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Protein

Zinc finger protein 554

Gene

ZNF554

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 292C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri324 – 346C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 554
Gene namesi
Name:ZNF554
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000172006.11
HGNCiHGNC:26629 ZNF554
neXtProtiNX_Q86TJ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915990

Polymorphism and mutation databases

BioMutaiZNF554
DMDMi74759371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748751 – 538Zinc finger protein 554Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ86TJ5
MaxQBiQ86TJ5
PaxDbiQ86TJ5
PeptideAtlasiQ86TJ5
PRIDEiQ86TJ5
ProteomicsDBi69708

PTM databases

iPTMnetiQ86TJ5
PhosphoSitePlusiQ86TJ5

Expressioni

Gene expression databases

BgeeiENSG00000172006
CleanExiHS_ZNF554
ExpressionAtlasiQ86TJ5 baseline and differential
GenevisibleiQ86TJ5 HS

Organism-specific databases

HPAiHPA060247
HPA063358

Interactioni

Protein-protein interaction databases

BioGridi125417, 8 interactors
STRINGi9606.ENSP00000321132

Structurei

3D structure databases

ProteinModelPortaliQ86TJ5
SMRiQ86TJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 148KRABPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 292C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri324 – 346C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129916
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ86TJ5
KOiK09228
OMAiMFVYLEN
OrthoDBiEOG091G02KC
PhylomeDBiQ86TJ5
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

Q86TJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTCAHLGRR ARLPAAQPSA CPGTCFSQEE RMAAGYLPRW SQELVTFEDV
60 70 80 90 100
SMDFSQEEWE LLEPAQKNLY REVMLENYRN VVSLEALKNQ CTDVGIKEGP
110 120 130 140 150
LSPAQTSQVT SLSSWTGYLL FQPVASSHLE QREALWIEEK GTPQASCSDW
160 170 180 190 200
MTVLRNQDST YKKVALQEEP ASGINMIKLI REDGGWKQLE DSHEDPQGLL
210 220 230 240 250
SQKASLHVVA VPQEKATAWH GFGENGNLSP ALVLSQGSSK GNHLCGSELD
260 270 280 290 300
ITSLASDSVL NHHQLGYADR RPCESNECGN AIRQNSHFIQ HGGKMFVYLE
310 320 330 340 350
NGQSLNHGMA LTIHNKINTA EKPFECHQCG KVFNRRHSLS EHQRIHTGEK
360 370 380 390 400
PYECQECGRA FTHSSTLTRH LRTHTGEKPY GCGECGKAFN RISSLTQHQR
410 420 430 440 450
IHTGEKPYKC EDCGKSFCQS SYLILHKRTH TGEKPYECSE CGKAFSDRSS
460 470 480 490 500
LNQHERTHTG ENPYECKQCG RAFSQRSSLV RHERTHTGEK PYRCQECGKA
510 520 530
FSQSSSLVTH QKTHSSQKTY KIIDCGKAFY QNRHLIGY
Length:538
Mass (Da):60,582
Last modified:June 1, 2003 - v1
Checksum:i00BF620D2028704C
GO

Sequence cautioni

The sequence AAH00113 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052861190E → G. Corresponds to variant dbSNP:rs867168Ensembl.1
Natural variantiVAR_052862211V → I. Corresponds to variant dbSNP:rs867169Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092136 mRNA Translation: BAC03814.1
BC000113 mRNA Translation: AAH00113.1 Different initiation.
BC047777 mRNA Translation: AAH47777.1
CCDSiCCDS42462.1
RefSeqiNP_001096121.1, NM_001102651.1
UniGeneiHs.307043

Genome annotation databases

EnsembliENST00000317243; ENSP00000321132; ENSG00000172006
GeneIDi115196
KEGGihsa:115196
UCSCiuc002lwm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN554_HUMAN
AccessioniPrimary (citable) accession number: Q86TJ5
Secondary accession number(s): Q8NAT3, Q9BWN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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