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Protein
Submitted name:

Full-length cDNA clone CS0DI063YK23 of Placenta of Homo sapiens (human)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi306Magnesium 1; catalyticUniRule annotation1
Metal bindingi306Magnesium 2; catalyticUniRule annotation1
Metal bindingi307Magnesium 2; via carbonyl oxygen; catalyticUniRule annotation1
Metal bindingi350Magnesium 1; catalyticUniRule annotation1
Metal bindingi350Magnesium 2; catalyticUniRule annotation1
Binding sitei394ATPUniRule annotation1
Binding sitei953ATPUniRule annotation1
Binding sitei1080ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 311ATPUniRule annotation6
Nucleotide bindingi348 – 350ATPUniRule annotation3
Nucleotide bindingi1033 – 1035ATPUniRule annotation3
Nucleotide bindingi1040 – 1044ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Full-length cDNA clone CS0DI063YK23 of Placenta of Homo sapiens (human)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei89 – 108HelicalSequence analysisAdd BLAST20
Transmembranei120 – 142HelicalSequence analysisAdd BLAST23
Transmembranei148 – 164HelicalSequence analysisAdd BLAST17
Transmembranei171 – 190HelicalSequence analysisAdd BLAST20
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei614 – 633HelicalSequence analysisAdd BLAST20
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Transmembranei692 – 713HelicalSequence analysisAdd BLAST22
Transmembranei748 – 765HelicalSequence analysisAdd BLAST18
Transmembranei772 – 793HelicalSequence analysisAdd BLAST22
Transmembranei818 – 835HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ86TZ7

Expressioni

Gene expression databases

GenevisibleiQ86TZ7 HS

Structurei

3D structure databases

ProteinModelPortaliQ86TZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini301 – 428Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini901 – 1046Guanylate cyclaseInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3619 Eukaryota
COG2114 LUCA
HOGENOMiHOG000006941
HOVERGENiHBG050458

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR032628 AC_N
IPR030672 Adcy
IPR009398 Adcy_conserved_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF16214 AC_N, 1 hit
PF06327 DUF1053, 1 hit
PF00211 Guanylate_cyc, 2 hits
PIRSFiPIRSF039050 Ade_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequencei

Sequence statusi: Fragment.

Q86TZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SPAPSPDLAH SAAPAPRAPA PGLGAGEIMA RLFSPRPPPS EDLFYETYYS
60 70 80 90 100
LSQQYPLLLL LLGIVLCALA ALLAVAWASG RELTSDPSFL TTVLCALGGF
110 120 130 140 150
SLLLGLASRE QRLQRWTRPL SGLVWVALLA LGHAFLFTGG VVSAWDQVSY
160 170 180 190 200
FLFVIFTAYA MLPLGMRDAA VAGLASSLSH LLVLGLYLGP QPDSRPALLP
210 220 230 240 250
QLAANAVLFL CGNVAGVYHK ALMERALRAT FREALSSLHS RRRLDTEKKH
260 270 280 290 300
QEHLLLSILP AYLAREMKAE IMARLQAGQG SRPESTNNFH SLYVKRHQGV
310 320 330 340 350
SVLYADIVGF TRLASECSPK ELVLMLNELF GKFDQIAKEH ECMRIKILGD
360 370 380 390 400
CYYCVSGLPL SLPDHAINCV RMGLDMCRAI RKLRAATGVD INMRVGVHSG
410 420 430 440 450
SVLCGVIGLQ KWQYDVWSHD VTLANHMEAG GVPGRVHITG ATLALLAGAY
460 470 480 490 500
AVEDAGMEHR DPYLRELGEP TYLVIDPRAE EEDEKGTAGG LLSSLEGLKM
510 520 530 540 550
RPSLLMTRYL ESWGAAKPFA HLSHGDSPVS TSTPLPEKTL ASFSTQWSLD
560 570 580 590 600
RSRTPRGLDD ELDTGDAKFF QVIEQLNSQK QWKQSKDFNP LTLYFREKEM
610 620 630 640 650
EKEYRLSAIP AFKYYEACTF LVFLSNFIIQ MLVTNRPPAL AITYSITFLL
660 670 680 690 700
FLLILFVCFS EDLMRCVLKG PKMLHWLPAL SGLVATRPGL RIALGTATIL
710 720 730 740 750
LVFAMAITSL FFFPTSSDCP FQAPNVSSMI SNLSWELPGS LPLISVPYSM
760 770 780 790 800
HCCTLGFLSC SLFLHMSFEL KLLLLLLWLA ASCSLFLHSH AWLSECLIVR
810 820 830 840 850
LYLGPLDSRP GVLKEPKLMG AISFFIFFFT LLVLARQNEY YCRLDFLWKK
860 870 880 890 900
KLRQEREETE TMENLTRLLL ENVLPAHVAP QFIGQNRRNE DLYHQSYECV
910 920 930 940 950
CVLFASVPDF KEFYSESNIN HEGLECLRLL NEIIADFDEL LSKPKFSGVE
960 970 980 990 1000
KIKTIGSTYM AATGLNATSG QDAQQDAERS CSHLGTMVEF AVALGSKLDV
1010 1020 1030 1040 1050
INKHSFNNFR LRVGLNHGPV VAGVIGAQKP QYDIWGNTVN VASRMESTGV
1060 1070 1080 1090 1100
LGKIQVTEET AWALQSLGYT CYSRGVIKVK GKGQLCTYFL NTDLTRTGPP

SATLG
Length:1,105
Mass (Da):122,352
Last modified:June 1, 2003 - v1
Checksum:i238E4973341EBCBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248285 mRNA Translation: CAD62613.1
RefSeqiNP_001185521.1, NM_001198592.1
UniGeneiHs.443428

Genome annotation databases

GeneIDi196883

Similar proteinsi

Entry informationi

Entry nameiQ86TZ7_HUMAN
AccessioniPrimary (citable) accession number: Q86TZ7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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