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Protein

Uncharacterized protein C14orf37

Gene

C14orf37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C14orf37
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19846. C14orf37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 714687ExtracellularSequence analysisAdd
BLAST
Transmembranei715 – 73521HelicalSequence analysisAdd
BLAST
Topological domaini736 – 77439CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941886.

Polymorphism and mutation databases

BioMutaiC14orf37.
DMDMi74750397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 774747Uncharacterized protein C14orf37PRO_0000252152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Modified residuei769 – 7691PhosphoserineCombined sources
Modified residuei770 – 7701PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ86TY3.
PRIDEiQ86TY3.

PTM databases

iPTMnetiQ86TY3.
PhosphoSiteiQ86TY3.

Expressioni

Gene expression databases

BgeeiQ86TY3.
CleanExiHS_C14orf37.
ExpressionAtlasiQ86TY3. baseline and differential.
GenevisibleiQ86TY3. HS.

Organism-specific databases

HPAiHPA001789.

Interactioni

Protein-protein interaction databases

BioGridi126910. 5 interactions.
STRINGi9606.ENSP00000267485.

Structurei

3D structure databases

ProteinModelPortaliQ86TY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi608 – 63629Glu-richAdd
BLAST
Compositional biasi740 – 7434Poly-Arg

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9G. Eukaryota.
ENOG410YWKQ. LUCA.
GeneTreeiENSGT00390000012816.
HOGENOMiHOG000013177.
HOVERGENiHBG081262.
InParanoidiQ86TY3.
OMAiEWDDTKL.
OrthoDBiEOG7BZVRX.
PhylomeDBiQ86TY3.
TreeFamiTF336099.

Family and domain databases

InterProiIPR031524. DUF4696.
[Graphical view]
PfamiPF15767. DUF4696. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGPIVLHIC LAFCSLLLFS VATQCLAFPK IERRREIAHV HAEKGQSDKM
60 70 80 90 100
NTDDLENSSV TSKQTPQLVV SEDPMMMSAV PSATSLNKAF SINKETQPGQ
110 120 130 140 150
AGLMQTERPG VSTPTESGVP SAEEVFGSSQ PERISPESGL AKAMLTIAIT
160 170 180 190 200
ATPSLTVDEK EELLTSTNFQ PIVEEITETT KGFLKYMDNQ SFATESQEGV
210 220 230 240 250
GLGHSPSSYV NTKEMLTTNP KTEKFEADTD HRTTSFPGAE STAGSEPGSL
260 270 280 290 300
TPDKEKPSQM TADNTQAAAT KQPLETSEYT LSVEPETDSL LGAPEVTVSV
310 320 330 340 350
STAVPAASAL SDEWDDTKLE SVSRIRTPKL GDNEETQVRT EMSQTAQVSH
360 370 380 390 400
EGMEGGQPWT EAAQVALGLP EGETHTGTAL LIAHGNERSP AFTDQSSFTP
410 420 430 440 450
TSLMEDMKVS IVNLLQSTGD FTESTKENDA LFFLETTVSV SVYESEADQL
460 470 480 490 500
LGNTMKDIIT QEMTTAVQEP DATLSMVTQE QVATLELIRD SGKTEEEKED
510 520 530 540 550
PSPVSDVPGV TQLSRRWEPL ATTISTTVVP LSFEVTPTVE EQMDTVTGPN
560 570 580 590 600
EEFTPVLGSP VTPPGIMVGE PSISPALPAL EASSERRTVV PSITRVNTAA
610 620 630 640 650
SYGLDQLESE EGQEDEDEED EEDEDEEEED EEEDEEDKDA DSLDEGLDGD
660 670 680 690 700
TELPGFTLPG ITSQEPGLEE GNMDLLEGAT YQVPDALEWE QQNQGLVRSW
710 720 730 740 750
MEKLKDKAGY MSGMLVPVGV GIAGALFILG ALYSIKVMNR RRRNGFKRHK
760 770
RKQREFNSMQ DRVMLLADSS EDEF
Length:774
Mass (Da):84,173
Last modified:June 1, 2003 - v1
Checksum:i0A74F08DF9BF5791
GO
Isoform 2 (identifier: Q86TY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-670: GQEDEDEEDE...ITSQEPGLEE → TGFHHVAQAR...LNPKHFATGV
     671-774: Missing.

Note: No experimental confirmation available.
Show »
Length:670
Mass (Da):72,067
Checksum:i6E34390F03EBEA4F
GO
Isoform 3 (identifier: Q86TY3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-542: Missing.

Note: No experimental confirmation available.
Show »
Length:232
Mass (Da):25,704
Checksum:i224C8EBE8707FEC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti753 – 7531Missing in AAH62772 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961T → I.
Corresponds to variant rs3829765 [ dbSNP | Ensembl ].
VAR_027782
Natural varianti391 – 3911A → V.
Corresponds to variant rs1018504 [ dbSNP | Ensembl ].
VAR_027783
Natural varianti528 – 5281V → F.
Corresponds to variant rs12886921 [ dbSNP | Ensembl ].
VAR_027784
Natural varianti613 – 6131Q → E.
Corresponds to variant rs2273442 [ dbSNP | Ensembl ].
VAR_027785

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 542542Missing in isoform 3. 1 PublicationVSP_020881Add
BLAST
Alternative sequencei612 – 67059GQEDE…PGLEE → TGFHHVAQARLKLLGLRSLP ASASQSVGITSVNSCTQPRK YLNSCLKWKLNPKHFATGV in isoform 2. 1 PublicationVSP_020882Add
BLAST
Alternative sequencei671 – 774104Missing in isoform 2. 1 PublicationVSP_020883Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161411 mRNA. Translation: CAD61887.1.
BX161448 mRNA. Translation: CAD61913.1.
AK292513 mRNA. Translation: BAF85202.1.
CH471061 Genomic DNA. Translation: EAW80713.1.
BC062772 mRNA. Translation: AAH62772.1.
CCDSiCCDS32089.1. [Q86TY3-1]
RefSeqiNP_001001872.2. NM_001001872.3. [Q86TY3-1]
NP_001307102.1. NM_001320173.1. [Q86TY3-2]
UniGeneiHs.26766.
Hs.535420.

Genome annotation databases

EnsembliENST00000267485; ENSP00000267485; ENSG00000139971. [Q86TY3-1]
GeneIDi145407.
KEGGihsa:145407.
UCSCiuc001xdc.4. human. [Q86TY3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161411 mRNA. Translation: CAD61887.1.
BX161448 mRNA. Translation: CAD61913.1.
AK292513 mRNA. Translation: BAF85202.1.
CH471061 Genomic DNA. Translation: EAW80713.1.
BC062772 mRNA. Translation: AAH62772.1.
CCDSiCCDS32089.1. [Q86TY3-1]
RefSeqiNP_001001872.2. NM_001001872.3. [Q86TY3-1]
NP_001307102.1. NM_001320173.1. [Q86TY3-2]
UniGeneiHs.26766.
Hs.535420.

3D structure databases

ProteinModelPortaliQ86TY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126910. 5 interactions.
STRINGi9606.ENSP00000267485.

PTM databases

iPTMnetiQ86TY3.
PhosphoSiteiQ86TY3.

Polymorphism and mutation databases

BioMutaiC14orf37.
DMDMi74750397.

Proteomic databases

PaxDbiQ86TY3.
PRIDEiQ86TY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267485; ENSP00000267485; ENSG00000139971. [Q86TY3-1]
GeneIDi145407.
KEGGihsa:145407.
UCSCiuc001xdc.4. human. [Q86TY3-1]

Organism-specific databases

CTDi145407.
GeneCardsiC14orf37.
HGNCiHGNC:19846. C14orf37.
HPAiHPA001789.
neXtProtiNX_Q86TY3.
PharmGKBiPA134941886.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG9G. Eukaryota.
ENOG410YWKQ. LUCA.
GeneTreeiENSGT00390000012816.
HOGENOMiHOG000013177.
HOVERGENiHBG081262.
InParanoidiQ86TY3.
OMAiEWDDTKL.
OrthoDBiEOG7BZVRX.
PhylomeDBiQ86TY3.
TreeFamiTF336099.

Miscellaneous databases

ChiTaRSiC14orf37. human.
GenomeRNAii145407.
NextBioi85091.
PROiQ86TY3.

Gene expression databases

BgeeiQ86TY3.
CleanExiHS_C14orf37.
ExpressionAtlasiQ86TY3. baseline and differential.
GenevisibleiQ86TY3. HS.

Family and domain databases

InterProiIPR031524. DUF4696.
[Graphical view]
PfamiPF15767. DUF4696. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Neuroblastoma and Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Kidney.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-769 AND SER-770, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCN037_HUMAN
AccessioniPrimary (citable) accession number: Q86TY3
Secondary accession number(s): A8K8Z8, Q6P5Q1, Q86TY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.