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Q86UA6

- RIP_HUMAN

UniProt

Q86UA6 - RIP_HUMAN

Protein

RPA-interacting protein

Gene

RPAIN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri137 – 21276RIP-typeAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein complex binding Source: MGI

    GO - Biological processi

    1. DNA-dependent DNA replication Source: MGI
    2. DNA recombination Source: MGI
    3. DNA repair Source: MGI
    4. protein import into nucleus Source: MGI
    5. response to UV Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RPA-interacting protein
    Short name:
    hRIP
    Gene namesi
    Name:RPAIN
    Synonyms:RIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28641. RPAIN.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleolus Source: HPA
    3. nucleus Source: HPA
    4. PML body Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi114 – 1141K → R: Abolishes sumoylation; when associated with N-103; R-121 and R-142. 1 Publication
    Mutagenesisi121 – 1211K → R: Induces a strong decrease in sumoylation; when associated with N-103. Abolishes sumoylation; when associated with N-103; R-114 and R-142. 1 Publication
    Mutagenesisi142 – 1421K → R: Abolishes sumoylation; when associated with N-103; R-114 and R-121. 1 Publication

    Organism-specific databases

    PharmGKBiPA145007849.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219RPA-interacting proteinPRO_0000076299Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki103 – 103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); in isoform 2Curated
    Cross-linki121 – 121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); in isoform 2Curated

    Post-translational modificationi

    Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ86UA6.
    PaxDbiQ86UA6.
    PRIDEiQ86UA6.

    PTM databases

    PhosphoSiteiQ86UA6.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ86UA6.
    BgeeiQ86UA6.
    CleanExiHS_RPAIN.
    GenevestigatoriQ86UA6.

    Organism-specific databases

    HPAiHPA023924.
    HPA031526.

    Interactioni

    Subunit structurei

    Interacts with the RPA1 subunit of RPA complex.1 Publication

    Protein-protein interaction databases

    BioGridi123995. 5 interactions.
    IntActiQ86UA6. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86UA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni164 – 18017Mediates nuclear exportAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RIP-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri137 – 21276RIP-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG46030.
    HOVERGENiHBG082800.
    InParanoidiQ86UA6.
    OrthoDBiEOG7673BZ.
    PhylomeDBiQ86UA6.
    TreeFamiTF326215.

    Family and domain databases

    InterProiIPR028156. RIP.
    IPR028159. RPA_interact_C_dom.
    IPR028155. RPA_interact_central.
    IPR028158. RPA_interact_N_dom.
    [Graphical view]
    PANTHERiPTHR31742. PTHR31742. 1 hit.
    PfamiPF14768. RPA_interact_C. 1 hit.
    PF14767. RPA_interact_M. 1 hit.
    PF14766. RPA_interact_N. 1 hit.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86UA6-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha, hRIPalpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAESLRSPRR SLYKLVGSPP WKEAFRQRCL ERMRNSRDRL LNRYRQAGSS    50
    GPGNSQNSFL VQEVMEEEWN ALQSVENCPE DLAQLEELID MAVLEEIQQE 100
    LIKQEQSIIS EYEKSLQFDE KCLSIMLAEW EANPLICPVC TKYNLRITSG 150
    VVVCQCGLSI PSHSSELTEQ KLRACLEGSI NEHSAHCPHT PEFSVTGGTE 200
    EKSSLLMSCL ACDTWAVIL 219

    Note: Major isoform with isoform 2.

    Length:219
    Mass (Da):24,784
    Last modified:June 1, 2003 - v1
    Checksum:i4AF573893850704E
    GO
    Isoform 2 (identifier: Q86UA6-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta, hRIPbeta

    The sequence of this isoform differs from the canonical sequence as follows:
         164-210: Missing.

    Note: Major isoform with isoform 1.

    Show »
    Length:172
    Mass (Da):19,727
    Checksum:i0B6AA34C1429D384
    GO
    Isoform 3 (identifier: Q86UA6-3) [UniParc]FASTAAdd to Basket

    Also known as: Gamma2

    The sequence of this isoform differs from the canonical sequence as follows:
         143-219: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be due to an intron retention.

    Show »
    Length:142
    Mass (Da):16,525
    Checksum:iB08C00B3708D8E58
    GO
    Isoform 4 (identifier: Q86UA6-4) [UniParc]FASTAAdd to Basket

    Also known as: Gamma1

    The sequence of this isoform differs from the canonical sequence as follows:
         142-145: KYNL → NLLS
         146-219: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:145
    Mass (Da):16,824
    Checksum:iA7977D77FC00B370
    GO
    Isoform 5 (identifier: Q86UA6-5) [UniParc]FASTAAdd to Basket

    Also known as: Delta2

    The sequence of this isoform differs from the canonical sequence as follows:
         105-106: EQ → VF
         107-219: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:106
    Mass (Da):12,399
    Checksum:i184280661713B68C
    GO
    Isoform 6 (identifier: Q86UA6-6) [UniParc]FASTAAdd to Basket

    Also known as: Delta3

    The sequence of this isoform differs from the canonical sequence as follows:
         105-106: EQ → GL
         107-219: Missing.

    Show »
    Length:106
    Mass (Da):12,323
    Checksum:i16B830661713B68C
    GO
    Isoform 7 (identifier: Q86UA6-7) [UniParc]FASTAAdd to Basket

    Also known as: Delta1, Delta 4

    The sequence of this isoform differs from the canonical sequence as follows:
         105-107: EQS → GTT
         108-219: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:107
    Mass (Da):12,412
    Checksum:iA2803830661713B6
    GO
    Isoform 8 (identifier: Q86UA6-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-219: ACDTWAVIL → VSVSWDPLCGKRDLWLVLFPP

    Note: No experimental confirmation available.

    Show »
    Length:231
    Mass (Da):26,221
    Checksum:i224CC8977EF906E9
    GO
    Isoform 9 (identifier: Q86UA6-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-219: YNLRITSGVV...LACDTWAVIL → PVILGL

    Note: No experimental confirmation available.

    Show »
    Length:148
    Mass (Da):17,118
    Checksum:i67DFE6F2628D308C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031K → N Common polymorphism; results in a decrease in sumoylation. 3 Publications
    Corresponds to variant rs12761 [ dbSNP | Ensembl ].
    VAR_023947

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei105 – 1073EQS → GTT in isoform 7. 2 PublicationsVSP_016402
    Alternative sequencei105 – 1062EQ → VF in isoform 5. 2 PublicationsVSP_016403
    Alternative sequencei105 – 1062EQ → GL in isoform 6. 3 PublicationsVSP_016404
    Alternative sequencei107 – 219113Missing in isoform 5 and isoform 6. 3 PublicationsVSP_016405Add
    BLAST
    Alternative sequencei108 – 219112Missing in isoform 7. 2 PublicationsVSP_016406Add
    BLAST
    Alternative sequencei142 – 1454KYNL → NLLS in isoform 4. 3 PublicationsVSP_016407
    Alternative sequencei143 – 21977Missing in isoform 3. 2 PublicationsVSP_016408Add
    BLAST
    Alternative sequencei143 – 21977YNLRI…WAVIL → PVILGL in isoform 9. CuratedVSP_046795Add
    BLAST
    Alternative sequencei146 – 21974Missing in isoform 4. 3 PublicationsVSP_016409Add
    BLAST
    Alternative sequencei164 – 21047Missing in isoform 2. 2 PublicationsVSP_016410Add
    BLAST
    Alternative sequencei211 – 2199ACDTWAVIL → VSVSWDPLCGKRDLWLVLFP P in isoform 8. 1 PublicationVSP_045356

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY775314 mRNA. Translation: AAX14368.1.
    AY775315 mRNA. Translation: AAX14369.1.
    AY775316 mRNA. Translation: AAX14370.1.
    AY775317 mRNA. Translation: AAX14371.1.
    AY775318 mRNA. Translation: AAX14372.1.
    AY775319 mRNA. Translation: AAX14373.1.
    AY775320 mRNA. Translation: AAX14374.1.
    AY775321 mRNA. Translation: AAX14375.1.
    AY775323 mRNA. Translation: AAX14377.1.
    AY680654 mRNA. Translation: AAT80872.1.
    AY680655 mRNA. Translation: AAT80873.1.
    AY680656 mRNA. Translation: AAT80874.1.
    AY680657 mRNA. Translation: AAT80875.1.
    AY680658 mRNA. Translation: AAT80876.1.
    AY680659 mRNA. Translation: AAT80877.1.
    AY680660 mRNA. Translation: AAT80878.1.
    AK295394 mRNA. Translation: BAG58348.1.
    AK300409 mRNA. Translation: BAG62139.1.
    AC004148 Genomic DNA. No translation available.
    BC004451 mRNA. Translation: AAH04451.1.
    BC046349 mRNA. Translation: AAH46349.1.
    BC051849 mRNA. Translation: AAH51849.1.
    CCDSiCCDS32536.1. [Q86UA6-1]
    CCDS54075.1. [Q86UA6-8]
    CCDS54076.1. [Q86UA6-2]
    CCDS54077.1. [Q86UA6-9]
    CCDS54079.1. [Q86UA6-6]
    RefSeqiNP_001028174.2. NM_001033002.3.
    NP_001153715.1. NM_001160243.1.
    NP_001153716.1. NM_001160244.1.
    NP_001153718.1. NM_001160246.1.
    NP_001153738.1. NM_001160266.1.
    UniGeneiHs.462086.
    Hs.555866.

    Genome annotation databases

    EnsembliENST00000536255; ENSP00000439939; ENSG00000129197.
    ENST00000539417; ENSP00000446453; ENSG00000129197.
    GeneIDi84268.
    KEGGihsa:84268.

    Polymorphism databases

    DMDMi74727468.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY775314 mRNA. Translation: AAX14368.1 .
    AY775315 mRNA. Translation: AAX14369.1 .
    AY775316 mRNA. Translation: AAX14370.1 .
    AY775317 mRNA. Translation: AAX14371.1 .
    AY775318 mRNA. Translation: AAX14372.1 .
    AY775319 mRNA. Translation: AAX14373.1 .
    AY775320 mRNA. Translation: AAX14374.1 .
    AY775321 mRNA. Translation: AAX14375.1 .
    AY775323 mRNA. Translation: AAX14377.1 .
    AY680654 mRNA. Translation: AAT80872.1 .
    AY680655 mRNA. Translation: AAT80873.1 .
    AY680656 mRNA. Translation: AAT80874.1 .
    AY680657 mRNA. Translation: AAT80875.1 .
    AY680658 mRNA. Translation: AAT80876.1 .
    AY680659 mRNA. Translation: AAT80877.1 .
    AY680660 mRNA. Translation: AAT80878.1 .
    AK295394 mRNA. Translation: BAG58348.1 .
    AK300409 mRNA. Translation: BAG62139.1 .
    AC004148 Genomic DNA. No translation available.
    BC004451 mRNA. Translation: AAH04451.1 .
    BC046349 mRNA. Translation: AAH46349.1 .
    BC051849 mRNA. Translation: AAH51849.1 .
    CCDSi CCDS32536.1. [Q86UA6-1 ]
    CCDS54075.1. [Q86UA6-8 ]
    CCDS54076.1. [Q86UA6-2 ]
    CCDS54077.1. [Q86UA6-9 ]
    CCDS54079.1. [Q86UA6-6 ]
    RefSeqi NP_001028174.2. NM_001033002.3.
    NP_001153715.1. NM_001160243.1.
    NP_001153716.1. NM_001160244.1.
    NP_001153718.1. NM_001160246.1.
    NP_001153738.1. NM_001160266.1.
    UniGenei Hs.462086.
    Hs.555866.

    3D structure databases

    ProteinModelPortali Q86UA6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123995. 5 interactions.
    IntActi Q86UA6. 4 interactions.

    PTM databases

    PhosphoSitei Q86UA6.

    Polymorphism databases

    DMDMi 74727468.

    Proteomic databases

    MaxQBi Q86UA6.
    PaxDbi Q86UA6.
    PRIDEi Q86UA6.

    Protocols and materials databases

    DNASUi 84268.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000536255 ; ENSP00000439939 ; ENSG00000129197 .
    ENST00000539417 ; ENSP00000446453 ; ENSG00000129197 .
    GeneIDi 84268.
    KEGGi hsa:84268.

    Organism-specific databases

    CTDi 84268.
    GeneCardsi GC17P005263.
    H-InvDB HIX0013468.
    HGNCi HGNC:28641. RPAIN.
    HPAi HPA023924.
    HPA031526.
    neXtProti NX_Q86UA6.
    PharmGKBi PA145007849.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46030.
    HOVERGENi HBG082800.
    InParanoidi Q86UA6.
    OrthoDBi EOG7673BZ.
    PhylomeDBi Q86UA6.
    TreeFami TF326215.

    Miscellaneous databases

    ChiTaRSi RPAIN. human.
    GeneWikii RPAIN.
    GenomeRNAii 84268.
    NextBioi 35534920.
    PROi Q86UA6.

    Gene expression databases

    ArrayExpressi Q86UA6.
    Bgeei Q86UA6.
    CleanExi HS_RPAIN.
    Genevestigatori Q86UA6.

    Family and domain databases

    InterProi IPR028156. RIP.
    IPR028159. RPA_interact_C_dom.
    IPR028155. RPA_interact_central.
    IPR028158. RPA_interact_N_dom.
    [Graphical view ]
    PANTHERi PTHR31742. PTHR31742. 1 hit.
    Pfami PF14768. RPA_interact_C. 1 hit.
    PF14767. RPA_interact_M. 1 hit.
    PF14766. RPA_interact_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, expression pattern, and subcellular location of human RIP isoforms."
      Chen J.-Z., Huang S.-D., Ji C.-N., Pang R.-Y., Xie Y., Xue J.-L.
      DNA Cell Biol. 24:464-469(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Sumoylation of the novel protein hRIPbeta is involved in replication protein A deposition in PML nuclear bodies."
      Park J., Seo T., Kim H., Choe J.
      Mol. Cell. Biol. 25:8202-8214(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4; 5; 6 AND 7), FUNCTION, SUBCELLULAR LOCATION, SUMOYLATION AT LYS-103 AND LYS-121, INTERACTION WITH RPA1, MUTAGENESIS OF LYS-114; LYS-121 AND LYS-142, VARIANT ASN-103.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 8), VARIANT ASN-103.
      Tissue: Corpus callosum and Placenta.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 6), VARIANT ASN-103.
      Tissue: Eye.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRIP_HUMAN
    AccessioniPrimary (citable) accession number: Q86UA6
    Secondary accession number(s): B4DI36
    , B4DTX7, E9PES3, J3KNH8, Q4G2Y0, Q4G2Y5, Q4G2Y8, Q6B4V9, Q6B4W0, Q6B4W1, Q6B4W4, Q86X49, Q9BT00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3