Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Suppressor APC domain-containing protein 2

Gene

SAPCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824).By similarity3 Publications

GO - Biological processi

  • establishment of mitotic spindle orientation Source: UniProtKB
  • negative regulation of protein localization to cell cortex Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • regulation of establishment of planar polarity Source: UniProtKB
  • symmetric cell division Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor APC domain-containing protein 2Curated
Alternative name(s):
Tumor specificity and mitosis phase-dependent expression protein
Short name:
TS/MDEP
p42.31 Publication
Gene namesi
Name:SAPCD2Imported
Synonyms:C9orf140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000186193.8.
HGNCiHGNC:28055. SAPCD2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi89958.
OpenTargetsiENSG00000186193.
PharmGKBiPA134959870.

Polymorphism and mutation databases

BioMutaiSAPCD2.
DMDMi147638520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865961 – 394Suppressor APC domain-containing protein 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphothreonineCombined sources1
Modified residuei284PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UD0.
MaxQBiQ86UD0.
PaxDbiQ86UD0.
PeptideAtlasiQ86UD0.
PRIDEiQ86UD0.

PTM databases

iPTMnetiQ86UD0.
PhosphoSitePlusiQ86UD0.

Expressioni

Tissue specificityi

Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824).2 Publications

Gene expression databases

BgeeiENSG00000186193.
CleanExiHS_C9orf140.
GenevisibleiQ86UD0. HS.

Organism-specific databases

HPAiHPA044154.

Interactioni

Subunit structurei

Interacts with a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1 (PubMed:26766442). Interacts with GPSM2 (via TPR motifs); this interaction is required to prevent GPSM2 anchoring at the mitotic apical cortex and is inhibited in presence of NUMA1 in a dose dependent manner (PubMed:26766442). Interacts with PARD3 (PubMed:26766442).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124649. 12 interactors.
CORUMiQ86UD0.
IntActiQ86UD0. 16 interactors.
STRINGi9606.ENSP00000386348.

Structurei

3D structure databases

ProteinModelPortaliQ86UD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 277Sequence analysisAdd BLAST51
Coiled coili336 – 384Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 174Pro-richAdd BLAST73

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410INQN. Eukaryota.
ENOG4110P7W. LUCA.
GeneTreeiENSGT00390000008072.
HOGENOMiHOG000035117.
HOVERGENiHBG062219.
InParanoidiQ86UD0.
OMAiWQGTDAR.
OrthoDBiEOG091G0DUU.
PhylomeDBiQ86UD0.
TreeFamiTF324086.

Family and domain databases

InterProiView protein in InterPro
IPR026828. Suppressor_APCD_1/2.
PANTHERiPTHR14907. PTHR14907. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86UD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAAMAERG RVPPPAPAPS TEGLPRAFLQ SLRTLFDILD DRRRGCVHLR
60 70 80 90 100
EIESRWQGTD ARELPRGVLE GLRQVAPASG YLTFERFVAG LRTSLLSADG
110 120 130 140 150
GPRDPTRAPA RPGDQPPPPP QRLVFAPADE PRTVLERKPL PLGVRAPLAG
160 170 180 190 200
PSAAARSPEQ LCAPAEAAPC PAEPERSQSA ALEPSSSADA GAVACRALEA
210 220 230 240 250
DSGDARRAPR ARGERRRHTI ASGVDCGLLK QMKELEQEKE VLLQGLEMMA
260 270 280 290 300
RGRDWYQQQL QRVQERQRRL GQSRASADFG AAGSPRPLGR LLPKVQEVAR
310 320 330 340 350
CLGELLAAAC ASRALPPSSS GPPCPALTST SPPVWQQQTI LMLKEQNRLL
360 370 380 390
TQEVTEKSER ITQLEQEKSA LIKQLFEARA LSQQDGGPLD STFI
Length:394
Mass (Da):42,637
Last modified:May 15, 2007 - v2
Checksum:i3BA880028B0A3108
GO

Sequence cautioni

Q86UD0: The sequence AAH48267 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Q86UD0: The sequence AAZ39408 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ150361 mRNA. Translation: AAZ39408.1. Different initiation.
AL807752 Genomic DNA. No translation available.
BC048267 mRNA. Translation: AAH48267.1. Different initiation.
CCDSiCCDS7027.2.
RefSeqiNP_848543.2. NM_178448.3.
UniGeneiHs.19322.

Genome annotation databases

EnsembliENST00000409687; ENSP00000386348; ENSG00000186193.
GeneIDi89958.
KEGGihsa:89958.
UCSCiuc011men.3. human.

Similar proteinsi

Entry informationi

Entry nameiSAPC2_HUMAN
AccessioniPrimary (citable) accession number: Q86UD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 25, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot