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Q86U17

- SPA11_HUMAN

UniProt

Q86U17 - SPA11_HUMAN

Protein

Serpin A11

Gene

SERPINA11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin A11
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19193. SERPINA11.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134988362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 422403Serpin A11PRO_0000041973Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ86U17.
    PRIDEiQ86U17.

    PTM databases

    PhosphoSiteiQ86U17.

    Expressioni

    Gene expression databases

    BgeeiQ86U17.
    CleanExiHS_SERPINA11.
    GenevestigatoriQ86U17.

    Organism-specific databases

    HPAiHPA003066.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335024.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86U17.
    SMRiQ86U17. Positions 55-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    InParanoidiQ86U17.
    OMAiWEVTTQS.
    OrthoDBiEOG7QC7W9.
    PhylomeDBiQ86U17.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86U17-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI    50
    TPTITNFALR LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL 100
    EGLGFNLTET PEADIHQGFR SLLHTLALPS PKLELKVGNS LFLDKRLKPR 150
    QHYLDSIKEL YGAFAFSANF TDSVTTGRQI NDYLRRQTYG QVVDCLPEFS 200
    QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL QVPMMHQKEM 250
    HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG 300
    QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN 350
    KTISKVSHKA MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL 400
    LLWEVTTQSL LFLGKVVNPV AG 422
    Length:422
    Mass (Da):46,989
    Last modified:September 27, 2005 - v2
    Checksum:i58536B32C91DC2F8
    GO

    Sequence cautioni

    The sequence CAD62587.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti230 – 2301E → A.
    Corresponds to variant rs1885137 [ dbSNP | Ensembl ].
    VAR_061791
    Natural varianti406 – 4061T → S.
    Corresponds to variant rs17752285 [ dbSNP | Ensembl ].
    VAR_034511

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248259 mRNA. Translation: CAD62587.1. Different initiation.
    BC146962 mRNA. Translation: AAI46963.1.
    CCDSiCCDS32149.1.
    RefSeqiNP_001073920.1. NM_001080451.1.
    UniGeneiHs.145890.

    Genome annotation databases

    EnsembliENST00000334708; ENSP00000335024; ENSG00000186910.
    GeneIDi256394.
    KEGGihsa:256394.
    UCSCiuc001ydd.1. human.

    Polymorphism databases

    DMDMi76363411.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248259 mRNA. Translation: CAD62587.1 . Different initiation.
    BC146962 mRNA. Translation: AAI46963.1 .
    CCDSi CCDS32149.1.
    RefSeqi NP_001073920.1. NM_001080451.1.
    UniGenei Hs.145890.

    3D structure databases

    ProteinModelPortali Q86U17.
    SMRi Q86U17. Positions 55-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335024.

    PTM databases

    PhosphoSitei Q86U17.

    Polymorphism databases

    DMDMi 76363411.

    Proteomic databases

    PaxDbi Q86U17.
    PRIDEi Q86U17.

    Protocols and materials databases

    DNASUi 256394.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334708 ; ENSP00000335024 ; ENSG00000186910 .
    GeneIDi 256394.
    KEGGi hsa:256394.
    UCSCi uc001ydd.1. human.

    Organism-specific databases

    CTDi 256394.
    GeneCardsi GC14M094908.
    HGNCi HGNC:19193. SERPINA11.
    HPAi HPA003066.
    neXtProti NX_Q86U17.
    PharmGKBi PA134988362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    InParanoidi Q86U17.
    OMAi WEVTTQS.
    OrthoDBi EOG7QC7W9.
    PhylomeDBi Q86U17.
    TreeFami TF343201.

    Miscellaneous databases

    GenomeRNAii 256394.
    NextBioi 92805.
    PROi Q86U17.

    Gene expression databases

    Bgeei Q86U17.
    CleanExi HS_SERPINA11.
    Genevestigatori Q86U17.

    Family and domain databases

    InterProi IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSPA11_HUMAN
    AccessioniPrimary (citable) accession number: Q86U17
    Secondary accession number(s): B2RV07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3