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Q86TW2

- ADCK1_HUMAN

UniProt

Q86TW2 - ADCK1_HUMAN

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Protein

Uncharacterized aarF domain-containing protein kinase 1

Gene

ADCK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831ATPBy similarity
Active sitei315 – 3151Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1699ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
Gene namesi
Name:ADCK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19038. ADCK1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 530513Uncharacterized aarF domain-containing protein kinase 1PRO_0000252249Add
BLAST

Proteomic databases

MaxQBiQ86TW2.
PaxDbiQ86TW2.
PRIDEiQ86TW2.

PTM databases

PhosphoSiteiQ86TW2.

Expressioni

Gene expression databases

BgeeiQ86TW2.
CleanExiHS_ADCK1.
ExpressionAtlasiQ86TW2. baseline and differential.
GenevestigatoriQ86TW2.

Organism-specific databases

HPAiHPA051012.
HPA055014.

Interactioni

Protein-protein interaction databases

BioGridi121401. 4 interactions.
IntActiQ86TW2. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ86TW2.
SMRiQ86TW2. Positions 308-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 467313Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0661.
GeneTreeiENSGT00550000074734.
HOGENOMiHOG000240338.
HOVERGENiHBG056527.
InParanoidiQ86TW2.
KOiK08869.
OMAiIWTDMKR.
OrthoDBiEOG7RBZ82.
PhylomeDBiQ86TW2.
TreeFamiTF314889.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86TW2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS
60 70 80 90 100
YDYLTSLKSV PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF
110 120 130 140 150
IKVGQHLGAL DYLLPEEYTS TLKVLHSQAP QSSMQEIRQV IREDLGKEIH
160 170 180 190 200
DLFQSFDDTP LGTASLAQVH KAVLHDGRTV AVKVQHPKVR AQSSKDILLM
210 220 230 240 250
EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA EKVSQMLRHF
260 270 280 290 300
DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK
310 320 330 340 350
MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR
360 370 380 390 400
LNYCHLWQSL IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI
410 420 430 440 450
SQAPVTATED LEIRNNAANY LPQISHLLNH VPRQMLLILK TNDLLRGIEA
460 470 480 490 500
ALGTRASASS FLNMSRCCIR ALAEHKKKNT CSFFRRTQIS FSEAFNLWQI
510 520 530
NLHELILRVK GLKLADRVLA LICWLFPAPL
Length:530
Mass (Da):60,577
Last modified:October 3, 2006 - v2
Checksum:iCBB1DFA87D0F41CF
GO
Isoform 2 (identifier: Q86TW2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-80: Missing.

Note: No experimental confirmation available.

Show »
Length:523
Mass (Da):59,719
Checksum:i94BEF675D2642ADB
GO
Isoform 3 (identifier: Q86TW2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-148: Missing.

Note: No experimental confirmation available.

Show »
Length:455
Mass (Da):51,999
Checksum:iE2B3FD7B4E5AAC7C
GO

Sequence cautioni

The sequence CAD62620.1 differs from that shown. Reason: Aberrant splicing.
The sequence CAD62620.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71K → N in BAG53397. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 14875Missing in isoform 3. 1 PublicationVSP_046794Add
BLAST
Alternative sequencei74 – 807Missing in isoform 2. 1 PublicationVSP_020885

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096919 mRNA. Translation: BAG53397.1.
AC008372 Genomic DNA. Translation: AAF23326.1.
CH471061 Genomic DNA. Translation: EAW81310.1.
BC058906 mRNA. Translation: AAH58906.1.
BX248292 mRNA. Translation: CAD62620.1. Sequence problems.
CCDSiCCDS45144.1. [Q86TW2-3]
CCDS9869.1. [Q86TW2-2]
RefSeqiNP_001136017.1. NM_001142545.1. [Q86TW2-3]
NP_065154.2. NM_020421.3. [Q86TW2-2]
UniGeneiHs.413208.

Genome annotation databases

EnsembliENST00000238561; ENSP00000238561; ENSG00000063761. [Q86TW2-2]
ENST00000341211; ENSP00000339663; ENSG00000063761. [Q86TW2-3]
GeneIDi57143.
KEGGihsa:57143.
UCSCiuc001xui.3. human. [Q86TW2-2]
uc001xuj.3. human.

Polymorphism databases

DMDMi115503784.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096919 mRNA. Translation: BAG53397.1 .
AC008372 Genomic DNA. Translation: AAF23326.1 .
CH471061 Genomic DNA. Translation: EAW81310.1 .
BC058906 mRNA. Translation: AAH58906.1 .
BX248292 mRNA. Translation: CAD62620.1 . Sequence problems.
CCDSi CCDS45144.1. [Q86TW2-3 ]
CCDS9869.1. [Q86TW2-2 ]
RefSeqi NP_001136017.1. NM_001142545.1. [Q86TW2-3 ]
NP_065154.2. NM_020421.3. [Q86TW2-2 ]
UniGenei Hs.413208.

3D structure databases

ProteinModelPortali Q86TW2.
SMRi Q86TW2. Positions 308-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121401. 4 interactions.
IntActi Q86TW2. 2 interactions.

PTM databases

PhosphoSitei Q86TW2.

Polymorphism databases

DMDMi 115503784.

Proteomic databases

MaxQBi Q86TW2.
PaxDbi Q86TW2.
PRIDEi Q86TW2.

Protocols and materials databases

DNASUi 57143.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000238561 ; ENSP00000238561 ; ENSG00000063761 . [Q86TW2-2 ]
ENST00000341211 ; ENSP00000339663 ; ENSG00000063761 . [Q86TW2-3 ]
GeneIDi 57143.
KEGGi hsa:57143.
UCSCi uc001xui.3. human. [Q86TW2-2 ]
uc001xuj.3. human.

Organism-specific databases

CTDi 57143.
GeneCardsi GC14P078266.
HGNCi HGNC:19038. ADCK1.
HPAi HPA051012.
HPA055014.
neXtProti NX_Q86TW2.
PharmGKBi PA134861355.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0661.
GeneTreei ENSGT00550000074734.
HOGENOMi HOG000240338.
HOVERGENi HBG056527.
InParanoidi Q86TW2.
KOi K08869.
OMAi IWTDMKR.
OrthoDBi EOG7RBZ82.
PhylomeDBi Q86TW2.
TreeFami TF314889.

Miscellaneous databases

GenomeRNAii 57143.
NextBioi 63087.
PROi Q86TW2.

Gene expression databases

Bgeei Q86TW2.
CleanExi HS_ADCK1.
ExpressionAtlasi Q86TW2. baseline and differential.
Genevestigatori Q86TW2.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view ]
Pfami PF03109. ABC1. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  5. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-93 (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiADCK1_HUMAN
AccessioniPrimary (citable) accession number: Q86TW2
Secondary accession number(s): B3KUD5, Q6PD65, Q9UIE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3