##gff-version 3 Q86U44 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Q86U44 UniProtKB Chain 2 580 . . . ID=PRO_0000207630;Note=N6-adenosine-methyltransferase catalytic subunit Q86U44 UniProtKB Region 1 70 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86U44 UniProtKB Region 198 219 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86U44 UniProtKB Region 396 410 . . . Note=Gate loop 1;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Region 450 454 . . . Note=Interaction with METTL14;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0007744|PDB:5IL0,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2;Dbxref=PMID:27281194 Q86U44 UniProtKB Region 462 479 . . . Note=Interphase loop;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Region 464 480 . . . Note=Interaction with METTL14;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0007744|PDB:5IL0,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2;Dbxref=PMID:27281194 Q86U44 UniProtKB Region 465 478 . . . Note=Positively charged region required for RNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Region 507 515 . . . Note=Gate loop 2;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Motif 210 215 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Compositional bias 13 34 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86U44 UniProtKB Compositional bias 43 64 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86U44 UniProtKB Binding site 377 378 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337,ECO:0000269|PubMed:27627798,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2,ECO:0007744|PDB:5K7U,ECO:0007744|PDB:5K7W,ECO:0007744|PDB:5L6D,ECO:0007744|PDB:5L6E;Dbxref=PMID:27281194,PMID:27373337,PMID:27627798 Q86U44 UniProtKB Binding site 395 395 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2,ECO:0007744|PDB:5K7U,ECO:0007744|PDB:5K7W;Dbxref=PMID:27281194,PMID:27373337 Q86U44 UniProtKB Binding site 513 513 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2,ECO:0007744|PDB:5K7U,ECO:0007744|PDB:5K7W;Dbxref=PMID:27281194,PMID:27373337 Q86U44 UniProtKB Binding site 536 539 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337,ECO:0000269|PubMed:27627798,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2,ECO:0007744|PDB:5K7U,ECO:0007744|PDB:5K7W,ECO:0007744|PDB:5L6D,ECO:0007744|PDB:5L6E;Dbxref=PMID:27281194,PMID:27373337,PMID:27627798 Q86U44 UniProtKB Binding site 549 550 . . . Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337,ECO:0000269|PubMed:27627798,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2,ECO:0007744|PDB:5K7U,ECO:0007744|PDB:5K7W,ECO:0007744|PDB:5L6D,ECO:0007744|PDB:5L6E;Dbxref=PMID:27281194,PMID:27373337,PMID:27627798 Q86U44 UniProtKB Site 438 438 . . . Note=Interaction with METTL14;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2;Dbxref=PMID:27281194 Q86U44 UniProtKB Site 441 441 . . . Note=Interaction with METTL14;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27281194,ECO:0007744|PDB:5IL1,ECO:0007744|PDB:5IL2;Dbxref=PMID:27281194 Q86U44 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Q86U44 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Modified residue 43 43 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:29348140,ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163,PMID:29348140 Q86U44 UniProtKB Modified residue 48 48 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Modified residue 50 50 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Modified residue 219 219 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:29348140,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163,PMID:29348140 Q86U44 UniProtKB Modified residue 243 243 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:29348140,ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648,PMID:29348140 Q86U44 UniProtKB Modified residue 348 348 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:29348140,ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163,PMID:29348140 Q86U44 UniProtKB Modified residue 350 350 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Cross-link 177 177 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29506078;Dbxref=PMID:29506078 Q86U44 UniProtKB Cross-link 211 211 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29506078;Dbxref=PMID:29506078 Q86U44 UniProtKB Cross-link 212 212 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29506078;Dbxref=PMID:29506078 Q86U44 UniProtKB Cross-link 215 215 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29506078;Dbxref=PMID:29506078 Q86U44 UniProtKB Alternative sequence 1 284 . . . ID=VSP_007864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Q86U44 UniProtKB Alternative sequence 486 505 . . . ID=VSP_007865;Note=In isoform 2. GVKGNPQGFNQGLDCDVIVA->SSSGAQFNRWSTKKNHLISY;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Q86U44 UniProtKB Alternative sequence 506 580 . . . ID=VSP_007866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Q86U44 UniProtKB Natural variant 406 406 . . . ID=VAR_076859;Note=Found in patients with large intestine cancer%3B uncertain significance%3B does not affect interaction with METTL14%3B abolished RNA methyltransferase activity in vitro. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27373337;Dbxref=PMID:27373337 Q86U44 UniProtKB Mutagenesis 2 2 . . . Note=Does not affect nuclear localization%2C interaction with METTL14 or WTAP or catalytic activity%3B when associated with A-43%3B A-48 and A-50. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 43 43 . . . Note=Does not affect nuclear localization%2C interaction with METTL14 or WTAP or catalytic activity%3B when associated with A-2%3B A-48 and A-50. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 48 48 . . . Note=Does not affect nuclear localization%2C interaction with METTL14 or WTAP or catalytic activity%3B when associated with A-2%3B A-43 and A-50. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 50 50 . . . Note=Does not affect nuclear localization%2C interaction with METTL14 or WTAP or catalytic activity%3B when associated with A-2%3B A-43 and A-48. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 177 177 . . . Note=In 4KR%3B strongly decreased sumoylation%3B when associated with 211-R--R-215. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29506078;Dbxref=PMID:29506078 Q86U44 UniProtKB Mutagenesis 211 215 . . . Note=Abolishes localization to the nucleus. KKSRK->GGSGG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 211 215 . . . Note=In 3KR%3B decreased sumoylation. In 4KR%3B strongly decreased sumoylation%3B when associated with R-177. KKSRK->RRSRR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29506078;Dbxref=PMID:29506078 Q86U44 UniProtKB Mutagenesis 219 219 . . . Note=Does not affect nuclear localization%2C interaction with METTL14 or WTAP or catalytic activity%3B when associated with A-243 and 348-A--A-350. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 243 243 . . . Note=Does not affect nuclear localization%2C interaction with METTL14 or WTAP or catalytic activity%3B when associated with A-219 and 348-A--A-350. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 294 294 . . . Note=Abolishes methyltransferase activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27373337;Dbxref=PMID:27373337 Q86U44 UniProtKB Mutagenesis 326 326 . . . Note=Abolishes methyltransferase activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27373337;Dbxref=PMID:27373337 Q86U44 UniProtKB Mutagenesis 348 350 . . . Note=Does not affect nuclear localization%2C interaction with METTL14 or WTAP or catalytic activity%3B when associated with A-219 and A-243. TPS->APA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29348140;Dbxref=PMID:29348140 Q86U44 UniProtKB Mutagenesis 377 377 . . . Note=Abolishes methyltransferase activity. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Mutagenesis 395 398 . . . Note=Loss of function. Abolishes ability to regulate primary miRNA processing. Does not affect ability to promote mRNA translation. Abolishes formation of m6A at DNA damage sites. DPPW->APPA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25799998,ECO:0000269|PubMed:27117702,ECO:0000269|PubMed:27627798,ECO:0000269|PubMed:28297716;Dbxref=PMID:25799998,PMID:27117702,PMID:27627798,PMID:28297716 Q86U44 UniProtKB Mutagenesis 395 395 . . . Note=Abolishes methyltransferase activity. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27373337;Dbxref=PMID:27281194,PMID:27373337 Q86U44 UniProtKB Mutagenesis 406 406 . . . Note=Strong reduction in methyltransferase activity. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27627798;Dbxref=PMID:27627798 Q86U44 UniProtKB Mutagenesis 462 479 . . . Note=Impaired RNA-binding and methyltransferase activities. QLQRIIRTGRTGHWLNHG->AAAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Mutagenesis 475 475 . . . Note=Decreased methyltransferase activity. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27373337;Dbxref=PMID:27373337 Q86U44 UniProtKB Mutagenesis 477 477 . . . Note=Decreased methyltransferase activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27373337;Dbxref=PMID:27373337 Q86U44 UniProtKB Mutagenesis 532 532 . . . Note=Abolishes methyltransferase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Mutagenesis 536 536 . . . Note=Slight reduction in methyltransferase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Mutagenesis 538 538 . . . Note=Slight reduction in methyltransferase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Mutagenesis 539 539 . . . Note=Abolishes methyltransferase activity. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27281194;Dbxref=PMID:27281194 Q86U44 UniProtKB Mutagenesis 549 549 . . . Note=Slight reduction in methyltransferase activity. Strong reduction in methyltransferase activity%3B when associated with A-550. N->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27627798;Dbxref=PMID:27281194,PMID:27627798 Q86U44 UniProtKB Mutagenesis 550 550 . . . Note=Slight reduction in methyltransferase activity. Strong reduction in methyltransferase activity%3B when associated with A-549. Q->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:27281194,ECO:0000269|PubMed:27627798;Dbxref=PMID:27281194,PMID:27627798 Q86U44 UniProtKB Sequence conflict 251 251 . . . Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86U44 UniProtKB Sequence conflict 263 264 . . . Note=KF->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86U44 UniProtKB Sequence conflict 382 382 . . . Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86U44 UniProtKB Sequence conflict 568 568 . . . Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86U44 UniProtKB Beta strand 372 376 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Turn 378 380 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Helix 383 386 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 390 394 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Turn 405 407 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NID Q86U44 UniProtKB Helix 411 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Helix 419 422 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 424 432 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Helix 436 446 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 450 460 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 464 466 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 473 477 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 480 489 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 498 506 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 510 512 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Helix 516 524 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 530 534 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Helix 537 539 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 544 548 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 553 555 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Helix 559 568 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IL2 Q86U44 UniProtKB Beta strand 570 572 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7NHG