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Protein

YrdC domain-containing protein, mitochondrial

Gene

YRDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the activity of some transporters.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32489-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
YrdC domain-containing protein, mitochondrial
Alternative name(s):
Dopamine receptor-interacting protein 3
Ischemia/reperfusion-inducible protein homolog
Short name:
hIRIP
Gene namesi
Name:YRDC
Synonyms:DRIP3, IRIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28905. YRDC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196449.
PharmGKBiPA142670553.

Polymorphism and mutation databases

BioMutaiYRDC.
DMDMi74750410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionSequence analysisAdd BLAST55
ChainiPRO_000034140256 – 279YrdC domain-containing protein, mitochondrialAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86U90.
MaxQBiQ86U90.
PaxDbiQ86U90.
PeptideAtlasiQ86U90.
PRIDEiQ86U90.

PTM databases

iPTMnetiQ86U90.
PhosphoSitePlusiQ86U90.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000196449.
CleanExiHS_YRDC.
GenevisibleiQ86U90. HS.

Organism-specific databases

HPAiHPA030147.

Interactioni

Subunit structurei

Interacts with RSC1A1.By similarity

Protein-protein interaction databases

BioGridi122814. 8 interactors.
STRINGi9606.ENSP00000362135.

Structurei

3D structure databases

ProteinModelPortaliQ86U90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 257YrdC-likePROSITE-ProRule annotationAdd BLAST191

Sequence similaritiesi

Belongs to the SUA5 family.Curated
Contains 1 YrdC-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3051. Eukaryota.
COG0009. LUCA.
GeneTreeiENSGT00390000015364.
HOGENOMiHOG000239829.
HOVERGENiHBG055700.
InParanoidiQ86U90.
OMAiWHEQPLA.
OrthoDBiEOG091G0KNT.
PhylomeDBiQ86U90.
TreeFamiTF314358.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR006070. YrdC-like_dom.
[Graphical view]
PfamiPF01300. Sua5_yciO_yrdC. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00057. TIGR00057. 1 hit.
PROSITEiPS51163. YRDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86U90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPARRCRGM RAAVAASVGL SEGPAGSRSG RLFRPPSPAP AAPGARLLRL
60 70 80 90 100
PGSGAVQAAS PERAGWTEAL RAAVAELRAG AVVAVPTDTL YGLACAASCS
110 120 130 140 150
AALRAVYRLK GRSEAKPLAV CLGRVADVYR YCRVRVPEGL LKDLLPGPVT
160 170 180 190 200
LVMERSEELN KDLNPFTPLV GIRIPDHAFM QDLAQMFEGP LALTSANLSS
210 220 230 240 250
QASSLNVEEF QDLWPQLSLV IDGGQIGDGQ SPECRLGSTV VDLSVPGKFG
260 270
IIRPGCALES TTAILQQKYG LLPSHASYL
Length:279
Mass (Da):29,328
Last modified:June 1, 2003 - v1
Checksum:iF8F5C30274E2BB12
GO

Sequence cautioni

The sequence AAH08984 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP37053 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP37054 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15668 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172561 mRNA. Translation: AAO41711.1.
AL929472 Genomic DNA. Translation: CAH70083.1.
CH471059 Genomic DNA. Translation: EAX07317.1.
BC008984 mRNA. Translation: AAH08984.3. Different initiation.
BC067857 mRNA. Translation: AAH67857.2.
BC068057 mRNA. Translation: AAH68057.1.
BC080186 mRNA. Translation: AAH80186.2.
AY286019 mRNA. Translation: AAP37053.1. Different initiation.
AY286020 mRNA. Translation: AAP37054.1. Different initiation.
AF250397 mRNA. Translation: AAQ14263.1.
AK027129 mRNA. Translation: BAB15668.1. Different initiation.
CCDSiCCDS30675.1.
RefSeqiNP_078916.3. NM_024640.3.
UniGeneiHs.301564.

Genome annotation databases

EnsembliENST00000373044; ENSP00000362135; ENSG00000196449.
GeneIDi79693.
KEGGihsa:79693.
UCSCiuc001cca.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172561 mRNA. Translation: AAO41711.1.
AL929472 Genomic DNA. Translation: CAH70083.1.
CH471059 Genomic DNA. Translation: EAX07317.1.
BC008984 mRNA. Translation: AAH08984.3. Different initiation.
BC067857 mRNA. Translation: AAH67857.2.
BC068057 mRNA. Translation: AAH68057.1.
BC080186 mRNA. Translation: AAH80186.2.
AY286019 mRNA. Translation: AAP37053.1. Different initiation.
AY286020 mRNA. Translation: AAP37054.1. Different initiation.
AF250397 mRNA. Translation: AAQ14263.1.
AK027129 mRNA. Translation: BAB15668.1. Different initiation.
CCDSiCCDS30675.1.
RefSeqiNP_078916.3. NM_024640.3.
UniGeneiHs.301564.

3D structure databases

ProteinModelPortaliQ86U90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122814. 8 interactors.
STRINGi9606.ENSP00000362135.

PTM databases

iPTMnetiQ86U90.
PhosphoSitePlusiQ86U90.

Polymorphism and mutation databases

BioMutaiYRDC.
DMDMi74750410.

Proteomic databases

EPDiQ86U90.
MaxQBiQ86U90.
PaxDbiQ86U90.
PeptideAtlasiQ86U90.
PRIDEiQ86U90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373044; ENSP00000362135; ENSG00000196449.
GeneIDi79693.
KEGGihsa:79693.
UCSCiuc001cca.2. human.

Organism-specific databases

CTDi79693.
GeneCardsiYRDC.
H-InvDBHIX0023600.
HGNCiHGNC:28905. YRDC.
HPAiHPA030147.
MIMi612276. gene.
neXtProtiNX_Q86U90.
OpenTargetsiENSG00000196449.
PharmGKBiPA142670553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3051. Eukaryota.
COG0009. LUCA.
GeneTreeiENSGT00390000015364.
HOGENOMiHOG000239829.
HOVERGENiHBG055700.
InParanoidiQ86U90.
OMAiWHEQPLA.
OrthoDBiEOG091G0KNT.
PhylomeDBiQ86U90.
TreeFamiTF314358.

Enzyme and pathway databases

BioCyciZFISH:G66-32489-MONOMER.

Miscellaneous databases

GenomeRNAii79693.
PROiQ86U90.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196449.
CleanExiHS_YRDC.
GenevisibleiQ86U90. HS.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR006070. YrdC-like_dom.
[Graphical view]
PfamiPF01300. Sua5_yciO_yrdC. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00057. TIGR00057. 1 hit.
PROSITEiPS51163. YRDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYRDC_HUMAN
AccessioniPrimary (citable) accession number: Q86U90
Secondary accession number(s): Q4W4X8
, Q6NVW3, Q7L4E4, Q7Z2I4, Q9H5F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.