Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86UE4

- LYRIC_HUMAN

UniProt

Q86UE4 - LYRIC_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein LYRIC

Gene

MTDH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.4 Publications

GO - Molecular functioni

  1. double-stranded RNA binding Source: MGI
  2. NF-kappaB binding Source: UniProtKB
  3. poly(A) RNA binding Source: UniProtKB
  4. RNA polymerase II transcription factor binding Source: UniProtKB
  5. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  2. negative regulation of apoptotic process Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. positive regulation of angiogenesis Source: UniProtKB
  5. positive regulation of autophagy Source: UniProtKB
  6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  7. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  8. positive regulation of protein kinase B signaling Source: UniProtKB
  9. tight junction assembly Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LYRIC
Alternative name(s):
3D3/LYRIC
Astrocyte elevated gene-1 protein
Short name:
AEG-1
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein
Gene namesi
Name:MTDH
Synonyms:AEG1, LYRIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:29608. MTDH.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane By similarity; Single-pass membrane protein By similarity. Cell junctiontight junction By similarity. Nucleusnucleolus By similarity. Cytoplasmperinuclear region
Note: In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848LumenalSequence AnalysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Topological domaini70 – 582513CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
  4. endoplasmic reticulum membrane Source: UniProtKB
  5. integral component of membrane Source: UniProtKB-KW
  6. intercellular canaliculus Source: UniProtKB
  7. nuclear body Source: UniProtKB
  8. nucleolus Source: HPA
  9. nucleus Source: UniProtKB
  10. perinuclear region of cytoplasm Source: UniProtKB
  11. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Protein LYRICPRO_0000084533Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431Phosphothreonine2 Publications
Modified residuei264 – 2641N6-acetyllysineBy similarity
Modified residuei298 – 2981Phosphoserine5 Publications
Modified residuei306 – 3061Phosphoserine1 Publication
Modified residuei308 – 3081Phosphoserine2 Publications
Modified residuei311 – 3111Phosphoserine1 Publication
Modified residuei344 – 3441Phosphoserine1 Publication
Modified residuei369 – 3691Phosphoserine1 Publication
Modified residuei415 – 4151Phosphoserine1 Publication
Modified residuei426 – 4261Phosphoserine5 Publications
Modified residuei458 – 4581Phosphothreonine1 Publication
Modified residuei568 – 5681Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86UE4.
PaxDbiQ86UE4.
PeptideAtlasiQ86UE4.
PRIDEiQ86UE4.

PTM databases

PhosphoSiteiQ86UE4.

Expressioni

Tissue specificityi

Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.1 Publication

Inductioni

By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.2 Publications

Gene expression databases

BgeeiQ86UE4.
CleanExiHS_MTDH.
ExpressionAtlasiQ86UE4. baseline and differential.
GenevestigatoriQ86UE4.

Organism-specific databases

HPAiHPA010932.
HPA015104.

Interactioni

Subunit structurei

Interacts with BCCIP, CREBBP/CBP and RELA/p65.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CREBBPQ927932EBI-1046588,EBI-81215

Protein-protein interaction databases

BioGridi124913. 19 interactions.
IntActiQ86UE4. 8 interactions.
STRINGi9606.ENSP00000338235.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QMGX-ray2.70F/G/H/I/J386-407[»]
ProteinModelPortaliQ86UE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7171Activation of NF-kappa-BAdd
BLAST
Regioni72 – 16998Interaction with BCCIPAdd
BLAST
Regioni101 – 205105Interaction with RELAAdd
BLAST
Regioni381 – 44363Lung-homing for mammary tumorsBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 679Poly-Leu
Compositional biasi441 – 45111Poly-LysAdd
BLAST
Compositional biasi573 – 5775Poly-Lys

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45896.
GeneTreeiENSGT00390000004343.
HOGENOMiHOG000113417.
HOVERGENiHBG052379.
InParanoidiQ86UE4.
OMAiGWNEKSV.
OrthoDBiEOG7XWPPV.
PhylomeDBiQ86UE4.
TreeFamiTF331350.

Sequencei

Sequence statusi: Complete.

Q86UE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARSWQDEL AQQAEEGSAR LREMLSVGLG FLRTELGLDL GLEPKRYPGW
60 70 80 90 100
VILVGTGALG LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAAVPAAAP
110 120 130 140 150
DDLALLKNLR SEEQKKKNRK KLSEKPKPNG RTVEVAEGEA VRTPQSVTAK
160 170 180 190 200
QPPEIDKKNE KSKKNKKKSK SDAKAVQNSS RHDGKEVDEG AWETKISHRE
210 220 230 240 250
KRQQRKRDKV LTDSGSLDST IPGIENTITV TTEQLTTASF PVGSKKNKGD
260 270 280 290 300
SHLNVQVSNF KSGKGDSTLQ VSSGLNENLT VNGGGWNEKS VKLSSQISAG
310 320 330 340 350
EEKWNSVSPA SAGKRKTEPS AWSQDTGDAN TNGKDWGRSW SDRSIFSGIG
360 370 380 390 400
STAEPVSQST TSDYQWDVSR NQPYIDDEWS GLNGLSSADP NSDWNAPAEE
410 420 430 440 450
WGNWVDEERA SLLKSQEPIP DDQKVSDDDK EKGEGALPTG KSKKKKKKKK
460 470 480 490 500
KQGEDNSTAQ DTEELEKEIR EDLPVNTSKT RPKQEKAFSL KTISTSDPAE
510 520 530 540 550
VLVKNSQPIK TLPPATSTEP SVILSKSDSD KSSSQVPPIL QETDKSKSNT
560 570 580
KQNSVPPSQT KSETSWESPK QIKKKKKARR ET
Length:582
Mass (Da):63,837
Last modified:December 21, 2004 - v2
Checksum:i2460D6218FD3A4C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781A → S in AAH09324. (PubMed:15489334)Curated
Sequence conflicti78 – 781A → S in AAH45642. (PubMed:15489334)Curated
Sequence conflicti145 – 1451Q → H in AAX84832. 1 PublicationCurated
Sequence conflicti543 – 5431T → A in AAX84832. 1 PublicationCurated
Sequence conflicti581 – 5811E → D in AAX84832. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171T → A.1 Publication
Corresponds to variant rs17854374 [ dbSNP | Ensembl ].
VAR_054661

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF501310 mRNA. Translation: AAP30791.1.
AY082966 mRNA. Translation: AAL92861.1.
AF411226 mRNA. Translation: AAO65771.1.
AY974040 mRNA. Translation: AAX84832.1.
BC009324 mRNA. Translation: AAH09324.1.
BC014977 mRNA. Translation: AAH14977.1.
BC045642 mRNA. Translation: AAH45642.1.
AK000745 mRNA. No translation available.
CCDSiCCDS6274.1.
RefSeqiNP_848927.2. NM_178812.3.
UniGeneiHs.377155.

Genome annotation databases

EnsembliENST00000336273; ENSP00000338235; ENSG00000147649.
GeneIDi92140.
KEGGihsa:92140.
UCSCiuc003yhz.3. human.

Polymorphism databases

DMDMi56749088.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF501310 mRNA. Translation: AAP30791.1 .
AY082966 mRNA. Translation: AAL92861.1 .
AF411226 mRNA. Translation: AAO65771.1 .
AY974040 mRNA. Translation: AAX84832.1 .
BC009324 mRNA. Translation: AAH09324.1 .
BC014977 mRNA. Translation: AAH14977.1 .
BC045642 mRNA. Translation: AAH45642.1 .
AK000745 mRNA. No translation available.
CCDSi CCDS6274.1.
RefSeqi NP_848927.2. NM_178812.3.
UniGenei Hs.377155.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4QMG X-ray 2.70 F/G/H/I/J 386-407 [» ]
ProteinModelPortali Q86UE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124913. 19 interactions.
IntActi Q86UE4. 8 interactions.
STRINGi 9606.ENSP00000338235.

PTM databases

PhosphoSitei Q86UE4.

Polymorphism databases

DMDMi 56749088.

Proteomic databases

MaxQBi Q86UE4.
PaxDbi Q86UE4.
PeptideAtlasi Q86UE4.
PRIDEi Q86UE4.

Protocols and materials databases

DNASUi 92140.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336273 ; ENSP00000338235 ; ENSG00000147649 .
GeneIDi 92140.
KEGGi hsa:92140.
UCSCi uc003yhz.3. human.

Organism-specific databases

CTDi 92140.
GeneCardsi GC08P098658.
HGNCi HGNC:29608. MTDH.
HPAi HPA010932.
HPA015104.
MIMi 610323. gene.
neXtProti NX_Q86UE4.
PharmGKBi PA142671307.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45896.
GeneTreei ENSGT00390000004343.
HOGENOMi HOG000113417.
HOVERGENi HBG052379.
InParanoidi Q86UE4.
OMAi GWNEKSV.
OrthoDBi EOG7XWPPV.
PhylomeDBi Q86UE4.
TreeFami TF331350.

Miscellaneous databases

ChiTaRSi MTDH. human.
GeneWikii MTDH.
GenomeRNAii 92140.
NextBioi 77609.
PROi Q86UE4.
SOURCEi Search...

Gene expression databases

Bgeei Q86UE4.
CleanExi HS_MTDH.
ExpressionAtlasi Q86UE4. baseline and differential.
Genevestigatori Q86UE4.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus."
    Sutherland H.G.E., Lam Y.W., Briers S., Lamond A.I., Bickmore W.A.
    Exp. Cell Res. 294:94-105(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells."
    Britt D.E., Yang D.-F., Yang D.-Q., Flanagan D.L., Callanan H., Lim Y.-P., Lin S.-H., Hixson D.C.
    Exp. Cell Res. 300:134-148(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Colon carcinoma.
  3. "Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1."
    Kang D.-C., Su Z.-Z., Sarkar D., Emdad L., Volsky D.J., Fisher P.B.
    Gene 353:8-15(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Fetal astrocyte.
  4. "LYRIC protein induces cell migration dependent on its cytoplasmic localization."
    Liang Y., Liu G.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-317.
    Tissue: Brain, Skin and Testis.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-582.
    Tissue: Hepatoma.
  7. Cited for: OVEREXPRESSION IN MAMMARY TUMORS.
  8. "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis."
    Brown D.M., Ruoslahti E.
    Cancer Cell 5:365-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: OVEREXPRESSION IN TUMORS.
  9. "Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis."
    Emdad L., Sarkar D., Su Z.-Z., Randolph A., Boukerche H., Valerie K., Fisher P.B.
    Cancer Res. 66:1509-1516(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RELA, INDUCTION.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-415 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells."
    Ash S.C., Yang D.Q., Britt D.E.
    Biochem. Biophys. Res. Commun. 371:333-338(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCCIP.
  12. "Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1."
    Sarkar D., Park E.S., Emdad L., Lee S.-G., Su Z.-Z., Fisher P.B.
    Cancer Res. 68:1478-1484(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CREBBP.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-298; SER-308; SER-311; SER-426; THR-458 AND SER-568, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer."
    Hu G., Chong R.A., Yang Q., Wei Y., Blanco M.A., Li F., Reiss M., Au J.L.-S., Haffty B.G., Kang Y.
    Cancer Cell 15:9-20(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344 AND SER-369, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-298; SER-306; SER-308 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-426, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLYRIC_HUMAN
AccessioniPrimary (citable) accession number: Q86UE4
Secondary accession number(s): Q05DH2
, Q52QU9, Q6PK07, Q8TCX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and the reciprocal effect is observed following overexpression.

Caution

Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3