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Protein

YrdC domain-containing protein, mitochondrial

Gene

YRDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the activity of some transporters.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
YrdC domain-containing protein, mitochondrial
Alternative name(s):
Dopamine receptor-interacting protein 3
Ischemia/reperfusion-inducible protein homolog
Short name:
hIRIP
Gene namesi
Name:YRDC
Synonyms:DRIP3, IRIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000196449.3
HGNCiHGNC:28905 YRDC
MIMi612276 gene
neXtProtiNX_Q86U90

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196449
PharmGKBiPA142670553

Polymorphism and mutation databases

BioMutaiYRDC
DMDMi74750410

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionSequence analysisAdd BLAST55
ChainiPRO_000034140256 – 279YrdC domain-containing protein, mitochondrialAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86U90
MaxQBiQ86U90
PaxDbiQ86U90
PeptideAtlasiQ86U90
PRIDEiQ86U90

PTM databases

iPTMnetiQ86U90
PhosphoSitePlusiQ86U90

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000196449
CleanExiHS_YRDC
GenevisibleiQ86U90 HS

Organism-specific databases

HPAiHPA030147

Interactioni

Subunit structurei

Interacts with RSC1A1.By similarity

Protein-protein interaction databases

BioGridi122814, 8 interactors
STRINGi9606.ENSP00000362135

Structurei

3D structure databases

ProteinModelPortaliQ86U90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 257YrdC-likePROSITE-ProRule annotationAdd BLAST191

Sequence similaritiesi

Belongs to the SUA5 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3051 Eukaryota
COG0009 LUCA
GeneTreeiENSGT00390000015364
HOGENOMiHOG000239829
HOVERGENiHBG055700
InParanoidiQ86U90
OMAiWHEQPLA
OrthoDBiEOG091G0KNT
PhylomeDBiQ86U90
TreeFamiTF314358

Family and domain databases

InterProiView protein in InterPro
IPR017945 DHBP_synth_RibB-like_a/b_dom
IPR006070 YrdC-like_dom
PfamiView protein in Pfam
PF01300 Sua5_yciO_yrdC, 1 hit
SUPFAMiSSF55821 SSF55821, 1 hit
TIGRFAMsiTIGR00057 TIGR00057, 1 hit
PROSITEiView protein in PROSITE
PS51163 YRDC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86U90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPARRCRGM RAAVAASVGL SEGPAGSRSG RLFRPPSPAP AAPGARLLRL
60 70 80 90 100
PGSGAVQAAS PERAGWTEAL RAAVAELRAG AVVAVPTDTL YGLACAASCS
110 120 130 140 150
AALRAVYRLK GRSEAKPLAV CLGRVADVYR YCRVRVPEGL LKDLLPGPVT
160 170 180 190 200
LVMERSEELN KDLNPFTPLV GIRIPDHAFM QDLAQMFEGP LALTSANLSS
210 220 230 240 250
QASSLNVEEF QDLWPQLSLV IDGGQIGDGQ SPECRLGSTV VDLSVPGKFG
260 270
IIRPGCALES TTAILQQKYG LLPSHASYL
Length:279
Mass (Da):29,328
Last modified:June 1, 2003 - v1
Checksum:iF8F5C30274E2BB12
GO

Sequence cautioni

The sequence AAH08984 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP37053 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP37054 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15668 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172561 mRNA Translation: AAO41711.1
AL929472 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07317.1
BC008984 mRNA Translation: AAH08984.3 Different initiation.
BC067857 mRNA Translation: AAH67857.2
BC068057 mRNA Translation: AAH68057.1
BC080186 mRNA Translation: AAH80186.2
AY286019 mRNA Translation: AAP37053.1 Different initiation.
AY286020 mRNA Translation: AAP37054.1 Different initiation.
AF250397 mRNA Translation: AAQ14263.1
AK027129 mRNA Translation: BAB15668.1 Different initiation.
CCDSiCCDS30675.1
RefSeqiNP_078916.3, NM_024640.3
UniGeneiHs.301564

Genome annotation databases

EnsembliENST00000373044; ENSP00000362135; ENSG00000196449
GeneIDi79693
KEGGihsa:79693
UCSCiuc001cca.2 human

Similar proteinsi

Entry informationi

Entry nameiYRDC_HUMAN
AccessioniPrimary (citable) accession number: Q86U90
Secondary accession number(s): Q4W4X8
, Q6NVW3, Q7L4E4, Q7Z2I4, Q9H5F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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