs.377155.

    Genome annotation databases

    EnsembliENST00000336273; ENSP00000338235; ENSG00000147649.
    GeneIDi92140.
    KEGGihsa:92140.
    UCSCiuc003yhz.3. human.

    Polymorphism databases

    DMDMi56749088.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF501310 mRNA. Translation: AAP30791.1 .
    AY082966 mRNA. Translation: AAL92861.1 .
    AF411226 mRNA. Translation: AAO65771.1 .
    AY974040 mRNA. Translation: AAX84832.1 .
    BC009324 mRNA. Translation: AAH09324.1 .
    BC014977 mRNA. Translation: AAH14977.1 .
    BC045642 mRNA. Translation: AAH45642.1 .
    AK000745 mRNA. No translation available.
    CCDSi CCDS6274.1.
    RefSeqi NP_848927.2. NM_178812.3.
    UniGenei Hs.377155.

    3D structure databases

    ProteinModelPortali Q86UE4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124913. 16 interactions.
    IntActi Q86UE4. 8 interactions.
    STRINGi 9606.ENSP00000338235.

    PTM databases

    PhosphoSitei Q86UE4.

    Polymorphism databases

    DMDMi 56749088.

    Proteomic databases

    MaxQBi Q86UE4.
    PaxDbi Q86UE4.
    PeptideAtlasi Q86UE4.
    PRIDEi Q86UE4.

    Protocols and materials databases

    DNASUi 92140.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336273 ; ENSP00000338235 ; ENSG00000147649 .
    GeneIDi 92140.
    KEGGi hsa:92140.
    UCSCi uc003yhz.3. human.

    Organism-specific databases

    CTDi 92140.
    GeneCardsi GC08P098658.
    HGNCi HGNC:29608. MTDH.
    HPAi HPA010932.
    HPA015104.
    MIMi 610323. gene.
    neXtProti NX_Q86UE4.
    PharmGKBi PA142671307.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45896.
    HOGENOMi HOG000113417.
    HOVERGENi HBG052379.
    InParanoidi Q86UE4.
    OMAi GWNEKSV.
    OrthoDBi EOG7XWPPV.
    PhylomeDBi Q86UE4.
    TreeFami TF331350.

    Miscellaneous databases

    ChiTaRSi MTDH. human.
    GeneWikii MTDH.
    GenomeRNAii 92140.
    NextBioi 77609.
    PROi Q86UE4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86UE4.
    Bgeei Q86UE4.
    CleanExi HS_MTDH.
    Genevestigatori Q86UE4.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus."
      Sutherland H.G.E., Lam Y.W., Briers S., Lamond A.I., Bickmore W.A.
      Exp. Cell Res. 294:94-105(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells."
      Britt D.E., Yang D.-F., Yang D.-Q., Flanagan D.L., Callanan H., Lim Y.-P., Lin S.-H., Hixson D.C.
      Exp. Cell Res. 300:134-148(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Tissue: Colon carcinoma.
    3. "Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1."
      Kang D.-C., Su Z.-Z., Sarkar D., Emdad L., Volsky D.J., Fisher P.B.
      Gene 353:8-15(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
      Tissue: Fetal astrocyte.
    4. "LYRIC protein induces cell migration dependent on its cytoplasmic localization."
      Liang Y., Liu G.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-317.
      Tissue: Brain, Skin and Testis.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-582.
      Tissue: Hepatoma.
    7. Cited for: OVEREXPRESSION IN MAMMARY TUMORS.
    8. "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis."
      Brown D.M., Ruoslahti E.
      Cancer Cell 5:365-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: OVEREXPRESSION IN TUMORS.
    9. "Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis."
      Emdad L., Sarkar D., Su Z.-Z., Randolph A., Boukerche H., Valerie K., Fisher P.B.
      Cancer Res. 66:1509-1516(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RELA, INDUCTION.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-415 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells."
      Ash S.C., Yang D.Q., Britt D.E.
      Biochem. Biophys. Res. Commun. 371:333-338(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCCIP.
    12. "Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1."
      Sarkar D., Park E.S., Emdad L., Lee S.-G., Su Z.-Z., Fisher P.B.
      Cancer Res. 68:1478-1484(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CREBBP.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-298; SER-308; SER-311; SER-426; THR-458 AND SER-568, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer."
      Hu G., Chong R.A., Yang Q., Wei Y., Blanco M.A., Li F., Reiss M., Au J.L.-S., Haffty B.G., Kang Y.
      Cancer Cell 15:9-20(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344 AND SER-369, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-298; SER-306; SER-308 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLYRIC_HUMAN
    AccessioniPrimary (citable) accession number: Q86UE4
    Secondary accession number(s): Q05DH2
    , Q52QU9, Q6PK07, Q8TCX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and the reciprocal effect is observed following overexpression.

    Caution

    Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3