Q86UC2 (RSPH3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Radial spoke head protein 3 homolog

Alternative name(s):
Radial spoke head-like protein 2

Gene names

Name:	RSPH3
Synonyms:	RSHL2, RSP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the flagellar radial spoke RSP3 family.
Sequence caution	The sequence AAK26432.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB71544.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI19235.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI19236.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86UC2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86UC2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     212-307: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Radial spoke head protein 3 homolog		PRO_0000313741
Regions
	Coiled coil	215 – 239	25	Potential
	Coiled coil	331 – 385	55	Potential
Natural variations
	Alternative sequence	212 – 307	96	Missing in isoform 2.		VSP_030128
	Natural variant	201	1	N → S. Corresponds to variant rs16889320 [ dbSNP | Ensembl ].		VAR_037720
	Natural variant	213	1	R → Q. Corresponds to variant rs34582178 [ dbSNP | Ensembl ].		VAR_037721
	Natural variant	398	1	R → Q. Corresponds to variant rs10455840 [ dbSNP | Ensembl ].		VAR_037722
	Natural variant	439	1	M → T. Corresponds to variant rs768994 [ dbSNP | Ensembl ].		VAR_037723
	Natural variant	484	1	E → K. Corresponds to variant rs12204826 [ dbSNP | Ensembl ].		VAR_037724
	Natural variant	518	1	G → D. Corresponds to variant rs3756987 [ dbSNP | Ensembl ].		VAR_037725
Experimental info
	Sequence conflict	99	1	L → S in BAB71615. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: EEAC4B64D1099019	FASTA	560	63,687
	10 20 30 40 50 60 MTVKPAKAAS LARNLAKRRR TYLGGAAGRS QEPEVPCAAV LPGKPGDRNC PEFPPPDRTL 70 80 90 100 110 120 GCWATDAAPA AGLCGAGSEP SIAPTSCAGN LPSRPPPLLS PLLASRNPCP WHYLHLSGSH 130 140 150 160 170 180 NTLAPTCFKA KLHRKRGSQP PDMASALTDR TSRAPSTYTY TSRPRALPCQ RSRYRDSLTQ 190 200 210 220 230 240 PDEEPMHYGN IMYDRRVIRG NTYALQTGPL LGRPDSLELQ RQREARKRAL ARKQAQEQLR 250 260 270 280 290 300 PQTPEPVEGR KHVDVQTELY LEEIADRIIE VDMECQTDAF LDRPPTPLFI PAKTGKDVAT 310 320 330 340 350 360 QILEGELFDF DLEVKPVLEV LVGKTIEQSL LEVMEEEELA NLRASQREYE ELRNSERAEV 370 380 390 400 410 420 QRLEEQERRH REEKERRKKQ QWEIMHKHNE TSQKIAARAF AQRYLADLLP SVFGSLRDSG 430 440 450 460 470 480 YFYDPIERDI EIGFLPWLMN EVEKTMEYSM VGRTVLDMLI REVVEKRLCM YEHGEDTHQS 490 500 510 520 530 540 PEPEDEPGGP GAMTESLEAS EFLEQSMSQT RELLLDGGYL QRTTYDRRSS QERKFMEERE 550 560 LLGQDEETAM RKSLGEEELS
	Isoform 2 [UniParc]. Checksum: EB69C3CDC21F115D	FASTA	464	52,686
	10 20 30 40 50 60 MTVKPAKAAS LARNLAKRRR TYLGGAAGRS QEPEVPCAAV LPGKPGDRNC PEFPPPDRTL 70 80 90 100 110 120 GCWATDAAPA AGLCGAGSEP SIAPTSCAGN LPSRPPPLLS PLLASRNPCP WHYLHLSGSH 130 140 150 160 170 180 NTLAPTCFKA KLHRKRGSQP PDMASALTDR TSRAPSTYTY TSRPRALPCQ RSRYRDSLTQ 190 200 210 220 230 240 PDEEPMHYGN IMYDRRVIRG NTYALQTGPL LFDFDLEVKP VLEVLVGKTI EQSLLEVMEE 250 260 270 280 290 300 EELANLRASQ REYEELRNSE RAEVQRLEEQ ERRHREEKER RKKQQWEIMH KHNETSQKIA 310 320 330 340 350 360 ARAFAQRYLA DLLPSVFGSL RDSGYFYDPI ERDIEIGFLP WLMNEVEKTM EYSMVGRTVL 370 380 390 400 410 420 DMLIREVVEK RLCMYEHGED THQSPEPEDE PGGPGAMTES LEASEFLEQS MSQTRELLLD 430 440 450 460 GGYLQRTTYD RRSSQERKFM EERELLGQDE ETAMRKSLGE EELS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-560 (ISOFORM 2). Tissue: Epithelium and Trachea.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[5]	"Molecular characterization of the human radial spoke protein 3 as an A-kinase anchoring protein." DeKorte M., Carr D.W. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-560 (ISOFORM 1). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057655 mRNA. Translation: BAB71544.1. Different initiation. AK057931 mRNA. Translation: BAB71615.1. AL035530 Genomic DNA. Translation: CAI19235.1. Different initiation. AL035530 Genomic DNA. Translation: CAI19236.1. Different initiation. CH471051 Genomic DNA. Translation: EAW47643.1. BC050604 mRNA. Translation: AAH50604.1. AF353618 mRNA. Translation: AAK26432.1. Different initiation.
IPI	IPI00065380. IPI00790586.
RefSeq	NP_114130.3. NM_031924.4.
UniGene	Hs.154628.
3D structure databases
ProteinModelPortal	Q86UC2.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1209207.
STRING	9606.ENSP00000252655.
PTM databases
PhosphoSite	Q86UC2.
Polymorphism databases
DMDM	74750415.
Proteomic databases
PaxDb	Q86UC2.
PRIDE	Q86UC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252655; ENSP00000252655; ENSG00000130363. ENST00000297262; ENSP00000297262; ENSG00000130363. ENST00000367069; ENSP00000356036; ENSG00000130363. ENST00000449822; ENSP00000393195; ENSG00000130363.
GeneID	83861.
KEGG	hsa:83861.
UCSC	uc003qrx.3. human. uc010kju.3. human.
Organism-specific databases
CTD	83861.
GeneCards	GC06M159397.
HGNC	HGNC:21054. RSPH3.
HPA	HPA039109. HPA040230.
neXtProt	NX_Q86UC2.
PharmGKB	PA162402248.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86709.
HOGENOM	HOG000259276.
HOVERGEN	HBG067489.
InParanoid	Q86UC2.
OMA	HNETSQK.
OrthoDB	EOG4ZGPD2.
Gene expression databases
Bgee	Q86UC2.
CleanEx	HS_RSPH3.
Genevestigator	Q86UC2.
Family and domain databases
InterPro	IPR009290. Radial_spoke_3. [Graphical view]
PANTHER	PTHR21648. PTHR21648. 1 hit.
Pfam	PF06098. Radial_spoke_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83861.
NextBio	72869.

Entry information

Entry name

RSPH3_HUMAN

Accession

Primary (citable) accession number: Q86UC2
Secondary accession number(s): Q96LQ5, Q96LX2, Q9BX75

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.