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Protein

Protein polybromo-1

Gene

PBRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1379 – 1447HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • DNA binding Source: UniProtKB-KW

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • chromatin remodeling Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SIGNORiQ86U86.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein polybromo-1
Short name:
hPB1
Alternative name(s):
BRG1-associated factor 180
Short name:
BAF180
Polybromo-1D
Gene namesi
Name:PBRM1
Synonyms:BAF180, PB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30064. PBRM1.

Subcellular locationi

GO - Cellular componenti

  • BAF-type complex Source: MGI
  • nuclear chromosome Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Renal cell carcinoma (RCC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRenal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
See also OMIM:144700

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi55193.
MIMi144700. phenotype.
OpenTargetsiENSG00000163939.
PharmGKBiPA162398846.

Chemistry databases

ChEMBLiCHEMBL1795184.
GuidetoPHARMACOLOGYi2738.

Polymorphism and mutation databases

BioMutaiPBRM1.
DMDMi73921624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112071 – 1689Protein polybromo-1Add BLAST1689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei134PhosphotyrosineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei414N6-acetyllysineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Cross-linki653Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei689PhosphoserineCombined sources1
Modified residuei948PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei1119PhosphoserineCombined sources1
Modified residuei1289PhosphotyrosineBy similarity1
Cross-linki1293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki1293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1398Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1405PhosphoserineCombined sources1
Modified residuei1453PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86U86.
MaxQBiQ86U86.
PeptideAtlasiQ86U86.
PRIDEiQ86U86.

PTM databases

iPTMnetiQ86U86.
PhosphoSitePlusiQ86U86.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000163939.
ExpressionAtlasiQ86U86. baseline and differential.
GenevisibleiQ86U86. HS.

Organism-specific databases

HPAiHPA015629.
HPA059373.

Interactioni

Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with PHF10/BAF45A (By similarity). Interacts with acetylated 'Lys-14' of histone H3 (H3K14ac), and may also interact with other acetylated or methylated Lys residues on histone H3.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARID2Q68CP95EBI-637807,EBI-637818
BRD1O95696-12EBI-637807,EBI-11700916
BRD1O95696-22EBI-637807,EBI-11017508
SMARCA4P515324EBI-637807,EBI-302489

Protein-protein interaction databases

BioGridi120490. 45 interactors.
DIPiDIP-33045N.
IntActiQ86U86. 17 interactors.
MINTiMINT-1195749.

Chemistry databases

BindingDBiQ86U86.

Structurei

Secondary structure

11689
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi46 – 59Combined sources14
Helixi68 – 72Combined sources5
Helixi78 – 80Combined sources3
Helixi82 – 87Combined sources6
Helixi94 – 102Combined sources9
Helixi109 – 126Combined sources18
Helixi132 – 152Combined sources21
Beta strandi176 – 178Combined sources3
Helixi179 – 195Combined sources17
Helixi206 – 208Combined sources3
Turni214 – 216Combined sources3
Helixi218 – 223Combined sources6
Helixi230 – 239Combined sources10
Helixi245 – 262Combined sources18
Helixi268 – 291Combined sources24
Helixi388 – 394Combined sources7
Beta strandi399 – 401Combined sources3
Helixi406 – 408Combined sources3
Turni414 – 416Combined sources3
Helixi418 – 423Combined sources6
Helixi430 – 438Combined sources9
Helixi445 – 462Combined sources18
Helixi468 – 490Combined sources23
Helixi511 – 532Combined sources22
Turni536 – 538Combined sources3
Helixi542 – 546Combined sources5
Turni552 – 554Combined sources3
Helixi556 – 561Combined sources6
Helixi568 – 576Combined sources9
Helixi583 – 600Combined sources18
Helixi606 – 625Combined sources20
Helixi657 – 671Combined sources15
Helixi680 – 684Combined sources5
Turni690 – 692Combined sources3
Helixi696 – 699Combined sources4
Beta strandi700 – 702Combined sources3
Helixi706 – 714Combined sources9
Helixi721 – 738Combined sources18
Helixi744 – 762Combined sources19
Turni763 – 765Combined sources3
Helixi777 – 790Combined sources14
Helixi800 – 804Combined sources5
Helixi822 – 830Combined sources9
Helixi837 – 854Combined sources18
Helixi860 – 882Combined sources23
Helixi889 – 892Combined sources4
Helixi895 – 909Combined sources15
Helixi910 – 913Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KTBNMR-B174-293[»]
3G0JX-ray1.78A/B645-766[»]
3HMFX-ray1.63A178-291[»]
3IU5X-ray1.63A43-154[»]
3IU6X-ray1.79A773-914[»]
3K2JX-ray2.20A/B388-494[»]
3LJWX-ray1.50A/B174-293[»]
3MB4X-ray1.66A/B645-766[»]
3TLPX-ray2.13A/B496-637[»]
4Q0NX-ray1.78A/B/C/D/E/F/G/H645-766[»]
4Q0OX-ray1.83A645-766[»]
4Y03X-ray1.94A/B645-766[»]
5E7DX-ray1.87A/B/C/D645-766[»]
5FH6X-ray2.30A/B/C/D645-766[»]
5FH7X-ray1.47A/B645-766[»]
5FH8X-ray1.55A/B/C/D645-766[»]
5HRVX-ray1.70A645-766[»]
5HRWX-ray1.80A/B645-766[»]
5HRXX-ray1.73A/B645-766[»]
5II1X-ray2.02A/B645-766[»]
5II2X-ray2.10A/B645-766[»]
5IIDX-ray2.40A/B645-766[»]
ProteinModelPortaliQ86U86.
SMRiQ86U86.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86U86.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 134Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini200 – 270Bromo 2PROSITE-ProRule annotationAdd BLAST71
Domaini400 – 470Bromo 3PROSITE-ProRule annotationAdd BLAST71
Domaini538 – 608Bromo 4PROSITE-ProRule annotationAdd BLAST71
Domaini676 – 746Bromo 5PROSITE-ProRule annotationAdd BLAST71
Domaini792 – 862Bromo 6PROSITE-ProRule annotationAdd BLAST71
Domaini956 – 1074BAH 1PROSITE-ProRule annotationAdd BLAST119
Domaini1156 – 1272BAH 2PROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi630 – 633Poly-Asp4
Compositional biasi1468 – 1599Pro-richAdd BLAST132

Sequence similaritiesi

Contains 2 BAH domains.PROSITE-ProRule annotation
Contains 6 bromo domains.PROSITE-ProRule annotation
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

GeneTreeiENSGT00390000003017.
HOVERGENiHBG079860.
InParanoidiQ86U86.
KOiK11757.
OMAiSRYSAKT.
OrthoDBiEOG091G00KN.
PhylomeDBiQ86U86.
TreeFamiTF106120.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
1.20.920.10. 6 hits.
InterProiIPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00439. Bromodomain. 6 hits.
PF00505. HMG_box. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00439. BAH. 2 hits.
SM00297. BROMO. 6 hits.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF47370. SSF47370. 6 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00633. BROMODOMAIN_1. 5 hits.
PS50014. BROMODOMAIN_2. 6 hits.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86U86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC
60 70 80 90 100
HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK
110 120 130 140 150
LKMEEYDDVN LLTADFQLLF NNAKSYYKPD SPEYKAACKL WDLYLRTRNE
160 170 180 190 200
FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA YLKEILEQLL EAIVVATNPS
210 220 230 240 250
GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG SYKSIHAMAK
260 270 280 290 300
DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR
310 320 330 340 350
TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ
360 370 380 390 400
YGSESEEDAA LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ
410 420 430 440 450
GQLIAEPFYH LPSKKKYPDY YQQIKMPISL QQIRTKLKNQ EYETLDHLEC
460 470 480 490 500
DLNLMFENAK RYNVPNSAIY KRVLKLQQVM QAKKKELARR DDIEDGDSMI
510 520 530 540 550
SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR RLCDLFMVKP
560 570 580 590 600
SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY
610 620 630 640 650
NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK
660 670 680 690 700
KSKYMTPMQQ KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI
710 720 730 740 750
KKPMDMEKIR SHMMANKYQD IDSMVEDFVM MFNNACTYNE PESLIYKDAL
760 770 780 790 800
VLHKVLLETR RDLEGDEDSH VPNVTLLIQE LIHNLFVSVM SHQDDEGRCY
810 820 830 840 850
SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF QEHMFEVLER
860 870 880 890 900
ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN
910 920 930 940 950
DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD
960 970 980 990 1000
CSFKNSMYHV GDYVYVEPAE ANLQPHIVCI ERLWEDSAGE KWLYGCWFYR
1010 1020 1030 1040 1050
PNETFHLATR KFLEKEVFKS DYYNKVPVSK ILGKCVVMFV KEYFKLCPEN
1060 1070 1080 1090 1100
FRDEDVFVCE SRYSAKTKSF KKIKLWTMPI SSVRFVPRDV PLPVVRVASV
1110 1120 1130 1140 1150
FANADKGDDE KNTDNSEDSR AEDNFNLEKE KEDVPVEMSN GEPGCHYFEQ
1160 1170 1180 1190 1200
LHYNDMWLKV GDCVFIKSHG LVRPRVGRIE KVWVRDGAAY FYGPIFIHPE
1210 1220 1230 1240 1250
ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP
1260 1270 1280 1290 1300
ENDILLCESR YNESDKQMKK FKGLKRFSLS AKVVDDEIYY FRKPIVPQKE
1310 1320 1330 1340 1350
PSPLLEKKIQ LLEAKFAELE GGDDDIEEMG EEDSEVIEPP SLPQLQTPLA
1360 1370 1380 1390 1400
SELDLMPYTP PQSTPKSAKG SAKKEGSKRK INMSGYILFS SEMRAVIKAQ
1410 1420 1430 1440 1450
HPDYSFGELS RLVGTEWRNL ETAKKAEYEE RAAKVAEQQE RERAAQQQQP
1460 1470 1480 1490 1500
SASPRAGTPV GALMGVVPPP TPMGMLNQQL TPVAGMMGGY PPGLPPLQGP
1510 1520 1530 1540 1550
VDGLVSMGSM QPLHPGGPPP HHLPPGVPGL PGIPPPGVMN QGVAPMVGTP
1560 1570 1580 1590 1600
APGGSPYGQQ VGVLGPPGQQ APPPYPGPHP AGPPVIQQPT TPMFVAPPPK
1610 1620 1630 1640 1650
TQRLLHSEAY LKYIEGLSAE SNSISKWDQT LAARRRDVHL SKEQESRLPS
1660 1670 1680
HWLKSKGAHT TMADALWRLR DLMLRDTLNI RQAYNLENV
Length:1,689
Mass (Da):192,948
Last modified:June 1, 2003 - v1
Checksum:i0A656E319C4FC748
GO
Isoform 2 (identifier: Q86U86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.

Show »
Length:1,634
Mass (Da):187,188
Checksum:iFAB1C935A9B8B4DD
GO
Isoform 3 (identifier: Q86U86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-332: RTPSNLAAARLTGPSHSKGSLGEERNPTSKYYR → S
     1430-1484: Missing.

Show »
Length:1,602
Mass (Da):183,690
Checksum:iB8BA103E359A48DA
GO
Isoform 4 (identifier: Q86U86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1336-1362: Missing.
     1430-1484: Missing.

Show »
Length:1,582
Mass (Da):181,085
Checksum:iA2B8A14FAB928A3C
GO
Isoform 5 (identifier: Q86U86-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.
     1485-1536: Missing.

Show »
Length:1,582
Mass (Da):182,118
Checksum:iBCBD5D8E42BAB076
GO
Isoform 6 (identifier: Q86U86-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     857-1689: Missing.

Show »
Length:856
Mass (Da):99,142
Checksum:iAE378B417E0493B3
GO
Isoform 7 (identifier: Q86U86-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1430-1484: Missing.
     1485-1536: Missing.

Show »
Length:1,597
Mass (Da):183,885
Checksum:i710520F65FF9E981
GO
Isoform 8 (identifier: Q86U86-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1485-1536: Missing.

Show »
Length:1,652
Mass (Da):189,645
Checksum:iE5BA80E11EE7E6C0
GO
Isoform 9 (identifier: Q86U86-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1430-1484: Missing.

Show »
Length:1,609
Mass (Da):184,043
Checksum:i38BB16B06929BFFC
GO

Sequence cautioni

The sequence AAI15010 differs from that shown. Contaminating sequence.Curated
The sequence AAI15011 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI15012 differs from that shown. Reason: Erroneous termination at position 78. Translated as Arg.Curated
The sequence BAB71210 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in AAI15011 (PubMed:15489334).Curated1
Sequence conflicti65G → S in AAI15011 (PubMed:15489334).Curated1
Sequence conflicti242Y → C in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti251D → V in AAI15011 (PubMed:15489334).Curated1
Sequence conflicti430L → P in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti553K → R in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti567D → Y in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti750L → P in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti792H → R in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti927Missing in AAI15010 (PubMed:15489334).Curated1
Sequence conflicti927Missing in BAB71210 (PubMed:14702039).Curated1
Sequence conflicti963Y → H in BAB71210 (PubMed:14702039).Curated1
Sequence conflicti1144G → V in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti1245R → K in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti1306E → G in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti1349L → P in AAI15010 (PubMed:15489334).Curated1
Sequence conflicti1488G → D in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti1568G → R in AAG34760 (PubMed:11078522).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06465349V → L Found in a lung cancer cell line. 1 Publication1
Natural variantiVAR_06465456T → A Found in a brain cancer cell line. 1 Publication1
Natural variantiVAR_06465557Missing Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_06465666R → G Found in a colon cancer cell line. 1 PublicationCorresponds to variant rs368888772dbSNPEnsembl.1
Natural variantiVAR_06465790Q → E Found in a bladder cancer cell line. 1 Publication1
Natural variantiVAR_064658144Y → F Found in a malignant melanoma cell line. 1 Publication1
Natural variantiVAR_064659160E → A Found in a malignant melanoma cell line. 1 Publication1
Natural variantiVAR_064660202R → C Found in a endometrial cancer cell line. 1 PublicationCorresponds to variant rs765525545dbSNPEnsembl.1
Natural variantiVAR_064661206E → K Found in hematopoietic and lymphoid cancer cell lines. 1 Publication1
Natural variantiVAR_064662226E → G Found in hematopoietic and lymphoid cancer cell lines. 1 Publication1
Natural variantiVAR_064663228I → V Found in a breast cancer cell line. 1 PublicationCorresponds to variant rs201022657dbSNPEnsembl.1
Natural variantiVAR_064664232T → P Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064665233I → T Found in a renal carcinoma cell line. 1 Publication1
Natural variantiVAR_064666256A → T Found in an ovary carcinoma cell line. 1 PublicationCorresponds to variant rs776146971dbSNPEnsembl.1
Natural variantiVAR_064667340G → A Found in a malignant melanoma cell line. 1 PublicationCorresponds to variant rs200106731dbSNPEnsembl.1
Natural variantiVAR_064668523M → I Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064669540R → S Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064670597A → D Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064671621K → E Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064672661K → N Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064673674D → E Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064674678R → C.1 Publication1
Natural variantiVAR_064675893Y → C Found in hematopoietic, lymphoid, lung and liver cancer cell lines. 1 PublicationCorresponds to variant rs753344888dbSNPEnsembl.1
Natural variantiVAR_064676895T → S Found in a lung cancer cell line. 1 Publication1
Natural variantiVAR_064677922E → Q Found in a breast cancer cell line. 1 Publication1
Natural variantiVAR_064678925K → Q Found in a colon cancer cell line. 1 Publication1
Natural variantiVAR_0646791079P → Y Requires 2 nucleotide substitutions; found in a colon cancer cell line. 1 Publication1
Natural variantiVAR_0646801098A → S Found in hematopoietic and lymphoid cancer cell lines. 1 PublicationCorresponds to variant rs201156614dbSNPEnsembl.1
Natural variantiVAR_0646811120R → Q Found in hematopoietic and lymphoid cancer cell lines. 1 PublicationCorresponds to variant rs35102895dbSNPEnsembl.1
Natural variantiVAR_0646821177G → S Found in a kidney cancer cell line. 1 Publication1
Natural variantiVAR_0646831204H → P Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_0646841209 – 1214Missing Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication6
Natural variantiVAR_0646851287E → Q Found in a breast cancer cell line. 1 Publication1
Natural variantiVAR_0646861414G → E Found in a lung cancer cell line. 1 Publication1
Natural variantiVAR_0646871503G → C Found in a stomach cancer cell line. 1 Publication1
Natural variantiVAR_0646881560Q → H Found in an endometrial cancer cell line. 1 Publication1
Natural variantiVAR_0646891614I → N Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_0646901647R → C Found in a breast cancer cell line. 1 PublicationCorresponds to variant rs200020801dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015231300 – 332RTPSN…SKYYR → S in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_035499513K → KRNTHDSEMLGLRRLS in isoform 7 and isoform 8. 2 Publications1
Alternative sequenceiVSP_015232857 – 1689Missing in isoform 6. 1 PublicationAdd BLAST833
Alternative sequenceiVSP_015233989 – 1013Missing in isoform 4 and isoform 9. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_0152341336 – 1362Missing in isoform 4. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_0152351430 – 1484Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7 and isoform 9. 4 PublicationsAdd BLAST55
Alternative sequenceiVSP_0152361485 – 1536Missing in isoform 5, isoform 7 and isoform 8. 3 PublicationsAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197569 mRNA. Translation: AAG34760.1.
AF225870 mRNA. Translation: AAG48939.1.
AF225871 mRNA. Translation: AAG48940.1.
AF225872 mRNA. Translation: AAG48941.1.
AF177387 mRNA. Translation: AAG48933.1.
AY281068 mRNA. Translation: AAP34197.1.
BC115009 mRNA. Translation: AAI15010.1. Different termination.
BC115010 mRNA. Translation: AAI15011.1. Different initiation.
BC115011 mRNA. Translation: AAI15012.1. Sequence problems.
BC129934 mRNA. Translation: AAI29935.1.
BC129935 mRNA. Translation: AAI29936.1.
AK056541 mRNA. Translation: BAB71210.1. Different initiation.
CCDSiCCDS43099.1. [Q86U86-4]
RefSeqiNP_060783.3. NM_018313.4. [Q86U86-4]
NP_851385.1. NM_181042.4.
XP_016862237.1. XM_017006748.1. [Q86U86-1]
XP_016862238.1. XM_017006749.1. [Q86U86-1]
XP_016862239.1. XM_017006750.1. [Q86U86-1]
XP_016862246.1. XM_017006757.1. [Q86U86-2]
XP_016862247.1. XM_017006758.1. [Q86U86-2]
UniGeneiHs.189920.

Genome annotation databases

EnsembliENST00000296302; ENSP00000296302; ENSG00000163939. [Q86U86-1]
ENST00000337303; ENSP00000338302; ENSG00000163939. [Q86U86-5]
ENST00000356770; ENSP00000349213; ENSG00000163939. [Q86U86-3]
ENST00000394830; ENSP00000378307; ENSG00000163939. [Q86U86-4]
ENST00000409057; ENSP00000386593; ENSG00000163939. [Q86U86-2]
ENST00000409114; ENSP00000386643; ENSG00000163939. [Q86U86-8]
ENST00000409767; ENSP00000386601; ENSG00000163939. [Q86U86-7]
ENST00000410007; ENSP00000386529; ENSG00000163939. [Q86U86-9]
ENST00000412587; ENSP00000404579; ENSG00000163939. [Q86U86-6]
GeneIDi55193.
KEGGihsa:55193.
UCSCiuc003deq.3. human. [Q86U86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197569 mRNA. Translation: AAG34760.1.
AF225870 mRNA. Translation: AAG48939.1.
AF225871 mRNA. Translation: AAG48940.1.
AF225872 mRNA. Translation: AAG48941.1.
AF177387 mRNA. Translation: AAG48933.1.
AY281068 mRNA. Translation: AAP34197.1.
BC115009 mRNA. Translation: AAI15010.1. Different termination.
BC115010 mRNA. Translation: AAI15011.1. Different initiation.
BC115011 mRNA. Translation: AAI15012.1. Sequence problems.
BC129934 mRNA. Translation: AAI29935.1.
BC129935 mRNA. Translation: AAI29936.1.
AK056541 mRNA. Translation: BAB71210.1. Different initiation.
CCDSiCCDS43099.1. [Q86U86-4]
RefSeqiNP_060783.3. NM_018313.4. [Q86U86-4]
NP_851385.1. NM_181042.4.
XP_016862237.1. XM_017006748.1. [Q86U86-1]
XP_016862238.1. XM_017006749.1. [Q86U86-1]
XP_016862239.1. XM_017006750.1. [Q86U86-1]
XP_016862246.1. XM_017006757.1. [Q86U86-2]
XP_016862247.1. XM_017006758.1. [Q86U86-2]
UniGeneiHs.189920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KTBNMR-B174-293[»]
3G0JX-ray1.78A/B645-766[»]
3HMFX-ray1.63A178-291[»]
3IU5X-ray1.63A43-154[»]
3IU6X-ray1.79A773-914[»]
3K2JX-ray2.20A/B388-494[»]
3LJWX-ray1.50A/B174-293[»]
3MB4X-ray1.66A/B645-766[»]
3TLPX-ray2.13A/B496-637[»]
4Q0NX-ray1.78A/B/C/D/E/F/G/H645-766[»]
4Q0OX-ray1.83A645-766[»]
4Y03X-ray1.94A/B645-766[»]
5E7DX-ray1.87A/B/C/D645-766[»]
5FH6X-ray2.30A/B/C/D645-766[»]
5FH7X-ray1.47A/B645-766[»]
5FH8X-ray1.55A/B/C/D645-766[»]
5HRVX-ray1.70A645-766[»]
5HRWX-ray1.80A/B645-766[»]
5HRXX-ray1.73A/B645-766[»]
5II1X-ray2.02A/B645-766[»]
5II2X-ray2.10A/B645-766[»]
5IIDX-ray2.40A/B645-766[»]
ProteinModelPortaliQ86U86.
SMRiQ86U86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120490. 45 interactors.
DIPiDIP-33045N.
IntActiQ86U86. 17 interactors.
MINTiMINT-1195749.

Chemistry databases

BindingDBiQ86U86.
ChEMBLiCHEMBL1795184.
GuidetoPHARMACOLOGYi2738.

PTM databases

iPTMnetiQ86U86.
PhosphoSitePlusiQ86U86.

Polymorphism and mutation databases

BioMutaiPBRM1.
DMDMi73921624.

Proteomic databases

EPDiQ86U86.
MaxQBiQ86U86.
PeptideAtlasiQ86U86.
PRIDEiQ86U86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296302; ENSP00000296302; ENSG00000163939. [Q86U86-1]
ENST00000337303; ENSP00000338302; ENSG00000163939. [Q86U86-5]
ENST00000356770; ENSP00000349213; ENSG00000163939. [Q86U86-3]
ENST00000394830; ENSP00000378307; ENSG00000163939. [Q86U86-4]
ENST00000409057; ENSP00000386593; ENSG00000163939. [Q86U86-2]
ENST00000409114; ENSP00000386643; ENSG00000163939. [Q86U86-8]
ENST00000409767; ENSP00000386601; ENSG00000163939. [Q86U86-7]
ENST00000410007; ENSP00000386529; ENSG00000163939. [Q86U86-9]
ENST00000412587; ENSP00000404579; ENSG00000163939. [Q86U86-6]
GeneIDi55193.
KEGGihsa:55193.
UCSCiuc003deq.3. human. [Q86U86-1]

Organism-specific databases

CTDi55193.
DisGeNETi55193.
GeneCardsiPBRM1.
H-InvDBHIX0003364.
HGNCiHGNC:30064. PBRM1.
HPAiHPA015629.
HPA059373.
MIMi144700. phenotype.
606083. gene.
neXtProtiNX_Q86U86.
OpenTargetsiENSG00000163939.
PharmGKBiPA162398846.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000003017.
HOVERGENiHBG079860.
InParanoidiQ86U86.
KOiK11757.
OMAiSRYSAKT.
OrthoDBiEOG091G00KN.
PhylomeDBiQ86U86.
TreeFamiTF106120.

Enzyme and pathway databases

ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SIGNORiQ86U86.

Miscellaneous databases

ChiTaRSiPBRM1. human.
EvolutionaryTraceiQ86U86.
GeneWikiiPBRM1.
GenomeRNAii55193.
PROiQ86U86.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163939.
ExpressionAtlasiQ86U86. baseline and differential.
GenevisibleiQ86U86. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
1.20.920.10. 6 hits.
InterProiIPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00439. Bromodomain. 6 hits.
PF00505. HMG_box. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00439. BAH. 2 hits.
SM00297. BROMO. 6 hits.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF47370. SSF47370. 6 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00633. BROMODOMAIN_1. 5 hits.
PS50014. BROMODOMAIN_2. 6 hits.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPB1_HUMAN
AccessioniPrimary (citable) accession number: Q86U86
Secondary accession number(s): A1L381
, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.