Q86U90 (YRDC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
YrdC domain-containing protein, mitochondrial

Alternative name(s):
Dopamine receptor-interacting protein 3
Ischemia/reperfusion-inducible protein homolog
Short name=hIRIP

Gene names

Name:	YRDC
Synonyms:	DRIP3, IRIP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate the activity of some transporters By similarity.
Subunit structure	Interacts with RSC1A1 By similarity.
Subcellular location	Mitochondrion Potential. Membrane; Peripheral membrane protein. Note: Predominantly localized in the plasma membrane By similarity.
Tissue specificity	Ubiquitously expressed. Ref.1
Sequence similarities	Belongs to the SUA5 family. Contains 1 YrdC-like domain.
Sequence caution	The sequence AAH08984.3 differs from that shown. Reason: Erroneous initiation. The sequence AAP37053.1 differs from that shown. Reason: Erroneous initiation. The sequence AAP37054.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB15668.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion
Domain	Transit peptide
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of transport Inferred from direct assay. Source: MGI
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 55	55	Mitochondrion Potential
	Chain	56 – 279	224	YrdC domain-containing protein, mitochondrial		PRO_0000341402
Regions
	Domain	67 – 257	191	YrdC-like
Amino acid modifications
	Modified residue	37	1	Phosphoserine Ref.8 Ref.10 Ref.12
	Modified residue	60	1	Phosphoserine Ref.9 Ref.11 Ref.12 Ref.13

Sequences

	Sequence		Length	Mass (Da)
	Q86U90 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F8F5C30274E2BB12	FASTA	279	29,328
	10 20 30 40 50 60 MSPARRCRGM RAAVAASVGL SEGPAGSRSG RLFRPPSPAP AAPGARLLRL PGSGAVQAAS 70 80 90 100 110 120 PERAGWTEAL RAAVAELRAG AVVAVPTDTL YGLACAASCS AALRAVYRLK GRSEAKPLAV 130 140 150 160 170 180 CLGRVADVYR YCRVRVPEGL LKDLLPGPVT LVMERSEELN KDLNPFTPLV GIRIPDHAFM 190 200 210 220 230 240 QDLAQMFEGP LALTSANLSS QASSLNVEEF QDLWPQLSLV IDGGQIGDGQ SPECRLGSTV 250 260 270 VDLSVPGKFG IIRPGCALES TTAILQQKYG LLPSHASYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and identification of a novel cDNA that encodes human yrdC protein." Chen J., Ji C., Gu S., Zhao E., Dai J., Huang L., Qian J., Ying K., Xie Y., Mao Y. J. Hum. Genet. 48:164-169(2003) [PubMed: 12730717] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph, Placenta and Skin.
[5]	"IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity." Jiang W., Prokopenko O., Wong L., Inouye M., Mirochnitchenko O. Mol. Cell. Biol. 25:6496-6508(2005) [PubMed: 16024787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-279.
[6]	"Cloning and characterization of DRIP3, a new protein that specifically interacts with the D1 dopamine receptor." Lafuente M.J., Nasir J. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-279.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-279. Tissue: Small intestine.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-60, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY172561 mRNA. Translation: AAO41711.1. AL929472 Genomic DNA. Translation: CAH70083.1. CH471059 Genomic DNA. Translation: EAX07317.1. BC008984 mRNA. Translation: AAH08984.3. Different initiation. BC067857 mRNA. Translation: AAH67857.2. BC068057 mRNA. Translation: AAH68057.1. BC080186 mRNA. Translation: AAH80186.2. AY286019 mRNA. Translation: AAP37053.1. Different initiation. AY286020 mRNA. Translation: AAP37054.1. Different initiation. AF250397 mRNA. Translation: AAQ14263.1. AK027129 mRNA. Translation: BAB15668.1. Different initiation.
IPI	IPI00384180.
RefSeq	NP_078916.3. NM_024640.3.
UniGene	Hs.301564.
3D structure databases
ProteinModelPortal	Q86U90.
SMR	Q86U90. Positions 67-268.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86U90.
PTM databases
PhosphoSite	Q86U90.
Polymorphism databases
DMDM	74750410.
Proteomic databases
PRIDE	Q86U90.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373044; ENSP00000362135; ENSG00000196449.
GeneID	79693.
KEGG	hsa:79693.
NMPDR	fig|9606.3.peg.885.
UCSC	uc001cca.1. human.
Organism-specific databases
CTD	79693.
GeneCards	GC01M038268.
H-InvDB	HIX0000442. HIX0023600.
HGNC	HGNC:28905. YRDC.
HPA	HPA030147.
MIM	612276. gene.
neXtProt	NX_Q86U90.
PharmGKB	PA142670553.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15137.
GeneTree	ENSGT00390000015364.
HOGENOM	HBG380182.
HOVERGEN	HBG055700.
InParanoid	Q86U90.
OMA	TIYGLAC.
OrthoDB	EOG4KD6N1.
PhylomeDB	Q86U90.
Gene expression databases
ArrayExpress	Q86U90.
Bgee	Q86U90.
CleanEx	HS_YRDC.
Genevestigator	Q86U90.
Family and domain databases
InterPro	IPR017945. DHBP_synth_RibB-like_a/b_dom. IPR004388. Sua5/YciO/YrdC/YwlC. IPR006070. Sua5/yciO/yrdC_N. [Graphical view]
Gene3D	G3DSA:3.90.870.10. DHBP_synth_RibB-like_a/b_dom. 1 hit.
Pfam	PF01300. Sua5_yciO_yrdC. 1 hit. [Graphical view]
SUPFAM	SSF55821. DHBP_synth_RibB-like_a/b_dom. 1 hit.
TIGRFAMs	TIGR00057. TIGR00057. 1 hit.
PROSITE	PS51163. YRDC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	68972.
SOURCE	Search...

Entry information

Entry name

YRDC_HUMAN

Accession

Primary (citable) accession number: Q86U90
Secondary accession number(s): Q4W4X8 , Q6NVW3, Q7L4E4, Q7Z2I4, Q9H5F8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.