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Reviewed, UniProtKB/Swiss-Prot Q86U10 (LPP60_HUMAN)

Last modified November 3, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    60 kDa lysophospholipase
    EC=3.1.1.5
Including the following 2 domains:
    1- Recommended name:
            L-asparaginase
              EC=3.5.1.1
        Alternative name(s):
            L-asparagine amidohydrolase
    2- Recommended name:
            Platelet-activating factor acetylhydrolase
                Short name=PAF acetylhydrolase
              EC=3.1.1.47
Gene names
Name: ASPG
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

L-asparagine + H2O = L-aspartate + NH3.

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Subunit structure

Monomer By similarity.

Sequence similarities

In the N-terminal section; belongs to the asparaginase 1 family.

Contains 5 ANK repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86U10-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86U10-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: MARAVGPERR...GLSEDTLVLP → MAGPSPPLRA...FRLLLFLSRS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 56756760 kDa lysophospholipase
PRO_0000324163

Regions

Repeat141 – 17030ANK 1
Repeat399 – 42931ANK 2
Repeat433 – 46230ANK 3
Repeat466 – 49530ANK 4
Repeat533 – 56230ANK 5
Region41 – 350310Asparaginase

Sites

Active site191 By similarity
Active site1161 By similarity
Active site1171 By similarity
Active site1871 By similarity

Amino acid modifications

Modified residue3901Phosphoserine By similarity

Natural variations

Alternative sequence1 – 6464MARAV…TLVLP → MAGPSPPLRAGVGRRLLGVA HPDLRPCLCGELQVEGGPGP VPGMLRTCYVRSPWRRGPSS ARGEQSGSGHLEQEEVQSGS LLFRLLLFLSRS in isoform 2.
VSP_032165
Natural variant951C → R: dbSNP rs1770984.
VAR_059131
Natural variant961L → V: dbSNP rs1744284.
VAR_059132
Natural variant3441S → R: dbSNP rs8012505.
VAR_059133

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: 6AD71C6F27B15DDE

FASTA56760,288
        10         20         30         40         50         60 
MARAVGPERR LLAVYTGGTI GMRSELGVLV PGTGLAAILR TLPMFHDEEH ARARGLSEDT 

        70         80         90        100        110        120 
LVLPPASRNQ RILYTVLECQ PLFDSSDMTI AEWVCLAQTI KRHYEQYHGF VVIHGTDTMA 

       130        140        150        160        170        180 
FAASMLSFML ENLQKTVILT GAQVPIHALW SDGRENLLGA LLMAGQYVIP EVCLFFQNQL 

       190        200        210        220        230        240 
FRGNRATKVD ARRFAAFCSP NLLPLATVGA DITINRELVR KVDGKAGLVV HSSMEQDVGL 

       250        260        270        280        290        300 
LRLYPGIPAA LVRAFLQPPL KGVVMETFGS GNGPTKPDLL QELRVATERG LVIVNCTHCL 

       310        320        330        340        350        360 
QGAVTTDYAA GMAMAGAGVI SGFDMTSEAA LAKLSYVLGQ PGLSLDVRKE LLTKDLRGEM 

       370        380        390        400        410        420 
TPPSVEERRP SLQGNTLGGG VSWLLSLSGS QEADALRNAL VPSLACAAAH AGDVEALQAL 

       430        440        450        460        470        480 
VELGSDLGLV DFNGQTPLHA AARGGHTEAV TMLLQRGVDV NTRDTDGFSP LLLAVRGRHP 

       490        500        510        520        530        540 
GVIGLLREAG ASLSTQELEE AGTELCRLAY RADLEGLQVW WQAGADLGQP GYDGHSALHV 

       550        560 
AEAAGNLAVV AFLQSLEGAV GAQAPCP 

« Hide

Isoform 2.

Checksum: 938C7A4F8C6A101C
Show »

FASTA59563,281

References

[1]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441 (ISOFORM 2).
Tissue: Fetal liver.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-441.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-439 (ISOFORM 1).
Tissue: Ovary.

Cross-references

Sequence databases

AL136001 Genomic DNA. No translation available.
BX247999 mRNA. Translation: CAD62331.1.
CH471061 Genomic DNA. Translation: EAW81858.1.
BC035836 mRNA. Translation: AAH35836.1.
IPIIPI00384125.
IPI00735641.
UniGeneHs.146239

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ86U10.

PTM databases

PhosphoSiteQ86U10.

Genome annotation databases

EnsemblENST00000299234; ENSP00000299234; ENSG00000166183; Homo sapiens. [Genome view]
ENST00000455920; ENSP00000389003; ENSG00000166183; Homo sapiens. [Genome view]
UCSCuc001yoo.1. human.
uc001yop.1. human.

Organism-specific databases

GeneCardsGC14P103622.
HGNCHGNC:20123. ASPG.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ86U10.

Enzyme and pathway databases

BRENDA3.1.1.47. 247.
3.1.1.5. 247.
3.5.1.1. 247.

Gene expression databases

BgeeQ86U10.
CleanExHS_ASPG.
GenevestigatorQ86U10.

Family and domain databases

InterProIPR002110. ANK.
IPR006033. AsnASEI.
IPR006034. Asp/Glutamnse.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PANTHERPTHR11707. Asp/Glutamnse. 1 hit.
PfamPF00023. Ank. 4 hits.
PF00710. Asparaginase. 1 hit.
[Graphical view]
PRINTSPR00139. ASNGLNASE.
ProDomPD003221. Asp/Glutamnse. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00248. ANK. 4 hits.
[Graphical view]
TIGRFAMsTIGR00519. asnASE_I. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS00144. ASN_GLN_ASE_1. False negative.
PS00917. ASN_GLN_ASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLPP60_HUMAN
AccessionPrimary (citable) accession number: Q86U10
Secondary accession number(s): Q8IV80
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 3, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents