Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA-processing factor 39

Gene

PRPF39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing.By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 39
Alternative name(s):
PRP39 homolog
Gene namesi
Name:PRPF39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000185246.17
HGNCiHGNC:20314 PRPF39
MIMi614907 gene
neXtProtiNX_Q86UA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185246
PharmGKBiPA142671127

Polymorphism and mutation databases

BioMutaiPRPF39
DMDMi223590245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596481 – 669Pre-mRNA-processing factor 39Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UA1
MaxQBiQ86UA1
PaxDbiQ86UA1
PeptideAtlasiQ86UA1
PRIDEiQ86UA1
ProteomicsDBi69784
69785 [Q86UA1-2]

PTM databases

iPTMnetiQ86UA1
PhosphoSitePlusiQ86UA1

Expressioni

Gene expression databases

BgeeiENSG00000185246
CleanExiHS_PRPF39
ExpressionAtlasiQ86UA1 baseline and differential
GenevisibleiQ86UA1 HS

Organism-specific databases

HPAiHPA001176

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TOLLIPQ9H0E24EBI-2803203,EBI-74615

Protein-protein interaction databases

BioGridi120347, 15 interactors
IntActiQ86UA1, 15 interactors
MINTiQ86UA1
STRINGi9606.ENSP00000348010

Structurei

3D structure databases

ProteinModelPortaliQ86UA1
SMRiQ86UA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati109 – 141HAT 1Add BLAST33
Repeati143 – 175HAT 2Add BLAST33
Repeati183 – 218HAT 3Add BLAST36
Repeati220 – 253HAT 4Add BLAST34
Repeati333 – 365HAT 5Add BLAST33
Repeati367 – 399HAT 6Add BLAST33
Repeati404 – 436HAT 7Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi665 – 668Poly-Pro4

Sequence similaritiesi

Belongs to the PRP39 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1258 Eukaryota
ENOG410XPVR LUCA
GeneTreeiENSGT00390000005033
HOGENOMiHOG000010277
HOVERGENiHBG082194
InParanoidiQ86UA1
KOiK13217
OMAiTGWVYLL
OrthoDBiEOG091G04J5
PhylomeDBiQ86UA1
TreeFamiTF314746

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR011990 TPR-like_helical_dom_sf
SMARTiView protein in SMART
SM00386 HAT, 7 hits
SUPFAMiSSF48452 SSF48452, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQNSHMDEYR NSSNGSTGNS SEVVVEHPTD FSTEIMNVTE MEQSPDDSPN
60 70 80 90 100
VNASTEETEM ASAVDLPVTL TETEANFPPE YEKFWKTVEN NPQDFTGWVY
110 120 130 140 150
LLQYVEQENH LMAARKAFDR FFIHYPYCYG YWKKYADLEK RHDNIKPSDE
160 170 180 190 200
VYRRGLQAIP LSVDLWIHYI NFLKETLDPG DPETNNTIRG TFEHAVLAAG
210 220 230 240 250
TDFRSDRLWE MYINWENEQG NLREVTAIYD RILGIPTQLY SHHFQRFKEH
260 270 280 290 300
VQNNLPRDLL TGEQFIQLRR ELASVNGHSG DDGPPGDDLP SGIEDITDPA
310 320 330 340 350
KLITEIENMR HRIIEIHQEM FNYNEHEVSK RWTFEEGIKR PYFHVKPLEK
360 370 380 390 400
AQLKNWKEYL EFEIENGTHE RVVVLFERCV ISCALYEEFW IKYAKYMENH
410 420 430 440 450
SIEGVRHVFS RACTIHLPKK PMVHMLWAAF EEQQGNINEA RNILKTFEEC
460 470 480 490 500
VLGLAMVRLR RVSLERRHGN LEEAEHLLQD AIKNAKSNNE SSFYAVKLAR
510 520 530 540 550
HLFKIQKNLP KSRKVLLEAI ERDKENTKLY LNLLEMEYSG DLKQNEENIL
560 570 580 590 600
NCFDKAVHGS LPIKMRITFS QRKVEFLEDF GSDVNKLLNA YDEHQTLLKE
610 620 630 640 650
QDSLKRKAEN GSEEPEEKKA HTEDTTSSST QMIDGDLQAN QAVYNYSAWY
660
QYNYQNPWNY GQYYPPPPT
Length:669
Mass (Da):78,430
Last modified:February 10, 2009 - v3
Checksum:i6213DEF58C536744
GO
Isoform 2 (identifier: Q86UA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-396: Missing.
     652-669: YNYQNPWNYGQYYPPPPT → VSLHNYNSLFIDVISIN

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):31,494
Checksum:iE69EF57F46C0564D
GO

Sequence cautioni

The sequence AAI25127 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25128 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti312R → G in AAI25128 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0214961 – 396Missing in isoform 2. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_021497652 – 669YNYQN…PPPPT → VSLHNYNSLFIDVISIN in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001990 mRNA Translation: BAA92024.1
AL121809 Genomic DNA No translation available.
BC051886 mRNA Translation: AAH51886.1
BC125126 mRNA Translation: AAI25127.1 Different initiation.
BC125127 mRNA Translation: AAI25128.1 Different initiation.
CCDSiCCDS9682.2 [Q86UA1-1]
RefSeqiNP_060392.3, NM_017922.3 [Q86UA1-1]
UniGeneiHs.274337

Genome annotation databases

EnsembliENST00000355765; ENSP00000348010; ENSG00000185246 [Q86UA1-1]
GeneIDi55015
KEGGihsa:55015
UCSCiuc001wvz.4 human [Q86UA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPRP39_HUMAN
AccessioniPrimary (citable) accession number: Q86UA1
Secondary accession number(s): Q08AL1, Q08AL2, Q9NUU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 10, 2009
Last modified: June 20, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health