##gff-version 3 Q86TL0 UniProtKB Chain 1 474 . . . ID=PRO_0000215853;Note=Cysteine protease ATG4D Q86TL0 UniProtKB Chain 64 474 . . . ID=PRO_0000423408;Note=Cysteine protease ATG4D%2C mitochondrial Q86TL0 UniProtKB Region 1 60 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86TL0 UniProtKB Region 64 103 . . . Note=Cryptic mitochondrial signal peptide Q86TL0 UniProtKB Compositional bias 15 31 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86TL0 UniProtKB Active site 144 144 . . . Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4P1 Q86TL0 UniProtKB Active site 356 356 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4P1 Q86TL0 UniProtKB Active site 358 358 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y4P1 Q86TL0 UniProtKB Site 63 64 . . . Note=Cleavage%3B by CASP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19549685;Dbxref=PMID:19549685 Q86TL0 UniProtKB Modified residue 467 467 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q86TL0 UniProtKB Alternative sequence 1 333 . . . ID=VSP_056671;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q86TL0 UniProtKB Natural variant 125 125 . . . ID=VAR_085353;Note=Found in patients with non-obstructive azoospermia%3B uncertain significance%3B decreased expression of MAP1LC3B%3B increased programmed cell death in spermatogenic cells. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33988247;Dbxref=dbSNP:rs1216040637,PMID:33988247 Q86TL0 UniProtKB Natural variant 273 273 . . . ID=VAR_085354;Note=Found in patients with non-obstructive azoospermia%3B uncertain significance. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33988247;Dbxref=dbSNP:rs145807760,PMID:33988247 Q86TL0 UniProtKB Natural variant 295 295 . . . ID=VAR_085355;Note=Found in patients with non-obstructive azoospermia%3B uncertain significance. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33988247;Dbxref=dbSNP:rs1261979779,PMID:33988247 Q86TL0 UniProtKB Natural variant 395 395 . . . ID=VAR_085356;Note=Found in patients with non-obstructive azoospermia%3B uncertain significance. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33988247;Dbxref=dbSNP:rs201291151,PMID:33988247 Q86TL0 UniProtKB Mutagenesis 63 63 . . . Note=Abolishes cleavage by CASP3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19549685;Dbxref=PMID:19549685