Q86TW2 (ADCK1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized aarF domain-containing protein kinase 1
EC=2.7.11.-

Gene names

Name:

ADCK1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence CAD62620.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAD62620.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86TW2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86TW2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     74-80: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 530	513	Uncharacterized aarF domain-containing protein kinase 1		PRO_0000252249
Regions
	Domain	155 – 467	313	Protein kinase
	Nucleotide binding	161 – 169	9	ATP By similarity
Sites
	Active site	315	1	Proton acceptor By similarity
	Binding site	183	1	ATP By similarity
Natural variations
	Alternative sequence	74 – 80	7	Missing in isoform 2.		VSP_020885

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: CBB1DFA87D0F41CF	FASTA	530	60,577
	10 20 30 40 50 60 MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS YDYLTSLKSV 70 80 90 100 110 120 PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF IKVGQHLGAL DYLLPEEYTS 130 140 150 160 170 180 TLKVLHSQAP QSSMQEIRQV IREDLGKEIH DLFQSFDDTP LGTASLAQVH KAVLHDGRTV 190 200 210 220 230 240 AVKVQHPKVR AQSSKDILLM EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA 250 260 270 280 290 300 EKVSQMLRHF DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK 310 320 330 340 350 360 MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR LNYCHLWQSL 370 380 390 400 410 420 IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI SQAPVTATED LEIRNNAANY 430 440 450 460 470 480 LPQISHLLNH VPRQMLLILK TNDLLRGIEA ALGTRASASS FLNMSRCCIR ALAEHKKKNT 490 500 510 520 530 CSFFRRTQIS FSEAFNLWQI NLHELILRVK GLKLADRVLA LICWLFPAPL
	Isoform 2 [UniParc]. Checksum: 94BEF675D2642ADB	FASTA	523	59,719
	10 20 30 40 50 60 MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS YDYLTSLKSV 70 80 90 100 110 120 PYGSEEYLQL RSKVHLRSAR RLCELCCANR GTFIKVGQHL GALDYLLPEE YTSTLKVLHS 130 140 150 160 170 180 QAPQSSMQEI RQVIREDLGK EIHDLFQSFD DTPLGTASLA QVHKAVLHDG RTVAVKVQHP 190 200 210 220 230 240 KVRAQSSKDI LLMEVLVLAV KQLFPEFEFM WLVDEAKKNL PLELDFLNEG RNAEKVSQML 250 260 270 280 290 300 RHFDFLKVPR IHWDLSTERV LLMEFVDGGQ VNDRDYMERN KIDVNEISRH LGKMYSEMIF 310 320 330 340 350 360 VNGFVHCDPH PGNVLVRKHP GTGKAEIVLL DHGLYQMLTE EFRLNYCHLW QSLIWTDMKR 370 380 390 400 410 420 VKEYSQRLGA GDLYPLFACM LTARSWDSVN RGISQAPVTA TEDLEIRNNA ANYLPQISHL 430 440 450 460 470 480 LNHVPRQMLL ILKTNDLLRG IEAALGTRAS ASSFLNMSRC CIRALAEHKK KNTCSFFRRT 490 500 510 520 QISFSEAFNL WQINLHELIL RVKGLKLADR VLALICWLFP APL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-93 (ISOFORM 1). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC058906 mRNA. Translation: AAH58906.1. BX248292 mRNA. Translation: CAD62620.1. Sequence problems.
IPI	IPI00412099. IPI00787836.
RefSeq	NP_065154.2. NM_020421.3.
UniGene	Hs.413208.
3D structure databases
ProteinModelPortal	Q86TW2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86TW2. 2 interactions.
STRING	9606.ENSP00000238561.
PTM databases
PhosphoSite	Q86TW2.
Polymorphism databases
DMDM	115503784.
Proteomic databases
PaxDb	Q86TW2.
PRIDE	Q86TW2.
Protocols and materials databases
DNASU	57143.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000238561; ENSP00000238561; ENSG00000063761.
GeneID	57143.
KEGG	hsa:57143.
UCSC	uc001xui.3. human.
Organism-specific databases
CTD	57143.
GeneCards	GC14P078266.
HGNC	HGNC:19038. ADCK1.
HPA	HPA051012.
neXtProt	NX_Q86TW2.
PharmGKB	PA134861355.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0661.
HOGENOM	HOG000240338.
HOVERGEN	HBG056527.
InParanoid	Q86TW2.
KO	K08869.
OMA	VGQHIGA.
OrthoDB	EOG4PZJ6F.
Gene expression databases
ArrayExpress	Q86TW2.
Bgee	Q86TW2.
CleanEx	HS_ADCK1.
Genevestigator	Q86TW2.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR004147. UbiB_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57143.
NextBio	63087.

Entry information

Entry name

ADCK1_HUMAN

Accession

Primary (citable) accession number: Q86TW2
Secondary accession number(s): Q6PD65

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.