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Protein

Transmembrane protein 135

Gene

TMEM135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in peroxisome organization.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 135
Alternative name(s):
Peroxisomal membrane protein 52
Short name:
PMP52
Gene namesi
Name:TMEM135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26167. TMEM135.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence analysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence analysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485658.

Polymorphism and mutation databases

BioMutaiTMEM135.
DMDMi215273901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Transmembrane protein 135PRO_0000284622Add
BLAST

Proteomic databases

EPDiQ86UB9.
MaxQBiQ86UB9.
PaxDbiQ86UB9.
PeptideAtlasiQ86UB9.
PRIDEiQ86UB9.

PTM databases

iPTMnetiQ86UB9.
PhosphoSiteiQ86UB9.

Expressioni

Developmental stagei

Up-regulated in bone marrow-derived mesenchymal stem cells during differentiation into adipocytes compared to osteoblasts.1 Publication

Gene expression databases

BgeeiQ86UB9.
CleanExiHS_TMEM135.
ExpressionAtlasiQ86UB9. baseline and differential.
GenevisibleiQ86UB9. HS.

Interactioni

Protein-protein interaction databases

BioGridi122392. 1 interaction.
STRINGi9606.ENSP00000306344.

Structurei

3D structure databases

ProteinModelPortaliQ86UB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1398. Eukaryota.
ENOG410YP91. LUCA.
GeneTreeiENSGT00390000000303.
HOGENOMiHOG000046223.
HOVERGENiHBG058944.
InParanoidiQ86UB9.
OMAiFLRWIRN.
OrthoDBiEOG7PZRXB.
PhylomeDBiQ86UB9.
TreeFamiTF314580.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR026749. Tmem135.
IPR031926. TMEM135_N.
[Graphical view]
PANTHERiPTHR12459. PTHR12459. 1 hit.
PfamiPF02466. Tim17. 1 hit.
PF15982. TMEM135_C_rich. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALSKSIPH NCYEIGHTWH PSCRVSFLQI TGGALEESLK IYAPLYLIAA
60 70 80 90 100
ILRKRKLDYY LHKLLPEILQ SASFLTANGA LYMAFFCILR KILGKFYSWT
110 120 130 140 150
PGFGAALPAS YVAILIERKS RRGLLTIYMA NLATETLFRM GVARGTITTL
160 170 180 190 200
RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF SALRFIVGKE EIPTHSFSPE
210 220 230 240 250
AAYAKVEQKR EQHEEKPGRM NMIGLVRKFV DSICKHGPRH RCCKHYEDNC
260 270 280 290 300
ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTQPSRLLS LFYNKENFQL
310 320 330 340 350
GAFLGSFVSI YKGTSCFLRW IRNLDDELHA IIAGFLAGIS MMFYKSTTIS
360 370 380 390 400
MYLASKLVET MYFKGIEAGK VPYFPHADTI IYSISTAICF QAAVMEVQTL
410 420 430 440 450
RPSYWKFLLR LTKGKFAVMN RKVLDVFGTG ASKHFQDFIP RLDPRYTTVT

PELPTEFS
Length:458
Mass (Da):52,291
Last modified:November 25, 2008 - v2
Checksum:iB6BDEC84237D5FE2
GO
Isoform 2 (identifier: Q86UB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-154: Missing.

Show »
Length:436
Mass (Da):49,914
Checksum:i20F8E048A3421016
GO

Sequence cautioni

The sequence BAB15233.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391I → T in BAB15233 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931P → H.1 Publication
Corresponds to variant rs17854687 [ dbSNP | Ensembl ].
VAR_031787
Natural varianti218 – 2181G → R.3 Publications
Corresponds to variant rs2276102 [ dbSNP | Ensembl ].
VAR_031788
Natural varianti430 – 4301G → A.
Corresponds to variant rs11235097 [ dbSNP | Ensembl ].
VAR_031789

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei133 – 15422Missing in isoform 2. 2 PublicationsVSP_024579Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834493 mRNA. Translation: CAD39151.1.
BX648678 mRNA. Translation: CAH10546.1.
AP000811 Genomic DNA. No translation available.
AP001102 Genomic DNA. No translation available.
AP002967 Genomic DNA. No translation available.
BC051462 mRNA. Translation: AAH51462.2.
AK025757 mRNA. Translation: BAB15233.1. Different initiation.
CCDSiCCDS53692.1. [Q86UB9-2]
CCDS8280.1. [Q86UB9-1]
RefSeqiNP_001162195.1. NM_001168724.1. [Q86UB9-2]
NP_075069.3. NM_022918.3. [Q86UB9-1]
UniGeneiHs.188591.
Hs.490745.

Genome annotation databases

EnsembliENST00000305494; ENSP00000306344; ENSG00000166575. [Q86UB9-1]
ENST00000340353; ENSP00000345513; ENSG00000166575. [Q86UB9-2]
GeneIDi65084.
KEGGihsa:65084.
UCSCiuc001pch.4. human. [Q86UB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834493 mRNA. Translation: CAD39151.1.
BX648678 mRNA. Translation: CAH10546.1.
AP000811 Genomic DNA. No translation available.
AP001102 Genomic DNA. No translation available.
AP002967 Genomic DNA. No translation available.
BC051462 mRNA. Translation: AAH51462.2.
AK025757 mRNA. Translation: BAB15233.1. Different initiation.
CCDSiCCDS53692.1. [Q86UB9-2]
CCDS8280.1. [Q86UB9-1]
RefSeqiNP_001162195.1. NM_001168724.1. [Q86UB9-2]
NP_075069.3. NM_022918.3. [Q86UB9-1]
UniGeneiHs.188591.
Hs.490745.

3D structure databases

ProteinModelPortaliQ86UB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122392. 1 interaction.
STRINGi9606.ENSP00000306344.

PTM databases

iPTMnetiQ86UB9.
PhosphoSiteiQ86UB9.

Polymorphism and mutation databases

BioMutaiTMEM135.
DMDMi215273901.

Proteomic databases

EPDiQ86UB9.
MaxQBiQ86UB9.
PaxDbiQ86UB9.
PeptideAtlasiQ86UB9.
PRIDEiQ86UB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305494; ENSP00000306344; ENSG00000166575. [Q86UB9-1]
ENST00000340353; ENSP00000345513; ENSG00000166575. [Q86UB9-2]
GeneIDi65084.
KEGGihsa:65084.
UCSCiuc001pch.4. human. [Q86UB9-1]

Organism-specific databases

CTDi65084.
GeneCardsiTMEM135.
H-InvDBHIX0010008.
HGNCiHGNC:26167. TMEM135.
MIMi616360. gene.
neXtProtiNX_Q86UB9.
PharmGKBiPA143485658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1398. Eukaryota.
ENOG410YP91. LUCA.
GeneTreeiENSGT00390000000303.
HOGENOMiHOG000046223.
HOVERGENiHBG058944.
InParanoidiQ86UB9.
OMAiFLRWIRN.
OrthoDBiEOG7PZRXB.
PhylomeDBiQ86UB9.
TreeFamiTF314580.

Miscellaneous databases

ChiTaRSiTMEM135. human.
GenomeRNAii65084.
PROiQ86UB9.
SOURCEiSearch...

Gene expression databases

BgeeiQ86UB9.
CleanExiHS_TMEM135.
ExpressionAtlasiQ86UB9. baseline and differential.
GenevisibleiQ86UB9. HS.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
IPR026749. Tmem135.
IPR031926. TMEM135_N.
[Graphical view]
PANTHERiPTHR12459. PTHR12459. 1 hit.
PfamiPF02466. Tim17. 1 hit.
PF15982. TMEM135_C_rich. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-218.
    Tissue: Endometrial adenocarcinoma and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS HIS-193 AND ARG-218.
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-458 (ISOFORM 2), VARIANT ARG-218.
  5. Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTM135_HUMAN
AccessioniPrimary (citable) accession number: Q86UB9
Secondary accession number(s): Q6AW91, Q8ND01, Q9H6M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.