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Protein

TBC1 domain family member 26

Gene

TBC1D26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:G66-30955-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 26
Gene namesi
Name:TBC1D26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28745. TBC1D26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000214946.
ENSG00000255104.
PharmGKBiPA162405218.

Polymorphism and mutation databases

BioMutaiTBC1D26.
DMDMi313104281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370191 – 250TBC1 domain family member 26Add BLAST250

Proteomic databases

PaxDbiQ86UD7.
PRIDEiQ86UD7.

PTM databases

iPTMnetiQ86UD7.
PhosphoSitePlusiQ86UD7.

Expressioni

Gene expression databases

BgeeiENSG00000214946.
CleanExiHS_TBC1D26.
ExpressionAtlasiQ86UD7. baseline and differential.
GenevisibleiQ86UD7. HS.

Organism-specific databases

HPAiHPA049122.
HPA050044.
HPA050460.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131653. 1 interactor.
STRINGi9606.ENSP00000410111.

Structurei

3D structure databases

ProteinModelPortaliQ86UD7.
SMRiQ86UD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 250Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1102. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000293177.
HOVERGENiHBG108547.
InParanoidiQ86UD7.
OMAiSRCCTSP.
OrthoDBiEOG091G0GK2.
PhylomeDBiQ86UD7.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 1 hit.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMDGDPYNL PAQGQGNIII TKYEQGHRAG AAVDLGHEQV DVRKYTNNLG
60 70 80 90 100
IVHEMELPHV SALEVKQRRK ESKRTNKWQK MLADWTKYRS TKKLSQRVYK
110 120 130 140 150
VIPLAVRGRA WSLLLDIDRI KSQNPGKYKV MKEKGKRSSR IIHCIQLDVS
160 170 180 190 200
HTLQKHMMFI QRFGVKQQEL CDILVAYSAY NPEVGYHRDL SRITAILLLC
210 220 230 240 250
LPEEDAFWAL TQLLAGERHS LWYSTAQILP GSRGSYRTRS RCCTSPSQRS
Length:250
Mass (Da):28,839
Last modified:November 30, 2010 - v3
Checksum:i8E26455DD725AD32
GO
Isoform 2 (identifier: Q86UD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-210: EVGYHRDLSRITAILLLCLPEEDAFWAL → VSIPGQRYSWDMCPYSQAWVSLGGVATS
     211-250: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):24,160
Checksum:i9390AF8F4D96B788
GO
Isoform 3 (identifier: Q86UD7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-86: QRRKESKRTNKWQKMLADWT → VRACACCVGGCFRDWESGGR
     87-250: Missing.

Note: No experimental confirmation available.
Show »
Length:86
Mass (Da):9,414
Checksum:i6C88B9B3657E3450
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59H → R in BAF85233 (PubMed:14702039).Curated1
Sequence conflicti59H → R in BAF98738 (PubMed:14702039).Curated1
Sequence conflicti59H → R in AAH28414 (PubMed:15489334).Curated1
Sequence conflicti59H → R in AAH47400 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043563206A → V.1 PublicationCorresponds to variant rs11650318dbSNPEnsembl.1
Natural variantiVAR_047676234G → S.1 PublicationCorresponds to variant rs17855672dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03382567 – 86QRRKE…LADWT → VRACACCVGGCFRDWESGGR in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_03382687 – 250Missing in isoform 3. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_033827183 – 210EVGYH…AFWAL → VSIPGQRYSWDMCPYSQAWV SLGGVATS in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_033828211 – 250Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292544 mRNA. Translation: BAF85233.1.
AK315847 mRNA. Translation: BAF98738.1.
AC005324 Genomic DNA. No translation available.
BC028414 mRNA. Translation: AAH28414.1.
BC047400 mRNA. Translation: AAH47400.1.
CCDSiCCDS42265.1. [Q86UD7-1]
RefSeqiNP_848666.2. NM_178571.4.
UniGeneiHs.434123.
Hs.567880.

Genome annotation databases

EnsembliENST00000437605; ENSP00000410111; ENSG00000255104. [Q86UD7-1]
ENST00000469477; ENSP00000434391; ENSG00000214946. [Q86UD7-1]
ENST00000579428; ENSP00000463097; ENSG00000214946. [Q86UD7-2]
ENST00000612583; ENSP00000478643; ENSG00000214946. [Q86UD7-2]
GeneIDi353149.
KEGGihsa:353149.
UCSCiuc010cou.2. human. [Q86UD7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292544 mRNA. Translation: BAF85233.1.
AK315847 mRNA. Translation: BAF98738.1.
AC005324 Genomic DNA. No translation available.
BC028414 mRNA. Translation: AAH28414.1.
BC047400 mRNA. Translation: AAH47400.1.
CCDSiCCDS42265.1. [Q86UD7-1]
RefSeqiNP_848666.2. NM_178571.4.
UniGeneiHs.434123.
Hs.567880.

3D structure databases

ProteinModelPortaliQ86UD7.
SMRiQ86UD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131653. 1 interactor.
STRINGi9606.ENSP00000410111.

PTM databases

iPTMnetiQ86UD7.
PhosphoSitePlusiQ86UD7.

Polymorphism and mutation databases

BioMutaiTBC1D26.
DMDMi313104281.

Proteomic databases

PaxDbiQ86UD7.
PRIDEiQ86UD7.

Protocols and materials databases

DNASUi353149.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437605; ENSP00000410111; ENSG00000255104. [Q86UD7-1]
ENST00000469477; ENSP00000434391; ENSG00000214946. [Q86UD7-1]
ENST00000579428; ENSP00000463097; ENSG00000214946. [Q86UD7-2]
ENST00000612583; ENSP00000478643; ENSG00000214946. [Q86UD7-2]
GeneIDi353149.
KEGGihsa:353149.
UCSCiuc010cou.2. human. [Q86UD7-1]

Organism-specific databases

CTDi353149.
GeneCardsiTBC1D26.
HGNCiHGNC:28745. TBC1D26.
HPAiHPA049122.
HPA050044.
HPA050460.
neXtProtiNX_Q86UD7.
OpenTargetsiENSG00000214946.
ENSG00000255104.
PharmGKBiPA162405218.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1102. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000293177.
HOVERGENiHBG108547.
InParanoidiQ86UD7.
OMAiSRCCTSP.
OrthoDBiEOG091G0GK2.
PhylomeDBiQ86UD7.

Enzyme and pathway databases

BioCyciZFISH:G66-30955-MONOMER.

Miscellaneous databases

GenomeRNAii353149.
PROiQ86UD7.

Gene expression databases

BgeeiENSG00000214946.
CleanExiHS_TBC1D26.
ExpressionAtlasiQ86UD7. baseline and differential.
GenevisibleiQ86UD7. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 1 hit.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC26_HUMAN
AccessioniPrimary (citable) accession number: Q86UD7
Secondary accession number(s): A8K929, Q4G172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.