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Q86UE3

- ZN546_HUMAN

UniProt

Q86UE3 - ZN546_HUMAN

Protein

Zinc finger protein 546

Gene

ZNF546

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri217 – 23923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri441 – 46323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57523C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri581 – 60323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri637 – 65923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri665 – 68723C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri693 – 71523C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri721 – 74323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri749 – 77123C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri777 – 79923C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri805 – 82723C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 546
    Alternative name(s):
    Zinc finger protein 49
    Gene namesi
    Name:ZNF546
    Synonyms:ZNF49
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:28671. ZNF546.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134881362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 836836Zinc finger protein 546PRO_0000234582Add
    BLAST

    Proteomic databases

    MaxQBiQ86UE3.
    PaxDbiQ86UE3.
    PRIDEiQ86UE3.

    PTM databases

    PhosphoSiteiQ86UE3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86UE3.
    BgeeiQ86UE3.
    CleanExiHS_ZNF546.
    GenevestigatoriQ86UE3.

    Organism-specific databases

    HPAiHPA030838.

    Interactioni

    Protein-protein interaction databases

    BioGridi130869. 2 interactions.
    IntActiQ86UE3. 1 interaction.
    STRINGi9606.ENSP00000339823.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UE3.
    SMRiQ86UE3. Positions 60-101, 214-827.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 13172KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri217 – 23923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri245 – 26723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 29523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri301 – 32323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri329 – 35123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri357 – 37923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri385 – 40723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri413 – 43523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri441 – 46323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57523C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri581 – 60323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri637 – 65923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri665 – 68723C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri693 – 71523C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri721 – 74323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri749 – 77123C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri777 – 79923C2H2-type 21PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri805 – 82723C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ86UE3.
    KOiK09228.
    OMAiFRLHYHL.
    PhylomeDBiQ86UE3.
    TreeFamiTF343410.

    Family and domain databases

    Gene3Di3.30.160.60. 22 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 22 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 22 hits.
    PS50157. ZINC_FINGER_C2H2_2. 22 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86UE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVDPPLHGP PNDFLIFQII PLHSLSIMPR FLWILCFSME ETQGELTSSC    50
    GSKTMANVSL AFRDVSIDLS QEEWECLDAV QRDLYKDVML ENYSNLVSLG 100
    YTIPKPDVIT LLEQEKEPWI VMREGTRNWF TDLEYKYITK NLLSEKNVCK 150
    IYLSQLQTGE KSKNTIHEDT IFRNGLQCKH EFERQERHQM GCVSQMLIQK 200
    QISHPLHPKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT GERPYKCMEC 250
    GKAFCRVGDL RVHHTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP 300
    YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI 350
    HTGERPYECK VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL 400
    VQHQKIHTGE KPYECKECGK SFSFHAELAR HRRIHTGEKP YECRECGKAF 450
    RLQTELTRHH RTHTGEKPYE CKECGKAFIC GYQLTLHLRT HTGEIPYECK 500
    ECGKTFSSRY HLTQHYRIHT GEKPYICNEC GKAFRLQGEL TRHHRIHTCE 550
    KPYECKECGK AFIHSNQFIS HQRIHTSEST YICKECGKIF SRRYNLTQHF 600
    KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST 650
    HLTQHHRIHT GEKPYECTEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN 700
    AFICSYRLTL HQRIHTGELP YECKECGKTF SRRYHLTQHF RLHTGEKPYS 750
    CKECGNAFRL QAELTRHHIV HTGEKPYKCK ECGKAFSVNS ELTRHHRIHT 800
    GEKPYQCKEC GKAFIRSDQL TLHQRNHISE EVLCIM 836
    Length:836
    Mass (Da):98,405
    Last modified:May 5, 2009 - v2
    Checksum:i81AC4B259DDBCB32
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151L → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035587
    Natural varianti201 – 2011Q → R.1 Publication
    Corresponds to variant rs17854378 [ dbSNP | Ensembl ].
    VAR_055271
    Natural varianti243 – 2431R → T.
    Corresponds to variant rs2111543 [ dbSNP | Ensembl ].
    VAR_055272
    Natural varianti253 – 2531A → V.
    Corresponds to variant rs2111544 [ dbSNP | Ensembl ].
    VAR_055273
    Natural varianti298 – 2981V → E.
    Corresponds to variant rs17710336 [ dbSNP | Ensembl ].
    VAR_055274
    Natural varianti427 – 4271E → G.
    Corresponds to variant rs12460371 [ dbSNP | Ensembl ].
    VAR_055275
    Natural varianti452 – 4521L → F.
    Corresponds to variant rs7255186 [ dbSNP | Ensembl ].
    VAR_055276
    Natural varianti652 – 6521L → F.
    Corresponds to variant rs12373540 [ dbSNP | Ensembl ].
    VAR_055277

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK292528 mRNA. Translation: BAF85217.1.
    CH471126 Genomic DNA. Translation: EAW56930.1.
    BC045649 mRNA. Translation: AAH45649.1.
    CCDSiCCDS12548.1.
    RefSeqiNP_848639.2. NM_178544.3.
    UniGeneiHs.666807.

    Genome annotation databases

    EnsembliENST00000347077; ENSP00000339823; ENSG00000187187.
    GeneIDi339327.
    KEGGihsa:339327.
    UCSCiuc002oms.2. human.

    Polymorphism databases

    DMDMi229462787.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK292528 mRNA. Translation: BAF85217.1 .
    CH471126 Genomic DNA. Translation: EAW56930.1 .
    BC045649 mRNA. Translation: AAH45649.1 .
    CCDSi CCDS12548.1.
    RefSeqi NP_848639.2. NM_178544.3.
    UniGenei Hs.666807.

    3D structure databases

    ProteinModelPortali Q86UE3.
    SMRi Q86UE3. Positions 60-101, 214-827.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130869. 2 interactions.
    IntActi Q86UE3. 1 interaction.
    STRINGi 9606.ENSP00000339823.

    PTM databases

    PhosphoSitei Q86UE3.

    Polymorphism databases

    DMDMi 229462787.

    Proteomic databases

    MaxQBi Q86UE3.
    PaxDbi Q86UE3.
    PRIDEi Q86UE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347077 ; ENSP00000339823 ; ENSG00000187187 .
    GeneIDi 339327.
    KEGGi hsa:339327.
    UCSCi uc002oms.2. human.

    Organism-specific databases

    CTDi 339327.
    GeneCardsi GC19P040503.
    HGNCi HGNC:28671. ZNF546.
    HPAi HPA030838.
    neXtProti NX_Q86UE3.
    PharmGKBi PA134881362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q86UE3.
    KOi K09228.
    OMAi FRLHYHL.
    PhylomeDBi Q86UE3.
    TreeFami TF343410.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 339327.
    NextBioi 97356.
    PROi Q86UE3.

    Gene expression databases

    ArrayExpressi Q86UE3.
    Bgeei Q86UE3.
    CleanExi HS_ZNF546.
    Genevestigatori Q86UE3.

    Family and domain databases

    Gene3Di 3.30.160.60. 22 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 22 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 22 hits.
    PS50157. ZINC_FINGER_C2H2_2. 22 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-201.
      Tissue: Testis.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-15.

    Entry informationi

    Entry nameiZN546_HUMAN
    AccessioniPrimary (citable) accession number: Q86UE3
    Secondary accession number(s): A8K913
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3