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Protein

Tetratricopeptide repeat protein 6

Gene

TTC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 6
Short name:
TPR repeat protein 6
Gene namesi
Name:TTC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19739. TTC6.

Pathology & Biotechi

Organism-specific databases

DisGeNETi319089.
OpenTargetsiENSG00000139865.

Polymorphism and mutation databases

DMDMi37088302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063841 – 520Tetratricopeptide repeat protein 6Add BLAST520

Proteomic databases

PaxDbiQ86TZ1.
PRIDEiQ86TZ1.

PTM databases

PhosphoSitePlusiQ86TZ1.

Expressioni

Gene expression databases

BgeeiENSG00000139865.
CleanExiHS_TTC6.
ExpressionAtlasiQ86TZ1. baseline and differential.
GenevisibleiQ86TZ1. HS.

Organism-specific databases

HPAiHPA069293.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000451131.

Structurei

3D structure databases

ProteinModelPortaliQ86TZ1.
SMRiQ86TZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 90TPR 1Add BLAST34
Repeati101 – 138TPR 2Add BLAST38
Repeati139 – 172TPR 3Add BLAST34
Repeati176 – 209TPR 4Add BLAST34
Repeati210 – 243TPR 5Add BLAST34
Repeati245 – 280TPR 6Add BLAST36
Repeati281 – 314TPR 7Add BLAST34
Repeati320 – 347TPR 8Add BLAST28
Repeati348 – 381TPR 9Add BLAST34
Repeati382 – 415TPR 10Add BLAST34
Repeati416 – 449TPR 11Add BLAST34
Repeati450 – 483TPR 12Add BLAST34
Repeati484 – 517TPR 13Add BLAST34

Sequence similaritiesi

Contains 13 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110941.
HOGENOMiHOG000132920.
InParanoidiQ86TZ1.
PhylomeDBiQ86TZ1.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 12 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 10 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMKYYDLAKF TIYQIAEMDK GLSELSPMQQ ALIYSFCENH DKAIEVLDGI
60 70 80 90 100
SWNRAEMTMC ALLAKVQMKA KRTKEAVEVL KKALDAISHS DKGPDATAIS
110 120 130 140 150
ADCLYNLGLC YMEEGNLQMT YKLAITDLTT AISMDKNSYT AFYNRALCYT
160 170 180 190 200
KIRELQMALT DYGIVLLLDA TETVKLNTFL NRGLIYVELG QYGFALEDFK
210 220 230 240 250
QAALISRTNG SLCHATAMCH HRINEFEEAV NFFTWALKIN PCFLDAYVGR
260 270 280 290 300
GNSYMEYGHD EATKQAQKDF LKALHINPAY IKARISFGYN LQAQGKFQKA
310 320 330 340 350
WNHFTIAIDT DPKNYLAYEG RAVVCLQMGN NFAAMQDINA AMKISTTAEF
360 370 380 390 400
LTNRGVIHEF MGHKQNAMKD YQDAITLNPK YSLAYFNAGN IYFHHRQFSQ
410 420 430 440 450
ASDYFSKALK FDPENEYVLM NRAITNTILK KYEEAKEDFA NVIESCPFWA
460 470 480 490 500
AVYFNRAHFY YCLKQYELAE EDLNKALSLK PNDALVYNFR AKVRGKIGLI
510 520
EEAMADYNQA LDLEDYASVI
Length:520
Mass (Da):59,379
Last modified:June 1, 2003 - v1
Checksum:i4F253FF28B54845E
GO
Isoform 2 (identifier: Q86TZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     119-119: M → MAFDSFTKAV...YRGVLKYYNK
     401-456: ASDYFSKALK...PFWAAVYFNR → EESLGLAWSL...CPRDEMDFTS
     457-520: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):60,701
Checksum:iEFCDAD2E1767CCED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03413287I → S.Corresponds to variant rs12896790dbSNPEnsembl.1
Natural variantiVAR_03413398A → T.Corresponds to variant rs17768654dbSNPEnsembl.1
Natural variantiVAR_024677140T → I.Corresponds to variant rs4901284dbSNPEnsembl.1
Natural variantiVAR_034134376T → S.Corresponds to variant rs17107176dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563211 – 17Missing in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_056322119M → MAFDSFTKAVKANPDFAESF YQRGLCKVKLHKDSSILDFN RAITLNPKHYQAYLSRVAFY GLKGRYSKAILNCNKAIKIY PESVRAYLYRGVLKYYNK in isoform 2. 1 Publication1
Alternative sequenceiVSP_056323401 – 456ASDYF…VYFNR → EESLGLAWSLSLDSFLRTGG ATFSSGVNPLQTLHRRMSIL SPLPPTCPRDEMDFTS in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_056324457 – 520Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161415 mRNA. Translation: CAD61890.1.
AL121790 Genomic DNA. No translation available.
AL136296 Genomic DNA. No translation available.
AL163151 Genomic DNA. No translation available.
AL359233 Genomic DNA. No translation available.
BC014342 mRNA. Translation: AAH14342.2.
BC103914 mRNA. Translation: AAI03915.1.
UniGeneiHs.659936.

Genome annotation databases

EnsembliENST00000267368; ENSP00000267368; ENSG00000139865. [Q86TZ1-1]
ENST00000476979; ENSP00000417788; ENSG00000139865. [Q86TZ1-1]
UCSCiuc001wuh.4. human. [Q86TZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161415 mRNA. Translation: CAD61890.1.
AL121790 Genomic DNA. No translation available.
AL136296 Genomic DNA. No translation available.
AL163151 Genomic DNA. No translation available.
AL359233 Genomic DNA. No translation available.
BC014342 mRNA. Translation: AAH14342.2.
BC103914 mRNA. Translation: AAI03915.1.
UniGeneiHs.659936.

3D structure databases

ProteinModelPortaliQ86TZ1.
SMRiQ86TZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000451131.

PTM databases

PhosphoSitePlusiQ86TZ1.

Polymorphism and mutation databases

DMDMi37088302.

Proteomic databases

PaxDbiQ86TZ1.
PRIDEiQ86TZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267368; ENSP00000267368; ENSG00000139865. [Q86TZ1-1]
ENST00000476979; ENSP00000417788; ENSG00000139865. [Q86TZ1-1]
UCSCiuc001wuh.4. human. [Q86TZ1-1]

Organism-specific databases

DisGeNETi319089.
GeneCardsiTTC6.
HGNCiHGNC:19739. TTC6.
HPAiHPA069293.
neXtProtiNX_Q86TZ1.
OpenTargetsiENSG00000139865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110941.
HOGENOMiHOG000132920.
InParanoidiQ86TZ1.
PhylomeDBiQ86TZ1.

Miscellaneous databases

PROiQ86TZ1.

Gene expression databases

BgeeiENSG00000139865.
CleanExiHS_TTC6.
ExpressionAtlasiQ86TZ1. baseline and differential.
GenevisibleiQ86TZ1. HS.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 12 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 10 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC6_HUMAN
AccessioniPrimary (citable) accession number: Q86TZ1
Secondary accession number(s): Q3SY88, Q96CE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.