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Protein

Store-operated calcium entry regulator STIMATE

Gene

TMEM110

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of store-operated Ca2+ entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca2+ influx following depletion of intracellular Ca2+ stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).2 Publications

GO - Molecular functioni

  • calcium channel regulator activity Source: UniProtKB

GO - Biological processi

  • activation of store-operated calcium channel activity Source: UniProtKB
  • calcium-mediated signaling using intracellular calcium source Source: UniProtKB
  • positive regulation of NFAT protein import into nucleus Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi8.A.65.1.1. the endoplasmic reticulum (er)-plasma membrane (pm) junctional competence regulator (tmem110) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Store-operated calcium entry regulator STIMATE1 Publication
Alternative name(s):
STIM-activating enhancer encoded by TMEM1101 Publication
Short name:
STIMATE1 Publication
Transmembrane protein 110Curated
Gene namesi
Name:TMEM110Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30526. TMEM110.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic2 PublicationsAdd
BLAST
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence analysisAdd
BLAST
Topological domaini215 – 29480Cytoplasmic2 PublicationsAdd
BLAST

GO - Cellular componenti

  • cortical endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi241 – 2466KVRYRR → QVQYQQ: Induces relocalization to cell membrane. 1 Publication

Organism-specific databases

PharmGKBiPA142670761.

Polymorphism and mutation databases

BioMutaiTMEM110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Store-operated calcium entry regulator STIMATEPRO_0000243915Add
BLAST

Proteomic databases

PaxDbiQ86TL2.
PeptideAtlasiQ86TL2.
PRIDEiQ86TL2.

PTM databases

iPTMnetiQ86TL2.
PhosphoSiteiQ86TL2.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000213533.
CleanExiHS_TMEM110.
ExpressionAtlasiQ86TL2. baseline and differential.
GenevisibleiQ86TL2. HS.

Organism-specific databases

HPAiHPA051855.

Interactioni

Subunit structurei

Homooligomer (PubMed:26322679). Interacts with STIM1 (PubMed:26322679).1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000347195.

Structurei

3D structure databases

ProteinModelPortaliQ86TL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni241 – 2466Required for localization in the endoplasmic reticulum1 Publication

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi149 – 1535GXXXG motif1 Publication

Domaini

The GXXXG motif may mediate oligomerization (PubMed:26322679). The C-terminus is necessary for its localization at ER-plasma membrane (ER-PM) junctions as well as for the store-dependent rearrangement of ER-PM junctions (PubMed:26644574).1 Publication1 Publication

Sequence similaritiesi

Belongs to the STIMATE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEJ9. Eukaryota.
ENOG4111FGH. LUCA.
GeneTreeiENSGT00390000018048.
HOGENOMiHOG000038493.
HOVERGENiHBG059486.
InParanoidiQ86TL2.
OrthoDBiEOG091G0K2S.
PhylomeDBiQ86TL2.
TreeFamiTF324457.

Family and domain databases

InterProiIPR022127. STIMATE/YPL162C.
[Graphical view]
PfamiPF12400. DUF3661. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86TL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPAGNASR GLPGGPPSTV ASGAGRCESG ALMHSFGIFL QGLLGVVAFS
60 70 80 90 100
TLMLKRFREP KHERRPWRIW FLDTSKQAIG MLFIHFANVY LADLTEEDPC
110 120 130 140 150
SLYLINFLLD ATVGMLLIYV GVRAVSVLVE WQQWESLRFG EYGDPLQCGA
160 170 180 190 200
WVGQCALYIV IMIFEKSVVF IVLLILQWKK VALLNPIENP DLKLAIVMLI
210 220 230 240 250
VPFFVNALMF WVVDNFLMRK GKTKAKLEER GANQDSRNGS KVRYRRAASH
260 270 280 290
EESESEILIS ADDEMEESDV EEDLRRLTPL KPVKKKKHRF GLPV
Length:294
Mass (Da):33,187
Last modified:June 1, 2003 - v1
Checksum:i8B112BB1CB3478E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099667 Genomic DNA. No translation available.
BC047015 mRNA. Translation: AAH47015.1.
CCDSiCCDS2866.1.
RefSeqiNP_940965.1. NM_198563.2.
UniGeneiHs.744189.

Genome annotation databases

EnsembliENST00000355083; ENSP00000347195; ENSG00000213533.
GeneIDi375346.
KEGGihsa:375346.
UCSCiuc062kra.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099667 Genomic DNA. No translation available.
BC047015 mRNA. Translation: AAH47015.1.
CCDSiCCDS2866.1.
RefSeqiNP_940965.1. NM_198563.2.
UniGeneiHs.744189.

3D structure databases

ProteinModelPortaliQ86TL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347195.

Protein family/group databases

TCDBi8.A.65.1.1. the endoplasmic reticulum (er)-plasma membrane (pm) junctional competence regulator (tmem110) family.

PTM databases

iPTMnetiQ86TL2.
PhosphoSiteiQ86TL2.

Polymorphism and mutation databases

BioMutaiTMEM110.

Proteomic databases

PaxDbiQ86TL2.
PeptideAtlasiQ86TL2.
PRIDEiQ86TL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355083; ENSP00000347195; ENSG00000213533.
GeneIDi375346.
KEGGihsa:375346.
UCSCiuc062kra.1. human.

Organism-specific databases

CTDi375346.
GeneCardsiTMEM110.
HGNCiHGNC:30526. TMEM110.
HPAiHPA051855.
neXtProtiNX_Q86TL2.
PharmGKBiPA142670761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJ9. Eukaryota.
ENOG4111FGH. LUCA.
GeneTreeiENSGT00390000018048.
HOGENOMiHOG000038493.
HOVERGENiHBG059486.
InParanoidiQ86TL2.
OrthoDBiEOG091G0K2S.
PhylomeDBiQ86TL2.
TreeFamiTF324457.

Miscellaneous databases

GenomeRNAii375346.
PROiQ86TL2.

Gene expression databases

BgeeiENSG00000213533.
CleanExiHS_TMEM110.
ExpressionAtlasiQ86TL2. baseline and differential.
GenevisibleiQ86TL2. HS.

Family and domain databases

InterProiIPR022127. STIMATE/YPL162C.
[Graphical view]
PfamiPF12400. DUF3661. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTIMA_HUMAN
AccessioniPrimary (citable) accession number: Q86TL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.