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Protein

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

DLST

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

(R)-lipoateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:DLSTImported
ORF Names:hCG_22359Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ86TQ8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 55Lipoyl-bindingInterPro annotationAdd BLAST30
Domaini134 – 3072-oxoacid_dhInterPro annotationAdd BLAST174

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili132 – 156Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0559 Eukaryota
COG0508 LUCA
HOVERGENiHBG000268

Family and domain databases

Gene3Di3.30.559.10, 1 hit
InterProiView protein in InterPro
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit

Sequencei

Sequence statusi: Fragment.

Q86TQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMTWLQSKP QRLQNLSQRE MSGGRKVPSP ANGVIEALLV PDGGKVEGGT
60 70 80 90 100
PLFTLRKTGA APAKAKPAEA PAAAAPKAEP TAAAVPPPAA PIPTQMPPVP
110 120 130 140 150
SPSQPPSGKP VSAVKPTVAP PLAEPGAGKG LRSEHREKMN RMRQRIAQRL
160 170 180 190 200
KEAQNTCAML TTFNEIDMSN IQEMRARHKE AFLKKHNLKL GFMSAFVKAS
210 220 230 240 250
AFALQEQPVV NAVIDDTTKE VVYRDYIDIS VAVATPRGLV VPVIRNVEAM
260 270 280 290 300
NFADIERTIT ELGEKARKNE LAIEDMDGGT FTISNGGVFG SLFGTPIINP

PQSAILG
Length:307
Mass (Da):32,808
Last modified:June 1, 2003 - v1
Checksum:i29C5CDC4D003BEFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei307Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248764 mRNA Translation: CAD66571.1
CH471061 Genomic DNA Translation: EAW81201.1
UniGeneiHs.525459

Similar proteinsi

Entry informationi

Entry nameiQ86TQ8_HUMAN
AccessioniPrimary (citable) accession number: Q86TQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health