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Protein

Nucleolar protein 9

Gene

NOP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32519-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 9
Gene namesi
Name:NOP9
Synonyms:C14orf21, KIAA2021
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19826. NOP9.

Pathology & Biotechi

Organism-specific databases

DisGeNETi161424.
OpenTargetsiENSG00000196943.
PharmGKBiPA134867241.

Polymorphism and mutation databases

BioMutaiNOP9.
DMDMi34921618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759271 – 636Nucleolar protein 9Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86U38.
MaxQBiQ86U38.
PaxDbiQ86U38.
PeptideAtlasiQ86U38.
PRIDEiQ86U38.

PTM databases

iPTMnetiQ86U38.
PhosphoSitePlusiQ86U38.

Expressioni

Gene expression databases

BgeeiENSG00000196943.
CleanExiHS_C14orf21.
ExpressionAtlasiQ86U38. baseline and differential.
GenevisibleiQ86U38. HS.

Organism-specific databases

HPAiHPA000850.

Interactioni

Protein-protein interaction databases

BioGridi127790. 58 interactors.
IntActiQ86U38. 32 interactors.
MINTiMINT-3035292.
STRINGi9606.ENSP00000267425.

Structurei

3D structure databases

ProteinModelPortaliQ86U38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati92 – 123Pumilio 1Add BLAST32
Repeati189 – 223Pumilio 2Add BLAST35
Repeati313 – 348Pumilio 3Add BLAST36
Repeati351 – 386Pumilio 4Add BLAST36
Repeati509 – 544Pumilio 5Add BLAST36
Repeati547 – 581Pumilio 6Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 169Poly-Glu8

Sequence similaritiesi

Belongs to the NOP9 family.Curated
Contains 6 pumilio repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2188. Eukaryota.
ENOG410YSWC. LUCA.
GeneTreeiENSGT00390000004964.
HOGENOMiHOG000015385.
HOVERGENiHBG051002.
InParanoidiQ86U38.
KOiK14790.
OMAiTVACHRC.
OrthoDBiEOG091G0525.
PhylomeDBiQ86U38.
TreeFamiTF327254.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
SMARTiSM00025. Pumilio. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86U38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGPRSPHK VGRRFPAGGK RGRGAKGSGR PLPGRKRQPW PPPDGRSEPA
60 70 80 90 100
PDSHPHLSPE ALGYFRRALS ALKEAPETGE ERDLMVHNIM KEVETQALAL
110 120 130 140 150
STNRTGSEML QELLGFSPLK PLCRVWAALR SNLRTVACHR CGVHVLQSAL
160 170 180 190 200
LQLPRLLGSA AEEEEEEEED GKDGPTETLE ELVLGLAAEV CDDFLVYCGD
210 220 230 240 250
THGSFVVRTL LQVLGGTILE SERARPRGSQ SSEAQKTPAQ ECKPADFEVP
260 270 280 290 300
ETFLNRLQDL SSSFLKDIAV FITDKISSFC LQVALQVLHR KLPQFCAHLC
310 320 330 340 350
NAVIGYLSTR GSSVDGSPLL LFLRDQTSSR LLEQVLLVLE PPRLQSLFEE
360 370 380 390 400
HLQGQLQTLA AHPIANFPLQ RLLDAVTTPE LLSPVFEELS PVLEAVLAQG
410 420 430 440 450
HPGVVIALVG ACRRVGAYQA KVLQLLLEAF HCAEPSSRQV ACVPLFATLM
460 470 480 490 500
AYEVYYGLTE EEGAVPAEHQ VAMAAARALG DVTVLGSLLL QHLLHFSTPG
510 520 530 540 550
LVLRSLGALT GPQLLSLAQS PAGSHVLDAI LTSPSVTRKL RRRVLQNLKG
560 570 580 590 600
QYVALACSRH GSRVLDAIWS GAALRARKEI AAELGEQNQE LIRDPFGHHV
610 620 630
ARNVALTTFL KRREAWEQQQ GAVAKRRRAL NSILED
Length:636
Mass (Da):69,438
Last modified:June 1, 2003 - v1
Checksum:i7978D14132A621B8
GO
Isoform 2 (identifier: Q86U38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     520-535: SPAGSHVLDAILTSPS → RPGRKLLLSLGSRTRS
     536-636: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):58,162
Checksum:i13A9B96986D215F6
GO

Sequence cautioni

The sequence BAC23117 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161A → AE in AAH25332 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05161251P → S.Corresponds to variant rs11848295dbSNPEnsembl.1
Natural variantiVAR_024600308S → N.1 PublicationCorresponds to variant rs4280164dbSNPEnsembl.1
Natural variantiVAR_036456497S → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036457626R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs374412139dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055693520 – 535SPAGS…LTSPS → RPGRKLLLSLGSRTRS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_055694536 – 636Missing in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095941 mRNA. Translation: BAC23117.1. Different initiation.
BX248018 mRNA. Translation: CAD62343.1.
AL096870 Genomic DNA. No translation available.
BC025332 mRNA. Translation: AAH25332.1.
CCDSiCCDS66616.1. [Q86U38-2]
CCDS9624.1. [Q86U38-1]
RefSeqiNP_001273296.1. NM_001286367.1. [Q86U38-2]
NP_777573.1. NM_174913.2. [Q86U38-1]
UniGeneiHs.708040.

Genome annotation databases

EnsembliENST00000267425; ENSP00000267425; ENSG00000196943. [Q86U38-1]
ENST00000396802; ENSP00000380020; ENSG00000196943. [Q86U38-2]
GeneIDi161424.
KEGGihsa:161424.
UCSCiuc001wol.3. human. [Q86U38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095941 mRNA. Translation: BAC23117.1. Different initiation.
BX248018 mRNA. Translation: CAD62343.1.
AL096870 Genomic DNA. No translation available.
BC025332 mRNA. Translation: AAH25332.1.
CCDSiCCDS66616.1. [Q86U38-2]
CCDS9624.1. [Q86U38-1]
RefSeqiNP_001273296.1. NM_001286367.1. [Q86U38-2]
NP_777573.1. NM_174913.2. [Q86U38-1]
UniGeneiHs.708040.

3D structure databases

ProteinModelPortaliQ86U38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127790. 58 interactors.
IntActiQ86U38. 32 interactors.
MINTiMINT-3035292.
STRINGi9606.ENSP00000267425.

PTM databases

iPTMnetiQ86U38.
PhosphoSitePlusiQ86U38.

Polymorphism and mutation databases

BioMutaiNOP9.
DMDMi34921618.

Proteomic databases

EPDiQ86U38.
MaxQBiQ86U38.
PaxDbiQ86U38.
PeptideAtlasiQ86U38.
PRIDEiQ86U38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267425; ENSP00000267425; ENSG00000196943. [Q86U38-1]
ENST00000396802; ENSP00000380020; ENSG00000196943. [Q86U38-2]
GeneIDi161424.
KEGGihsa:161424.
UCSCiuc001wol.3. human. [Q86U38-1]

Organism-specific databases

CTDi161424.
DisGeNETi161424.
GeneCardsiNOP9.
H-InvDBHIX0011567.
HGNCiHGNC:19826. NOP9.
HPAiHPA000850.
neXtProtiNX_Q86U38.
OpenTargetsiENSG00000196943.
PharmGKBiPA134867241.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2188. Eukaryota.
ENOG410YSWC. LUCA.
GeneTreeiENSGT00390000004964.
HOGENOMiHOG000015385.
HOVERGENiHBG051002.
InParanoidiQ86U38.
KOiK14790.
OMAiTVACHRC.
OrthoDBiEOG091G0525.
PhylomeDBiQ86U38.
TreeFamiTF327254.

Enzyme and pathway databases

BioCyciZFISH:G66-32519-MONOMER.

Miscellaneous databases

GenomeRNAii161424.
PROiQ86U38.

Gene expression databases

BgeeiENSG00000196943.
CleanExiHS_C14orf21.
ExpressionAtlasiQ86U38. baseline and differential.
GenevisibleiQ86U38. HS.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
SMARTiSM00025. Pumilio. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNOP9_HUMAN
AccessioniPrimary (citable) accession number: Q86U38
Secondary accession number(s): A8MY76, Q8IVF0, Q8TBS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.