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Q86TM6

- SYVN1_HUMAN

UniProt

Q86TM6 - SYVN1_HUMAN

Protein

E3 ubiquitin-protein ligase synoviolin

Gene

SYVN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.10 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri291 – 33040RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. endoplasmic reticulum unfolded protein response Source: Reactome
    4. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
    5. in utero embryonic development Source: Ensembl
    6. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    7. protein N-linked glycosylation via asparagine Source: UniProtKB
    8. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Stress response, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_18273. XBP1(S) activates chaperone genes.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase synoviolin (EC:6.3.2.-)
    Alternative name(s):
    Synovial apoptosis inhibitor 1
    Gene namesi
    Name:SYVN1
    Synonyms:HRD1, KIAA1810
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:20738. SYVN1.

    Subcellular locationi

    Endoplasmic reticulum membrane 4 Publications; Multi-pass membrane protein 4 Publications

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi329 – 3291C → S: Abolishes E3 ligase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA128394735.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 617595E3 ubiquitin-protein ligase synoviolinPRO_0000280548Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei613 – 6131Phosphoserine2 Publications

    Post-translational modificationi

    Not N-glycosylated.
    Auto-ubiquitinated.3 Publications

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ86TM6.
    PaxDbiQ86TM6.
    PRIDEiQ86TM6.

    PTM databases

    PhosphoSiteiQ86TM6.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level).3 Publications

    Inductioni

    By endoplasmic reticulum stress-inducing agents such as thapsigargin, tunicamycin or brefeldin A, but not by heat shock.2 Publications

    Gene expression databases

    ArrayExpressiQ86TM6.
    BgeeiQ86TM6.
    CleanExiHS_SYVN1.
    GenevestigatoriQ86TM6.

    Organism-specific databases

    HPAiHPA005480.
    HPA024300.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with p53/TP53 and HTT. Interacts with VCP, HERPUD1 and DERL1. Part of a complex containing SYVN1, HERPUD1, VIMP and DERL1; which probably transfer misfolded proteins from the ER to VCP. Part of a complex containing SYVN1, SEL1L and DERL2. Interacts with UBXN6. Interacts with SEL1L; recruits ERLEC1 and OS9. May form a complex with ERLEC1; HSPA5; OS9 AND SEL1L.8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERN1O754602EBI-947849,EBI-371750
    TP53P046375EBI-947849,EBI-366083

    Protein-protein interaction databases

    BioGridi124085. 56 interactions.
    IntActiQ86TM6. 17 interactions.
    MINTiMINT-4052103.
    STRINGi9606.ENSP00000366395.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86TM6.
    SMRiQ86TM6. Positions 291-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 4119LumenalSequence AnalysisAdd
    BLAST
    Topological domaini63 – 9836CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini120 – 14021LumenalSequence AnalysisAdd
    BLAST
    Topological domaini162 – 1698CytoplasmicSequence Analysis
    Topological domaini191 – 22434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini246 – 617372CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni236 – 27035Interaction with p53/TP53Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi339 – 478140Pro-richAdd
    BLAST

    Domaini

    The RING-type zinc finger is required for E3 ligase activity.

    Sequence similaritiesi

    Belongs to the HRD1 family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri291 – 33040RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5243.
    HOGENOMiHOG000294196.
    HOVERGENiHBG094015.
    InParanoidiQ86TM6.
    KOiK10601.
    OMAiHHYLSTV.
    OrthoDBiEOG7V766G.
    PhylomeDBiQ86TM6.
    TreeFamiTF318635.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86TM6-1) [UniParc]FASTAAdd to Basket

    Also known as: b, long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA    50
    FVLVFLLGKV MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS 100
    PRFVALFTLL LFLKCFHWLA EDRVDFMERS PNISWLFHCR IVSLMFLLGI 150
    LDFLFVSHAY HSILTRGASV QLVFGFEYAI LMTMVLTIFI KYVLHSVDLQ 200
    SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF PLFAIRPMYL 250
    AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT 300
    GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD 350
    QGPPPAPHPP PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS 400
    GEAVAPPSTS AAALSRPSGA ATTTAAGTSA TAASATASGP GSGSAPEAGP 450
    APGFPFPPPW MGMPLPPPFA FPPMPVPPAG FAGLTPEELR ALEGHERQHL 500
    EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV NSTEETATTV 550
    VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA 600
    AELRRRRLQK LESPVAH 617
    Length:617
    Mass (Da):67,685
    Last modified:March 20, 2007 - v2
    Checksum:iB8A6BACBAF9673C1
    GO
    Isoform 2 (identifier: Q86TM6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         127-177: Missing.
         411-411: Missing.

    Show »
    Length:565
    Mass (Da):61,732
    Checksum:i8C2226662D099D15
    GO
    Isoform 3 (identifier: Q86TM6-3) [UniParc]FASTAAdd to Basket

    Also known as: a, short

    The sequence of this isoform differs from the canonical sequence as follows:
         411-411: Missing.

    Show »
    Length:616
    Mass (Da):67,614
    Checksum:i3D035485BDF67376
    GO

    Sequence cautioni

    The sequence BAB47439.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451M → I in BAC24801. (PubMed:12459480)Curated
    Sequence conflicti145 – 1451M → I in AAL26903. (PubMed:14593114)Curated
    Sequence conflicti545 – 5451E → G in BAC57449. (PubMed:12975321)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei127 – 17751Missing in isoform 2. 1 PublicationVSP_023777Add
    BLAST
    Alternative sequencei411 – 4111Missing in isoform 2 and isoform 3. 4 PublicationsVSP_023778

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085847 mRNA. Translation: BAC24801.1.
    AB024690 mRNA. Translation: BAC57449.1.
    AF317634 mRNA. Translation: AAL26903.1.
    AB058713 mRNA. Translation: BAB47439.1. Different initiation.
    AL834262 mRNA. Translation: CAD38937.1.
    BC030530 mRNA. Translation: AAH30530.1.
    CCDSiCCDS31605.1. [Q86TM6-1]
    CCDS8097.1. [Q86TM6-3]
    RefSeqiNP_115807.1. NM_032431.2. [Q86TM6-3]
    NP_757385.1. NM_172230.2. [Q86TM6-1]
    UniGeneiHs.75859.

    Genome annotation databases

    EnsembliENST00000294256; ENSP00000294256; ENSG00000162298. [Q86TM6-3]
    ENST00000307289; ENSP00000302035; ENSG00000162298. [Q86TM6-2]
    ENST00000377190; ENSP00000366395; ENSG00000162298. [Q86TM6-1]
    ENST00000526060; ENSP00000436984; ENSG00000162298. [Q86TM6-3]
    GeneIDi84447.
    KEGGihsa:84447.
    UCSCiuc001odb.3. human. [Q86TM6-1]
    uc001odc.3. human. [Q86TM6-3]
    uc009yqc.3. human. [Q86TM6-2]

    Polymorphism databases

    DMDMi134035039.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085847 mRNA. Translation: BAC24801.1 .
    AB024690 mRNA. Translation: BAC57449.1 .
    AF317634 mRNA. Translation: AAL26903.1 .
    AB058713 mRNA. Translation: BAB47439.1 . Different initiation.
    AL834262 mRNA. Translation: CAD38937.1 .
    BC030530 mRNA. Translation: AAH30530.1 .
    CCDSi CCDS31605.1. [Q86TM6-1 ]
    CCDS8097.1. [Q86TM6-3 ]
    RefSeqi NP_115807.1. NM_032431.2. [Q86TM6-3 ]
    NP_757385.1. NM_172230.2. [Q86TM6-1 ]
    UniGenei Hs.75859.

    3D structure databases

    ProteinModelPortali Q86TM6.
    SMRi Q86TM6. Positions 291-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124085. 56 interactions.
    IntActi Q86TM6. 17 interactions.
    MINTi MINT-4052103.
    STRINGi 9606.ENSP00000366395.

    PTM databases

    PhosphoSitei Q86TM6.

    Polymorphism databases

    DMDMi 134035039.

    Proteomic databases

    MaxQBi Q86TM6.
    PaxDbi Q86TM6.
    PRIDEi Q86TM6.

    Protocols and materials databases

    DNASUi 84447.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294256 ; ENSP00000294256 ; ENSG00000162298 . [Q86TM6-3 ]
    ENST00000307289 ; ENSP00000302035 ; ENSG00000162298 . [Q86TM6-2 ]
    ENST00000377190 ; ENSP00000366395 ; ENSG00000162298 . [Q86TM6-1 ]
    ENST00000526060 ; ENSP00000436984 ; ENSG00000162298 . [Q86TM6-3 ]
    GeneIDi 84447.
    KEGGi hsa:84447.
    UCSCi uc001odb.3. human. [Q86TM6-1 ]
    uc001odc.3. human. [Q86TM6-3 ]
    uc009yqc.3. human. [Q86TM6-2 ]

    Organism-specific databases

    CTDi 84447.
    GeneCardsi GC11M064894.
    HGNCi HGNC:20738. SYVN1.
    HPAi HPA005480.
    HPA024300.
    MIMi 608046. gene.
    neXtProti NX_Q86TM6.
    PharmGKBi PA128394735.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5243.
    HOGENOMi HOG000294196.
    HOVERGENi HBG094015.
    InParanoidi Q86TM6.
    KOi K10601.
    OMAi HHYLSTV.
    OrthoDBi EOG7V766G.
    PhylomeDBi Q86TM6.
    TreeFami TF318635.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_18273. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    ChiTaRSi SYVN1. human.
    GeneWikii SYVN1.
    GenomeRNAii 84447.
    NextBioi 74217.
    PROi Q86TM6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86TM6.
    Bgeei Q86TM6.
    CleanExi HS_SYVN1.
    Genevestigatori Q86TM6.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation."
      Kaneko M., Ishiguro M., Niinuma Y., Uesugi M., Nomura Y.
      FEBS Lett. 532:147-152(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-329, INDUCTION BY ER STRESS, AUTOUBIQUITINATION.
    2. "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1."
      Nadav E., Shmueli A., Barr H., Gonen H., Ciechanover A., Reiss Y.
      Biochem. Biophys. Res. Commun. 303:91-97(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AUTOUBIQUITINATION.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AUTOUBIQUITINATION.
      Tissue: Articular cartilage.
    4. "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum."
      Kikkert M., Doolman R., Dai M., Avner R., Hassink G., van Voorden S., Thanedar S., Roitelman J., Chau V., Wiertz E.
      J. Biol. Chem. 279:3525-3534(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INDUCTION BY ER STRESS, LACK OF GLYCOSYLATION, SUBCELLULAR LOCATION, TOPOLOGY.
    5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Amygdala.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Blood.
    8. "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway."
      Schulze A., Standera S., Buerger E., Kikkert M., van Voorden S., Wiertz E., Koning F., Kloetzel P.-M., Seeger M.
      J. Mol. Biol. 354:1021-1027(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, HOMODIMERIZATION, INTERACTION WITH VCP; HERPUD1 AND DERL1, IDENTIFICATION IN A COMPLEX WITH HERPUD1; VIMP AND DERL1.
    9. "Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane."
      Ye Y., Shibata Y., Kikkert M., van Voorden S., Wiertz E., Rapoport T.A.
      Proc. Natl. Acad. Sci. U.S.A. 102:14132-14138(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VCP, SUBCELLULAR LOCATION.
    10. "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane."
      Lilley B.N., Ploegh H.L.
      Proc. Natl. Acad. Sci. U.S.A. 102:14296-14301(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH DERL2 AND SEL1L, INTERACTION WITH SEL1L.
    11. "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin."
      Omura T., Kaneko M., Okuma Y., Orba Y., Nagashima K., Takahashi R., Fujitani N., Matsumura S., Hata A., Kubota K., Murahashi K., Uehara T., Nomura Y.
      J. Neurochem. 99:1456-1469(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery."
      Arteaga M.F., Wang L., Ravid T., Hochstrasser M., Canessa C.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:11178-11183(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. Cited for: FUNCTION, INTERACTION WITH TP53.
    14. "Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin."
      Yang H., Zhong X., Ballar P., Luo S., Shen Y., Rubinsztein D.C., Monteiro M.J., Fang S.
      Exp. Cell Res. 313:538-550(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HTT.
    15. Cited for: INTERACTION WITH UBXN6.
    16. "Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP."
      Hosokawa N., Wada I., Nagasawa K., Moriyama T., Okawa K., Nagata K.
      J. Biol. Chem. 283:20914-20924(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ERLEC1; HSPA5; OS9 AND SEL1L.
    17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD."
      Christianson J.C., Shaler T.A., Tyler R.E., Kopito R.R.
      Nat. Cell Biol. 10:272-282(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ERLEC1; OS9 AND SEL1L.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein."
      Sato T., Sako Y., Sho M., Momohara M., Suico M.A., Shuto T., Nishitoh H., Okiyoneda T., Kokame K., Kaneko M., Taura M., Miyata M., Chosa K., Koga T., Morino-Koga S., Wada I., Kai H.
      Mol. Cell 47:99-110(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ERAD PATHWAY.

    Entry informationi

    Entry nameiSYVN1_HUMAN
    AccessioniPrimary (citable) accession number: Q86TM6
    Secondary accession number(s): Q8N3K3
    , Q8N6E8, Q96JL5, Q96PK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3