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Protein

Tetratricopeptide repeat protein 7B

Gene

TTC7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211).2 Publications

GO - Biological processi

  • establishment of protein localization to plasma membrane Source: UniProtKB
  • phosphatidylinositol phosphorylation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 7B
Short name:
TPR repeat protein 7B
Alternative name(s):
Tetratricopeptide repeat protein 7-like-1
Short name:
TPR repeat protein 7-like-1
Gene namesi
Name:TTC7B
Synonyms:TTC7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19858. TTC7B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134947112.

Polymorphism and mutation databases

BioMutaiTTC7B.
DMDMi226693616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 843843Tetratricopeptide repeat protein 7BPRO_0000106387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei160 – 1601PhosphoserineBy similarity
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei625 – 6251PhosphoserineBy similarity
Modified residuei629 – 6291PhosphoserineBy similarity
Modified residuei630 – 6301PhosphoserineBy similarity
Modified residuei673 – 6731PhosphoserineCombined sources
Modified residuei677 – 6771PhosphoserineBy similarity
Modified residuei678 – 6781PhosphoserineCombined sources
Modified residuei681 – 6811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86TV6.
MaxQBiQ86TV6.
PaxDbiQ86TV6.
PRIDEiQ86TV6.

PTM databases

iPTMnetiQ86TV6.
PhosphoSiteiQ86TV6.

Expressioni

Gene expression databases

BgeeiQ86TV6.
CleanExiHS_TTC7B.
ExpressionAtlasiQ86TV6. baseline and differential.
GenevisibleiQ86TV6. HS.

Organism-specific databases

HPAiHPA058363.
HPA059577.

Interactioni

Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899). Interacts with PI4KA, interaction is direct (PubMed:26571211). Interacts with EFR3 (EFR3A or EFR3B), interaction is direct (PubMed:26571211). Interacts with FAM126 (FAM126A or FAM126B), interaction is direct (PubMed:26571211). Association with the PI4K complex is strongly reduced by TMEM150A (PubMed:25608530).3 Publications

Protein-protein interaction databases

BioGridi126922. 2 interactions.
STRINGi9606.ENSP00000336127.

Structurei

Secondary structure

1
843
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 1911Combined sources
Turni23 – 253Combined sources
Helixi26 – 327Combined sources
Helixi43 – 5917Combined sources
Helixi73 – 8816Combined sources
Helixi93 – 11018Combined sources
Helixi113 – 12311Combined sources
Helixi125 – 1273Combined sources
Helixi135 – 1395Combined sources
Helixi141 – 15212Combined sources
Helixi172 – 19221Combined sources
Helixi216 – 23217Combined sources
Helixi235 – 24713Combined sources
Turni252 – 2543Combined sources
Helixi255 – 27218Combined sources
Turni275 – 2773Combined sources
Beta strandi281 – 2833Combined sources
Helixi324 – 33916Combined sources
Helixi364 – 37411Combined sources
Turni375 – 3773Combined sources
Helixi379 – 38911Combined sources
Turni390 – 3923Combined sources
Helixi397 – 41014Combined sources
Helixi413 – 42614Combined sources
Helixi432 – 44211Combined sources
Helixi448 – 45811Combined sources
Helixi466 – 48621Combined sources
Helixi490 – 51021Combined sources
Helixi515 – 52713Combined sources
Helixi531 – 54414Combined sources
Helixi549 – 56113Combined sources
Helixi565 – 57814Combined sources
Helixi583 – 59614Combined sources
Helixi599 – 61618Combined sources
Helixi692 – 70918Combined sources
Helixi712 – 72514Combined sources
Helixi730 – 74314Combined sources
Helixi746 – 75914Combined sources
Helixi764 – 77714Combined sources
Helixi780 – 79314Combined sources
Helixi798 – 81114Combined sources
Helixi814 – 82916Combined sources
Helixi836 – 8383Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5DSEX-ray2.90A/C7-843[»]
ProteinModelPortaliQ86TV6.
SMRiQ86TV6. Positions 97-123, 366-393, 416-610, 696-831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati97 – 13135TPR 1Add
BLAST
Repeati219 – 25234TPR 2Add
BLAST
Repeati363 – 39634TPR 3Add
BLAST
Repeati397 – 43034TPR 4Add
BLAST
Repeati479 – 51436TPR 5Add
BLAST
Repeati516 – 54833TPR 6Add
BLAST
Repeati549 – 58234TPR 7Add
BLAST
Repeati696 – 72934TPR 8Add
BLAST
Repeati730 – 76334TPR 9Add
BLAST
Repeati765 – 79733TPR 10Add
BLAST
Repeati798 – 83134TPR 11Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi329 – 3335Poly-Leu

Sequence similaritiesi

Contains 11 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4162. Eukaryota.
ENOG410XQ09. LUCA.
GeneTreeiENSGT00390000014400.
HOGENOMiHOG000045494.
HOVERGENiHBG059763.
InParanoidiQ86TV6.
OMAiRSECQWE.
OrthoDBiEOG773XFC.
PhylomeDBiQ86TV6.
TreeFamiTF313783.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATKKAGSRL ETEIERCRSE CQWERIPELV KQLSAKLIAN DDMAELLLGE
60 70 80 90 100
SKLEQYLKEH PLRQGASPRG PKPQLTEVRK HLTAALDRGN LKSEFLQESN
110 120 130 140 150
LIMAKLNYVE GDYKEALNIY ARVGLDDLPL TAVPPYRLRV IAEAYATKGL
160 170 180 190 200
CLEKLPISSS TSNLHVDREQ DVITCYEKAG DIALLYLQEI ERVILSNIQN
210 220 230 240 250
RSPKPGPAPH DQELGFFLET GLQRAHVLYF KNGNLTRGVG RFRELLRAVE
260 270 280 290 300
TRTTQNLRMT IARQLAEILL RGMCEQSYWN PLEDPPCQSP LDDPLRKGAN
310 320 330 340 350
TKTYTLTRRA RVYSGENIFC PQENTEEALL LLLISESMAN RDAVLSRIPE
360 370 380 390 400
HKSDRLISLQ SASVVYDLLT IALGRRGQYE MLSECLERAM KFAFEEFHLW
410 420 430 440 450
YQFALSLMAA GKSARAVKVL KECIRLKPDD ATIPLLAAKL CMGSLHWLEE
460 470 480 490 500
AEKFAKTVVD VGEKTSEFKA KGYLALGLTY SLQATDASLR GMQEVLQRKA
510 520 530 540 550
LLAFQRAHSL SPTDHQAAFY LALQLAISRQ IPEALGYVRQ ALQLQGDDAN
560 570 580 590 600
SLHLLALLLS AQKHYHDALN IIDMALSEYP ENFILLFSKV KLQSLCRGPD
610 620 630 640 650
EALLTCKHML QIWKSCYNLT NPSDSGRGSS LLDRTIADRR QLNTITLPDF
660 670 680 690 700
SDPETGSVHA TSVAASRVEQ ALSEVASSLQ SSAPKQGPLH PWMTLAQIWL
710 720 730 740 750
HAAEVYIGIG KPAEATACTQ EAANLFPMSH NVLYMRGQIA ELRGSMDEAR
760 770 780 790 800
RWYEEALAIS PTHVKSMQRL ALILHQLGRY SLAEKILRDA VQVNSTAHEV
810 820 830 840
WNGLGEVLQA QGNDAAATEC FLTALELEAS SPAVPFTIIP RVL
Note: No experimental confirmation available. Derived from EST data.
Length:843
Mass (Da):94,179
Last modified:April 14, 2009 - v3
Checksum:iADAB8B36878AABDA
GO
Isoform 2 (identifier: Q86TV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     656-656: G → GNSPEAYFHGFPSLFSVS

Note: No experimental confirmation available.
Show »
Length:860
Mass (Da):96,047
Checksum:i23F1D3C39CB9D77B
GO

Sequence cautioni

The sequence CAI46128.1 differs from that shown. Reason: Frameshift at position 718. Curated
The sequence CAI46128.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei656 – 6561G → GNSPEAYFHGFPSLFSVS in isoform 2. 1 PublicationVSP_008061

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096869 Genomic DNA. No translation available.
AL122020 Genomic DNA. No translation available.
AL139193 Genomic DNA. No translation available.
AL832848 mRNA. Translation: CAI46128.1. Sequence problems.
BX247966 mRNA. Translation: CAD62305.1.
BX248275 mRNA. Translation: CAD62603.1.
BC048270 mRNA. Translation: AAH48270.2.
CCDSiCCDS32140.1. [Q86TV6-1]
RefSeqiNP_001010854.1. NM_001010854.1. [Q86TV6-1]
NP_001307350.1. NM_001320421.1.
UniGeneiHs.655697.

Genome annotation databases

EnsembliENST00000328459; ENSP00000336127; ENSG00000165914. [Q86TV6-1]
GeneIDi145567.
KEGGihsa:145567.
UCSCiuc001xyp.4. human. [Q86TV6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096869 Genomic DNA. No translation available.
AL122020 Genomic DNA. No translation available.
AL139193 Genomic DNA. No translation available.
AL832848 mRNA. Translation: CAI46128.1. Sequence problems.
BX247966 mRNA. Translation: CAD62305.1.
BX248275 mRNA. Translation: CAD62603.1.
BC048270 mRNA. Translation: AAH48270.2.
CCDSiCCDS32140.1. [Q86TV6-1]
RefSeqiNP_001010854.1. NM_001010854.1. [Q86TV6-1]
NP_001307350.1. NM_001320421.1.
UniGeneiHs.655697.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5DSEX-ray2.90A/C7-843[»]
ProteinModelPortaliQ86TV6.
SMRiQ86TV6. Positions 97-123, 366-393, 416-610, 696-831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126922. 2 interactions.
STRINGi9606.ENSP00000336127.

PTM databases

iPTMnetiQ86TV6.
PhosphoSiteiQ86TV6.

Polymorphism and mutation databases

BioMutaiTTC7B.
DMDMi226693616.

Proteomic databases

EPDiQ86TV6.
MaxQBiQ86TV6.
PaxDbiQ86TV6.
PRIDEiQ86TV6.

Protocols and materials databases

DNASUi145567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328459; ENSP00000336127; ENSG00000165914. [Q86TV6-1]
GeneIDi145567.
KEGGihsa:145567.
UCSCiuc001xyp.4. human. [Q86TV6-1]

Organism-specific databases

CTDi145567.
GeneCardsiTTC7B.
H-InvDBHIX0011885.
HGNCiHGNC:19858. TTC7B.
HPAiHPA058363.
HPA059577.
neXtProtiNX_Q86TV6.
PharmGKBiPA134947112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4162. Eukaryota.
ENOG410XQ09. LUCA.
GeneTreeiENSGT00390000014400.
HOGENOMiHOG000045494.
HOVERGENiHBG059763.
InParanoidiQ86TV6.
OMAiRSECQWE.
OrthoDBiEOG773XFC.
PhylomeDBiQ86TV6.
TreeFamiTF313783.

Miscellaneous databases

ChiTaRSiTTC7B. human.
GenomeRNAii145567.
PROiQ86TV6.

Gene expression databases

BgeeiQ86TV6.
CleanExiHS_TTC7B.
ExpressionAtlasiQ86TV6. baseline and differential.
GenevisibleiQ86TV6. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 7 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-843 (ISOFORM 1).
    Tissue: Lymph node.
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 197-843 (ISOFORMS 1 AND 2).
    Tissue: Neuroblastoma and Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 260-843 (ISOFORM 1).
    Tissue: Liver.
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-673, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity."
    Nakatsu F., Baskin J.M., Chung J., Tanner L.B., Shui G., Lee S.Y., Pirruccello M., Hao M., Ingolia N.T., Wenk M.R., De Camilli P.
    J. Cell Biol. 199:1003-1016(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE PI4K COMPLEX.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "Plasticity of PI4KIIIalpha interactions at the plasma membrane."
    Chung J., Nakatsu F., Baskin J.M., De Camilli P.
    EMBO Rep. 16:312-320(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PI4K COMPLEX.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 8-750 IN COMPLEX WITH FAM126A, FUNCTION, IDENTIFICATION IN THE PI4K COMPLEX.

Entry informationi

Entry nameiTTC7B_HUMAN
AccessioniPrimary (citable) accession number: Q86TV6
Secondary accession number(s): Q86U24, Q86VT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 14, 2009
Last modified: June 8, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.