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Protein

Tetratricopeptide repeat protein 7B

Gene

TTC7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211).2 Publications

GO - Biological processi

  • establishment of protein localization to plasma membrane Source: UniProtKB
  • phosphatidylinositol phosphorylation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 7B
Short name:
TPR repeat protein 7B
Alternative name(s):
Tetratricopeptide repeat protein 7-like-1
Short name:
TPR repeat protein 7-like-1
Gene namesi
Name:TTC7B
Synonyms:TTC7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19858. TTC7B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi145567.
OpenTargetsiENSG00000165914.
PharmGKBiPA134947112.

Polymorphism and mutation databases

BioMutaiTTC7B.
DMDMi226693616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063871 – 843Tetratricopeptide repeat protein 7BAdd BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineCombined sources1
Modified residuei202PhosphoserineBy similarity1
Modified residuei625PhosphoserineBy similarity1
Modified residuei629PhosphoserineBy similarity1
Modified residuei630PhosphoserineBy similarity1
Modified residuei673PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86TV6.
MaxQBiQ86TV6.
PaxDbiQ86TV6.
PeptideAtlasiQ86TV6.
PRIDEiQ86TV6.

PTM databases

iPTMnetiQ86TV6.
PhosphoSitePlusiQ86TV6.

Expressioni

Gene expression databases

BgeeiENSG00000165914.
CleanExiHS_TTC7B.
ExpressionAtlasiQ86TV6. baseline and differential.
GenevisibleiQ86TV6. HS.

Organism-specific databases

HPAiHPA058363.
HPA059577.

Interactioni

Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899). Interacts with PI4KA, interaction is direct (PubMed:26571211). Interacts with EFR3 (EFR3A or EFR3B), interaction is direct (PubMed:26571211). Interacts with FAM126 (FAM126A or FAM126B), interaction is direct (PubMed:26571211). Association with the PI4K complex is strongly reduced by TMEM150A (PubMed:25608530).3 Publications

Protein-protein interaction databases

BioGridi126922. 2 interactors.
IntActiQ86TV6. 3 interactors.
STRINGi9606.ENSP00000336127.

Structurei

Secondary structure

1843
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 19Combined sources11
Turni23 – 25Combined sources3
Helixi26 – 32Combined sources7
Helixi43 – 59Combined sources17
Helixi73 – 88Combined sources16
Helixi93 – 110Combined sources18
Helixi113 – 123Combined sources11
Helixi125 – 127Combined sources3
Helixi135 – 139Combined sources5
Helixi141 – 152Combined sources12
Helixi172 – 192Combined sources21
Helixi216 – 232Combined sources17
Helixi235 – 247Combined sources13
Turni252 – 254Combined sources3
Helixi255 – 272Combined sources18
Turni275 – 277Combined sources3
Beta strandi281 – 283Combined sources3
Helixi324 – 339Combined sources16
Helixi364 – 374Combined sources11
Turni375 – 377Combined sources3
Helixi379 – 389Combined sources11
Turni390 – 392Combined sources3
Helixi397 – 410Combined sources14
Helixi413 – 426Combined sources14
Helixi432 – 442Combined sources11
Helixi448 – 458Combined sources11
Helixi466 – 486Combined sources21
Helixi490 – 510Combined sources21
Helixi515 – 527Combined sources13
Helixi531 – 544Combined sources14
Helixi549 – 561Combined sources13
Helixi565 – 578Combined sources14
Helixi583 – 596Combined sources14
Helixi599 – 616Combined sources18
Helixi692 – 709Combined sources18
Helixi712 – 725Combined sources14
Helixi730 – 743Combined sources14
Helixi746 – 759Combined sources14
Helixi764 – 777Combined sources14
Helixi780 – 793Combined sources14
Helixi798 – 811Combined sources14
Helixi814 – 829Combined sources16
Helixi836 – 838Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DSEX-ray2.90A/C7-843[»]
ProteinModelPortaliQ86TV6.
SMRiQ86TV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 131TPR 1Add BLAST35
Repeati219 – 252TPR 2Add BLAST34
Repeati363 – 396TPR 3Add BLAST34
Repeati397 – 430TPR 4Add BLAST34
Repeati479 – 514TPR 5Add BLAST36
Repeati516 – 548TPR 6Add BLAST33
Repeati549 – 582TPR 7Add BLAST34
Repeati696 – 729TPR 8Add BLAST34
Repeati730 – 763TPR 9Add BLAST34
Repeati765 – 797TPR 10Add BLAST33
Repeati798 – 831TPR 11Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi329 – 333Poly-Leu5

Sequence similaritiesi

Contains 11 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4162. Eukaryota.
ENOG410XQ09. LUCA.
GeneTreeiENSGT00390000014400.
HOGENOMiHOG000045494.
HOVERGENiHBG059763.
InParanoidiQ86TV6.
OMAiRSECQWE.
OrthoDBiEOG091G07XU.
PhylomeDBiQ86TV6.
TreeFamiTF313783.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATKKAGSRL ETEIERCRSE CQWERIPELV KQLSAKLIAN DDMAELLLGE
60 70 80 90 100
SKLEQYLKEH PLRQGASPRG PKPQLTEVRK HLTAALDRGN LKSEFLQESN
110 120 130 140 150
LIMAKLNYVE GDYKEALNIY ARVGLDDLPL TAVPPYRLRV IAEAYATKGL
160 170 180 190 200
CLEKLPISSS TSNLHVDREQ DVITCYEKAG DIALLYLQEI ERVILSNIQN
210 220 230 240 250
RSPKPGPAPH DQELGFFLET GLQRAHVLYF KNGNLTRGVG RFRELLRAVE
260 270 280 290 300
TRTTQNLRMT IARQLAEILL RGMCEQSYWN PLEDPPCQSP LDDPLRKGAN
310 320 330 340 350
TKTYTLTRRA RVYSGENIFC PQENTEEALL LLLISESMAN RDAVLSRIPE
360 370 380 390 400
HKSDRLISLQ SASVVYDLLT IALGRRGQYE MLSECLERAM KFAFEEFHLW
410 420 430 440 450
YQFALSLMAA GKSARAVKVL KECIRLKPDD ATIPLLAAKL CMGSLHWLEE
460 470 480 490 500
AEKFAKTVVD VGEKTSEFKA KGYLALGLTY SLQATDASLR GMQEVLQRKA
510 520 530 540 550
LLAFQRAHSL SPTDHQAAFY LALQLAISRQ IPEALGYVRQ ALQLQGDDAN
560 570 580 590 600
SLHLLALLLS AQKHYHDALN IIDMALSEYP ENFILLFSKV KLQSLCRGPD
610 620 630 640 650
EALLTCKHML QIWKSCYNLT NPSDSGRGSS LLDRTIADRR QLNTITLPDF
660 670 680 690 700
SDPETGSVHA TSVAASRVEQ ALSEVASSLQ SSAPKQGPLH PWMTLAQIWL
710 720 730 740 750
HAAEVYIGIG KPAEATACTQ EAANLFPMSH NVLYMRGQIA ELRGSMDEAR
760 770 780 790 800
RWYEEALAIS PTHVKSMQRL ALILHQLGRY SLAEKILRDA VQVNSTAHEV
810 820 830 840
WNGLGEVLQA QGNDAAATEC FLTALELEAS SPAVPFTIIP RVL
Note: No experimental confirmation available. Derived from EST data.
Length:843
Mass (Da):94,179
Last modified:April 14, 2009 - v3
Checksum:iADAB8B36878AABDA
GO
Isoform 2 (identifier: Q86TV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     656-656: G → GNSPEAYFHGFPSLFSVS

Note: No experimental confirmation available.
Show »
Length:860
Mass (Da):96,047
Checksum:i23F1D3C39CB9D77B
GO

Sequence cautioni

The sequence CAI46128 differs from that shown. Reason: Frameshift at position 718.Curated
The sequence CAI46128 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008061656G → GNSPEAYFHGFPSLFSVS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096869 Genomic DNA. No translation available.
AL122020 Genomic DNA. No translation available.
AL139193 Genomic DNA. No translation available.
AL832848 mRNA. Translation: CAI46128.1. Sequence problems.
BX247966 mRNA. Translation: CAD62305.1.
BX248275 mRNA. Translation: CAD62603.1.
BC048270 mRNA. Translation: AAH48270.2.
CCDSiCCDS32140.1. [Q86TV6-1]
RefSeqiNP_001010854.1. NM_001010854.1. [Q86TV6-1]
NP_001307350.1. NM_001320421.1.
XP_016876534.1. XM_017021045.1. [Q86TV6-2]
XP_016876535.1. XM_017021046.1.
UniGeneiHs.655697.

Genome annotation databases

EnsembliENST00000328459; ENSP00000336127; ENSG00000165914. [Q86TV6-1]
GeneIDi145567.
KEGGihsa:145567.
UCSCiuc001xyp.4. human. [Q86TV6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096869 Genomic DNA. No translation available.
AL122020 Genomic DNA. No translation available.
AL139193 Genomic DNA. No translation available.
AL832848 mRNA. Translation: CAI46128.1. Sequence problems.
BX247966 mRNA. Translation: CAD62305.1.
BX248275 mRNA. Translation: CAD62603.1.
BC048270 mRNA. Translation: AAH48270.2.
CCDSiCCDS32140.1. [Q86TV6-1]
RefSeqiNP_001010854.1. NM_001010854.1. [Q86TV6-1]
NP_001307350.1. NM_001320421.1.
XP_016876534.1. XM_017021045.1. [Q86TV6-2]
XP_016876535.1. XM_017021046.1.
UniGeneiHs.655697.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DSEX-ray2.90A/C7-843[»]
ProteinModelPortaliQ86TV6.
SMRiQ86TV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126922. 2 interactors.
IntActiQ86TV6. 3 interactors.
STRINGi9606.ENSP00000336127.

PTM databases

iPTMnetiQ86TV6.
PhosphoSitePlusiQ86TV6.

Polymorphism and mutation databases

BioMutaiTTC7B.
DMDMi226693616.

Proteomic databases

EPDiQ86TV6.
MaxQBiQ86TV6.
PaxDbiQ86TV6.
PeptideAtlasiQ86TV6.
PRIDEiQ86TV6.

Protocols and materials databases

DNASUi145567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328459; ENSP00000336127; ENSG00000165914. [Q86TV6-1]
GeneIDi145567.
KEGGihsa:145567.
UCSCiuc001xyp.4. human. [Q86TV6-1]

Organism-specific databases

CTDi145567.
DisGeNETi145567.
GeneCardsiTTC7B.
H-InvDBHIX0011885.
HGNCiHGNC:19858. TTC7B.
HPAiHPA058363.
HPA059577.
neXtProtiNX_Q86TV6.
OpenTargetsiENSG00000165914.
PharmGKBiPA134947112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4162. Eukaryota.
ENOG410XQ09. LUCA.
GeneTreeiENSGT00390000014400.
HOGENOMiHOG000045494.
HOVERGENiHBG059763.
InParanoidiQ86TV6.
OMAiRSECQWE.
OrthoDBiEOG091G07XU.
PhylomeDBiQ86TV6.
TreeFamiTF313783.

Miscellaneous databases

ChiTaRSiTTC7B. human.
GenomeRNAii145567.
PROiQ86TV6.

Gene expression databases

BgeeiENSG00000165914.
CleanExiHS_TTC7B.
ExpressionAtlasiQ86TV6. baseline and differential.
GenevisibleiQ86TV6. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC7B_HUMAN
AccessioniPrimary (citable) accession number: Q86TV6
Secondary accession number(s): Q86U24, Q86VT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.