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Protein

Zinc finger protein 554

Gene

ZNF554

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29222C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 554
Gene namesi
Name:ZNF554
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26629. ZNF554.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915990.

Polymorphism and mutation databases

BioMutaiZNF554.
DMDMi74759371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Zinc finger protein 554PRO_0000274875Add
BLAST

Proteomic databases

MaxQBiQ86TJ5.
PaxDbiQ86TJ5.
PRIDEiQ86TJ5.

PTM databases

iPTMnetiQ86TJ5.
PhosphoSiteiQ86TJ5.

Expressioni

Gene expression databases

BgeeiQ86TJ5.
CleanExiHS_ZNF554.
ExpressionAtlasiQ86TJ5. baseline and differential.
GenevisibleiQ86TJ5. HS.

Organism-specific databases

HPAiHPA060247.

Interactioni

Protein-protein interaction databases

BioGridi125417. 2 interactions.
STRINGi9606.ENSP00000321132.

Structurei

3D structure databases

ProteinModelPortaliQ86TJ5.
SMRiQ86TJ5. Positions 45-84, 271-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 148104KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29222C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86TJ5.
KOiK09228.
OMAiMFVYLEN.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ86TJ5.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86TJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTCAHLGRR ARLPAAQPSA CPGTCFSQEE RMAAGYLPRW SQELVTFEDV
60 70 80 90 100
SMDFSQEEWE LLEPAQKNLY REVMLENYRN VVSLEALKNQ CTDVGIKEGP
110 120 130 140 150
LSPAQTSQVT SLSSWTGYLL FQPVASSHLE QREALWIEEK GTPQASCSDW
160 170 180 190 200
MTVLRNQDST YKKVALQEEP ASGINMIKLI REDGGWKQLE DSHEDPQGLL
210 220 230 240 250
SQKASLHVVA VPQEKATAWH GFGENGNLSP ALVLSQGSSK GNHLCGSELD
260 270 280 290 300
ITSLASDSVL NHHQLGYADR RPCESNECGN AIRQNSHFIQ HGGKMFVYLE
310 320 330 340 350
NGQSLNHGMA LTIHNKINTA EKPFECHQCG KVFNRRHSLS EHQRIHTGEK
360 370 380 390 400
PYECQECGRA FTHSSTLTRH LRTHTGEKPY GCGECGKAFN RISSLTQHQR
410 420 430 440 450
IHTGEKPYKC EDCGKSFCQS SYLILHKRTH TGEKPYECSE CGKAFSDRSS
460 470 480 490 500
LNQHERTHTG ENPYECKQCG RAFSQRSSLV RHERTHTGEK PYRCQECGKA
510 520 530
FSQSSSLVTH QKTHSSQKTY KIIDCGKAFY QNRHLIGY
Length:538
Mass (Da):60,582
Last modified:June 1, 2003 - v1
Checksum:i00BF620D2028704C
GO

Sequence cautioni

The sequence AAH00113.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901E → G.
Corresponds to variant rs867168 [ dbSNP | Ensembl ].
VAR_052861
Natural varianti211 – 2111V → I.
Corresponds to variant rs867169 [ dbSNP | Ensembl ].
VAR_052862

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092136 mRNA. Translation: BAC03814.1.
BC000113 mRNA. Translation: AAH00113.1. Different initiation.
BC047777 mRNA. Translation: AAH47777.1.
CCDSiCCDS42462.1.
RefSeqiNP_001096121.1. NM_001102651.1.
UniGeneiHs.307043.

Genome annotation databases

EnsembliENST00000317243; ENSP00000321132; ENSG00000172006.
GeneIDi115196.
KEGGihsa:115196.
UCSCiuc002lwm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092136 mRNA. Translation: BAC03814.1.
BC000113 mRNA. Translation: AAH00113.1. Different initiation.
BC047777 mRNA. Translation: AAH47777.1.
CCDSiCCDS42462.1.
RefSeqiNP_001096121.1. NM_001102651.1.
UniGeneiHs.307043.

3D structure databases

ProteinModelPortaliQ86TJ5.
SMRiQ86TJ5. Positions 45-84, 271-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125417. 2 interactions.
STRINGi9606.ENSP00000321132.

PTM databases

iPTMnetiQ86TJ5.
PhosphoSiteiQ86TJ5.

Polymorphism and mutation databases

BioMutaiZNF554.
DMDMi74759371.

Proteomic databases

MaxQBiQ86TJ5.
PaxDbiQ86TJ5.
PRIDEiQ86TJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317243; ENSP00000321132; ENSG00000172006.
GeneIDi115196.
KEGGihsa:115196.
UCSCiuc002lwm.3. human.

Organism-specific databases

CTDi115196.
GeneCardsiZNF554.
HGNCiHGNC:26629. ZNF554.
HPAiHPA060247.
neXtProtiNX_Q86TJ5.
PharmGKBiPA134915990.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ86TJ5.
KOiK09228.
OMAiMFVYLEN.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ86TJ5.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii115196.
NextBioi79526.
PROiQ86TJ5.

Gene expression databases

BgeeiQ86TJ5.
CleanExiHS_ZNF554.
ExpressionAtlasiQ86TJ5. baseline and differential.
GenevisibleiQ86TJ5. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and PNS.

Entry informationi

Entry nameiZN554_HUMAN
AccessioniPrimary (citable) accession number: Q86TJ5
Secondary accession number(s): Q8NAT3, Q9BWN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.