Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized protein C14orf37

Gene

C14orf37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C14orf37
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139971.15.
HGNCiHGNC:19846. C14orf37.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 714ExtracellularSequence analysisAdd BLAST687
Transmembranei715 – 735HelicalSequence analysisAdd BLAST21
Topological domaini736 – 774CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi145407.
OpenTargetsiENSG00000139971.
PharmGKBiPA134941886.

Polymorphism and mutation databases

BioMutaiC14orf37.
DMDMi74750397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000025215228 – 774Uncharacterized protein C14orf37Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei769PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ86TY3.
PeptideAtlasiQ86TY3.
PRIDEiQ86TY3.

PTM databases

iPTMnetiQ86TY3.
PhosphoSitePlusiQ86TY3.

Expressioni

Gene expression databases

BgeeiENSG00000139971.
CleanExiHS_C14orf37.
ExpressionAtlasiQ86TY3. baseline and differential.
GenevisibleiQ86TY3. HS.

Organism-specific databases

HPAiHPA001580.
HPA001789.

Interactioni

Protein-protein interaction databases

BioGridi126910. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ86TY3.
SMRiQ86TY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi608 – 636Glu-richAdd BLAST29
Compositional biasi740 – 743Poly-Arg4

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9G. Eukaryota.
ENOG410YWKQ. LUCA.
GeneTreeiENSGT00390000012816.
HOGENOMiHOG000013177.
HOVERGENiHBG081262.
InParanoidiQ86TY3.
OMAiEWDDTKL.
OrthoDBiEOG091G058M.
PhylomeDBiQ86TY3.
TreeFamiTF336099.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR031524. DUF4696.
PfamiView protein in Pfam
PF15767. DUF4696. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGPIVLHIC LAFCSLLLFS VATQCLAFPK IERRREIAHV HAEKGQSDKM
60 70 80 90 100
NTDDLENSSV TSKQTPQLVV SEDPMMMSAV PSATSLNKAF SINKETQPGQ
110 120 130 140 150
AGLMQTERPG VSTPTESGVP SAEEVFGSSQ PERISPESGL AKAMLTIAIT
160 170 180 190 200
ATPSLTVDEK EELLTSTNFQ PIVEEITETT KGFLKYMDNQ SFATESQEGV
210 220 230 240 250
GLGHSPSSYV NTKEMLTTNP KTEKFEADTD HRTTSFPGAE STAGSEPGSL
260 270 280 290 300
TPDKEKPSQM TADNTQAAAT KQPLETSEYT LSVEPETDSL LGAPEVTVSV
310 320 330 340 350
STAVPAASAL SDEWDDTKLE SVSRIRTPKL GDNEETQVRT EMSQTAQVSH
360 370 380 390 400
EGMEGGQPWT EAAQVALGLP EGETHTGTAL LIAHGNERSP AFTDQSSFTP
410 420 430 440 450
TSLMEDMKVS IVNLLQSTGD FTESTKENDA LFFLETTVSV SVYESEADQL
460 470 480 490 500
LGNTMKDIIT QEMTTAVQEP DATLSMVTQE QVATLELIRD SGKTEEEKED
510 520 530 540 550
PSPVSDVPGV TQLSRRWEPL ATTISTTVVP LSFEVTPTVE EQMDTVTGPN
560 570 580 590 600
EEFTPVLGSP VTPPGIMVGE PSISPALPAL EASSERRTVV PSITRVNTAA
610 620 630 640 650
SYGLDQLESE EGQEDEDEED EEDEDEEEED EEEDEEDKDA DSLDEGLDGD
660 670 680 690 700
TELPGFTLPG ITSQEPGLEE GNMDLLEGAT YQVPDALEWE QQNQGLVRSW
710 720 730 740 750
MEKLKDKAGY MSGMLVPVGV GIAGALFILG ALYSIKVMNR RRRNGFKRHK
760 770
RKQREFNSMQ DRVMLLADSS EDEF
Length:774
Mass (Da):84,173
Last modified:June 1, 2003 - v1
Checksum:i0A74F08DF9BF5791
GO
Isoform 2 (identifier: Q86TY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-670: GQEDEDEEDE...ITSQEPGLEE → TGFHHVAQAR...LNPKHFATGV
     671-774: Missing.

Note: No experimental confirmation available.
Show »
Length:670
Mass (Da):72,067
Checksum:i6E34390F03EBEA4F
GO
Isoform 3 (identifier: Q86TY3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-542: Missing.

Note: No experimental confirmation available.
Show »
Length:232
Mass (Da):25,704
Checksum:i224C8EBE8707FEC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti753Missing in AAH62772 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02778296T → I. Corresponds to variant dbSNP:rs3829765Ensembl.1
Natural variantiVAR_027783391A → V. Corresponds to variant dbSNP:rs1018504Ensembl.1
Natural variantiVAR_027784528V → F. Corresponds to variant dbSNP:rs12886921Ensembl.1
Natural variantiVAR_027785613Q → E. Corresponds to variant dbSNP:rs2273442Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0208811 – 542Missing in isoform 3. 1 PublicationAdd BLAST542
Alternative sequenceiVSP_020882612 – 670GQEDE…PGLEE → TGFHHVAQARLKLLGLRSLP ASASQSVGITSVNSCTQPRK YLNSCLKWKLNPKHFATGV in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_020883671 – 774Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161411 mRNA. Translation: CAD61887.1.
BX161448 mRNA. Translation: CAD61913.1.
AK292513 mRNA. Translation: BAF85202.1.
CH471061 Genomic DNA. Translation: EAW80713.1.
BC062772 mRNA. Translation: AAH62772.1.
CCDSiCCDS32089.1. [Q86TY3-1]
RefSeqiNP_001001872.2. NM_001001872.3. [Q86TY3-1]
NP_001307102.1. NM_001320173.1. [Q86TY3-2]
XP_016876518.1. XM_017021029.1. [Q86TY3-1]
UniGeneiHs.26766.
Hs.535420.

Genome annotation databases

EnsembliENST00000267485; ENSP00000267485; ENSG00000139971. [Q86TY3-1]
GeneIDi145407.
KEGGihsa:145407.
UCSCiuc001xdc.4. human. [Q86TY3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCN037_HUMAN
AccessioniPrimary (citable) accession number: Q86TY3
Secondary accession number(s): A8K8Z8, Q6P5Q1, Q86TY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations