SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86U86

- PB1_HUMAN

UniProt

Q86U86 - PB1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein polybromo-1
Gene
PBRM1, BAF180, PB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1379 – 144769HMG box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. chromatin binding Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. chromatin remodeling Source: UniProtKB
  2. heart development Source: Ensembl
  3. mitotic nuclear division Source: UniProtKB
  4. negative regulation of cell proliferation Source: UniProtKB
  5. placenta development Source: Ensembl
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein polybromo-1
Short name:
hPB1
Alternative name(s):
BRG1-associated factor 180
Short name:
BAF180
Polybromo-1D
Gene namesi
Name:PBRM1
Synonyms:BAF180, PB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30064. PBRM1.

Subcellular locationi

GO - Cellular componenti

  1. kinetochore Source: Ensembl
  2. nuclear chromosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

MIMi144700. phenotype.
PharmGKBiPA162398846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16891689Protein polybromo-1
PRO_0000211207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphoserine2 Publications
Modified residuei39 – 391Phosphoserine4 Publications
Modified residuei131 – 1311Phosphoserine1 Publication
Modified residuei316 – 3161Phosphoserine1 Publication
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei353 – 3531Phosphoserine4 Publications
Modified residuei355 – 3551Phosphoserine4 Publications
Modified residuei371 – 3711Phosphoserine1 Publication
Modified residuei375 – 3751Phosphoserine1 Publication
Modified residuei414 – 4141N6-acetyllysine By similarity
Modified residuei498 – 4981Phosphoserine1 Publication
Modified residuei636 – 6361Phosphoserine3 Publications
Modified residuei648 – 6481Phosphoserine1 Publication
Modified residuei1289 – 12891Phosphotyrosine By similarity
Modified residuei1405 – 14051Phosphoserine2 Publications
Modified residuei1453 – 14531Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ86U86.
PaxDbiQ86U86.
PRIDEiQ86U86.

PTM databases

PhosphoSiteiQ86U86.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ86U86.
BgeeiQ86U86.
GenevestigatoriQ86U86.

Organism-specific databases

HPAiHPA015629.

Interactioni

Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with PHF10/BAF45A By similarity. Interacts with acetylated 'Lys-14' of histone H3 (H3K14ac), and may also interact with other acetylated or methylated Lys residues on histone H3.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARID2Q68CP95EBI-637807,EBI-637818
SMARCA4P515324EBI-637807,EBI-302489

Protein-protein interaction databases

BioGridi120490. 32 interactions.
DIPiDIP-33045N.
IntActiQ86U86. 14 interactions.
MINTiMINT-1195749.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi46 – 5914
Helixi68 – 725
Helixi78 – 803
Helixi82 – 876
Helixi94 – 1029
Helixi109 – 12618
Helixi132 – 15221
Beta strandi176 – 1783
Helixi179 – 19517
Helixi206 – 2083
Turni214 – 2163
Helixi218 – 2236
Helixi230 – 23910
Helixi245 – 26218
Helixi268 – 29124
Helixi388 – 3947
Beta strandi399 – 4013
Helixi406 – 4083
Turni414 – 4163
Helixi418 – 4236
Helixi430 – 4389
Helixi445 – 46218
Helixi468 – 49023
Helixi511 – 53222
Turni536 – 5383
Helixi542 – 5465
Turni552 – 5543
Helixi556 – 5616
Helixi568 – 5769
Helixi583 – 60018
Helixi606 – 62520
Helixi657 – 67115
Helixi680 – 6845
Turni690 – 6923
Helixi694 – 6996
Beta strandi700 – 7023
Helixi706 – 7149
Helixi721 – 73818
Helixi744 – 76219
Turni763 – 7653
Helixi777 – 79014
Helixi800 – 8045
Helixi822 – 8309
Helixi837 – 85418
Helixi860 – 88223
Helixi889 – 8924
Helixi895 – 90915
Helixi910 – 9134

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KTBNMR-B174-293[»]
3G0JX-ray1.78A/B645-766[»]
3HMFX-ray1.63A178-291[»]
3IU5X-ray1.63A43-154[»]
3IU6X-ray1.79A773-914[»]
3K2JX-ray2.20A/B388-494[»]
3LJWX-ray1.50A/B174-293[»]
3MB4X-ray1.66A/B645-766[»]
3TLPX-ray2.13A/B496-637[»]
4Q0NX-ray1.78A/B/C/D/E/F/G/H645-766[»]
4Q0OX-ray1.83A645-766[»]
ProteinModelPortaliQ86U86.
SMRiQ86U86. Positions 26-293, 383-766, 773-914, 957-1102, 1160-1272, 1370-1444.

Miscellaneous databases

EvolutionaryTraceiQ86U86.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 13471Bromo 1
Add
BLAST
Domaini200 – 27071Bromo 2
Add
BLAST
Domaini400 – 47071Bromo 3
Add
BLAST
Domaini538 – 60871Bromo 4
Add
BLAST
Domaini676 – 74671Bromo 5
Add
BLAST
Domaini792 – 86271Bromo 6
Add
BLAST
Domaini956 – 1074119BAH 1
Add
BLAST
Domaini1156 – 1272117BAH 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi630 – 6334Poly-Asp
Compositional biasi1468 – 1599132Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 2 BAH domains.
Contains 6 bromo domains.

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiCOG5076.
HOVERGENiHBG079860.
InParanoidiQ86U86.
KOiK11757.
OMAiILGKCVV.
OrthoDBiEOG78H3S6.
PhylomeDBiQ86U86.
TreeFamiTF106120.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
1.20.920.10. 6 hits.
InterProiIPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00439. Bromodomain. 6 hits.
PF00505. HMG_box. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00439. BAH. 2 hits.
SM00297. BROMO. 6 hits.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF47370. SSF47370. 6 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00633. BROMODOMAIN_1. 5 hits.
PS50014. BROMODOMAIN_2. 6 hits.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86U86-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC     50
HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK 100
LKMEEYDDVN LLTADFQLLF NNAKSYYKPD SPEYKAACKL WDLYLRTRNE 150
FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA YLKEILEQLL EAIVVATNPS 200
GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG SYKSIHAMAK 250
DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR 300
TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ 350
YGSESEEDAA LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ 400
GQLIAEPFYH LPSKKKYPDY YQQIKMPISL QQIRTKLKNQ EYETLDHLEC 450
DLNLMFENAK RYNVPNSAIY KRVLKLQQVM QAKKKELARR DDIEDGDSMI 500
SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR RLCDLFMVKP 550
SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY 600
NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK 650
KSKYMTPMQQ KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI 700
KKPMDMEKIR SHMMANKYQD IDSMVEDFVM MFNNACTYNE PESLIYKDAL 750
VLHKVLLETR RDLEGDEDSH VPNVTLLIQE LIHNLFVSVM SHQDDEGRCY 800
SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF QEHMFEVLER 850
ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN 900
DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD 950
CSFKNSMYHV GDYVYVEPAE ANLQPHIVCI ERLWEDSAGE KWLYGCWFYR 1000
PNETFHLATR KFLEKEVFKS DYYNKVPVSK ILGKCVVMFV KEYFKLCPEN 1050
FRDEDVFVCE SRYSAKTKSF KKIKLWTMPI SSVRFVPRDV PLPVVRVASV 1100
FANADKGDDE KNTDNSEDSR AEDNFNLEKE KEDVPVEMSN GEPGCHYFEQ 1150
LHYNDMWLKV GDCVFIKSHG LVRPRVGRIE KVWVRDGAAY FYGPIFIHPE 1200
ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP 1250
ENDILLCESR YNESDKQMKK FKGLKRFSLS AKVVDDEIYY FRKPIVPQKE 1300
PSPLLEKKIQ LLEAKFAELE GGDDDIEEMG EEDSEVIEPP SLPQLQTPLA 1350
SELDLMPYTP PQSTPKSAKG SAKKEGSKRK INMSGYILFS SEMRAVIKAQ 1400
HPDYSFGELS RLVGTEWRNL ETAKKAEYEE RAAKVAEQQE RERAAQQQQP 1450
SASPRAGTPV GALMGVVPPP TPMGMLNQQL TPVAGMMGGY PPGLPPLQGP 1500
VDGLVSMGSM QPLHPGGPPP HHLPPGVPGL PGIPPPGVMN QGVAPMVGTP 1550
APGGSPYGQQ VGVLGPPGQQ APPPYPGPHP AGPPVIQQPT TPMFVAPPPK 1600
TQRLLHSEAY LKYIEGLSAE SNSISKWDQT LAARRRDVHL SKEQESRLPS 1650
HWLKSKGAHT TMADALWRLR DLMLRDTLNI RQAYNLENV 1689
Length:1,689
Mass (Da):192,948
Last modified:June 1, 2003 - v1
Checksum:i0A656E319C4FC748
GO
Isoform 2 (identifier: Q86U86-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.

Show »
Length:1,634
Mass (Da):187,188
Checksum:iFAB1C935A9B8B4DD
GO
Isoform 3 (identifier: Q86U86-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-332: RTPSNLAAARLTGPSHSKGSLGEERNPTSKYYR → S
     1430-1484: Missing.

Show »
Length:1,602
Mass (Da):183,690
Checksum:iB8BA103E359A48DA
GO
Isoform 4 (identifier: Q86U86-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1336-1362: Missing.
     1430-1484: Missing.

Show »
Length:1,582
Mass (Da):181,085
Checksum:iA2B8A14FAB928A3C
GO
Isoform 5 (identifier: Q86U86-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.
     1485-1536: Missing.

Show »
Length:1,582
Mass (Da):182,118
Checksum:iBCBD5D8E42BAB076
GO
Isoform 6 (identifier: Q86U86-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     857-1689: Missing.

Show »
Length:856
Mass (Da):99,142
Checksum:iAE378B417E0493B3
GO
Isoform 7 (identifier: Q86U86-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1430-1484: Missing.
     1485-1536: Missing.

Show »
Length:1,597
Mass (Da):183,885
Checksum:i710520F65FF9E981
GO
Isoform 8 (identifier: Q86U86-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1485-1536: Missing.

Show »
Length:1,652
Mass (Da):189,645
Checksum:iE5BA80E11EE7E6C0
GO
Isoform 9 (identifier: Q86U86-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1430-1484: Missing.

Show »
Length:1,609
Mass (Da):184,043
Checksum:i38BB16B06929BFFC
GO

Sequence cautioni

The sequence AAI15010.1 differs from that shown. Reason: Contaminating sequence.
The sequence AAI15011.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB71210.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI15012.1 differs from that shown. Reason: Erroneous termination at position 78. Translated as Arg.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491V → L Found in a lung cancer cell line. 1 Publication
VAR_064653
Natural varianti56 – 561T → A Found in a brain cancer cell line. 1 Publication
VAR_064654
Natural varianti57 – 571Missing Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064655
Natural varianti66 – 661R → G Found in a colon cancer cell line. 1 Publication
VAR_064656
Natural varianti90 – 901Q → E Found in a bladder cancer cell line. 1 Publication
VAR_064657
Natural varianti144 – 1441Y → F Found in a malignant melanoma cell line. 1 Publication
VAR_064658
Natural varianti160 – 1601E → A Found in a malignant melanoma cell line. 1 Publication
VAR_064659
Natural varianti202 – 2021R → C Found in a endometrial cancer cell line. 1 Publication
VAR_064660
Natural varianti206 – 2061E → K Found in hematopoietic and lymphoid cancer cell lines. 1 Publication
VAR_064661
Natural varianti226 – 2261E → G Found in hematopoietic and lymphoid cancer cell lines. 1 Publication
VAR_064662
Natural varianti228 – 2281I → V Found in a breast cancer cell line. 1 Publication
Corresponds to variant rs201022657 [ dbSNP | Ensembl ].
VAR_064663
Natural varianti232 – 2321T → P Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064664
Natural varianti233 – 2331I → T Found in a renal carcinoma cell line. 1 Publication
VAR_064665
Natural varianti256 – 2561A → T Found in an ovary carcinoma cell line. 1 Publication
VAR_064666
Natural varianti340 – 3401G → A Found in a malignant melanoma cell line. 1 Publication
VAR_064667
Natural varianti523 – 5231M → I Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064668
Natural varianti540 – 5401R → S Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064669
Natural varianti597 – 5971A → D Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064670
Natural varianti621 – 6211K → E Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064671
Natural varianti661 – 6611K → N Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064672
Natural varianti674 – 6741D → E Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064673
Natural varianti678 – 6781R → C.1 Publication
VAR_064674
Natural varianti893 – 8931Y → C Found in hematopoietic, lymphoid, lung and liver cancer cell lines. 1 Publication
VAR_064675
Natural varianti895 – 8951T → S Found in a lung cancer cell line. 1 Publication
VAR_064676
Natural varianti922 – 9221E → Q Found in a breast cancer cell line. 1 Publication
VAR_064677
Natural varianti925 – 9251K → Q Found in a colon cancer cell line. 1 Publication
VAR_064678
Natural varianti1079 – 10791P → Y Requires 2 nucleotide substitutions; found in a colon cancer cell line. 1 Publication
VAR_064679
Natural varianti1098 – 10981A → S Found in hematopoietic and lymphoid cancer cell lines. 1 Publication
VAR_064680
Natural varianti1120 – 11201R → Q Found in hematopoietic and lymphoid cancer cell lines. 1 Publication
VAR_064681
Natural varianti1177 – 11771G → S Found in a kidney cancer cell line. 1 Publication
VAR_064682
Natural varianti1204 – 12041H → P Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064683
Natural varianti1209 – 12146Missing Found in a case of clear cell renal carcinoma; somatic mutation.
VAR_064684
Natural varianti1287 – 12871E → Q Found in a breast cancer cell line. 1 Publication
VAR_064685
Natural varianti1414 – 14141G → E Found in a lung cancer cell line. 1 Publication
VAR_064686
Natural varianti1503 – 15031G → C Found in a stomach cancer cell line. 1 Publication
VAR_064687
Natural varianti1560 – 15601Q → H Found in an endometrial cancer cell line. 1 Publication
VAR_064688
Natural varianti1614 – 16141I → N Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication
VAR_064689
Natural varianti1647 – 16471R → C Found in a breast cancer cell line. 1 Publication
VAR_064690

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei300 – 33233RTPSN…SKYYR → S in isoform 3.
VSP_015231Add
BLAST
Alternative sequencei513 – 5131K → KRNTHDSEMLGLRRLS in isoform 7 and isoform 8.
VSP_035499
Alternative sequencei857 – 1689833Missing in isoform 6.
VSP_015232Add
BLAST
Alternative sequencei989 – 101325Missing in isoform 4 and isoform 9.
VSP_015233Add
BLAST
Alternative sequencei1336 – 136227Missing in isoform 4.
VSP_015234Add
BLAST
Alternative sequencei1430 – 148455Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7 and isoform 9.
VSP_015235Add
BLAST
Alternative sequencei1485 – 153652Missing in isoform 5, isoform 7 and isoform 8.
VSP_015236Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → T in AAI15011. 1 Publication
Sequence conflicti65 – 651G → S in AAI15011. 1 Publication
Sequence conflicti242 – 2421Y → C in AAI15012. 1 Publication
Sequence conflicti251 – 2511D → V in AAI15011. 1 Publication
Sequence conflicti430 – 4301L → P in AAI15012. 1 Publication
Sequence conflicti553 – 5531K → R in AAG34760. 1 Publication
Sequence conflicti567 – 5671D → Y in AAI15012. 1 Publication
Sequence conflicti750 – 7501L → P in AAI15012. 1 Publication
Sequence conflicti792 – 7921H → R in AAI15012. 1 Publication
Sequence conflicti927 – 9271Missing in AAI15010. 1 Publication
Sequence conflicti927 – 9271Missing in BAB71210. 1 Publication
Sequence conflicti963 – 9631Y → H in BAB71210. 1 Publication
Sequence conflicti1144 – 11441G → V in AAG34760. 1 Publication
Sequence conflicti1245 – 12451R → K in AAG34760. 1 Publication
Sequence conflicti1306 – 13061E → G in AAG34760. 1 Publication
Sequence conflicti1349 – 13491L → P in AAI15010. 1 Publication
Sequence conflicti1488 – 14881G → D in AAI15012. 1 Publication
Sequence conflicti1568 – 15681G → R in AAG34760. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF197569 mRNA. Translation: AAG34760.1.
AF225870 mRNA. Translation: AAG48939.1.
AF225871 mRNA. Translation: AAG48940.1.
AF225872 mRNA. Translation: AAG48941.1.
AF177387 mRNA. Translation: AAG48933.1.
AY281068 mRNA. Translation: AAP34197.1.
BC115009 mRNA. Translation: AAI15010.1. Different termination.
BC115010 mRNA. Translation: AAI15011.1. Different initiation.
BC115011 mRNA. Translation: AAI15012.1. Sequence problems.
BC129934 mRNA. Translation: AAI29935.1.
BC129935 mRNA. Translation: AAI29936.1.
AK056541 mRNA. Translation: BAB71210.1. Different initiation.
CCDSiCCDS43099.1. [Q86U86-4]
RefSeqiNP_060783.3. NM_018313.4. [Q86U86-4]
UniGeneiHs.189920.

Genome annotation databases

EnsembliENST00000296302; ENSP00000296302; ENSG00000163939. [Q86U86-1]
ENST00000337303; ENSP00000338302; ENSG00000163939. [Q86U86-5]
ENST00000356770; ENSP00000349213; ENSG00000163939. [Q86U86-3]
ENST00000394830; ENSP00000378307; ENSG00000163939. [Q86U86-4]
ENST00000409057; ENSP00000386593; ENSG00000163939. [Q86U86-2]
ENST00000409114; ENSP00000386643; ENSG00000163939. [Q86U86-8]
ENST00000409767; ENSP00000386601; ENSG00000163939. [Q86U86-7]
ENST00000410007; ENSP00000386529; ENSG00000163939. [Q86U86-9]
ENST00000412587; ENSP00000404579; ENSG00000163939. [Q86U86-6]
GeneIDi55193.
KEGGihsa:55193.
UCSCiuc003deq.2. human. [Q86U86-5]
uc003der.2. human. [Q86U86-3]
uc003des.2. human. [Q86U86-1]
uc003det.2. human. [Q86U86-7]
uc003deu.2. human. [Q86U86-8]
uc003dew.2. human. [Q86U86-2]
uc003dey.2. human. [Q86U86-4]
uc010hmk.1. human. [Q86U86-9]

Polymorphism databases

DMDMi73921624.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF197569 mRNA. Translation: AAG34760.1 .
AF225870 mRNA. Translation: AAG48939.1 .
AF225871 mRNA. Translation: AAG48940.1 .
AF225872 mRNA. Translation: AAG48941.1 .
AF177387 mRNA. Translation: AAG48933.1 .
AY281068 mRNA. Translation: AAP34197.1 .
BC115009 mRNA. Translation: AAI15010.1 . Different termination.
BC115010 mRNA. Translation: AAI15011.1 . Different initiation.
BC115011 mRNA. Translation: AAI15012.1 . Sequence problems.
BC129934 mRNA. Translation: AAI29935.1 .
BC129935 mRNA. Translation: AAI29936.1 .
AK056541 mRNA. Translation: BAB71210.1 . Different initiation.
CCDSi CCDS43099.1. [Q86U86-4 ]
RefSeqi NP_060783.3. NM_018313.4. [Q86U86-4 ]
UniGenei Hs.189920.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KTB NMR - B 174-293 [» ]
3G0J X-ray 1.78 A/B 645-766 [» ]
3HMF X-ray 1.63 A 178-291 [» ]
3IU5 X-ray 1.63 A 43-154 [» ]
3IU6 X-ray 1.79 A 773-914 [» ]
3K2J X-ray 2.20 A/B 388-494 [» ]
3LJW X-ray 1.50 A/B 174-293 [» ]
3MB4 X-ray 1.66 A/B 645-766 [» ]
3TLP X-ray 2.13 A/B 496-637 [» ]
4Q0N X-ray 1.78 A/B/C/D/E/F/G/H 645-766 [» ]
4Q0O X-ray 1.83 A 645-766 [» ]
ProteinModelPortali Q86U86.
SMRi Q86U86. Positions 26-293, 383-766, 773-914, 957-1102, 1160-1272, 1370-1444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120490. 32 interactions.
DIPi DIP-33045N.
IntActi Q86U86. 14 interactions.
MINTi MINT-1195749.

Chemistry

ChEMBLi CHEMBL1795184.

PTM databases

PhosphoSitei Q86U86.

Polymorphism databases

DMDMi 73921624.

Proteomic databases

MaxQBi Q86U86.
PaxDbi Q86U86.
PRIDEi Q86U86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296302 ; ENSP00000296302 ; ENSG00000163939 . [Q86U86-1 ]
ENST00000337303 ; ENSP00000338302 ; ENSG00000163939 . [Q86U86-5 ]
ENST00000356770 ; ENSP00000349213 ; ENSG00000163939 . [Q86U86-3 ]
ENST00000394830 ; ENSP00000378307 ; ENSG00000163939 . [Q86U86-4 ]
ENST00000409057 ; ENSP00000386593 ; ENSG00000163939 . [Q86U86-2 ]
ENST00000409114 ; ENSP00000386643 ; ENSG00000163939 . [Q86U86-8 ]
ENST00000409767 ; ENSP00000386601 ; ENSG00000163939 . [Q86U86-7 ]
ENST00000410007 ; ENSP00000386529 ; ENSG00000163939 . [Q86U86-9 ]
ENST00000412587 ; ENSP00000404579 ; ENSG00000163939 . [Q86U86-6 ]
GeneIDi 55193.
KEGGi hsa:55193.
UCSCi uc003deq.2. human. [Q86U86-5 ]
uc003der.2. human. [Q86U86-3 ]
uc003des.2. human. [Q86U86-1 ]
uc003det.2. human. [Q86U86-7 ]
uc003deu.2. human. [Q86U86-8 ]
uc003dew.2. human. [Q86U86-2 ]
uc003dey.2. human. [Q86U86-4 ]
uc010hmk.1. human. [Q86U86-9 ]

Organism-specific databases

CTDi 55193.
GeneCardsi GC03M052579.
H-InvDB HIX0003364.
HGNCi HGNC:30064. PBRM1.
HPAi HPA015629.
MIMi 144700. phenotype.
606083. gene.
neXtProti NX_Q86U86.
PharmGKBi PA162398846.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5076.
HOVERGENi HBG079860.
InParanoidi Q86U86.
KOi K11757.
OMAi ILGKCVV.
OrthoDBi EOG78H3S6.
PhylomeDBi Q86U86.
TreeFami TF106120.

Miscellaneous databases

ChiTaRSi PBRM1. human.
EvolutionaryTracei Q86U86.
GeneWikii PBRM1.
GenomeRNAii 55193.
NextBioi 59051.
PROi Q86U86.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86U86.
Bgeei Q86U86.
Genevestigatori Q86U86.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
1.20.920.10. 6 hits.
InterProi IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF01426. BAH. 2 hits.
PF00439. Bromodomain. 6 hits.
PF00505. HMG_box. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00439. BAH. 2 hits.
SM00297. BROMO. 6 hits.
SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
SSF47370. SSF47370. 6 hits.
PROSITEi PS51038. BAH. 2 hits.
PS00633. BROMODOMAIN_1. 5 hits.
PS50014. BROMODOMAIN_2. 6 hits.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes."
    Xue Y., Canman J.C., Lee C.S., Nie Z., Yang D., Moreno G.T., Young M.K., Salmon E.D., Wang W.
    Proc. Natl. Acad. Sci. U.S.A. 97:13015-13020(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE PBAF COMPLEX.
  2. "cDNA cloning of the human polybromo-1 gene on chromosome 3p21."
    Horikawa I., Barrett J.C.
    DNA Seq. 13:211-215(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 5 AND 6), TISSUE SPECIFICITY.
  3. "The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer."
    Sekine I., Sato M., Sunaga N., Toyooka S., Peyton M., Parsons R., Wang W., Gazdar A.F., Minna J.D.
    Oncogene 24:2735-2738(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4; 7; 8 AND 9).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-1127 (ISOFORM 7).
    Tissue: Teratocarcinoma.
  6. "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription."
    Lemon B., Inouye C., King D.S., Tjian R.
    Nature 414:924-928(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PBAF COMPLEX, IDENTIFICATION IN A SWI/SNF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1453, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-39; SER-131; SER-316; SER-319; SER-353; SER-355 AND SER-1405, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-39; SER-353; SER-355; SER-371; SER-375; SER-498 AND SER-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-353; SER-355; SER-636; SER-1405 AND SER-1453, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: FUNCTION AS NEGATIVE REGULATOR OF CELL PROLIFERATION, INVOLVEMENT IN RCC, VARIANTS LEU-49; ALA-56; ILE-57 DEL; GLY-66; GLU-90; PHE-144; ALA-160; CYS-202; LYS-206; GLY-226; VAL-228; PRO-232; THR-233; THR-256; ALA-340; ILE-523; SER-540; ASP-597; GLU-621; ASN-661; GLU-674; CYS-678; CYS-893; SER-895; GLN-922; GLN-925; TYR-1079; SER-1098; GLN-1120; SER-1177; PRO-1204; 1209-MET--GLU-1214 DEL; GLN-1287; GLU-1414; CYS-1503; HIS-1560; ASN-1614 AND CYS-1647.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353; SER-355; SER-636; SER-648 AND SER-1453, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Recent advances in understanding chromatin remodeling by SWI/SNF complexes."
    Martens J.A., Winston F.
    Curr. Opin. Genet. Dev. 13:136-142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON SWI/SNF CHROMATIN-REMODELING COMPLEXES.
  17. "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes."
    Yan Z., Cui K., Murray D.M., Ling C., Xue Y., Gerstein A., Parsons R., Zhao K., Wang W.
    Genes Dev. 19:1662-1667(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PBAF COMPLEX.
  18. "Structural insights into selective histone H3 recognition by the human polybromo bromodomain 2."
    Charlop-Powers Z., Zeng L., Zhang Q., Zhou M.M.
    Cell Res. 20:529-538(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 174-293, INTERACTION WITH ACETYLATED HISTONE H3.
  19. Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 43-917, INTERACTION WITH HISTONE H3.

Entry informationi

Entry nameiPB1_HUMAN
AccessioniPrimary (citable) accession number: Q86U86
Secondary accession number(s): A1L381
, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi