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Protein

Uncharacterized aarF domain-containing protein kinase 1

Gene

ADCK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183ATPBy similarity1
Active sitei315Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi161 – 169ATPBy similarity9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
Gene namesi
Name:ADCK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000063761.15
HGNCiHGNC:19038 ADCK1
neXtProtiNX_Q86TW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000063761
PharmGKBiPA134861355

Polymorphism and mutation databases

BioMutaiADCK1
DMDMi115503784

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000025224918 – 530Uncharacterized aarF domain-containing protein kinase 1Add BLAST513

Proteomic databases

MaxQBiQ86TW2
PaxDbiQ86TW2
PeptideAtlasiQ86TW2
PRIDEiQ86TW2
ProteomicsDBi69740
69741 [Q86TW2-2]

PTM databases

iPTMnetiQ86TW2
PhosphoSitePlusiQ86TW2

Expressioni

Gene expression databases

BgeeiENSG00000063761
CleanExiHS_ADCK1
ExpressionAtlasiQ86TW2 baseline and differential
GenevisibleiQ86TW2 HS

Organism-specific databases

HPAiHPA051012
HPA055014

Interactioni

Protein-protein interaction databases

BioGridi121401, 38 interactors
IntActiQ86TW2, 4 interactors
STRINGi9606.ENSP00000238561

Structurei

3D structure databases

ProteinModelPortaliQ86TW2
SMRiQ86TW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 467Protein kinaseAdd BLAST313

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1235 Eukaryota
COG0661 LUCA
GeneTreeiENSGT00550000074734
HOGENOMiHOG000240338
HOVERGENiHBG056527
InParanoidiQ86TW2
KOiK08869
OMAiPYVKGNS
OrthoDBiEOG091G06EF
PhylomeDBiQ86TW2
TreeFamiTF314889

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR004147 UbiB_dom
PfamiView protein in Pfam
PF03109 ABC1, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS
60 70 80 90 100
YDYLTSLKSV PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF
110 120 130 140 150
IKVGQHLGAL DYLLPEEYTS TLKVLHSQAP QSSMQEIRQV IREDLGKEIH
160 170 180 190 200
DLFQSFDDTP LGTASLAQVH KAVLHDGRTV AVKVQHPKVR AQSSKDILLM
210 220 230 240 250
EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA EKVSQMLRHF
260 270 280 290 300
DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK
310 320 330 340 350
MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR
360 370 380 390 400
LNYCHLWQSL IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI
410 420 430 440 450
SQAPVTATED LEIRNNAANY LPQISHLLNH VPRQMLLILK TNDLLRGIEA
460 470 480 490 500
ALGTRASASS FLNMSRCCIR ALAEHKKKNT CSFFRRTQIS FSEAFNLWQI
510 520 530
NLHELILRVK GLKLADRVLA LICWLFPAPL
Length:530
Mass (Da):60,577
Last modified:October 3, 2006 - v2
Checksum:iCBB1DFA87D0F41CF
GO
Isoform 2 (identifier: Q86TW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-80: Missing.

Note: No experimental confirmation available.
Show »
Length:523
Mass (Da):59,719
Checksum:i94BEF675D2642ADB
GO
Isoform 3 (identifier: Q86TW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-148: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):51,999
Checksum:iE2B3FD7B4E5AAC7C
GO

Sequence cautioni

The sequence CAD62620 differs from that shown. Aberrant splicing.Curated
The sequence CAD62620 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7K → N in BAG53397 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04679474 – 148Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_02088574 – 80Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096919 mRNA Translation: BAG53397.1
AC008372 Genomic DNA Translation: AAF23326.1
CH471061 Genomic DNA Translation: EAW81310.1
BC058906 mRNA Translation: AAH58906.1
BX248292 mRNA Translation: CAD62620.1 Sequence problems.
CCDSiCCDS45144.1 [Q86TW2-3]
CCDS9869.1 [Q86TW2-2]
RefSeqiNP_001136017.1, NM_001142545.1 [Q86TW2-3]
NP_065154.2, NM_020421.3 [Q86TW2-2]
UniGeneiHs.413208

Genome annotation databases

EnsembliENST00000238561; ENSP00000238561; ENSG00000063761 [Q86TW2-2]
ENST00000341211; ENSP00000339663; ENSG00000063761 [Q86TW2-3]
GeneIDi57143
KEGGihsa:57143
UCSCiuc001xui.3 human [Q86TW2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiADCK1_HUMAN
AccessioniPrimary (citable) accession number: Q86TW2
Secondary accession number(s): B3KUD5, Q6PD65, Q9UIE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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