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Q86UE3 (ZN546_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Zinc finger protein 546
Alternative name(s):
Zinc finger protein 49
Gene names
Name:ZNF546
Synonyms:ZNF49
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length836 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 22 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 836836Zinc finger protein 546
PRO_0000234582

Regions

Domain60 – 13172KRAB
Zinc finger217 – 23923C2H2-type 1
Zinc finger245 – 26723C2H2-type 2
Zinc finger273 – 29523C2H2-type 3
Zinc finger301 – 32323C2H2-type 4
Zinc finger329 – 35123C2H2-type 5
Zinc finger357 – 37923C2H2-type 6
Zinc finger385 – 40723C2H2-type 7
Zinc finger413 – 43523C2H2-type 8
Zinc finger441 – 46323C2H2-type 9
Zinc finger469 – 49123C2H2-type 10
Zinc finger497 – 51923C2H2-type 11
Zinc finger525 – 54723C2H2-type 12
Zinc finger553 – 57523C2H2-type 13
Zinc finger581 – 60323C2H2-type 14
Zinc finger609 – 63123C2H2-type 15
Zinc finger637 – 65923C2H2-type 16
Zinc finger665 – 68723C2H2-type 17
Zinc finger693 – 71523C2H2-type 18
Zinc finger721 – 74323C2H2-type 19
Zinc finger749 – 77123C2H2-type 20
Zinc finger777 – 79923C2H2-type 21
Zinc finger805 – 82723C2H2-type 22

Natural variations

Natural variant151L → V in a breast cancer sample; somatic mutation. Ref.4
VAR_035587
Natural variant2011Q → R. Ref.3
Corresponds to variant rs17854378 [ dbSNP | Ensembl ].
VAR_055271
Natural variant2431R → T.
Corresponds to variant rs2111543 [ dbSNP | Ensembl ].
VAR_055272
Natural variant2531A → V.
Corresponds to variant rs2111544 [ dbSNP | Ensembl ].
VAR_055273
Natural variant2981V → E.
Corresponds to variant rs17710336 [ dbSNP | Ensembl ].
VAR_055274
Natural variant4271E → G.
Corresponds to variant rs12460371 [ dbSNP | Ensembl ].
VAR_055275
Natural variant4521L → F.
Corresponds to variant rs7255186 [ dbSNP | Ensembl ].
VAR_055276
Natural variant6521L → F.
Corresponds to variant rs12373540 [ dbSNP | Ensembl ].
VAR_055277

Sequences

Sequence LengthMass (Da)Tools
Q86UE3 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 81AC4B259DDBCB32

FASTA83698,405
        10         20         30         40         50         60 
MQVDPPLHGP PNDFLIFQII PLHSLSIMPR FLWILCFSME ETQGELTSSC GSKTMANVSL 

        70         80         90        100        110        120 
AFRDVSIDLS QEEWECLDAV QRDLYKDVML ENYSNLVSLG YTIPKPDVIT LLEQEKEPWI 

       130        140        150        160        170        180 
VMREGTRNWF TDLEYKYITK NLLSEKNVCK IYLSQLQTGE KSKNTIHEDT IFRNGLQCKH 

       190        200        210        220        230        240 
EFERQERHQM GCVSQMLIQK QISHPLHPKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT 

       250        260        270        280        290        300 
GERPYKCMEC GKAFCRVGDL RVHHTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP 

       310        320        330        340        350        360 
YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI HTGERPYECK 

       370        380        390        400        410        420 
VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL VQHQKIHTGE KPYECKECGK 

       430        440        450        460        470        480 
SFSFHAELAR HRRIHTGEKP YECRECGKAF RLQTELTRHH RTHTGEKPYE CKECGKAFIC 

       490        500        510        520        530        540 
GYQLTLHLRT HTGEIPYECK ECGKTFSSRY HLTQHYRIHT GEKPYICNEC GKAFRLQGEL 

       550        560        570        580        590        600 
TRHHRIHTCE KPYECKECGK AFIHSNQFIS HQRIHTSEST YICKECGKIF SRRYNLTQHF 

       610        620        630        640        650        660 
KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST HLTQHHRIHT 

       670        680        690        700        710        720 
GEKPYECTEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN AFICSYRLTL HQRIHTGELP 

       730        740        750        760        770        780 
YECKECGKTF SRRYHLTQHF RLHTGEKPYS CKECGNAFRL QAELTRHHIV HTGEKPYKCK 

       790        800        810        820        830 
ECGKAFSVNS ELTRHHRIHT GEKPYQCKEC GKAFIRSDQL TLHQRNHISE EVLCIM 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-201.
Tissue: Testis.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK292528 mRNA. Translation: BAF85217.1.
CH471126 Genomic DNA. Translation: EAW56930.1.
BC045649 mRNA. Translation: AAH45649.1.
CCDSCCDS12548.1.
RefSeqNP_848639.2. NM_178544.3.
UniGeneHs.666807.

3D structure databases

ProteinModelPortalQ86UE3.
SMRQ86UE3. Positions 60-101, 214-827.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130869. 2 interactions.
IntActQ86UE3. 1 interaction.
STRING9606.ENSP00000339823.

PTM databases

PhosphoSiteQ86UE3.

Polymorphism databases

DMDM229462787.

Proteomic databases

MaxQBQ86UE3.
PaxDbQ86UE3.
PRIDEQ86UE3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000347077; ENSP00000339823; ENSG00000187187.
GeneID339327.
KEGGhsa:339327.
UCSCuc002oms.2. human.

Organism-specific databases

CTD339327.
GeneCardsGC19P040503.
HGNCHGNC:28671. ZNF546.
HPAHPA030838.
neXtProtNX_Q86UE3.
PharmGKBPA134881362.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ86UE3.
KOK09228.
OMAFRLHYHL.
PhylomeDBQ86UE3.
TreeFamTF343410.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ86UE3.
BgeeQ86UE3.
CleanExHS_ZNF546.
GenevestigatorQ86UE3.

Family and domain databases

Gene3D3.30.160.60. 22 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 22 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 22 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339327.
NextBio97356.
PROQ86UE3.

Entry information

Entry nameZN546_HUMAN
AccessionPrimary (citable) accession number: Q86UE3
Secondary accession number(s): A8K913
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM