Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolar protein 9

Gene

NOP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 9
Gene namesi
Name:NOP9
Synonyms:C14orf21, KIAA2021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19826. NOP9.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134867241.

Polymorphism and mutation databases

BioMutaiNOP9.
DMDMi34921618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Nucleolar protein 9PRO_0000075927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86U38.
MaxQBiQ86U38.
PaxDbiQ86U38.
PRIDEiQ86U38.

PTM databases

iPTMnetiQ86U38.
PhosphoSiteiQ86U38.

Expressioni

Gene expression databases

BgeeiQ86U38.
CleanExiHS_C14orf21.
ExpressionAtlasiQ86U38. baseline and differential.
GenevisibleiQ86U38. HS.

Organism-specific databases

HPAiHPA000850.

Interactioni

Protein-protein interaction databases

BioGridi127790. 57 interactions.
IntActiQ86U38. 32 interactions.
MINTiMINT-3035292.
STRINGi9606.ENSP00000267425.

Structurei

3D structure databases

ProteinModelPortaliQ86U38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati92 – 12332Pumilio 1Add
BLAST
Repeati189 – 22335Pumilio 2Add
BLAST
Repeati313 – 34836Pumilio 3Add
BLAST
Repeati351 – 38636Pumilio 4Add
BLAST
Repeati509 – 54436Pumilio 5Add
BLAST
Repeati547 – 58135Pumilio 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1698Poly-Glu

Sequence similaritiesi

Belongs to the NOP9 family.Curated
Contains 6 pumilio repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2188. Eukaryota.
ENOG410YSWC. LUCA.
GeneTreeiENSGT00390000004964.
HOGENOMiHOG000015385.
HOVERGENiHBG051002.
InParanoidiQ86U38.
KOiK14790.
OMAiTVACHRC.
OrthoDBiEOG79SDX4.
PhylomeDBiQ86U38.
TreeFamiTF327254.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
SMARTiSM00025. Pumilio. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86U38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGPRSPHK VGRRFPAGGK RGRGAKGSGR PLPGRKRQPW PPPDGRSEPA
60 70 80 90 100
PDSHPHLSPE ALGYFRRALS ALKEAPETGE ERDLMVHNIM KEVETQALAL
110 120 130 140 150
STNRTGSEML QELLGFSPLK PLCRVWAALR SNLRTVACHR CGVHVLQSAL
160 170 180 190 200
LQLPRLLGSA AEEEEEEEED GKDGPTETLE ELVLGLAAEV CDDFLVYCGD
210 220 230 240 250
THGSFVVRTL LQVLGGTILE SERARPRGSQ SSEAQKTPAQ ECKPADFEVP
260 270 280 290 300
ETFLNRLQDL SSSFLKDIAV FITDKISSFC LQVALQVLHR KLPQFCAHLC
310 320 330 340 350
NAVIGYLSTR GSSVDGSPLL LFLRDQTSSR LLEQVLLVLE PPRLQSLFEE
360 370 380 390 400
HLQGQLQTLA AHPIANFPLQ RLLDAVTTPE LLSPVFEELS PVLEAVLAQG
410 420 430 440 450
HPGVVIALVG ACRRVGAYQA KVLQLLLEAF HCAEPSSRQV ACVPLFATLM
460 470 480 490 500
AYEVYYGLTE EEGAVPAEHQ VAMAAARALG DVTVLGSLLL QHLLHFSTPG
510 520 530 540 550
LVLRSLGALT GPQLLSLAQS PAGSHVLDAI LTSPSVTRKL RRRVLQNLKG
560 570 580 590 600
QYVALACSRH GSRVLDAIWS GAALRARKEI AAELGEQNQE LIRDPFGHHV
610 620 630
ARNVALTTFL KRREAWEQQQ GAVAKRRRAL NSILED
Length:636
Mass (Da):69,438
Last modified:June 1, 2003 - v1
Checksum:i7978D14132A621B8
GO
Isoform 2 (identifier: Q86U38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     520-535: SPAGSHVLDAILTSPS → RPGRKLLLSLGSRTRS
     536-636: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):58,162
Checksum:i13A9B96986D215F6
GO

Sequence cautioni

The sequence BAC23117.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1611A → AE in AAH25332 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511P → S.
Corresponds to variant rs11848295 [ dbSNP | Ensembl ].
VAR_051612
Natural varianti308 – 3081S → N.1 Publication
Corresponds to variant rs4280164 [ dbSNP | Ensembl ].
VAR_024600
Natural varianti497 – 4971S → Y in a breast cancer sample; somatic mutation. 1 Publication
VAR_036456
Natural varianti626 – 6261R → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_036457

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei520 – 53516SPAGS…LTSPS → RPGRKLLLSLGSRTRS in isoform 2. 1 PublicationVSP_055693Add
BLAST
Alternative sequencei536 – 636101Missing in isoform 2. 1 PublicationVSP_055694Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095941 mRNA. Translation: BAC23117.1. Different initiation.
BX248018 mRNA. Translation: CAD62343.1.
AL096870 Genomic DNA. No translation available.
BC025332 mRNA. Translation: AAH25332.1.
CCDSiCCDS66616.1. [Q86U38-2]
CCDS9624.1. [Q86U38-1]
RefSeqiNP_001273296.1. NM_001286367.1. [Q86U38-2]
NP_777573.1. NM_174913.2. [Q86U38-1]
UniGeneiHs.708040.

Genome annotation databases

EnsembliENST00000267425; ENSP00000267425; ENSG00000196943. [Q86U38-1]
ENST00000396802; ENSP00000380020; ENSG00000196943. [Q86U38-2]
GeneIDi161424.
KEGGihsa:161424.
UCSCiuc001wol.3. human. [Q86U38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095941 mRNA. Translation: BAC23117.1. Different initiation.
BX248018 mRNA. Translation: CAD62343.1.
AL096870 Genomic DNA. No translation available.
BC025332 mRNA. Translation: AAH25332.1.
CCDSiCCDS66616.1. [Q86U38-2]
CCDS9624.1. [Q86U38-1]
RefSeqiNP_001273296.1. NM_001286367.1. [Q86U38-2]
NP_777573.1. NM_174913.2. [Q86U38-1]
UniGeneiHs.708040.

3D structure databases

ProteinModelPortaliQ86U38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127790. 57 interactions.
IntActiQ86U38. 32 interactions.
MINTiMINT-3035292.
STRINGi9606.ENSP00000267425.

PTM databases

iPTMnetiQ86U38.
PhosphoSiteiQ86U38.

Polymorphism and mutation databases

BioMutaiNOP9.
DMDMi34921618.

Proteomic databases

EPDiQ86U38.
MaxQBiQ86U38.
PaxDbiQ86U38.
PRIDEiQ86U38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267425; ENSP00000267425; ENSG00000196943. [Q86U38-1]
ENST00000396802; ENSP00000380020; ENSG00000196943. [Q86U38-2]
GeneIDi161424.
KEGGihsa:161424.
UCSCiuc001wol.3. human. [Q86U38-1]

Organism-specific databases

CTDi161424.
GeneCardsiNOP9.
H-InvDBHIX0011567.
HGNCiHGNC:19826. NOP9.
HPAiHPA000850.
neXtProtiNX_Q86U38.
PharmGKBiPA134867241.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2188. Eukaryota.
ENOG410YSWC. LUCA.
GeneTreeiENSGT00390000004964.
HOGENOMiHOG000015385.
HOVERGENiHBG051002.
InParanoidiQ86U38.
KOiK14790.
OMAiTVACHRC.
OrthoDBiEOG79SDX4.
PhylomeDBiQ86U38.
TreeFamiTF327254.

Miscellaneous databases

GenomeRNAii161424.
NextBioi35465042.
PROiQ86U38.

Gene expression databases

BgeeiQ86U38.
CleanExiHS_C14orf21.
ExpressionAtlasiQ86U38. baseline and differential.
GenevisibleiQ86U38. HS.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
SMARTiSM00025. Pumilio. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-308.
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] TYR-497 AND GLN-626.

Entry informationi

Entry nameiNOP9_HUMAN
AccessioniPrimary (citable) accession number: Q86U38
Secondary accession number(s): A8MY76, Q8IVF0, Q8TBS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: April 13, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.