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Q86TW2

- ADCK1_HUMAN

UniProt

Q86TW2 - ADCK1_HUMAN

Protein

Uncharacterized aarF domain-containing protein kinase 1

Gene

ADCK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei183 – 1831ATPBy similarity
    Active sitei315 – 3151Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi161 – 1699ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
    Gene namesi
    Name:ADCK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19038. ADCK1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134861355.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 530513Uncharacterized aarF domain-containing protein kinase 1PRO_0000252249Add
    BLAST

    Proteomic databases

    MaxQBiQ86TW2.
    PaxDbiQ86TW2.
    PRIDEiQ86TW2.

    PTM databases

    PhosphoSiteiQ86TW2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86TW2.
    BgeeiQ86TW2.
    CleanExiHS_ADCK1.
    GenevestigatoriQ86TW2.

    Organism-specific databases

    HPAiHPA051012.
    HPA055014.

    Interactioni

    Protein-protein interaction databases

    BioGridi121401. 1 interaction.
    IntActiQ86TW2. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86TW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini155 – 467313Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0661.
    HOGENOMiHOG000240338.
    HOVERGENiHBG056527.
    InParanoidiQ86TW2.
    KOiK08869.
    OMAiIWTDMKR.
    OrthoDBiEOG7RBZ82.
    PhylomeDBiQ86TW2.
    TreeFamiTF314889.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view]
    PfamiPF03109. ABC1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86TW2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS    50
    YDYLTSLKSV PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF 100
    IKVGQHLGAL DYLLPEEYTS TLKVLHSQAP QSSMQEIRQV IREDLGKEIH 150
    DLFQSFDDTP LGTASLAQVH KAVLHDGRTV AVKVQHPKVR AQSSKDILLM 200
    EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA EKVSQMLRHF 250
    DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK 300
    MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR 350
    LNYCHLWQSL IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI 400
    SQAPVTATED LEIRNNAANY LPQISHLLNH VPRQMLLILK TNDLLRGIEA 450
    ALGTRASASS FLNMSRCCIR ALAEHKKKNT CSFFRRTQIS FSEAFNLWQI 500
    NLHELILRVK GLKLADRVLA LICWLFPAPL 530
    Length:530
    Mass (Da):60,577
    Last modified:October 3, 2006 - v2
    Checksum:iCBB1DFA87D0F41CF
    GO
    Isoform 2 (identifier: Q86TW2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-80: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:523
    Mass (Da):59,719
    Checksum:i94BEF675D2642ADB
    GO
    Isoform 3 (identifier: Q86TW2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-148: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:455
    Mass (Da):51,999
    Checksum:iE2B3FD7B4E5AAC7C
    GO

    Sequence cautioni

    The sequence CAD62620.1 differs from that shown. Reason: Aberrant splicing.
    The sequence CAD62620.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71K → N in BAG53397. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei74 – 14875Missing in isoform 3. 1 PublicationVSP_046794Add
    BLAST
    Alternative sequencei74 – 807Missing in isoform 2. 1 PublicationVSP_020885

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096919 mRNA. Translation: BAG53397.1.
    AC008372 Genomic DNA. Translation: AAF23326.1.
    CH471061 Genomic DNA. Translation: EAW81310.1.
    BC058906 mRNA. Translation: AAH58906.1.
    BX248292 mRNA. Translation: CAD62620.1. Sequence problems.
    CCDSiCCDS45144.1. [Q86TW2-3]
    CCDS9869.1. [Q86TW2-2]
    RefSeqiNP_001136017.1. NM_001142545.1. [Q86TW2-3]
    NP_065154.2. NM_020421.3. [Q86TW2-2]
    UniGeneiHs.413208.

    Genome annotation databases

    EnsembliENST00000238561; ENSP00000238561; ENSG00000063761. [Q86TW2-2]
    ENST00000341211; ENSP00000339663; ENSG00000063761. [Q86TW2-3]
    GeneIDi57143.
    KEGGihsa:57143.
    UCSCiuc001xui.3. human. [Q86TW2-2]
    uc001xuj.3. human.

    Polymorphism databases

    DMDMi115503784.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096919 mRNA. Translation: BAG53397.1 .
    AC008372 Genomic DNA. Translation: AAF23326.1 .
    CH471061 Genomic DNA. Translation: EAW81310.1 .
    BC058906 mRNA. Translation: AAH58906.1 .
    BX248292 mRNA. Translation: CAD62620.1 . Sequence problems.
    CCDSi CCDS45144.1. [Q86TW2-3 ]
    CCDS9869.1. [Q86TW2-2 ]
    RefSeqi NP_001136017.1. NM_001142545.1. [Q86TW2-3 ]
    NP_065154.2. NM_020421.3. [Q86TW2-2 ]
    UniGenei Hs.413208.

    3D structure databases

    ProteinModelPortali Q86TW2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121401. 1 interaction.
    IntActi Q86TW2. 2 interactions.

    PTM databases

    PhosphoSitei Q86TW2.

    Polymorphism databases

    DMDMi 115503784.

    Proteomic databases

    MaxQBi Q86TW2.
    PaxDbi Q86TW2.
    PRIDEi Q86TW2.

    Protocols and materials databases

    DNASUi 57143.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000238561 ; ENSP00000238561 ; ENSG00000063761 . [Q86TW2-2 ]
    ENST00000341211 ; ENSP00000339663 ; ENSG00000063761 . [Q86TW2-3 ]
    GeneIDi 57143.
    KEGGi hsa:57143.
    UCSCi uc001xui.3. human. [Q86TW2-2 ]
    uc001xuj.3. human.

    Organism-specific databases

    CTDi 57143.
    GeneCardsi GC14P078266.
    HGNCi HGNC:19038. ADCK1.
    HPAi HPA051012.
    HPA055014.
    neXtProti NX_Q86TW2.
    PharmGKBi PA134861355.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0661.
    HOGENOMi HOG000240338.
    HOVERGENi HBG056527.
    InParanoidi Q86TW2.
    KOi K08869.
    OMAi IWTDMKR.
    OrthoDBi EOG7RBZ82.
    PhylomeDBi Q86TW2.
    TreeFami TF314889.

    Miscellaneous databases

    GenomeRNAii 57143.
    NextBioi 63087.
    PROi Q86TW2.

    Gene expression databases

    ArrayExpressi Q86TW2.
    Bgeei Q86TW2.
    CleanExi HS_ADCK1.
    Genevestigatori Q86TW2.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004147. UbiB_dom.
    [Graphical view ]
    Pfami PF03109. ABC1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    5. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-93 (ISOFORM 1).
      Tissue: Placenta.

    Entry informationi

    Entry nameiADCK1_HUMAN
    AccessioniPrimary (citable) accession number: Q86TW2
    Secondary accession number(s): B3KUD5, Q6PD65, Q9UIE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3