Q86UE3 (ZN546_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 546

Alternative name(s):
Zinc finger protein 49

Gene names

Name:	ZNF546
Synonyms:	ZNF49

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 22 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 836	836	Zinc finger protein 546		PRO_0000234582
Regions
	Domain	60 – 131	72	KRAB
	Zinc finger	217 – 239	23	C2H2-type 1
	Zinc finger	245 – 267	23	C2H2-type 2
	Zinc finger	273 – 295	23	C2H2-type 3
	Zinc finger	301 – 323	23	C2H2-type 4
	Zinc finger	329 – 351	23	C2H2-type 5
	Zinc finger	357 – 379	23	C2H2-type 6
	Zinc finger	385 – 407	23	C2H2-type 7
	Zinc finger	413 – 435	23	C2H2-type 8
	Zinc finger	441 – 463	23	C2H2-type 9
	Zinc finger	469 – 491	23	C2H2-type 10
	Zinc finger	497 – 519	23	C2H2-type 11
	Zinc finger	525 – 547	23	C2H2-type 12
	Zinc finger	553 – 575	23	C2H2-type 13
	Zinc finger	581 – 603	23	C2H2-type 14
	Zinc finger	609 – 631	23	C2H2-type 15
	Zinc finger	637 – 659	23	C2H2-type 16
	Zinc finger	665 – 687	23	C2H2-type 17
	Zinc finger	693 – 715	23	C2H2-type 18
	Zinc finger	721 – 743	23	C2H2-type 19
	Zinc finger	749 – 771	23	C2H2-type 20
	Zinc finger	777 – 799	23	C2H2-type 21
	Zinc finger	805 – 827	23	C2H2-type 22
Natural variations
	Natural variant	15	1	L → V in a breast cancer sample; somatic mutation. Ref.4		VAR_035587
	Natural variant	201	1	Q → R. Ref.3 Corresponds to variant rs17854378 [ dbSNP | Ensembl ].		VAR_055271
	Natural variant	243	1	R → T. Corresponds to variant rs2111543 [ dbSNP | Ensembl ].		VAR_055272
	Natural variant	253	1	A → V. Corresponds to variant rs2111544 [ dbSNP | Ensembl ].		VAR_055273
	Natural variant	298	1	V → E. Corresponds to variant rs17710336 [ dbSNP | Ensembl ].		VAR_055274
	Natural variant	427	1	E → G. Corresponds to variant rs12460371 [ dbSNP | Ensembl ].		VAR_055275
	Natural variant	452	1	L → F. Corresponds to variant rs7255186 [ dbSNP | Ensembl ].		VAR_055276
	Natural variant	652	1	L → F. Corresponds to variant rs12373540 [ dbSNP | Ensembl ].		VAR_055277

Sequences

	Sequence		Length	Mass (Da)
	Q86UE3 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 81AC4B259DDBCB32	FASTA	836	98,405
	10 20 30 40 50 60 MQVDPPLHGP PNDFLIFQII PLHSLSIMPR FLWILCFSME ETQGELTSSC GSKTMANVSL 70 80 90 100 110 120 AFRDVSIDLS QEEWECLDAV QRDLYKDVML ENYSNLVSLG YTIPKPDVIT LLEQEKEPWI 130 140 150 160 170 180 VMREGTRNWF TDLEYKYITK NLLSEKNVCK IYLSQLQTGE KSKNTIHEDT IFRNGLQCKH 190 200 210 220 230 240 EFERQERHQM GCVSQMLIQK QISHPLHPKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT 250 260 270 280 290 300 GERPYKCMEC GKAFCRVGDL RVHHTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP 310 320 330 340 350 360 YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI HTGERPYECK 370 380 390 400 410 420 VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL VQHQKIHTGE KPYECKECGK 430 440 450 460 470 480 SFSFHAELAR HRRIHTGEKP YECRECGKAF RLQTELTRHH RTHTGEKPYE CKECGKAFIC 490 500 510 520 530 540 GYQLTLHLRT HTGEIPYECK ECGKTFSSRY HLTQHYRIHT GEKPYICNEC GKAFRLQGEL 550 560 570 580 590 600 TRHHRIHTCE KPYECKECGK AFIHSNQFIS HQRIHTSEST YICKECGKIF SRRYNLTQHF 610 620 630 640 650 660 KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST HLTQHHRIHT 670 680 690 700 710 720 GEKPYECTEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN AFICSYRLTL HQRIHTGELP 730 740 750 760 770 780 YECKECGKTF SRRYHLTQHF RLHTGEKPYS CKECGNAFRL QAELTRHHIV HTGEKPYKCK 790 800 810 820 830 ECGKAFSVNS ELTRHHRIHT GEKPYQCKEC GKAFIRSDQL TLHQRNHISE EVLCIM

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-201. Tissue: Testis.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK292528 mRNA. Translation: BAF85217.1. CH471126 Genomic DNA. Translation: EAW56930.1. BC045649 mRNA. Translation: AAH45649.1.
IPI	IPI00328713.
RefSeq	NP_848639.2. NM_178544.3.
UniGene	Hs.666807.
3D structure databases
ProteinModelPortal	Q86UE3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86UE3. 1 interaction.
STRING	9606.ENSP00000339823.
PTM databases
PhosphoSite	Q86UE3.
Polymorphism databases
DMDM	229462787.
Proteomic databases
PaxDb	Q86UE3.
PRIDE	Q86UE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000347077; ENSP00000339823; ENSG00000187187.
GeneID	339327.
KEGG	hsa:339327.
UCSC	uc002oms.2. human.
Organism-specific databases
CTD	339327.
GeneCards	GC19P040503.
HGNC	HGNC:28671. ZNF546.
HPA	HPA030838.
neXtProt	NX_Q86UE3.
PharmGKB	PA134881362.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q86UE3.
KO	K09228.
OMA	FRLHYHL.
OrthoDB	EOG4J9MZ8.
PhylomeDB	Q86UE3.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q86UE3.
CleanEx	HS_ZNF546.
Genevestigator	Q86UE3.
GermOnline	ENSG00000187187. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 22 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 22 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 22 hits. PS50157. ZINC_FINGER_C2H2_2. 22 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	339327.
NextBio	97356.

Entry information

Entry name

ZN546_HUMAN

Accession

Primary (citable) accession number: Q86UE3
Secondary accession number(s): A8K913

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.