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Protein

Suppressor APC domain-containing protein 2

Gene

SAPCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33083-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor APC domain-containing protein 2
Alternative name(s):
Tumor specificity and mitosis phase-dependent expression protein
Short name:
TS/MDEP
p42.3
Gene namesi
Name:SAPCD2
Synonyms:C9orf140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28055. SAPCD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi89958.
OpenTargetsiENSG00000186193.
PharmGKBiPA134959870.

Polymorphism and mutation databases

BioMutaiSAPCD2.
DMDMi147638520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865961 – 394Suppressor APC domain-containing protein 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphothreonineCombined sources1
Modified residuei284PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UD0.
MaxQBiQ86UD0.
PaxDbiQ86UD0.
PeptideAtlasiQ86UD0.
PRIDEiQ86UD0.

PTM databases

iPTMnetiQ86UD0.
PhosphoSitePlusiQ86UD0.

Expressioni

Tissue specificityi

Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney. Undetectable in non-cancerous adult tissues. Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa. Expressed preferentially in M and G1 phases, compared to S and G2 phases.1 Publication

Gene expression databases

BgeeiENSG00000186193.
CleanExiHS_C9orf140.
GenevisibleiQ86UD0. HS.

Organism-specific databases

HPAiHPA044154.

Interactioni

Protein-protein interaction databases

BioGridi124649. 10 interactors.
IntActiQ86UD0. 10 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ86UD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 277Sequence analysisAdd BLAST51
Coiled coili336 – 384Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 174Pro-richAdd BLAST73

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410INQN. Eukaryota.
ENOG4110P7W. LUCA.
GeneTreeiENSGT00390000008072.
HOGENOMiHOG000035117.
HOVERGENiHBG062219.
InParanoidiQ86UD0.
OMAiARDWYMM.
OrthoDBiEOG091G0DUU.
PhylomeDBiQ86UD0.
TreeFamiTF324086.

Family and domain databases

InterProiIPR026828. Suppressor_APCD_1/2.
[Graphical view]
PANTHERiPTHR14907. PTHR14907. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86UD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAAMAERG RVPPPAPAPS TEGLPRAFLQ SLRTLFDILD DRRRGCVHLR
60 70 80 90 100
EIESRWQGTD ARELPRGVLE GLRQVAPASG YLTFERFVAG LRTSLLSADG
110 120 130 140 150
GPRDPTRAPA RPGDQPPPPP QRLVFAPADE PRTVLERKPL PLGVRAPLAG
160 170 180 190 200
PSAAARSPEQ LCAPAEAAPC PAEPERSQSA ALEPSSSADA GAVACRALEA
210 220 230 240 250
DSGDARRAPR ARGERRRHTI ASGVDCGLLK QMKELEQEKE VLLQGLEMMA
260 270 280 290 300
RGRDWYQQQL QRVQERQRRL GQSRASADFG AAGSPRPLGR LLPKVQEVAR
310 320 330 340 350
CLGELLAAAC ASRALPPSSS GPPCPALTST SPPVWQQQTI LMLKEQNRLL
360 370 380 390
TQEVTEKSER ITQLEQEKSA LIKQLFEARA LSQQDGGPLD STFI
Length:394
Mass (Da):42,637
Last modified:May 15, 2007 - v2
Checksum:i3BA880028B0A3108
GO

Sequence cautioni

The sequence AAH48267 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAZ39408 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ150361 mRNA. Translation: AAZ39408.1. Different initiation.
AL807752 Genomic DNA. Translation: CAI12778.2.
BC048267 mRNA. Translation: AAH48267.1. Different initiation.
CCDSiCCDS7027.2.
RefSeqiNP_848543.2. NM_178448.3.
UniGeneiHs.19322.

Genome annotation databases

EnsembliENST00000409687; ENSP00000386348; ENSG00000186193.
GeneIDi89958.
KEGGihsa:89958.
UCSCiuc011men.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ150361 mRNA. Translation: AAZ39408.1. Different initiation.
AL807752 Genomic DNA. Translation: CAI12778.2.
BC048267 mRNA. Translation: AAH48267.1. Different initiation.
CCDSiCCDS7027.2.
RefSeqiNP_848543.2. NM_178448.3.
UniGeneiHs.19322.

3D structure databases

ProteinModelPortaliQ86UD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124649. 10 interactors.
IntActiQ86UD0. 10 interactors.

PTM databases

iPTMnetiQ86UD0.
PhosphoSitePlusiQ86UD0.

Polymorphism and mutation databases

BioMutaiSAPCD2.
DMDMi147638520.

Proteomic databases

EPDiQ86UD0.
MaxQBiQ86UD0.
PaxDbiQ86UD0.
PeptideAtlasiQ86UD0.
PRIDEiQ86UD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409687; ENSP00000386348; ENSG00000186193.
GeneIDi89958.
KEGGihsa:89958.
UCSCiuc011men.3. human.

Organism-specific databases

CTDi89958.
DisGeNETi89958.
GeneCardsiSAPCD2.
H-InvDBHIX0025736.
HIX0167636.
HIX0201218.
HGNCiHGNC:28055. SAPCD2.
HPAiHPA044154.
MIMi612057. gene.
neXtProtiNX_Q86UD0.
OpenTargetsiENSG00000186193.
PharmGKBiPA134959870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INQN. Eukaryota.
ENOG4110P7W. LUCA.
GeneTreeiENSGT00390000008072.
HOGENOMiHOG000035117.
HOVERGENiHBG062219.
InParanoidiQ86UD0.
OMAiARDWYMM.
OrthoDBiEOG091G0DUU.
PhylomeDBiQ86UD0.
TreeFamiTF324086.

Enzyme and pathway databases

BioCyciZFISH:G66-33083-MONOMER.

Miscellaneous databases

GenomeRNAii89958.
PROiQ86UD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186193.
CleanExiHS_C9orf140.
GenevisibleiQ86UD0. HS.

Family and domain databases

InterProiIPR026828. Suppressor_APCD_1/2.
[Graphical view]
PANTHERiPTHR14907. PTHR14907. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSAPC2_HUMAN
AccessioniPrimary (citable) accession number: Q86UD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.