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Protein

Transmembrane protein 110

Gene

TMEM110

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 110
Gene namesi
Name:TMEM110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30526. TMEM110.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Transmembrane protein 110PRO_0000243915Add
BLAST

Proteomic databases

PaxDbiQ86TL2.
PRIDEiQ86TL2.

PTM databases

PhosphoSiteiQ86TL2.

Expressioni

Gene expression databases

BgeeiQ86TL2.
CleanExiHS_TMEM110.
ExpressionAtlasiQ86TL2. baseline.
GenevestigatoriQ86TL2.

Organism-specific databases

HPAiHPA051855.

Interactioni

Protein-protein interaction databases

BioGridi131975. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ86TL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG75442.
GeneTreeiENSGT00390000018048.
HOGENOMiHOG000038493.
HOVERGENiHBG059486.
InParanoidiQ86TL2.
PhylomeDBiQ86TL2.
TreeFamiTF324457.

Family and domain databases

InterProiIPR022127. DUF3661_TM.
[Graphical view]
PfamiPF12400. DUF3661. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86TL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPAGNASR GLPGGPPSTV ASGAGRCESG ALMHSFGIFL QGLLGVVAFS
60 70 80 90 100
TLMLKRFREP KHERRPWRIW FLDTSKQAIG MLFIHFANVY LADLTEEDPC
110 120 130 140 150
SLYLINFLLD ATVGMLLIYV GVRAVSVLVE WQQWESLRFG EYGDPLQCGA
160 170 180 190 200
WVGQCALYIV IMIFEKSVVF IVLLILQWKK VALLNPIENP DLKLAIVMLI
210 220 230 240 250
VPFFVNALMF WVVDNFLMRK GKTKAKLEER GANQDSRNGS KVRYRRAASH
260 270 280 290
EESESEILIS ADDEMEESDV EEDLRRLTPL KPVKKKKHRF GLPV
Length:294
Mass (Da):33,187
Last modified:June 1, 2003 - v1
Checksum:i8B112BB1CB3478E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047015 mRNA. Translation: AAH47015.1.
CCDSiCCDS2866.1.
RefSeqiNP_940965.1. NM_198563.2.
UniGeneiHs.744189.

Genome annotation databases

EnsembliENST00000355083; ENSP00000347195; ENSG00000213533.
GeneIDi375346.
KEGGihsa:375346.
UCSCiuc003dgd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047015 mRNA. Translation: AAH47015.1.
CCDSiCCDS2866.1.
RefSeqiNP_940965.1. NM_198563.2.
UniGeneiHs.744189.

3D structure databases

ProteinModelPortaliQ86TL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131975. 1 interaction.

PTM databases

PhosphoSiteiQ86TL2.

Proteomic databases

PaxDbiQ86TL2.
PRIDEiQ86TL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355083; ENSP00000347195; ENSG00000213533.
GeneIDi375346.
KEGGihsa:375346.
UCSCiuc003dgd.3. human.

Organism-specific databases

CTDi375346.
GeneCardsiGC03M052870.
HGNCiHGNC:30526. TMEM110.
HPAiHPA051855.
neXtProtiNX_Q86TL2.
PharmGKBiPA142670761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG75442.
GeneTreeiENSGT00390000018048.
HOGENOMiHOG000038493.
HOVERGENiHBG059486.
InParanoidiQ86TL2.
PhylomeDBiQ86TL2.
TreeFamiTF324457.

Miscellaneous databases

GenomeRNAii375346.
NextBioi100495.
PROiQ86TL2.

Gene expression databases

BgeeiQ86TL2.
CleanExiHS_TMEM110.
ExpressionAtlasiQ86TL2. baseline.
GenevestigatoriQ86TL2.

Family and domain databases

InterProiIPR022127. DUF3661_TM.
[Graphical view]
PfamiPF12400. DUF3661. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTM110_HUMAN
AccessioniPrimary (citable) accession number: Q86TL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.