Q86U86 (PB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein polybromo-1
Short name=hPB1

Alternative name(s):
BRG1-associated factor 180
Short name=BAF180
Polybromo-1D

Gene names

Name:	PBRM1
Synonyms:	BAF180, PB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1689 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation. Ref.13
Subunit structure	Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with PHF10/BAF45A By similarity. Ref.1 Ref.6 Ref.16
Subcellular location	Nucleus.
Tissue specificity	Widely expressed. Ref.2
Involvement in disease	Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13
Sequence similarities	Contains 2 BAH domains. Contains 6 bromo domains. Contains 1 HMG box DNA-binding domain.
Sequence caution	The sequence AAI15010.1 differs from that shown. Reason: Contaminating sequence. The sequence AAI15011.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI15012.1 differs from that shown. Reason: Erroneous termination at position 78. Translated as Arg. The sequence BAB71210.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Domain	Bromodomain Repeat
Ligand	DNA-binding
Molecular function	Chromatin regulator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin remodeling Traceable author statement Ref.1. Source: UniProtKB heart development Inferred from electronic annotation. Source: Compara mitosis Traceable author statement Ref.1. Source: UniProtKB negative regulation of cell proliferation Inferred from mutant phenotype Ref.13. Source: UniProtKB placenta development Inferred from electronic annotation. Source: Compara regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	kinetochore Inferred from electronic annotation. Source: Compara nuclear chromosome Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ARID2	Q68CP9	5	EBI-637807,EBI-637818
SMARCA4	P51532	4	EBI-637807,EBI-302489

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86U86-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86U86-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.

Isoform 3 (identifier: Q86U86-3)

The sequence of this isoform differs from the canonical sequence as follows:
     300-332: RTPSNLAAARLTGPSHSKGSLGEERNPTSKYYR → S
     1430-1484: Missing.

Isoform 4 (identifier: Q86U86-4)

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1336-1362: Missing.
     1430-1484: Missing.

Isoform 5 (identifier: Q86U86-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.
     1485-1536: Missing.

Isoform 6 (identifier: Q86U86-6)

The sequence of this isoform differs from the canonical sequence as follows:
     857-1689: Missing.

Isoform 7 (identifier: Q86U86-7)

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1430-1484: Missing.
     1485-1536: Missing.

Isoform 8 (identifier: Q86U86-8)

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1485-1536: Missing.

Isoform 9 (identifier: Q86U86-9)

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1430-1484: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1689

1689

Protein polybromo-1

PRO_0000211207

Regions

Domain

64 – 134

71

Bromo 1

Domain

200 – 270

71

Bromo 2

Domain

400 – 470

71

Bromo 3

Domain

538 – 608

71

Bromo 4

Domain

676 – 746

71

Bromo 5

Domain

792 – 862

71

Bromo 6

Domain

956 – 1074

119

BAH 1

Domain

1156 – 1272

117

BAH 2

DNA binding

1379 – 1447

69

HMG box

Compositional bias

630 – 633

4

Poly-Asp

Compositional bias

1468 – 1599

132

Pro-rich

Amino acid modifications

Modified residue

10

1

Phosphoserine Ref.9 Ref.10

Modified residue

39

1

Phosphoserine Ref.7 Ref.9 Ref.10 Ref.11

Modified residue

131

1

Phosphoserine Ref.9

Modified residue

316

1

Phosphoserine Ref.9

Modified residue

319

1

Phosphoserine Ref.9

Modified residue

353

1

Phosphoserine Ref.9 Ref.10 Ref.11 Ref.14

Modified residue

355

1

Phosphoserine Ref.9 Ref.10 Ref.11 Ref.14

Modified residue

371

1

Phosphoserine Ref.10

Modified residue

375

1

Phosphoserine Ref.10

Modified residue

498

1

Phosphoserine Ref.10

Modified residue

636

1

Phosphoserine Ref.10 Ref.11 Ref.14

Modified residue

648

1

Phosphoserine Ref.14

Modified residue

1405

1

Phosphoserine Ref.9 Ref.11

Modified residue

1453

1

Phosphoserine Ref.8 Ref.11 Ref.14

Natural variations

Alternative sequence

300 – 332

33

RTPSN…SKYYR → S in isoform 3.

VSP_015231

Alternative sequence

513

1

K → KRNTHDSEMLGLRRLS in isoform 7 and isoform 8.

VSP_035499

Alternative sequence

857 – 1689

833

Missing in isoform 6.

VSP_015232

Alternative sequence

989 – 1013

25

Missing in isoform 4 and isoform 9.

VSP_015233

Alternative sequence

1336 – 1362

27

Missing in isoform 4.

VSP_015234

Alternative sequence

1430 – 1484

55

Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7 and isoform 9.

VSP_015235

Alternative sequence

1485 – 1536

52

Missing in isoform 5, isoform 7 and isoform 8.

VSP_015236

Natural variant

49

1

V → L Found in a lung cancer cell line. Ref.13

VAR_064653

Natural variant

56

1

T → A Found in a brain cancer cell line. Ref.13

VAR_064654

Natural variant

57

1

Missing Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064655

Natural variant

66

1

R → G Found in a colon cancer cell line. Ref.13

VAR_064656

Natural variant

90

1

Q → E Found in a bladder cancer cell line. Ref.13

VAR_064657

Natural variant

144

1

Y → F Found in a malignant melanoma cell line. Ref.13

VAR_064658

Natural variant

160

1

E → A Found in a malignant melanoma cell line. Ref.13

VAR_064659

Natural variant

202

1

R → C Found in a endometrial cancer cell line. Ref.13

VAR_064660

Natural variant

206

1

E → K Found in hematopoietic and lymphoid cancer cell lines. Ref.13

VAR_064661

Natural variant

226

1

E → G Found in hematopoietic and lymphoid cancer cell lines. Ref.13

VAR_064662

Natural variant

228

1

I → V Found in a breast cancer cell line. Ref.13

VAR_064663

Natural variant

232

1

T → P Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064664

Natural variant

233

1

I → T Found in a renal carcinoma cell line. Ref.13

VAR_064665

Natural variant

256

1

A → T Found in an ovary carcinoma cell line. Ref.13

VAR_064666

Natural variant

340

1

G → A Found in a malignant melanoma cell line. Ref.13

VAR_064667

Natural variant

523

1

M → I Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064668

Natural variant

540

1

R → S Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064669

Natural variant

597

1

A → D Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064670

Natural variant

621

1

K → E Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064671

Natural variant

661

1

K → N Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064672

Natural variant

674

1

D → E Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064673

Natural variant

678

1

R → C. Ref.13

VAR_064674

Natural variant

893

1

Y → C Found in hematopoietic, lymphoid, lung and liver cancer cell lines. Ref.13

VAR_064675

Natural variant

895

1

T → S Found in a lung cancer cell line. Ref.13

VAR_064676

Natural variant

922

1

E → Q Found in a breast cancer cell line. Ref.13

VAR_064677

Natural variant

925

1

K → Q Found in a colon cancer cell line. Ref.13

VAR_064678

Natural variant

1079

1

P → Y Requires 2 nucleotide substitutions; found in a colon cancer cell line. Ref.13

VAR_064679

Natural variant

1098

1

A → S Found in hematopoietic and lymphoid cancer cell lines. Ref.13

VAR_064680

Natural variant

1120

1

R → Q Found in hematopoietic and lymphoid cancer cell lines. Ref.13

VAR_064681

Natural variant

1177

1

G → S Found in a kidney cancer cell line. Ref.13

VAR_064682

Natural variant

1204

1

H → P Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064683

Natural variant

1209 – 1214

6

Missing Found in a case of clear cell renal carcinoma; somatic mutation.

VAR_064684

Natural variant

1287

1

E → Q Found in a breast cancer cell line. Ref.13

VAR_064685

Natural variant

1414

1

G → E Found in a lung cancer cell line. Ref.13

VAR_064686

Natural variant

1503

1

G → C Found in a stomach cancer cell line. Ref.13

VAR_064687

Natural variant

1560

1

Q → H Found in an endometrial cancer cell line. Ref.13

VAR_064688

Natural variant

1614

1

I → N Found in a case of clear cell renal carcinoma; somatic mutation. Ref.13

VAR_064689

Natural variant

1647

1

R → C Found in a breast cancer cell line. Ref.13

VAR_064690

Experimental info

Sequence conflict

1

1

M → T in AAI15011. Ref.4

Sequence conflict

65

1

G → S in AAI15011. Ref.4

Sequence conflict

242

1

Y → C in AAI15012. Ref.4

Sequence conflict

251

1

D → V in AAI15011. Ref.4

Sequence conflict

430

1

L → P in AAI15012. Ref.4

Sequence conflict

553

1

K → R in AAG34760. Ref.1

Sequence conflict

567

1

D → Y in AAI15012. Ref.4

Sequence conflict

750

1

L → P in AAI15012. Ref.4

Sequence conflict

792

1

H → R in AAI15012. Ref.4

Sequence conflict

927

1

Missing in AAI15010. Ref.4

Sequence conflict

927

1

Missing in BAB71210. Ref.5

Sequence conflict

963

1

Y → H in BAB71210. Ref.5

Sequence conflict

1144

1

G → V in AAG34760. Ref.1

Sequence conflict

1245

1

R → K in AAG34760. Ref.1

Sequence conflict

1306

1

E → G in AAG34760. Ref.1

Sequence conflict

1349

1

L → P in AAI15010. Ref.4

Sequence conflict

1488

1

G → D in AAI15012. Ref.4

Sequence conflict

1568

1

G → R in AAG34760. Ref.1

Secondary structure

1

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1689

Helix Strand Turn

Details...

Helix

46 – 59

14

Helix

68 – 72

5

Helix

78 – 80

3

Helix

82 – 87

6

Helix

94 – 102

9

Helix

109 – 126

18

Helix

132 – 152

21

Beta strand

176 – 178

3

Helix

179 – 195

17

Helix

206 – 208

3

Turn

214 – 216

3

Helix

218 – 223

6

Helix

230 – 239

10

Helix

245 – 262

18

Helix

268 – 291

24

Helix

388 – 394

7

Beta strand

399 – 401

3

Helix

406 – 408

3

Turn

414 – 416

3

Helix

418 – 423

6

Helix

430 – 438

9

Helix

445 – 462

18

Helix

468 – 490

23

Helix

511 – 532

22

Turn

536 – 538

3

Helix

542 – 546

5

Turn

552 – 554

3

Helix

556 – 561

6

Helix

568 – 576

9

Helix

583 – 600

18

Helix

606 – 625

20

Helix

657 – 671

15

Helix

680 – 684

5

Turn

690 – 692

3

Helix

694 – 699

6

Beta strand

700 – 702

3

Helix

706 – 714

9

Helix

721 – 738

18

Helix

744 – 762

19

Turn

763 – 765

3

Helix

777 – 790

14

Helix

800 – 804

5

Helix

822 – 830

9

Helix

837 – 854

18

Helix

860 – 882

23

Helix

889 – 892

4

Helix

895 – 909

15

Helix

910 – 913

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0A656E319C4FC748	FASTA	1,689	192,948
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 550 560 570 580 590 600 RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 610 620 630 640 650 660 NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK KSKYMTPMQQ 670 680 690 700 710 720 KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 730 740 750 760 770 780 IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 790 800 810 820 830 840 LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF 850 860 870 880 890 900 QEHMFEVLER ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN 910 920 930 940 950 960 DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD CSFKNSMYHV 970 980 990 1000 1010 1020 GDYVYVEPAE ANLQPHIVCI ERLWEDSAGE KWLYGCWFYR PNETFHLATR KFLEKEVFKS 1030 1040 1050 1060 1070 1080 DYYNKVPVSK ILGKCVVMFV KEYFKLCPEN FRDEDVFVCE SRYSAKTKSF KKIKLWTMPI 1090 1100 1110 1120 1130 1140 SSVRFVPRDV PLPVVRVASV FANADKGDDE KNTDNSEDSR AEDNFNLEKE KEDVPVEMSN 1150 1160 1170 1180 1190 1200 GEPGCHYFEQ LHYNDMWLKV GDCVFIKSHG LVRPRVGRIE KVWVRDGAAY FYGPIFIHPE 1210 1220 1230 1240 1250 1260 ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP ENDILLCESR 1270 1280 1290 1300 1310 1320 YNESDKQMKK FKGLKRFSLS AKVVDDEIYY FRKPIVPQKE PSPLLEKKIQ LLEAKFAELE 1330 1340 1350 1360 1370 1380 GGDDDIEEMG EEDSEVIEPP SLPQLQTPLA SELDLMPYTP PQSTPKSAKG SAKKEGSKRK 1390 1400 1410 1420 1430 1440 INMSGYILFS SEMRAVIKAQ HPDYSFGELS RLVGTEWRNL ETAKKAEYEE RAAKVAEQQE 1450 1460 1470 1480 1490 1500 RERAAQQQQP SASPRAGTPV GALMGVVPPP TPMGMLNQQL TPVAGMMGGY PPGLPPLQGP 1510 1520 1530 1540 1550 1560 VDGLVSMGSM QPLHPGGPPP HHLPPGVPGL PGIPPPGVMN QGVAPMVGTP APGGSPYGQQ 1570 1580 1590 1600 1610 1620 VGVLGPPGQQ APPPYPGPHP AGPPVIQQPT TPMFVAPPPK TQRLLHSEAY LKYIEGLSAE 1630 1640 1650 1660 1670 1680 SNSISKWDQT LAARRRDVHL SKEQESRLPS HWLKSKGAHT TMADALWRLR DLMLRDTLNI RQAYNLENV
	Isoform 2 [UniParc]. Checksum: FAB1C935A9B8B4DD	FASTA	1,634	187,188
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 550 560 570 580 590 600 RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 610 620 630 640 650 660 NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK KSKYMTPMQQ 670 680 690 700 710 720 KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 730 740 750 760 770 780 IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 790 800 810 820 830 840 LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF 850 860 870 880 890 900 QEHMFEVLER ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN 910 920 930 940 950 960 DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD CSFKNSMYHV 970 980 990 1000 1010 1020 GDYVYVEPAE ANLQPHIVCI ERLWEDSAGE KWLYGCWFYR PNETFHLATR KFLEKEVFKS 1030 1040 1050 1060 1070 1080 DYYNKVPVSK ILGKCVVMFV KEYFKLCPEN FRDEDVFVCE SRYSAKTKSF KKIKLWTMPI 1090 1100 1110 1120 1130 1140 SSVRFVPRDV PLPVVRVASV FANADKGDDE KNTDNSEDSR AEDNFNLEKE KEDVPVEMSN 1150 1160 1170 1180 1190 1200 GEPGCHYFEQ LHYNDMWLKV GDCVFIKSHG LVRPRVGRIE KVWVRDGAAY FYGPIFIHPE 1210 1220 1230 1240 1250 1260 ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP ENDILLCESR 1270 1280 1290 1300 1310 1320 YNESDKQMKK FKGLKRFSLS AKVVDDEIYY FRKPIVPQKE PSPLLEKKIQ LLEAKFAELE 1330 1340 1350 1360 1370 1380 GGDDDIEEMG EEDSEVIEPP SLPQLQTPLA SELDLMPYTP PQSTPKSAKG SAKKEGSKRK 1390 1400 1410 1420 1430 1440 INMSGYILFS SEMRAVIKAQ HPDYSFGELS RLVGTEWRNL ETAKKAEYEG MMGGYPPGLP 1450 1460 1470 1480 1490 1500 PLQGPVDGLV SMGSMQPLHP GGPPPHHLPP GVPGLPGIPP PGVMNQGVAP MVGTPAPGGS 1510 1520 1530 1540 1550 1560 PYGQQVGVLG PPGQQAPPPY PGPHPAGPPV IQQPTTPMFV APPPKTQRLL HSEAYLKYIE 1570 1580 1590 1600 1610 1620 GLSAESNSIS KWDQTLAARR RDVHLSKEQE SRLPSHWLKS KGAHTTMADA LWRLRDLMLR 1630 DTLNIRQAYN LENV
	Isoform 3 [UniParc]. Checksum: B8BA103E359A48DA	FASTA	1,602	183,690
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMS 310 320 330 340 350 360 NKRAVQGGRL SAITMALQYG SESEEDAALA AARYEEGESE AESITSFMDV SNPFYQLYDT 370 380 390 400 410 420 VRSCRNNQGQ LIAEPFYHLP SKKKYPDYYQ QIKMPISLQQ IRTKLKNQEY ETLDHLECDL 430 440 450 460 470 480 NLMFENAKRY NVPNSAIYKR VLKLQQVMQA KKKELARRDD IEDGDSMISS ATSDTGSAKR 490 500 510 520 530 540 KSKKNIRKQR MKILFNVVLE AREPGSGRRL CDLFMVKPSK KDYPDYYKII LEPMDLKIIE 550 560 570 580 590 600 HNIRNDKYAG EEGMIEDMKL MFRNARHYNE EGSQVYNDAH ILEKLLKEKR KELGPLPDDD 610 620 630 640 650 660 DMASPKLKLS RKSGISPKKS KYMTPMQQKL NEVYEAVKNY TDKRGRRLSA IFLRLPSRSE 670 680 690 700 710 720 LPDYYLTIKK PMDMEKIRSH MMANKYQDID SMVEDFVMMF NNACTYNEPE SLIYKDALVL 730 740 750 760 770 780 HKVLLETRRD LEGDEDSHVP NVTLLIQELI HNLFVSVMSH QDDEGRCYSD SLAEIPAVDP 790 800 810 820 830 840 NFPNKPPLTF DIIRKNVENN RYRRLDLFQE HMFEVLERAR RMNRTDSEIY EDAVELQQFF 850 860 870 880 890 900 IKIRDELCKN GEILLSPALS YTTKHLHNDV EKERKEKLPK EIEEDKLKRE EEKREAEKSE 910 920 930 940 950 960 DSSGAAGLSG LHRTYSQDCS FKNSMYHVGD YVYVEPAEAN LQPHIVCIER LWEDSAGEKW 970 980 990 1000 1010 1020 LYGCWFYRPN ETFHLATRKF LEKEVFKSDY YNKVPVSKIL GKCVVMFVKE YFKLCPENFR 1030 1040 1050 1060 1070 1080 DEDVFVCESR YSAKTKSFKK IKLWTMPISS VRFVPRDVPL PVVRVASVFA NADKGDDEKN 1090 1100 1110 1120 1130 1140 TDNSEDSRAE DNFNLEKEKE DVPVEMSNGE PGCHYFEQLH YNDMWLKVGD CVFIKSHGLV 1150 1160 1170 1180 1190 1200 RPRVGRIEKV WVRDGAAYFY GPIFIHPEET EHEPTKMFYK KEVFLSNLEE TCPMTCILGK 1210 1220 1230 1240 1250 1260 CAVLSFKDFL SCRPTEIPEN DILLCESRYN ESDKQMKKFK GLKRFSLSAK VVDDEIYYFR 1270 1280 1290 1300 1310 1320 KPIVPQKEPS PLLEKKIQLL EAKFAELEGG DDDIEEMGEE DSEVIEPPSL PQLQTPLASE 1330 1340 1350 1360 1370 1380 LDLMPYTPPQ STPKSAKGSA KKEGSKRKIN MSGYILFSSE MRAVIKAQHP DYSFGELSRL 1390 1400 1410 1420 1430 1440 VGTEWRNLET AKKAEYEGMM GGYPPGLPPL QGPVDGLVSM GSMQPLHPGG PPPHHLPPGV 1450 1460 1470 1480 1490 1500 PGLPGIPPPG VMNQGVAPMV GTPAPGGSPY GQQVGVLGPP GQQAPPPYPG PHPAGPPVIQ 1510 1520 1530 1540 1550 1560 QPTTPMFVAP PPKTQRLLHS EAYLKYIEGL SAESNSISKW DQTLAARRRD VHLSKEQESR 1570 1580 1590 1600 LPSHWLKSKG AHTTMADALW RLRDLMLRDT LNIRQAYNLE NV
	Isoform 4 [UniParc]. Checksum: A2B8A14FAB928A3C	FASTA	1,582	181,085
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 550 560 570 580 590 600 RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 610 620 630 640 650 660 NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK KSKYMTPMQQ 670 680 690 700 710 720 KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 730 740 750 760 770 780 IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 790 800 810 820 830 840 LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF 850 860 870 880 890 900 QEHMFEVLER ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN 910 920 930 940 950 960 DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD CSFKNSMYHV 970 980 990 1000 1010 1020 GDYVYVEPAE ANLQPHIVCI ERLWEDSAEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK 1030 1040 1050 1060 1070 1080 LCPENFRDED VFVCESRYSA KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD 1090 1100 1110 1120 1130 1140 KGDDEKNTDN SEDSRAEDNF NLEKEKEDVP VEMSNGEPGC HYFEQLHYND MWLKVGDCVF 1150 1160 1170 1180 1190 1200 IKSHGLVRPR VGRIEKVWVR DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP 1210 1220 1230 1240 1250 1260 MTCILGKCAV LSFKDFLSCR PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD 1270 1280 1290 1300 1310 1320 DEIYYFRKPI VPQKEPSPLL EKKIQLLEAK FAELEGGDDD IEEMGEEDSE STPKSAKGSA 1330 1340 1350 1360 1370 1380 KKEGSKRKIN MSGYILFSSE MRAVIKAQHP DYSFGELSRL VGTEWRNLET AKKAEYEGMM 1390 1400 1410 1420 1430 1440 GGYPPGLPPL QGPVDGLVSM GSMQPLHPGG PPPHHLPPGV PGLPGIPPPG VMNQGVAPMV 1450 1460 1470 1480 1490 1500 GTPAPGGSPY GQQVGVLGPP GQQAPPPYPG PHPAGPPVIQ QPTTPMFVAP PPKTQRLLHS 1510 1520 1530 1540 1550 1560 EAYLKYIEGL SAESNSISKW DQTLAARRRD VHLSKEQESR LPSHWLKSKG AHTTMADALW 1570 1580 RLRDLMLRDT LNIRQAYNLE NV
	Isoform 5 [UniParc]. Checksum: BCBD5D8E42BAB076	FASTA	1,582	182,118
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 550 560 570 580 590 600 RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 610 620 630 640 650 660 NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK KSKYMTPMQQ 670 680 690 700 710 720 KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 730 740 750 760 770 780 IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 790 800 810 820 830 840 LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF 850 860 870 880 890 900 QEHMFEVLER ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN 910 920 930 940 950 960 DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD CSFKNSMYHV 970 980 990 1000 1010 1020 GDYVYVEPAE ANLQPHIVCI ERLWEDSAGE KWLYGCWFYR PNETFHLATR KFLEKEVFKS 1030 1040 1050 1060 1070 1080 DYYNKVPVSK ILGKCVVMFV KEYFKLCPEN FRDEDVFVCE SRYSAKTKSF KKIKLWTMPI 1090 1100 1110 1120 1130 1140 SSVRFVPRDV PLPVVRVASV FANADKGDDE KNTDNSEDSR AEDNFNLEKE KEDVPVEMSN 1150 1160 1170 1180 1190 1200 GEPGCHYFEQ LHYNDMWLKV GDCVFIKSHG LVRPRVGRIE KVWVRDGAAY FYGPIFIHPE 1210 1220 1230 1240 1250 1260 ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP ENDILLCESR 1270 1280 1290 1300 1310 1320 YNESDKQMKK FKGLKRFSLS AKVVDDEIYY FRKPIVPQKE PSPLLEKKIQ LLEAKFAELE 1330 1340 1350 1360 1370 1380 GGDDDIEEMG EEDSEVIEPP SLPQLQTPLA SELDLMPYTP PQSTPKSAKG SAKKEGSKRK 1390 1400 1410 1420 1430 1440 INMSGYILFS SEMRAVIKAQ HPDYSFGELS RLVGTEWRNL ETAKKAEYEG VMNQGVAPMV 1450 1460 1470 1480 1490 1500 GTPAPGGSPY GQQVGVLGPP GQQAPPPYPG PHPAGPPVIQ QPTTPMFVAP PPKTQRLLHS 1510 1520 1530 1540 1550 1560 EAYLKYIEGL SAESNSISKW DQTLAARRRD VHLSKEQESR LPSHWLKSKG AHTTMADALW 1570 1580 RLRDLMLRDT LNIRQAYNLE NV
	Isoform 6 [UniParc]. Checksum: AE378B417E0493B3	FASTA	856	99,142
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 550 560 570 580 590 600 RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 610 620 630 640 650 660 NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK KSKYMTPMQQ 670 680 690 700 710 720 KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 730 740 750 760 770 780 IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 790 800 810 820 830 840 LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF 850 QEHMFEVLER ARRMNR
	Isoform 7 [UniParc]. Checksum: 710520F65FF9E981	FASTA	1,597	183,885
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKRNTHDSE MLGLRRLSSK KNIRKQRMKI 550 560 570 580 590 600 LFNVVLEARE PGSGRRLCDL FMVKPSKKDY PDYYKIILEP MDLKIIEHNI RNDKYAGEEG 610 620 630 640 650 660 MIEDMKLMFR NARHYNEEGS QVYNDAHILE KLLKEKRKEL GPLPDDDDMA SPKLKLSRKS 670 680 690 700 710 720 GISPKKSKYM TPMQQKLNEV YEAVKNYTDK RGRRLSAIFL RLPSRSELPD YYLTIKKPMD 730 740 750 760 770 780 MEKIRSHMMA NKYQDIDSMV EDFVMMFNNA CTYNEPESLI YKDALVLHKV LLETRRDLEG 790 800 810 820 830 840 DEDSHVPNVT LLIQELIHNL FVSVMSHQDD EGRCYSDSLA EIPAVDPNFP NKPPLTFDII 850 860 870 880 890 900 RKNVENNRYR RLDLFQEHMF EVLERARRMN RTDSEIYEDA VELQQFFIKI RDELCKNGEI 910 920 930 940 950 960 LLSPALSYTT KHLHNDVEKE RKEKLPKEIE EDKLKREEEK REAEKSEDSS GAAGLSGLHR 970 980 990 1000 1010 1020 TYSQDCSFKN SMYHVGDYVY VEPAEANLQP HIVCIERLWE DSAGEKWLYG CWFYRPNETF 1030 1040 1050 1060 1070 1080 HLATRKFLEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK LCPENFRDED VFVCESRYSA 1090 1100 1110 1120 1130 1140 KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD KGDDEKNTDN SEDSRAEDNF 1150 1160 1170 1180 1190 1200 NLEKEKEDVP VEMSNGEPGC HYFEQLHYND MWLKVGDCVF IKSHGLVRPR VGRIEKVWVR 1210 1220 1230 1240 1250 1260 DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP MTCILGKCAV LSFKDFLSCR 1270 1280 1290 1300 1310 1320 PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD DEIYYFRKPI VPQKEPSPLL 1330 1340 1350 1360 1370 1380 EKKIQLLEAK FAELEGGDDD IEEMGEEDSE VIEPPSLPQL QTPLASELDL MPYTPPQSTP 1390 1400 1410 1420 1430 1440 KSAKGSAKKE GSKRKINMSG YILFSSEMRA VIKAQHPDYS FGELSRLVGT EWRNLETAKK 1450 1460 1470 1480 1490 1500 AEYEGVMNQG VAPMVGTPAP GGSPYGQQVG VLGPPGQQAP PPYPGPHPAG PPVIQQPTTP 1510 1520 1530 1540 1550 1560 MFVAPPPKTQ RLLHSEAYLK YIEGLSAESN SISKWDQTLA ARRRDVHLSK EQESRLPSHW 1570 1580 1590 LKSKGAHTTM ADALWRLRDL MLRDTLNIRQ AYNLENV
	Isoform 8 [UniParc]. Checksum: E5BA80E11EE7E6C0	FASTA	1,652	189,645
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKRNTHDSE MLGLRRLSSK KNIRKQRMKI 550 560 570 580 590 600 LFNVVLEARE PGSGRRLCDL FMVKPSKKDY PDYYKIILEP MDLKIIEHNI RNDKYAGEEG 610 620 630 640 650 660 MIEDMKLMFR NARHYNEEGS QVYNDAHILE KLLKEKRKEL GPLPDDDDMA SPKLKLSRKS 670 680 690 700 710 720 GISPKKSKYM TPMQQKLNEV YEAVKNYTDK RGRRLSAIFL RLPSRSELPD YYLTIKKPMD 730 740 750 760 770 780 MEKIRSHMMA NKYQDIDSMV EDFVMMFNNA CTYNEPESLI YKDALVLHKV LLETRRDLEG 790 800 810 820 830 840 DEDSHVPNVT LLIQELIHNL FVSVMSHQDD EGRCYSDSLA EIPAVDPNFP NKPPLTFDII 850 860 870 880 890 900 RKNVENNRYR RLDLFQEHMF EVLERARRMN RTDSEIYEDA VELQQFFIKI RDELCKNGEI 910 920 930 940 950 960 LLSPALSYTT KHLHNDVEKE RKEKLPKEIE EDKLKREEEK REAEKSEDSS GAAGLSGLHR 970 980 990 1000 1010 1020 TYSQDCSFKN SMYHVGDYVY VEPAEANLQP HIVCIERLWE DSAGEKWLYG CWFYRPNETF 1030 1040 1050 1060 1070 1080 HLATRKFLEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK LCPENFRDED VFVCESRYSA 1090 1100 1110 1120 1130 1140 KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD KGDDEKNTDN SEDSRAEDNF 1150 1160 1170 1180 1190 1200 NLEKEKEDVP VEMSNGEPGC HYFEQLHYND MWLKVGDCVF IKSHGLVRPR VGRIEKVWVR 1210 1220 1230 1240 1250 1260 DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP MTCILGKCAV LSFKDFLSCR 1270 1280 1290 1300 1310 1320 PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD DEIYYFRKPI VPQKEPSPLL 1330 1340 1350 1360 1370 1380 EKKIQLLEAK FAELEGGDDD IEEMGEEDSE VIEPPSLPQL QTPLASELDL MPYTPPQSTP 1390 1400 1410 1420 1430 1440 KSAKGSAKKE GSKRKINMSG YILFSSEMRA VIKAQHPDYS FGELSRLVGT EWRNLETAKK 1450 1460 1470 1480 1490 1500 AEYEERAAKV AEQQERERAA QQQQPSASPR AGTPVGALMG VVPPPTPMGM LNQQLTPVAG 1510 1520 1530 1540 1550 1560 VMNQGVAPMV GTPAPGGSPY GQQVGVLGPP GQQAPPPYPG PHPAGPPVIQ QPTTPMFVAP 1570 1580 1590 1600 1610 1620 PPKTQRLLHS EAYLKYIEGL SAESNSISKW DQTLAARRRD VHLSKEQESR LPSHWLKSKG 1630 1640 1650 AHTTMADALW RLRDLMLRDT LNIRQAYNLE NV
	Isoform 9 [UniParc]. Checksum: 38BB16B06929BFFC	FASTA	1,609	184,043
	10 20 30 40 50 60 MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 70 80 90 100 110 120 KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 130 140 150 160 170 180 NNAKSYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA 190 200 210 220 230 240 YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 250 260 270 280 290 300 SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 310 320 330 340 350 360 TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 370 380 390 400 410 420 LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFYH LPSKKKYPDY 430 440 450 460 470 480 YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 490 500 510 520 530 540 QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 550 560 570 580 590 600 RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 610 620 630 640 650 660 NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK KSKYMTPMQQ 670 680 690 700 710 720 KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 730 740 750 760 770 780 IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 790 800 810 820 830 840 LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF 850 860 870 880 890 900 QEHMFEVLER ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN 910 920 930 940 950 960 DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD CSFKNSMYHV 970 980 990 1000 1010 1020 GDYVYVEPAE ANLQPHIVCI ERLWEDSAEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK 1030 1040 1050 1060 1070 1080 LCPENFRDED VFVCESRYSA KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD 1090 1100 1110 1120 1130 1140 KGDDEKNTDN SEDSRAEDNF NLEKEKEDVP VEMSNGEPGC HYFEQLHYND MWLKVGDCVF 1150 1160 1170 1180 1190 1200 IKSHGLVRPR VGRIEKVWVR DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP 1210 1220 1230 1240 1250 1260 MTCILGKCAV LSFKDFLSCR PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD 1270 1280 1290 1300 1310 1320 DEIYYFRKPI VPQKEPSPLL EKKIQLLEAK FAELEGGDDD IEEMGEEDSE VIEPPSLPQL 1330 1340 1350 1360 1370 1380 QTPLASELDL MPYTPPQSTP KSAKGSAKKE GSKRKINMSG YILFSSEMRA VIKAQHPDYS 1390 1400 1410 1420 1430 1440 FGELSRLVGT EWRNLETAKK AEYEGMMGGY PPGLPPLQGP VDGLVSMGSM QPLHPGGPPP 1450 1460 1470 1480 1490 1500 HHLPPGVPGL PGIPPPGVMN QGVAPMVGTP APGGSPYGQQ VGVLGPPGQQ APPPYPGPHP 1510 1520 1530 1540 1550 1560 AGPPVIQQPT TPMFVAPPPK TQRLLHSEAY LKYIEGLSAE SNSISKWDQT LAARRRDVHL 1570 1580 1590 1600 SKEQESRLPS HWLKSKGAHT TMADALWRLR DLMLRDTLNI RQAYNLENV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes." Xue Y., Canman J.C., Lee C.S., Nie Z., Yang D., Moreno G.T., Young M.K., Salmon E.D., Wang W. Proc. Natl. Acad. Sci. U.S.A. 97:13015-13020(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), MASS SPECTROMETRY, IDENTIFICATION IN THE PBAF COMPLEX.
[2]	"cDNA cloning of the human polybromo-1 gene on chromosome 3p21." Horikawa I., Barrett J.C. DNA Seq. 13:211-215(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 5 AND 6), TISSUE SPECIFICITY.
[3]	"The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer." Sekine I., Sato M., Sunaga N., Toyooka S., Peyton M., Parsons R., Wang W., Gazdar A.F., Minna J.D. Oncogene 24:2735-2738(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4; 7; 8 AND 9).
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-1127 (ISOFORM 7). Tissue: Teratocarcinoma.
[6]	"Selectivity of chromatin-remodelling cofactors for ligand-activated transcription." Lemon B., Inouye C., King D.S., Tjian R. Nature 414:924-928(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE PBAF COMPLEX, IDENTIFICATION IN A SWI/SNF COMPLEX, MASS SPECTROMETRY.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1453, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-39; SER-131; SER-316; SER-319; SER-353; SER-355 AND SER-1405, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-39; SER-353; SER-355; SER-371; SER-375; SER-498 AND SER-636, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-353; SER-355; SER-636; SER-1405 AND SER-1453, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A. Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS NEGATIVE REGULATOR OF CELL PROLIFERATION, INVOLVEMENT IN RCC, VARIANTS LEU-49; ALA-56; ILE-57 DEL; GLY-66; GLU-90; PHE-144; ALA-160; CYS-202; LYS-206; GLY-226; VAL-228; PRO-232; THR-233; THR-256; ALA-340; ILE-523; SER-540; ASP-597; GLU-621; ASN-661; GLU-674; CYS-678; CYS-893; SER-895; GLN-922; GLN-925; TYR-1079; SER-1098; GLN-1120; SER-1177; PRO-1204; 1209-MET--GLU-1214 DEL; GLN-1287; GLU-1414; CYS-1503; HIS-1560; ASN-1614 AND CYS-1647.
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353; SER-355; SER-636; SER-648 AND SER-1453, MASS SPECTROMETRY.
[15]	"Recent advances in understanding chromatin remodeling by SWI/SNF complexes." Martens J.A., Winston F. Curr. Opin. Genet. Dev. 13:136-142(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW ON SWI/SNF CHROMATIN-REMODELING COMPLEXES.
[16]	"PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes." Yan Z., Cui K., Murray D.M., Ling C., Xue Y., Gerstein A., Parsons R., Zhao K., Wang W. Genes Dev. 19:1662-1667(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE PBAF COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF197569 mRNA. Translation: AAG34760.1.
AF225870 mRNA. Translation: AAG48939.1.
AF225871 mRNA. Translation: AAG48940.1.
AF225872 mRNA. Translation: AAG48941.1.
AF177387 mRNA. Translation: AAG48933.1.
AY281068 mRNA. Translation: AAP34197.1.
BC115009 mRNA. Translation: AAI15010.1. Different termination.
BC115010 mRNA. Translation: AAI15011.1. Different initiation.
BC115011 mRNA. Translation: AAI15012.1. Sequence problems.
BC129934 mRNA. Translation: AAI29935.1.
BC129935 mRNA. Translation: AAI29936.1.
AK056541 mRNA. Translation: BAB71210.1. Different initiation.

IPI

IPI00023097.
IPI00301041.
IPI00334894.
IPI00384176.
IPI00398781.
IPI00640304.
IPI00873041.
IPI00909142.
IPI00910435.

RefSeq

NP_060783.3. NM_018313.4.

UniGene

Hs.189920.
Hs.476320.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KTB	NMR	-	B	174-293	[»]
3G0J	X-ray	1.78	A/B	645-766	[»]
3HMF	X-ray	1.63	A	178-291	[»]
3IU5	X-ray	1.63	A	43-156	[»]
3IU6	X-ray	1.79	A	773-917	[»]
3K2J	X-ray	2.20	A/B	388-494	[»]
3LJW	X-ray	1.50	A/B	174-293	[»]
3MB4	X-ray	1.66	A/B	645-766	[»]
3TLP	X-ray	2.13	A/B	496-637	[»]

ProteinModelPortal

Q86U86.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-33045N.

IntAct

Q86U86. 11 interactions.

MINT

MINT-1195749.

PTM databases

PhosphoSite

Q86U86.

Polymorphism databases

DMDM

73921624.

Proteomic databases

PaxDb

Q86U86.

PRIDE

Q86U86.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000296302; ENSP00000296302; ENSG00000163939.
ENST00000337303; ENSP00000338302; ENSG00000163939.
ENST00000356770; ENSP00000349213; ENSG00000163939.
ENST00000394830; ENSP00000378307; ENSG00000163939.
ENST00000409057; ENSP00000386593; ENSG00000163939.
ENST00000409114; ENSP00000386643; ENSG00000163939.
ENST00000409767; ENSP00000386601; ENSG00000163939.
ENST00000410007; ENSP00000386529; ENSG00000163939.
ENST00000412587; ENSP00000404579; ENSG00000163939.

GeneID

55193.

KEGG

hsa:55193.

UCSC

uc003deq.2. human.
uc003der.2. human.
uc003des.2. human.
uc003det.2. human.
uc003deu.2. human.
uc003dew.2. human.
uc003dey.2. human.
uc010hmk.1. human.

Organism-specific databases

CTD

55193.

GeneCards

GC03M052579.

H-InvDB

HIX0003364.

HGNC

HGNC:30064. PBRM1.

HPA

HPA015629.

MIM

144700. phenotype.
606083. gene.

neXtProt

NX_Q86U86.

PharmGKB

PA162398846.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5076.

HOVERGEN

HBG079860.

InParanoid

Q86U86.

KO

K11757.

OMA

WLKVGDC.

PhylomeDB

Q86U86.

Gene expression databases

ArrayExpress

Q86U86.

Bgee

Q86U86.

Genevestigator

Q86U86.

GermOnline

ENSG00000163939. Homo sapiens.

Family and domain databases

Gene3D

1.10.30.10. 1 hit.
1.20.920.10. 6 hits.

InterPro

IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR009071. HMG_box_dom.
[Graphical view]

Pfam

PF01426. BAH. 2 hits.
PF00439. Bromodomain. 6 hits.
PF00505. HMG_box. 1 hit.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00439. BAH. 2 hits.
SM00297. BROMO. 6 hits.
SM00398. HMG. 1 hit.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 6 hits.
SSF47095. HMG-box. 1 hit.

PROSITE

PS51038. BAH. 2 hits.
PS00633. BROMODOMAIN_1. 5 hits.
PS50014. BROMODOMAIN_2. 6 hits.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1795184.

ChiTaRS

PBRM1. human.

EvolutionaryTrace

Q86U86.

GenomeRNAi

55193.

NextBio

59051.

SOURCE

Search...

Entry information

Entry name

PB1_HUMAN

Accession

Primary (citable) accession number: Q86U86
Secondary accession number(s): A1L381 , A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.