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Protein

Nucleolar protein 9

Gene

NOP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 9
Gene namesi
Name:NOP9
Synonyms:C14orf21, KIAA2021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000196943.12
HGNCiHGNC:19826 NOP9
neXtProtiNX_Q86U38

Pathology & Biotechi

Organism-specific databases

DisGeNETi161424
OpenTargetsiENSG00000196943
PharmGKBiPA134867241

Polymorphism and mutation databases

BioMutaiNOP9
DMDMi34921618

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759271 – 636Nucleolar protein 9Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86U38
MaxQBiQ86U38
PaxDbiQ86U38
PeptideAtlasiQ86U38
PRIDEiQ86U38

PTM databases

iPTMnetiQ86U38
PhosphoSitePlusiQ86U38

Expressioni

Gene expression databases

BgeeiENSG00000196943
CleanExiHS_C14orf21
ExpressionAtlasiQ86U38 baseline and differential
GenevisibleiQ86U38 HS

Organism-specific databases

HPAiHPA000850

Interactioni

Protein-protein interaction databases

BioGridi127790, 68 interactors
IntActiQ86U38, 33 interactors
MINTiQ86U38
STRINGi9606.ENSP00000267425

Structurei

3D structure databases

ProteinModelPortaliQ86U38
SMRiQ86U38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 123Pumilio 1Add BLAST32
Repeati189 – 223Pumilio 2Add BLAST35
Repeati313 – 348Pumilio 3Add BLAST36
Repeati351 – 386Pumilio 4Add BLAST36
Repeati509 – 544Pumilio 5Add BLAST36
Repeati547 – 581Pumilio 6Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 169Poly-Glu8

Sequence similaritiesi

Belongs to the NOP9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2188 Eukaryota
ENOG410YSWC LUCA
GeneTreeiENSGT00390000004964
HOGENOMiHOG000015385
HOVERGENiHBG051002
InParanoidiQ86U38
KOiK14790
OMAiFLRDQTS
OrthoDBiEOG091G0525
PhylomeDBiQ86U38
TreeFamiTF327254

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001313 Pumilio_RNA-bd_rpt
SMARTiView protein in SMART
SM00025 Pumilio, 6 hits
SUPFAMiSSF48371 SSF48371, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86U38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGPRSPHK VGRRFPAGGK RGRGAKGSGR PLPGRKRQPW PPPDGRSEPA
60 70 80 90 100
PDSHPHLSPE ALGYFRRALS ALKEAPETGE ERDLMVHNIM KEVETQALAL
110 120 130 140 150
STNRTGSEML QELLGFSPLK PLCRVWAALR SNLRTVACHR CGVHVLQSAL
160 170 180 190 200
LQLPRLLGSA AEEEEEEEED GKDGPTETLE ELVLGLAAEV CDDFLVYCGD
210 220 230 240 250
THGSFVVRTL LQVLGGTILE SERARPRGSQ SSEAQKTPAQ ECKPADFEVP
260 270 280 290 300
ETFLNRLQDL SSSFLKDIAV FITDKISSFC LQVALQVLHR KLPQFCAHLC
310 320 330 340 350
NAVIGYLSTR GSSVDGSPLL LFLRDQTSSR LLEQVLLVLE PPRLQSLFEE
360 370 380 390 400
HLQGQLQTLA AHPIANFPLQ RLLDAVTTPE LLSPVFEELS PVLEAVLAQG
410 420 430 440 450
HPGVVIALVG ACRRVGAYQA KVLQLLLEAF HCAEPSSRQV ACVPLFATLM
460 470 480 490 500
AYEVYYGLTE EEGAVPAEHQ VAMAAARALG DVTVLGSLLL QHLLHFSTPG
510 520 530 540 550
LVLRSLGALT GPQLLSLAQS PAGSHVLDAI LTSPSVTRKL RRRVLQNLKG
560 570 580 590 600
QYVALACSRH GSRVLDAIWS GAALRARKEI AAELGEQNQE LIRDPFGHHV
610 620 630
ARNVALTTFL KRREAWEQQQ GAVAKRRRAL NSILED
Length:636
Mass (Da):69,438
Last modified:June 1, 2003 - v1
Checksum:i7978D14132A621B8
GO
Isoform 2 (identifier: Q86U38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     520-535: SPAGSHVLDAILTSPS → RPGRKLLLSLGSRTRS
     536-636: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):58,162
Checksum:i13A9B96986D215F6
GO

Sequence cautioni

The sequence BAC23117 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161A → AE in AAH25332 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05161251P → S. Corresponds to variant dbSNP:rs11848295Ensembl.1
Natural variantiVAR_024600308S → N1 PublicationCorresponds to variant dbSNP:rs4280164Ensembl.1
Natural variantiVAR_036456497S → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036457626R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs374412139Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055693520 – 535SPAGS…LTSPS → RPGRKLLLSLGSRTRS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_055694536 – 636Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095941 mRNA Translation: BAC23117.1 Different initiation.
BX248018 mRNA Translation: CAD62343.1
AL096870 Genomic DNA No translation available.
BC025332 mRNA Translation: AAH25332.1
CCDSiCCDS66616.1 [Q86U38-2]
CCDS9624.1 [Q86U38-1]
RefSeqiNP_001273296.1, NM_001286367.1 [Q86U38-2]
NP_777573.1, NM_174913.2 [Q86U38-1]
UniGeneiHs.708040

Genome annotation databases

EnsembliENST00000267425; ENSP00000267425; ENSG00000196943 [Q86U38-1]
ENST00000396802; ENSP00000380020; ENSG00000196943 [Q86U38-2]
GeneIDi161424
KEGGihsa:161424
UCSCiuc001wol.3 human [Q86U38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNOP9_HUMAN
AccessioniPrimary (citable) accession number: Q86U38
Secondary accession number(s): A8MY76, Q8IVF0, Q8TBS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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