Q86U17 (SPA11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serpin A11

Gene names

Name:

SERPINA11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the serpin family.
Sequence caution	The sequence CAD62587.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 422	403	Serpin A11		PRO_0000041973
Amino acid modifications
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	230	1	E → A. Corresponds to variant rs1885137 [ dbSNP | Ensembl ].		VAR_061791
	Natural variant	406	1	T → S. Corresponds to variant rs17752285 [ dbSNP | Ensembl ].		VAR_034511

Sequences

	Sequence		Length	Mass (Da)
	Q86U17 [UniParc]. Last modified September 27, 2005. Version 2. Checksum: 58536B32C91DC2F8	FASTA	422	46,989
	10 20 30 40 50 60 MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI TPTITNFALR 70 80 90 100 110 120 LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL EGLGFNLTET PEADIHQGFR 130 140 150 160 170 180 SLLHTLALPS PKLELKVGNS LFLDKRLKPR QHYLDSIKEL YGAFAFSANF TDSVTTGRQI 190 200 210 220 230 240 NDYLRRQTYG QVVDCLPEFS QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL 250 260 270 280 290 300 QVPMMHQKEM HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG 310 320 330 340 350 360 QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN KTISKVSHKA 370 380 390 400 410 420 MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL LLWEVTTQSL LFLGKVVNPV AG

References

[1]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248259 mRNA. Translation: CAD62587.1. Different initiation. BC146962 mRNA. Translation: AAI46963.1.
IPI	IPI00333828.
RefSeq	NP_001073920.1. NM_001080451.1.
UniGene	Hs.145890.
3D structure databases
ProteinModelPortal	Q86U17.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000335024.
Protein family/group databases
MEROPS	I04.955.
PTM databases
PhosphoSite	Q86U17.
Polymorphism databases
DMDM	76363411.
Proteomic databases
PaxDb	Q86U17.
PRIDE	Q86U17.
Protocols and materials databases
DNASU	256394.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334708; ENSP00000335024; ENSG00000186910.
GeneID	256394.
KEGG	hsa:256394.
UCSC	uc001ydd.1. human.
Organism-specific databases
CTD	256394.
GeneCards	GC14M094908.
HGNC	HGNC:19193. SERPINA11.
HPA	HPA003066. HPA055433.
neXtProt	NX_Q86U17.
PharmGKB	PA134988362.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4826.
HOGENOM	HOG000238521.
HOVERGEN	HBG005957.
InParanoid	Q86U17.
OMA	HQKEMHR.
OrthoDB	EOG4FFD1T.
Gene expression databases
Bgee	Q86U17.
CleanEx	HS_SERPINA11.
Genevestigator	Q86U17.
Family and domain databases
InterPro	IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	256394.
NextBio	92805.

Entry information

Entry name

SPA11_HUMAN

Accession

Primary (citable) accession number: Q86U17
Secondary accession number(s): B2RV07

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.