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Protein

Zinc finger protein 546

Gene

ZNF546

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri217 – 239C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33387-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 546
Alternative name(s):
Zinc finger protein 49
Gene namesi
Name:ZNF546
Synonyms:ZNF49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28671. ZNF546.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187187.
ENSG00000281526.
PharmGKBiPA134881362.

Polymorphism and mutation databases

BioMutaiZNF546.
DMDMi229462787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345821 – 836Zinc finger protein 546Add BLAST836

Proteomic databases

MaxQBiQ86UE3.
PaxDbiQ86UE3.
PeptideAtlasiQ86UE3.
PRIDEiQ86UE3.

PTM databases

iPTMnetiQ86UE3.
PhosphoSitePlusiQ86UE3.

Expressioni

Gene expression databases

BgeeiENSG00000187187.
CleanExiHS_ZNF546.
ExpressionAtlasiQ86UE3. baseline and differential.
GenevisibleiQ86UE3. HS.

Organism-specific databases

HPAiHPA030838.

Interactioni

Protein-protein interaction databases

IntActiQ86UE3. 1 interactor.
STRINGi9606.ENSP00000339823.

Structurei

3D structure databases

ProteinModelPortaliQ86UE3.
SMRiQ86UE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 131KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri217 – 239C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86UE3.
KOiK09228.
OMAiQSYLIQH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86UE3.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 22 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 22 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 22 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVDPPLHGP PNDFLIFQII PLHSLSIMPR FLWILCFSME ETQGELTSSC
60 70 80 90 100
GSKTMANVSL AFRDVSIDLS QEEWECLDAV QRDLYKDVML ENYSNLVSLG
110 120 130 140 150
YTIPKPDVIT LLEQEKEPWI VMREGTRNWF TDLEYKYITK NLLSEKNVCK
160 170 180 190 200
IYLSQLQTGE KSKNTIHEDT IFRNGLQCKH EFERQERHQM GCVSQMLIQK
210 220 230 240 250
QISHPLHPKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT GERPYKCMEC
260 270 280 290 300
GKAFCRVGDL RVHHTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP
310 320 330 340 350
YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI
360 370 380 390 400
HTGERPYECK VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL
410 420 430 440 450
VQHQKIHTGE KPYECKECGK SFSFHAELAR HRRIHTGEKP YECRECGKAF
460 470 480 490 500
RLQTELTRHH RTHTGEKPYE CKECGKAFIC GYQLTLHLRT HTGEIPYECK
510 520 530 540 550
ECGKTFSSRY HLTQHYRIHT GEKPYICNEC GKAFRLQGEL TRHHRIHTCE
560 570 580 590 600
KPYECKECGK AFIHSNQFIS HQRIHTSEST YICKECGKIF SRRYNLTQHF
610 620 630 640 650
KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST
660 670 680 690 700
HLTQHHRIHT GEKPYECTEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN
710 720 730 740 750
AFICSYRLTL HQRIHTGELP YECKECGKTF SRRYHLTQHF RLHTGEKPYS
760 770 780 790 800
CKECGNAFRL QAELTRHHIV HTGEKPYKCK ECGKAFSVNS ELTRHHRIHT
810 820 830
GEKPYQCKEC GKAFIRSDQL TLHQRNHISE EVLCIM
Length:836
Mass (Da):98,405
Last modified:May 5, 2009 - v2
Checksum:i81AC4B259DDBCB32
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03558715L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055271201Q → R.1 PublicationCorresponds to variant rs17854378dbSNPEnsembl.1
Natural variantiVAR_055272243R → T.Corresponds to variant rs2111543dbSNPEnsembl.1
Natural variantiVAR_055273253A → V.Corresponds to variant rs2111544dbSNPEnsembl.1
Natural variantiVAR_055274298V → E.Corresponds to variant rs17710336dbSNPEnsembl.1
Natural variantiVAR_055275427E → G.Corresponds to variant rs12460371dbSNPEnsembl.1
Natural variantiVAR_055276452L → F.Corresponds to variant rs7255186dbSNPEnsembl.1
Natural variantiVAR_055277652L → F.Corresponds to variant rs12373540dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292528 mRNA. Translation: BAF85217.1.
CH471126 Genomic DNA. Translation: EAW56930.1.
BC045649 mRNA. Translation: AAH45649.1.
CCDSiCCDS12548.1.
RefSeqiNP_001284692.1. NM_001297763.1.
NP_848639.2. NM_178544.4.
XP_011525201.1. XM_011526899.2.
UniGeneiHs.125008.
Hs.666807.

Genome annotation databases

EnsembliENST00000347077; ENSP00000339823; ENSG00000187187.
ENST00000626389; ENSP00000487125; ENSG00000281526.
GeneIDi339327.
KEGGihsa:339327.
UCSCiuc002oms.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292528 mRNA. Translation: BAF85217.1.
CH471126 Genomic DNA. Translation: EAW56930.1.
BC045649 mRNA. Translation: AAH45649.1.
CCDSiCCDS12548.1.
RefSeqiNP_001284692.1. NM_001297763.1.
NP_848639.2. NM_178544.4.
XP_011525201.1. XM_011526899.2.
UniGeneiHs.125008.
Hs.666807.

3D structure databases

ProteinModelPortaliQ86UE3.
SMRiQ86UE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86UE3. 1 interactor.
STRINGi9606.ENSP00000339823.

PTM databases

iPTMnetiQ86UE3.
PhosphoSitePlusiQ86UE3.

Polymorphism and mutation databases

BioMutaiZNF546.
DMDMi229462787.

Proteomic databases

MaxQBiQ86UE3.
PaxDbiQ86UE3.
PeptideAtlasiQ86UE3.
PRIDEiQ86UE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347077; ENSP00000339823; ENSG00000187187.
ENST00000626389; ENSP00000487125; ENSG00000281526.
GeneIDi339327.
KEGGihsa:339327.
UCSCiuc002oms.3. human.

Organism-specific databases

CTDi339327.
GeneCardsiZNF546.
HGNCiHGNC:28671. ZNF546.
HPAiHPA030838.
neXtProtiNX_Q86UE3.
OpenTargetsiENSG00000187187.
ENSG00000281526.
PharmGKBiPA134881362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86UE3.
KOiK09228.
OMAiQSYLIQH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86UE3.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:G66-33387-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii339327.
PROiQ86UE3.

Gene expression databases

BgeeiENSG00000187187.
CleanExiHS_ZNF546.
ExpressionAtlasiQ86UE3. baseline and differential.
GenevisibleiQ86UE3. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 22 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 22 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 22 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN546_HUMAN
AccessioniPrimary (citable) accession number: Q86UE3
Secondary accession number(s): A8K913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.