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Protein

Zinc finger protein 329

Gene

ZNF329

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 329
Gene namesi
Name:ZNF329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14209. ZNF329.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181894.
PharmGKBiPA37858.

Polymorphism and mutation databases

BioMutaiZNF329.
DMDMi296453050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072881 – 541Zinc finger protein 329Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UD4.
MaxQBiQ86UD4.
PaxDbiQ86UD4.
PeptideAtlasiQ86UD4.
PRIDEiQ86UD4.

PTM databases

iPTMnetiQ86UD4.
PhosphoSitePlusiQ86UD4.

Expressioni

Gene expression databases

BgeeiENSG00000181894.
CleanExiHS_ZNF329.
ExpressionAtlasiQ86UD4. baseline and differential.
GenevisibleiQ86UD4. HS.

Organism-specific databases

HPAiHPA044373.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ15EBI-7233259,EBI-739624
KRT40Q6A1623EBI-7233259,EBI-10171697
KRTAP10-5P603703EBI-7233259,EBI-10172150
KRTAP10-7P604093EBI-7233259,EBI-10172290
MEOX2A4D1273EBI-7233259,EBI-10172134
MTUS2Q5JR593EBI-7233259,EBI-742948
OPTNQ96CV93EBI-7233259,EBI-748974
TRIM37O949723EBI-7233259,EBI-741602
TRIM41Q8WV443EBI-7233259,EBI-725997

Protein-protein interaction databases

BioGridi122798. 11 interactors.
IntActiQ86UD4. 15 interactors.
MINTiMINT-1194772.
STRINGi9606.ENSP00000350773.

Structurei

3D structure databases

ProteinModelPortaliQ86UD4.
SMRiQ86UD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133773.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86UD4.
OMAiCNQCQKL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86UD4.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86UD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLKMTTRNF PEREVPCDVE VERFTREVPC LSSLGDGWDC ENQEGHLRQS
60 70 80 90 100
ALTLEKPGTQ EAICEYPGFG EHLIASSDLP PSQRVLATNG FHAPDSNVSG
110 120 130 140 150
LDCDPALPSY PKSYADKRTG DSDACGKGFN HSMEVIHGRN PVREKPYKYP
160 170 180 190 200
ESVKSFNHFT SLGHQKIMKR GKKSYEGKNF ENIFTLSSSL NENQRNLPGE
210 220 230 240 250
KQYRCTECGK CFKRNSSLVL HHRTHTGEKP YTCNECGKSF SKNYNLIVHQ
260 270 280 290 300
RIHTGEKPYE CSKCGKAFSD GSALTQHQRI HTGEKPYECL ECGKTFNRNS
310 320 330 340 350
SLILHQRTHT GEKPYRCNEC GKPFTDISHL TVHLRIHTGE KPYECSKCGK
360 370 380 390 400
AFRDGSYLTQ HERTHTGEKP FECAECGKSF NRNSHLIVHQ KIHSGEKPYE
410 420 430 440 450
CKECGKTFIE SAYLIRHQRI HTGEKPYGCN QCQKLFRNIA GLIRHQRTHT
460 470 480 490 500
GEKPYECNQC GKAFRDSSCL TKHQRIHTKE TPYQCPECGK SFKQNSHLAV
510 520 530 540
HQRLHSREGP SRCPQCGKMF QKSSSLVRHQ RAHLGEQPME T
Length:541
Mass (Da):61,725
Last modified:May 18, 2010 - v2
Checksum:i4C56F21B845BF69F
GO

Sequence cautioni

The sequence BAB14154 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122S → N in AAH47501 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06042899S → N.Corresponds to variant rs2279333dbSNPEnsembl.1
Natural variantiVAR_035403182N → D.Corresponds to variant rs34255209dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022648 mRNA. Translation: BAB14154.1. Different initiation.
AK090893 mRNA. Translation: BAG52244.1.
AK096542 mRNA. Translation: BAG53319.1.
AC008751 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72560.1.
BC047501 mRNA. Translation: AAH47501.1.
CCDSiCCDS12972.1.
RefSeqiNP_078896.3. NM_024620.3.
XP_006723444.1. XM_006723381.2.
XP_006723445.1. XM_006723382.3.
XP_006723446.1. XM_006723383.3.
XP_006723447.1. XM_006723384.3.
XP_011525617.1. XM_011527315.1.
XP_011525618.1. XM_011527316.2.
XP_016882796.1. XM_017027307.1.
XP_016882797.1. XM_017027308.1.
XP_016882798.1. XM_017027309.1.
XP_016882799.1. XM_017027310.1.
XP_016882800.1. XM_017027311.1.
UniGeneiHs.458377.

Genome annotation databases

EnsembliENST00000358067; ENSP00000350773; ENSG00000181894.
ENST00000500161; ENSP00000439527; ENSG00000181894.
ENST00000597186; ENSP00000470323; ENSG00000181894.
ENST00000598312; ENSP00000470008; ENSG00000181894.
GeneIDi79673.
KEGGihsa:79673.
UCSCiuc002qrn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022648 mRNA. Translation: BAB14154.1. Different initiation.
AK090893 mRNA. Translation: BAG52244.1.
AK096542 mRNA. Translation: BAG53319.1.
AC008751 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72560.1.
BC047501 mRNA. Translation: AAH47501.1.
CCDSiCCDS12972.1.
RefSeqiNP_078896.3. NM_024620.3.
XP_006723444.1. XM_006723381.2.
XP_006723445.1. XM_006723382.3.
XP_006723446.1. XM_006723383.3.
XP_006723447.1. XM_006723384.3.
XP_011525617.1. XM_011527315.1.
XP_011525618.1. XM_011527316.2.
XP_016882796.1. XM_017027307.1.
XP_016882797.1. XM_017027308.1.
XP_016882798.1. XM_017027309.1.
XP_016882799.1. XM_017027310.1.
XP_016882800.1. XM_017027311.1.
UniGeneiHs.458377.

3D structure databases

ProteinModelPortaliQ86UD4.
SMRiQ86UD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122798. 11 interactors.
IntActiQ86UD4. 15 interactors.
MINTiMINT-1194772.
STRINGi9606.ENSP00000350773.

PTM databases

iPTMnetiQ86UD4.
PhosphoSitePlusiQ86UD4.

Polymorphism and mutation databases

BioMutaiZNF329.
DMDMi296453050.

Proteomic databases

EPDiQ86UD4.
MaxQBiQ86UD4.
PaxDbiQ86UD4.
PeptideAtlasiQ86UD4.
PRIDEiQ86UD4.

Protocols and materials databases

DNASUi79673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358067; ENSP00000350773; ENSG00000181894.
ENST00000500161; ENSP00000439527; ENSG00000181894.
ENST00000597186; ENSP00000470323; ENSG00000181894.
ENST00000598312; ENSP00000470008; ENSG00000181894.
GeneIDi79673.
KEGGihsa:79673.
UCSCiuc002qrn.4. human.

Organism-specific databases

CTDi79673.
GeneCardsiZNF329.
HGNCiHGNC:14209. ZNF329.
HPAiHPA044373.
neXtProtiNX_Q86UD4.
OpenTargetsiENSG00000181894.
PharmGKBiPA37858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133773.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86UD4.
OMAiCNQCQKL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ86UD4.
TreeFamiTF341817.

Miscellaneous databases

ChiTaRSiZNF329. human.
GenomeRNAii79673.
PROiQ86UD4.

Gene expression databases

BgeeiENSG00000181894.
CleanExiHS_ZNF329.
ExpressionAtlasiQ86UD4. baseline and differential.
GenevisibleiQ86UD4. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN329_HUMAN
AccessioniPrimary (citable) accession number: Q86UD4
Secondary accession number(s): B3KR32, Q9H9R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.