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Q86U17 (SPA11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin A11
Gene names
Name:SERPINA11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the serpin family.

Sequence caution

The sequence CAD62587.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of endopeptidase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of proteolysis

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 422403Serpin A11
PRO_0000041973

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation3501N-linked (GlcNAc...) Potential

Natural variations

Natural variant2301E → A.
Corresponds to variant rs1885137 [ dbSNP | Ensembl ].
VAR_061791
Natural variant4061T → S.
Corresponds to variant rs17752285 [ dbSNP | Ensembl ].
VAR_034511

Sequences

Sequence LengthMass (Da)Tools
Q86U17 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 58536B32C91DC2F8

FASTA42246,989
        10         20         30         40         50         60 
MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI TPTITNFALR 

        70         80         90        100        110        120 
LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL EGLGFNLTET PEADIHQGFR 

       130        140        150        160        170        180 
SLLHTLALPS PKLELKVGNS LFLDKRLKPR QHYLDSIKEL YGAFAFSANF TDSVTTGRQI 

       190        200        210        220        230        240 
NDYLRRQTYG QVVDCLPEFS QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL 

       250        260        270        280        290        300 
QVPMMHQKEM HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG 

       310        320        330        340        350        360 
QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN KTISKVSHKA 

       370        380        390        400        410        420 
MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL LLWEVTTQSL LFLGKVVNPV 


AG 

« Hide

References

[1]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248259 mRNA. Translation: CAD62587.1. Different initiation.
BC146962 mRNA. Translation: AAI46963.1.
RefSeqNP_001073920.1. NM_001080451.1.
UniGeneHs.145890.

3D structure databases

ProteinModelPortalQ86U17.
SMRQ86U17. Positions 55-420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000335024.

PTM databases

PhosphoSiteQ86U17.

Polymorphism databases

DMDM76363411.

Proteomic databases

PaxDbQ86U17.
PRIDEQ86U17.

Protocols and materials databases

DNASU256394.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334708; ENSP00000335024; ENSG00000186910.
GeneID256394.
KEGGhsa:256394.
UCSCuc001ydd.1. human.

Organism-specific databases

CTD256394.
GeneCardsGC14M094908.
HGNCHGNC:19193. SERPINA11.
HPAHPA003066.
neXtProtNX_Q86U17.
PharmGKBPA134988362.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238521.
HOVERGENHBG005957.
InParanoidQ86U17.
OMAWEVTTQS.
OrthoDBEOG7QC7W9.
PhylomeDBQ86U17.
TreeFamTF343201.

Gene expression databases

BgeeQ86U17.
CleanExHS_SERPINA11.
GenevestigatorQ86U17.

Family and domain databases

InterProIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi256394.
NextBio92805.
PROQ86U17.

Entry information

Entry nameSPA11_HUMAN
AccessionPrimary (citable) accession number: Q86U17
Secondary accession number(s): B2RV07
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: April 16, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM