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Protein

Store-operated calcium entry regulator STIMATE

Gene

TMEM110

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of store-operated Ca2+ entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca2+ influx following depletion of intracellular Ca2+ stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).2 Publications

GO - Molecular functioni

  • calcium channel regulator activity Source: UniProtKB

GO - Biological processi

  • activation of store-operated calcium channel activity Source: UniProtKB
  • calcium-mediated signaling using intracellular calcium source Source: UniProtKB
  • positive regulation of NFAT protein import into nucleus Source: UniProtKB

Protein family/group databases

TCDBi8.A.65.1.1. the endoplasmic reticulum (er)-plasma membrane (pm) junctional competence regulator (tmem110) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Store-operated calcium entry regulator STIMATE1 Publication
Alternative name(s):
STIM-activating enhancer encoded by TMEM1101 Publication
Short name:
STIMATE1 Publication
Transmembrane protein 110Curated
Gene namesi
Name:TMEM110Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000213533.11.
HGNCiHGNC:30526. TMEM110.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28Cytoplasmic2 PublicationsAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 294Cytoplasmic2 PublicationsAdd BLAST80

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi241 – 246KVRYRR → QVQYQQ: Induces relocalization to cell membrane. 1 Publication6

Organism-specific databases

OpenTargetsiENSG00000213533.
PharmGKBiPA142670761.

Polymorphism and mutation databases

BioMutaiTMEM110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439151 – 294Store-operated calcium entry regulator STIMATEAdd BLAST294

Proteomic databases

PaxDbiQ86TL2.
PeptideAtlasiQ86TL2.
PRIDEiQ86TL2.

PTM databases

iPTMnetiQ86TL2.
PhosphoSitePlusiQ86TL2.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000213533.
CleanExiHS_TMEM110.
ExpressionAtlasiQ86TL2. baseline and differential.
GenevisibleiQ86TL2. HS.

Organism-specific databases

HPAiHPA051855.

Interactioni

Subunit structurei

Homooligomer (PubMed:26322679). Interacts with STIM1 (PubMed:26322679).1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000347195.

Structurei

3D structure databases

ProteinModelPortaliQ86TL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 246Required for localization in the endoplasmic reticulum1 Publication6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi149 – 153GXXXG motif1 Publication5

Domaini

The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).1 Publication1 Publication

Sequence similaritiesi

Belongs to the STIMATE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEJ9. Eukaryota.
ENOG4111FGH. LUCA.
GeneTreeiENSGT00390000018048.
HOGENOMiHOG000038493.
HOVERGENiHBG059486.
InParanoidiQ86TL2.
OrthoDBiEOG091G0K2S.
PhylomeDBiQ86TL2.
TreeFamiTF324457.

Family and domain databases

InterProiView protein in InterPro
IPR022127. STIMATE/YPL162C.
PfamiView protein in Pfam
PF12400. STIMATE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86TL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPAGNASR GLPGGPPSTV ASGAGRCESG ALMHSFGIFL QGLLGVVAFS
60 70 80 90 100
TLMLKRFREP KHERRPWRIW FLDTSKQAIG MLFIHFANVY LADLTEEDPC
110 120 130 140 150
SLYLINFLLD ATVGMLLIYV GVRAVSVLVE WQQWESLRFG EYGDPLQCGA
160 170 180 190 200
WVGQCALYIV IMIFEKSVVF IVLLILQWKK VALLNPIENP DLKLAIVMLI
210 220 230 240 250
VPFFVNALMF WVVDNFLMRK GKTKAKLEER GANQDSRNGS KVRYRRAASH
260 270 280 290
EESESEILIS ADDEMEESDV EEDLRRLTPL KPVKKKKHRF GLPV
Length:294
Mass (Da):33,187
Last modified:June 1, 2003 - v1
Checksum:i8B112BB1CB3478E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099667 Genomic DNA. No translation available.
BC047015 mRNA. Translation: AAH47015.1.
CCDSiCCDS2866.1.
RefSeqiNP_940965.1. NM_198563.2.
UniGeneiHs.744189.

Genome annotation databases

EnsembliENST00000355083; ENSP00000347195; ENSG00000213533.
GeneIDi375346.
KEGGihsa:375346.
UCSCiuc062kra.1. human.

Similar proteinsi

Entry informationi

Entry nameiSTIMA_HUMAN
AccessioniPrimary (citable) accession number: Q86TL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 27, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families