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Protein

Basic immunoglobulin-like variable motif-containing protein

Gene

BIVM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Basic immunoglobulin-like variable motif-containing protein
Gene namesi
Name:BIVM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:16034. BIVM.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular space Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25366.

Polymorphism and mutation databases

BioMutaiBIVM.
DMDMi182627634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Basic immunoglobulin-like variable motif-containing proteinPRO_0000328955Add
BLAST

Proteomic databases

MaxQBiQ86UB2.
PaxDbiQ86UB2.
PRIDEiQ86UB2.

PTM databases

iPTMnetiQ86UB2.
PhosphoSiteiQ86UB2.

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher level in spleen, ovary, small intestine, colon, peripheral blood leukocytes and liver. Also expressed in testis, ovary, aorta, appendix, trachea, pituitary gland, bladder, uterus, spinal cord, salivary gland, stomach, mammary gland and bone marrow. Weakly or not expressed in fetal spleen, adult thymus and certain cancer cell lines.1 Publication

Gene expression databases

BgeeiQ86UB2.
CleanExiHS_BIVM.
GenevisibleiQ86UB2. HS.

Organism-specific databases

HPAiHPA050126.

Interactioni

Protein-protein interaction databases

BioGridi120192. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ86UB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BIVM family.Curated

Phylogenomic databases

eggNOGiENOG410II7C. Eukaryota.
ENOG410ZTQY. LUCA.
GeneTreeiENSGT00510000048601.
HOGENOMiHOG000095232.
HOVERGENiHBG107500.
InParanoidiQ86UB2.
OrthoDBiEOG780RM5.
PhylomeDBiQ86UB2.
TreeFamiTF331304.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNVAETERS NDSGNGEHKS ERKSPEENLQ GAVKSFCTSA SGAPLGPKGD
60 70 80 90 100
GHYPWSCPVT HTREKIYAIC SDYAFLNQAT SIYKTPNPSR SPCLPDSTSL
110 120 130 140 150
SAGNNSSRYI GIPTSTSEII YNEENSLENL SNSLGKLPLA WEIDKSEFDG
160 170 180 190 200
VTTNSKHKSG NAKKQVSKRK TSDKKGRYQK ECPQHSPLED IKQRKVLDLR
210 220 230 240 250
RWYCISRPQY KTSCGISSLI SCWNFLYSTM GAGNLPPITQ EEALHILGFQ
260 270 280 290 300
PPFEDIRFGP FTGNTTLMRW FRQINDHFHV KGCSYVLYKP HGKNKTAGET
310 320 330 340 350
ASGALSKLTR GLKDESLAYI YHCQNHYFCP IGFEATPVKA NKAFSRGPLS
360 370 380 390 400
PQEVEYWILI GESSRKHPAI HCKKWADIVT DLNTQNPEYL DIRHLERGLQ
410 420 430 440 450
YRKTKKVGGN LHCIIAFQRL NWQRFGLWNF PFGTIRQESQ PPTHAQGIAK
460 470 480 490 500
SESEDNISKK QHGRLGRSFS ASFHQDSAWK KMSSIHERRN SGYQGYSDYD

GND
Length:503
Mass (Da):56,774
Last modified:April 8, 2008 - v3
Checksum:iDC383629599388CF
GO
Isoform 2 (identifier: Q86UB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.
     406-406: K → KPTFFSSQ

Note: No experimental confirmation available.
Show »
Length:281
Mass (Da):32,106
Checksum:iF4D19A6E8926B5C7
GO

Sequence cautioni

The sequence AAH51813.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA90986.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241N → D in BAA90986 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 229229Missing in isoform 2. 1 PublicationVSP_032855Add
BLAST
Alternative sequencei406 – 4061K → KPTFFSSQ in isoform 2. 1 PublicationVSP_032856

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157769 Genomic DNA. No translation available.
BC051813 mRNA. Translation: AAH51813.2. Different initiation.
BC112339 mRNA. Translation: AAI12340.1.
AK000166 mRNA. Translation: BAA90986.1. Different initiation.
CCDSiCCDS53879.1. [Q86UB2-2]
CCDS9505.1. [Q86UB2-1]
RefSeqiNP_001153068.1. NM_001159596.1. [Q86UB2-2]
NP_060163.2. NM_017693.3. [Q86UB2-1]
UniGeneiHs.288809.

Genome annotation databases

EnsembliENST00000257336; ENSP00000257336; ENSG00000134897. [Q86UB2-1]
ENST00000448849; ENSP00000412794; ENSG00000134897. [Q86UB2-2]
GeneIDi54841.
KEGGihsa:54841.
UCSCiuc001vps.4. human. [Q86UB2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157769 Genomic DNA. No translation available.
BC051813 mRNA. Translation: AAH51813.2. Different initiation.
BC112339 mRNA. Translation: AAI12340.1.
AK000166 mRNA. Translation: BAA90986.1. Different initiation.
CCDSiCCDS53879.1. [Q86UB2-2]
CCDS9505.1. [Q86UB2-1]
RefSeqiNP_001153068.1. NM_001159596.1. [Q86UB2-2]
NP_060163.2. NM_017693.3. [Q86UB2-1]
UniGeneiHs.288809.

3D structure databases

ProteinModelPortaliQ86UB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120192. 1 interaction.

PTM databases

iPTMnetiQ86UB2.
PhosphoSiteiQ86UB2.

Polymorphism and mutation databases

BioMutaiBIVM.
DMDMi182627634.

Proteomic databases

MaxQBiQ86UB2.
PaxDbiQ86UB2.
PRIDEiQ86UB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257336; ENSP00000257336; ENSG00000134897. [Q86UB2-1]
ENST00000448849; ENSP00000412794; ENSG00000134897. [Q86UB2-2]
GeneIDi54841.
KEGGihsa:54841.
UCSCiuc001vps.4. human. [Q86UB2-1]

Organism-specific databases

CTDi54841.
GeneCardsiBIVM.
HGNCiHGNC:16034. BIVM.
HPAiHPA050126.
neXtProtiNX_Q86UB2.
PharmGKBiPA25366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II7C. Eukaryota.
ENOG410ZTQY. LUCA.
GeneTreeiENSGT00510000048601.
HOGENOMiHOG000095232.
HOVERGENiHBG107500.
InParanoidiQ86UB2.
OrthoDBiEOG780RM5.
PhylomeDBiQ86UB2.
TreeFamiTF331304.

Miscellaneous databases

GenomeRNAii54841.
PROiQ86UB2.

Gene expression databases

BgeeiQ86UB2.
CleanExiHS_BIVM.
GenevisibleiQ86UB2. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-503 (ISOFORM 1).
    Tissue: Eye.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-503 (ISOFORM 1).
    Tissue: Colon.
  4. "BIVM, a novel gene widely distributed among deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia."
    Yoder J.A., Hawke N.A., Eason D.D., Mueller M.G., Davids B.J., Gillin F.D., Litman G.W.
    Genomics 79:750-755(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBIVM_HUMAN
AccessioniPrimary (citable) accession number: Q86UB2
Secondary accession number(s): Q2M1J2, Q9NXM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.