Q86TZ7 (Q86TZ7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Full-length cDNA clone CS0DI063YK23 of Placenta of Homo sapiens (human) EMBL CAD62613.1
Organism	Homo sapiens (Human) EMBL CAD62613.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1105 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. RuleBase RU000405

Ontologies

Keywords
Ligand	Nucleotide-binding SAAS SAAS001054
Molecular function	Lyase SAAS SAAS001054 RuleBase RU000405
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara cAMP biosynthetic process Inferred from electronic annotation. Source: GOC intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	dendrite Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: InterPro intracellular Inferred from electronic annotation. Source: Compara
Molecular_function	adenylate cyclase activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAD62613.1

Sequences

	Sequence		Length	Mass (Da)
	Q86TZ7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 238E4973341EBCBB	FASTA	1,105	122,352
	10 20 30 40 50 60 SPAPSPDLAH SAAPAPRAPA PGLGAGEIMA RLFSPRPPPS EDLFYETYYS LSQQYPLLLL 70 80 90 100 110 120 LLGIVLCALA ALLAVAWASG RELTSDPSFL TTVLCALGGF SLLLGLASRE QRLQRWTRPL 130 140 150 160 170 180 SGLVWVALLA LGHAFLFTGG VVSAWDQVSY FLFVIFTAYA MLPLGMRDAA VAGLASSLSH 190 200 210 220 230 240 LLVLGLYLGP QPDSRPALLP QLAANAVLFL CGNVAGVYHK ALMERALRAT FREALSSLHS 250 260 270 280 290 300 RRRLDTEKKH QEHLLLSILP AYLAREMKAE IMARLQAGQG SRPESTNNFH SLYVKRHQGV 310 320 330 340 350 360 SVLYADIVGF TRLASECSPK ELVLMLNELF GKFDQIAKEH ECMRIKILGD CYYCVSGLPL 370 380 390 400 410 420 SLPDHAINCV RMGLDMCRAI RKLRAATGVD INMRVGVHSG SVLCGVIGLQ KWQYDVWSHD 430 440 450 460 470 480 VTLANHMEAG GVPGRVHITG ATLALLAGAY AVEDAGMEHR DPYLRELGEP TYLVIDPRAE 490 500 510 520 530 540 EEDEKGTAGG LLSSLEGLKM RPSLLMTRYL ESWGAAKPFA HLSHGDSPVS TSTPLPEKTL 550 560 570 580 590 600 ASFSTQWSLD RSRTPRGLDD ELDTGDAKFF QVIEQLNSQK QWKQSKDFNP LTLYFREKEM 610 620 630 640 650 660 EKEYRLSAIP AFKYYEACTF LVFLSNFIIQ MLVTNRPPAL AITYSITFLL FLLILFVCFS 670 680 690 700 710 720 EDLMRCVLKG PKMLHWLPAL SGLVATRPGL RIALGTATIL LVFAMAITSL FFFPTSSDCP 730 740 750 760 770 780 FQAPNVSSMI SNLSWELPGS LPLISVPYSM HCCTLGFLSC SLFLHMSFEL KLLLLLLWLA 790 800 810 820 830 840 ASCSLFLHSH AWLSECLIVR LYLGPLDSRP GVLKEPKLMG AISFFIFFFT LLVLARQNEY 850 860 870 880 890 900 YCRLDFLWKK KLRQEREETE TMENLTRLLL ENVLPAHVAP QFIGQNRRNE DLYHQSYECV 910 920 930 940 950 960 CVLFASVPDF KEFYSESNIN HEGLECLRLL NEIIADFDEL LSKPKFSGVE KIKTIGSTYM 970 980 990 1000 1010 1020 AATGLNATSG QDAQQDAERS CSHLGTMVEF AVALGSKLDV INKHSFNNFR LRVGLNHGPV 1030 1040 1050 1060 1070 1080 VAGVIGAQKP QYDIWGNTVN VASRMESTGV LGKIQVTEET AWALQSLGYT CYSRGVIKVK 1090 1100 GKGQLCTYFL NTDLTRTGPP SATLG

References

[1]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL CAD62613.1.
[2]	Genoscope Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL CAD62613.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248285 mRNA. Translation: CAD62613.1.
IPI	IPI00465156.
RefSeq	NP_001185521.1. NM_001198592.1.
UniGene	Hs.443428.
3D structure databases
HSSP	HSSP built from PDB template 1CJK based on UniProtKB P26769.
ProteinModelPortal	Q86TZ7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86TZ7.
Proteomic databases
PRIDE	Q86TZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	196883.
KEGG	hsa:196883.
Organism-specific databases
CTD	196883.
Phylogenomic databases
HOGENOM	HOG000006941.
HOVERGEN	HBG050458.
KO	K08044.
Gene expression databases
ArrayExpress	Q86TZ7.
Bgee	Q86TZ7.
Family and domain databases
Gene3D	3.30.70.1230. 2 hits.
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Adenylate_cyclase-like. [Graphical view]
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 2 hits.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q86TZ7.
GenomeRNAi	196883.
NextBio	89574.

Entry information

Entry name

Q86TZ7_HUMAN

Accession

Primary (citable) accession number: Q86TZ7

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	March 6, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.