Unreviewed, UniProtKB/TrEMBL Q86UB5 (Q86UB5_HUMAN)

Names and origin

Protein names

Submitted name:
    NLRP1 protein EMBL AAH51787.1

Gene names

Name:

NLRP1 EMBL AAH51787.1

Organism

Homo sapiens (Human) EMBL AAH51787.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 NACHT domain. Spearmint SPM007111

Ontologies

Keywords
Domain	Leucine-rich repeat Spearmint SPM000767
Ligand	ATP-binding Spearmint SPM007111 Nucleotide-binding
Gene Ontology (GO)
Biological process	defense response Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q86UB5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7C834D47BBD490FE	FASTA	1,375	154,871
	10 20 30 40 50 60 MAGGAWGRLA CYLEFLKKEE LKEFQLLLAN KAHSRSSSGE TPAQPEKTSG MEVASYLVAQ 70 80 90 100 110 120 YGEQRAWDLA LHTWEQMGLR SLCAQAQEGA GHSPSFPYSP SEPHLGSPSQ PTSTAVLMPW 130 140 150 160 170 180 IHELPAGCTQ GSERRVLRQL PDTSGRRWRE ISASLLYQAL PSSPDHESPS QESPNAPTST 190 200 210 220 230 240 AVLGSWGSPP QPSLAPREQE APGTQWPLDE TSGIYYTEIR EREREKSEKG RPPWAAVVGT 250 260 270 280 290 300 PPQAHTSLQP HHHPWEPSVR ESLCSTWPWK NEDFNQKFTQ LLLLQRSHPR SQDPLVKRSW 310 320 330 340 350 360 PDYVEENRGH LIEIRDLFGP GLDTQEPRIV ILQGAAGIGK STLARQVKEA WGRGQLYGDR 370 380 390 400 410 420 FQHVFYFSCR ELAQSKVVSL AELIGKDGTA TPAPIRQILS RPERLLFILD GVDEPGWVLQ 430 440 450 460 470 480 EPSSELCLHW SQPQPADALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG 490 500 510 520 530 540 FSESSRKEYF YRYFTDERQA IRAFRLVKSN KELWALCLVP WVSWLACTCL MQQMKRKEKL 550 560 570 580 590 600 TLTSKTTTTL CLHYLAQALQ AQPLGPQLRD LCSLAAEGIW QKKTLFSPDD LRKHGLDGAI 610 620 630 640 650 660 ISTFLKMGIL QEHPIPLSYS FIHLCFQEFF AAMSYVLEDE KGRGKHSNCI IDLEKTLEAY 670 680 690 700 710 720 GIHGLFGAST TRFLLGLLSD EGEREMENIF HCRLSQGRNL MQWVPSLQLL LQPHSLESLH 730 740 750 760 770 780 CLYETRNKTF LTQVMAHFEE MGMCVETDME LLVCTFCIKF SRHVKKLQLI EGRQHRSTWS 790 800 810 820 830 840 PTMVVLFRWV PVTDAYWQIL FSVLKVTRNL KELDLSGNSL SHSAVKSLCK TLRRPRCLLE 850 860 870 880 890 900 TLRLAGCGLT AEDCKDLAFG LRANQTLTEL DLSFNVLTDA GAKHLCQRLR QPSCKLQRLQ 910 920 930 940 950 960 LVSCGLTSDC CQDLASVLSA SPSLKELDLQ QNNLDDVGVR LLCEGLRHPA CKLIRLGLDQ 970 980 990 1000 1010 1020 TTLSDEMRQE LRALEQEKPQ LLIFSRRKPS VMTPTEGLDT GEMSNSTSSL KRQRLGSERA 1030 1040 1050 1060 1070 1080 ASHVAQANLK LLDVSKIFPI AEIAGKSHEE SSPEVVPVEL LCVPSPASQG DLHTKPLGTD 1090 1100 1110 1120 1130 1140 DDFWGPTGPV ATEVVDKEKN LYRVHFPVAG SYRWPNTGLC FVMREAVTVE IEFCVWDQFL 1150 1160 1170 1180 1190 1200 GEINPQHSWM VAGPLLDIKA EPGAVEAVHL PHFVALQGGH VDTSLFQMAH FKEEGMLLEK 1210 1220 1230 1240 1250 1260 PARVELHHIV LENPSFSPLG VLLKMIHNAL RFIPVTSVVL LYHRVHPEEV TFHLYLIPSD 1270 1280 1290 1300 1310 1320 CSIRKAIDDL EMKFQFVRIH KPPPLTPLYM GCRYTVSGSG SGMLEILPKE LELCYRSPGE 1330 1340 1350 1360 1370 DQLFSEFYVG HLGSGIRLQV KDKKDETLVW EALVKPGRNT SQPWNLRCNR DARRY

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood EMBL AAH51787.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC051787 mRNA. Translation: AAH51787.1.
UniGene	Hs.104305 Hs.652273
3D structure databases
HSSP	HSSP built from PDB template 1PN5 based on UniProtKB Q9C000.
SMR	Q86UB5. Positions 1-93.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000091592. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:14374. NALP1.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q86UB5.
Gene expression databases
ArrayExpress	Q86UB5.
Family and domain databases
InterPro	IPR011029. DEATH_like. IPR001611. Leu-rich_rpt. IPR007111. NACHT_NTPase. IPR004020. Pyrin. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 1 hit.
Pfam	PF00560. LRR_1. 3 hits. PF05729. NACHT. 1 hit. PF02758. PAAD_DAPIN. 1 hit. [Graphical view]
PRINTS	PR00019. LEURICHRPT.
PROSITE	PS50824. DAPIN. 1 hit. PS50837. NACHT. 1 hit. [Graphical view]

Entry information

Entry name

Q86UB5_HUMAN

Accession

Primary (citable) accession number: Q86UB5

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)