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Protein

Uncharacterized aarF domain-containing protein kinase 1

Gene

ADCK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831ATPBy similarity
Active sitei315 – 3151Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1699ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
Gene namesi
Name:ADCK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19038. ADCK1.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861355.

Polymorphism and mutation databases

BioMutaiADCK1.
DMDMi115503784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 530513Uncharacterized aarF domain-containing protein kinase 1PRO_0000252249Add
BLAST

Proteomic databases

MaxQBiQ86TW2.
PaxDbiQ86TW2.
PRIDEiQ86TW2.

PTM databases

PhosphoSiteiQ86TW2.

Expressioni

Gene expression databases

BgeeiQ86TW2.
CleanExiHS_ADCK1.
ExpressionAtlasiQ86TW2. baseline and differential.
GenevestigatoriQ86TW2.

Organism-specific databases

HPAiHPA051012.
HPA055014.

Interactioni

Protein-protein interaction databases

BioGridi121401. 6 interactions.
IntActiQ86TW2. 2 interactions.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 467313Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0661.
GeneTreeiENSGT00550000074734.
HOGENOMiHOG000240338.
HOVERGENiHBG056527.
InParanoidiQ86TW2.
KOiK08869.
OMAiIWTDMKR.
OrthoDBiEOG7RBZ82.
PhylomeDBiQ86TW2.
TreeFamiTF314889.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS
60 70 80 90 100
YDYLTSLKSV PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF
110 120 130 140 150
IKVGQHLGAL DYLLPEEYTS TLKVLHSQAP QSSMQEIRQV IREDLGKEIH
160 170 180 190 200
DLFQSFDDTP LGTASLAQVH KAVLHDGRTV AVKVQHPKVR AQSSKDILLM
210 220 230 240 250
EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA EKVSQMLRHF
260 270 280 290 300
DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK
310 320 330 340 350
MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR
360 370 380 390 400
LNYCHLWQSL IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI
410 420 430 440 450
SQAPVTATED LEIRNNAANY LPQISHLLNH VPRQMLLILK TNDLLRGIEA
460 470 480 490 500
ALGTRASASS FLNMSRCCIR ALAEHKKKNT CSFFRRTQIS FSEAFNLWQI
510 520 530
NLHELILRVK GLKLADRVLA LICWLFPAPL
Length:530
Mass (Da):60,577
Last modified:October 3, 2006 - v2
Checksum:iCBB1DFA87D0F41CF
GO
Isoform 2 (identifier: Q86TW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-80: Missing.

Note: No experimental confirmation available.

Show »
Length:523
Mass (Da):59,719
Checksum:i94BEF675D2642ADB
GO
Isoform 3 (identifier: Q86TW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-148: Missing.

Note: No experimental confirmation available.

Show »
Length:455
Mass (Da):51,999
Checksum:iE2B3FD7B4E5AAC7C
GO

Sequence cautioni

The sequence CAD62620.1 differs from that shown.Aberrant splicing.Curated
The sequence CAD62620.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71K → N in BAG53397 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 14875Missing in isoform 3. 1 PublicationVSP_046794Add
BLAST
Alternative sequencei74 – 807Missing in isoform 2. 1 PublicationVSP_020885

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096919 mRNA. Translation: BAG53397.1.
AC008372 Genomic DNA. Translation: AAF23326.1.
CH471061 Genomic DNA. Translation: EAW81310.1.
BC058906 mRNA. Translation: AAH58906.1.
BX248292 mRNA. Translation: CAD62620.1. Sequence problems.
CCDSiCCDS45144.1. [Q86TW2-3]
CCDS9869.1. [Q86TW2-2]
RefSeqiNP_001136017.1. NM_001142545.1. [Q86TW2-3]
NP_065154.2. NM_020421.3. [Q86TW2-2]
UniGeneiHs.413208.

Genome annotation databases

EnsembliENST00000238561; ENSP00000238561; ENSG00000063761. [Q86TW2-2]
ENST00000341211; ENSP00000339663; ENSG00000063761. [Q86TW2-3]
GeneIDi57143.
KEGGihsa:57143.
UCSCiuc001xui.3. human. [Q86TW2-2]
uc001xuj.3. human.

Polymorphism and mutation databases

BioMutaiADCK1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096919 mRNA. Translation: BAG53397.1.
AC008372 Genomic DNA. Translation: AAF23326.1.
CH471061 Genomic DNA. Translation: EAW81310.1.
BC058906 mRNA. Translation: AAH58906.1.
BX248292 mRNA. Translation: CAD62620.1. Sequence problems.
CCDSiCCDS45144.1. [Q86TW2-3]
CCDS9869.1. [Q86TW2-2]
RefSeqiNP_001136017.1. NM_001142545.1. [Q86TW2-3]
NP_065154.2. NM_020421.3. [Q86TW2-2]
UniGeneiHs.413208.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121401. 6 interactions.
IntActiQ86TW2. 2 interactions.

PTM databases

PhosphoSiteiQ86TW2.

Polymorphism and mutation databases

BioMutaiADCK1.
DMDMi115503784.

Proteomic databases

MaxQBiQ86TW2.
PaxDbiQ86TW2.
PRIDEiQ86TW2.

Protocols and materials databases

DNASUi57143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238561; ENSP00000238561; ENSG00000063761. [Q86TW2-2]
ENST00000341211; ENSP00000339663; ENSG00000063761. [Q86TW2-3]
GeneIDi57143.
KEGGihsa:57143.
UCSCiuc001xui.3. human. [Q86TW2-2]
uc001xuj.3. human.

Organism-specific databases

CTDi57143.
GeneCardsiGC14P078266.
HGNCiHGNC:19038. ADCK1.
HPAiHPA051012.
HPA055014.
neXtProtiNX_Q86TW2.
PharmGKBiPA134861355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0661.
GeneTreeiENSGT00550000074734.
HOGENOMiHOG000240338.
HOVERGENiHBG056527.
InParanoidiQ86TW2.
KOiK08869.
OMAiIWTDMKR.
OrthoDBiEOG7RBZ82.
PhylomeDBiQ86TW2.
TreeFamiTF314889.

Miscellaneous databases

ChiTaRSiADCK1. human.
GenomeRNAii57143.
NextBioi63087.
PROiQ86TW2.

Gene expression databases

BgeeiQ86TW2.
CleanExiHS_ADCK1.
ExpressionAtlasiQ86TW2. baseline and differential.
GenevestigatoriQ86TW2.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  5. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-93 (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiADCK1_HUMAN
AccessioniPrimary (citable) accession number: Q86TW2
Secondary accession number(s): B3KUD5, Q6PD65, Q9UIE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: April 29, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.