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Q86UE3

- ZN546_HUMAN

UniProt

Q86UE3 - ZN546_HUMAN

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Protein

Zinc finger protein 546

Gene

ZNF546

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri217 – 23923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri637 – 65923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri693 – 71523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri721 – 74323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri749 – 77123C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri777 – 79923C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri805 – 82723C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 546
Alternative name(s):
Zinc finger protein 49
Gene namesi
Name:ZNF546
Synonyms:ZNF49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:28671. ZNF546.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Zinc finger protein 546PRO_0000234582Add
BLAST

Proteomic databases

MaxQBiQ86UE3.
PaxDbiQ86UE3.
PRIDEiQ86UE3.

PTM databases

PhosphoSiteiQ86UE3.

Expressioni

Gene expression databases

BgeeiQ86UE3.
CleanExiHS_ZNF546.
ExpressionAtlasiQ86UE3. baseline and differential.
GenevestigatoriQ86UE3.

Organism-specific databases

HPAiHPA030838.

Interactioni

Protein-protein interaction databases

BioGridi130869. 2 interactions.
IntActiQ86UE3. 1 interaction.
STRINGi9606.ENSP00000339823.

Structurei

3D structure databases

ProteinModelPortaliQ86UE3.
SMRiQ86UE3. Positions 60-101, 214-827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 13172KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri217 – 23923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri245 – 26723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri273 – 29523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri301 – 32323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri329 – 35123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri357 – 37923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri385 – 40723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 43523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri441 – 46323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri637 – 65923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri693 – 71523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri721 – 74323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri749 – 77123C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri777 – 79923C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri805 – 82723C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118979.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86UE3.
KOiK09228.
OMAiFRLHYHL.
PhylomeDBiQ86UE3.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 22 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 22 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 22 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UE3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVDPPLHGP PNDFLIFQII PLHSLSIMPR FLWILCFSME ETQGELTSSC
60 70 80 90 100
GSKTMANVSL AFRDVSIDLS QEEWECLDAV QRDLYKDVML ENYSNLVSLG
110 120 130 140 150
YTIPKPDVIT LLEQEKEPWI VMREGTRNWF TDLEYKYITK NLLSEKNVCK
160 170 180 190 200
IYLSQLQTGE KSKNTIHEDT IFRNGLQCKH EFERQERHQM GCVSQMLIQK
210 220 230 240 250
QISHPLHPKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT GERPYKCMEC
260 270 280 290 300
GKAFCRVGDL RVHHTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP
310 320 330 340 350
YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI
360 370 380 390 400
HTGERPYECK VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL
410 420 430 440 450
VQHQKIHTGE KPYECKECGK SFSFHAELAR HRRIHTGEKP YECRECGKAF
460 470 480 490 500
RLQTELTRHH RTHTGEKPYE CKECGKAFIC GYQLTLHLRT HTGEIPYECK
510 520 530 540 550
ECGKTFSSRY HLTQHYRIHT GEKPYICNEC GKAFRLQGEL TRHHRIHTCE
560 570 580 590 600
KPYECKECGK AFIHSNQFIS HQRIHTSEST YICKECGKIF SRRYNLTQHF
610 620 630 640 650
KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST
660 670 680 690 700
HLTQHHRIHT GEKPYECTEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN
710 720 730 740 750
AFICSYRLTL HQRIHTGELP YECKECGKTF SRRYHLTQHF RLHTGEKPYS
760 770 780 790 800
CKECGNAFRL QAELTRHHIV HTGEKPYKCK ECGKAFSVNS ELTRHHRIHT
810 820 830
GEKPYQCKEC GKAFIRSDQL TLHQRNHISE EVLCIM
Length:836
Mass (Da):98,405
Last modified:May 5, 2009 - v2
Checksum:i81AC4B259DDBCB32
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_035587
Natural varianti201 – 2011Q → R.1 Publication
Corresponds to variant rs17854378 [ dbSNP | Ensembl ].
VAR_055271
Natural varianti243 – 2431R → T.
Corresponds to variant rs2111543 [ dbSNP | Ensembl ].
VAR_055272
Natural varianti253 – 2531A → V.
Corresponds to variant rs2111544 [ dbSNP | Ensembl ].
VAR_055273
Natural varianti298 – 2981V → E.
Corresponds to variant rs17710336 [ dbSNP | Ensembl ].
VAR_055274
Natural varianti427 – 4271E → G.
Corresponds to variant rs12460371 [ dbSNP | Ensembl ].
VAR_055275
Natural varianti452 – 4521L → F.
Corresponds to variant rs7255186 [ dbSNP | Ensembl ].
VAR_055276
Natural varianti652 – 6521L → F.
Corresponds to variant rs12373540 [ dbSNP | Ensembl ].
VAR_055277

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292528 mRNA. Translation: BAF85217.1.
CH471126 Genomic DNA. Translation: EAW56930.1.
BC045649 mRNA. Translation: AAH45649.1.
CCDSiCCDS12548.1.
RefSeqiNP_848639.2. NM_178544.4.
UniGeneiHs.125008.
Hs.666807.

Genome annotation databases

EnsembliENST00000347077; ENSP00000339823; ENSG00000187187.
GeneIDi339327.
KEGGihsa:339327.
UCSCiuc002oms.2. human.

Polymorphism databases

DMDMi229462787.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292528 mRNA. Translation: BAF85217.1 .
CH471126 Genomic DNA. Translation: EAW56930.1 .
BC045649 mRNA. Translation: AAH45649.1 .
CCDSi CCDS12548.1.
RefSeqi NP_848639.2. NM_178544.4.
UniGenei Hs.125008.
Hs.666807.

3D structure databases

ProteinModelPortali Q86UE3.
SMRi Q86UE3. Positions 60-101, 214-827.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130869. 2 interactions.
IntActi Q86UE3. 1 interaction.
STRINGi 9606.ENSP00000339823.

PTM databases

PhosphoSitei Q86UE3.

Polymorphism databases

DMDMi 229462787.

Proteomic databases

MaxQBi Q86UE3.
PaxDbi Q86UE3.
PRIDEi Q86UE3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347077 ; ENSP00000339823 ; ENSG00000187187 .
GeneIDi 339327.
KEGGi hsa:339327.
UCSCi uc002oms.2. human.

Organism-specific databases

CTDi 339327.
GeneCardsi GC19P040503.
HGNCi HGNC:28671. ZNF546.
HPAi HPA030838.
neXtProti NX_Q86UE3.
PharmGKBi PA134881362.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118979.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q86UE3.
KOi K09228.
OMAi FRLHYHL.
PhylomeDBi Q86UE3.
TreeFami TF343410.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 339327.
NextBioi 97356.
PROi Q86UE3.

Gene expression databases

Bgeei Q86UE3.
CleanExi HS_ZNF546.
ExpressionAtlasi Q86UE3. baseline and differential.
Genevestigatori Q86UE3.

Family and domain databases

Gene3Di 3.30.160.60. 22 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 22 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 22 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-201.
    Tissue: Testis.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-15.

Entry informationi

Entry nameiZN546_HUMAN
AccessioniPrimary (citable) accession number: Q86UE3
Secondary accession number(s): A8K913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3