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Q86U17

- SPA11_HUMAN

UniProt

Q86U17 - SPA11_HUMAN

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Protein

Serpin A11

Gene
SERPINA11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A11
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19193. SERPINA11.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 422403Serpin A11PRO_0000041973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86U17.
PRIDEiQ86U17.

PTM databases

PhosphoSiteiQ86U17.

Expressioni

Gene expression databases

BgeeiQ86U17.
CleanExiHS_SERPINA11.
GenevestigatoriQ86U17.

Organism-specific databases

HPAiHPA003066.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335024.

Structurei

3D structure databases

ProteinModelPortaliQ86U17.
SMRiQ86U17. Positions 55-419.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ86U17.
OMAiWEVTTQS.
OrthoDBiEOG7QC7W9.
PhylomeDBiQ86U17.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86U17-1 [UniParc]FASTAAdd to Basket

« Hide

MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI    50
TPTITNFALR LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL 100
EGLGFNLTET PEADIHQGFR SLLHTLALPS PKLELKVGNS LFLDKRLKPR 150
QHYLDSIKEL YGAFAFSANF TDSVTTGRQI NDYLRRQTYG QVVDCLPEFS 200
QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL QVPMMHQKEM 250
HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG 300
QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN 350
KTISKVSHKA MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL 400
LLWEVTTQSL LFLGKVVNPV AG 422
Length:422
Mass (Da):46,989
Last modified:September 27, 2005 - v2
Checksum:i58536B32C91DC2F8
GO

Sequence cautioni

The sequence CAD62587.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti230 – 2301E → A.
Corresponds to variant rs1885137 [ dbSNP | Ensembl ].
VAR_061791
Natural varianti406 – 4061T → S.
Corresponds to variant rs17752285 [ dbSNP | Ensembl ].
VAR_034511

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248259 mRNA. Translation: CAD62587.1. Different initiation.
BC146962 mRNA. Translation: AAI46963.1.
CCDSiCCDS32149.1.
RefSeqiNP_001073920.1. NM_001080451.1.
UniGeneiHs.145890.

Genome annotation databases

EnsembliENST00000334708; ENSP00000335024; ENSG00000186910.
GeneIDi256394.
KEGGihsa:256394.
UCSCiuc001ydd.1. human.

Polymorphism databases

DMDMi76363411.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248259 mRNA. Translation: CAD62587.1 . Different initiation.
BC146962 mRNA. Translation: AAI46963.1 .
CCDSi CCDS32149.1.
RefSeqi NP_001073920.1. NM_001080451.1.
UniGenei Hs.145890.

3D structure databases

ProteinModelPortali Q86U17.
SMRi Q86U17. Positions 55-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335024.

PTM databases

PhosphoSitei Q86U17.

Polymorphism databases

DMDMi 76363411.

Proteomic databases

PaxDbi Q86U17.
PRIDEi Q86U17.

Protocols and materials databases

DNASUi 256394.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334708 ; ENSP00000335024 ; ENSG00000186910 .
GeneIDi 256394.
KEGGi hsa:256394.
UCSCi uc001ydd.1. human.

Organism-specific databases

CTDi 256394.
GeneCardsi GC14M094908.
HGNCi HGNC:19193. SERPINA11.
HPAi HPA003066.
neXtProti NX_Q86U17.
PharmGKBi PA134988362.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
InParanoidi Q86U17.
OMAi WEVTTQS.
OrthoDBi EOG7QC7W9.
PhylomeDBi Q86U17.
TreeFami TF343201.

Miscellaneous databases

GenomeRNAii 256394.
NextBioi 92805.
PROi Q86U17.

Gene expression databases

Bgeei Q86U17.
CleanExi HS_SERPINA11.
Genevestigatori Q86U17.

Family and domain databases

InterProi IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSPA11_HUMAN
AccessioniPrimary (citable) accession number: Q86U17
Secondary accession number(s): B2RV07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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