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Protein

Transcriptional adapter 2-beta

Gene

TADA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 4947ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 2-beta
Alternative name(s):
ADA2-like protein beta
Short name:
ADA2-beta
Gene namesi
Name:TADA2B
Synonyms:ADA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30781. TADA2B.

Subcellular locationi

GO - Cellular componenti

  • SAGA-type complex Source: BHF-UCL
  • STAGA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664556.

Polymorphism and mutation databases

BioMutaiTADA2B.
DMDMi166225686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Transcriptional adapter 2-betaPRO_0000313711Add
BLAST

Proteomic databases

EPDiQ86TJ2.
MaxQBiQ86TJ2.
PaxDbiQ86TJ2.
PeptideAtlasiQ86TJ2.
PRIDEiQ86TJ2.

PTM databases

iPTMnetiQ86TJ2.
PhosphoSiteiQ86TJ2.

Expressioni

Gene expression databases

BgeeiENSG00000173011.
ExpressionAtlasiQ86TJ2. baseline and differential.
GenevisibleiQ86TJ2. HS.

Organism-specific databases

HPAiHPA035770.
HPA041452.

Interactioni

Subunit structurei

Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex.2 Publications

Protein-protein interaction databases

BioGridi125041. 23 interactions.
IntActiQ86TJ2. 3 interactions.
STRINGi9606.ENSP00000308022.

Structurei

3D structure databases

ProteinModelPortaliQ86TJ2.
SMRiQ86TJ2. Positions 70-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 11854SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SANT domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 4947ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0457. Eukaryota.
COG5114. LUCA.
GeneTreeiENSGT00530000063657.
HOGENOMiHOG000007843.
HOVERGENiHBG102016.
InParanoidiQ86TJ2.
KOiK15127.
OMAiNMHKERI.
OrthoDBiEOG091G0CQZ.
PhylomeDBiQ86TJ2.
TreeFamiTF313975.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELGKKYCV YCLAEVSPLR FRCTECQDIE LCPECFSAGA EIGHHRRYHG
60 70 80 90 100
YQLVDGGRFT LWGPEAEGGW TSREEQLLLD AIEQFGFGNW EDMAAHVGAS
110 120 130 140 150
RTPQEVMEHY VSMYIHGNLG KACIPDTIPN RVTDHTCPSG GPLSPSLTTP
160 170 180 190 200
LPPLDISVAE QQQLGYMPLR DDYEIEYDQD AETLISGLSV NYDDDDVEIE
210 220 230 240 250
LKRAHVDMYV RKLKERQRRK NIARDYNLVP AFLGKDKKEK EKALKRKITK
260 270 280 290 300
EEKELRLKLR PLYQFMSCKE FDDLFENMHK EKMLRAKIRE LQRYRRNGIT
310 320 330 340 350
KMEESAEYEA ARHKREKRKE NKNLAGSKRG KEDGKDSEFA AIENLPGFEL
360 370 380 390 400
LSDREKVLCS SLNLSPARYV TVKTIIIKDH LQKRQGIPSK SRLPSYLDKV
410 420
LKKRILNFLT ESGWISRDAS
Length:420
Mass (Da):48,470
Last modified:January 15, 2008 - v2
Checksum:i89C3365128DF5EBC
GO
Isoform 2 (identifier: Q86TJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-90: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):39,914
Checksum:iB4171B04BBBB32C9
GO
Isoform 3 (identifier: Q86TJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:328
Mass (Da):37,967
Checksum:iBD6453E0703FE736
GO

Sequence cautioni

The sequence AAH47794 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI01338 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511E → K in CAE46064 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 3. 2 PublicationsVSP_030109Add
BLAST
Alternative sequencei16 – 9075Missing in isoform 2. 1 PublicationVSP_030110Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093974 mRNA. Translation: BAG52792.1.
AK096655 mRNA. Translation: BAG53348.1.
AC097382 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82372.1.
BC047794 mRNA. Translation: AAH47794.1. Sequence problems.
BC101334 mRNA. Translation: AAI01335.1.
BC101335 mRNA. Translation: AAI01336.1.
BC101336 mRNA. Translation: AAI01337.1.
BC101337 mRNA. Translation: AAI01338.1. Different initiation.
BX641147 mRNA. Translation: CAE46064.1.
CCDSiCCDS47007.1. [Q86TJ2-1]
RefSeqiNP_689506.2. NM_152293.2. [Q86TJ2-1]
XP_011511897.1. XM_011513595.1. [Q86TJ2-3]
UniGeneiHs.518614.

Genome annotation databases

EnsembliENST00000310074; ENSP00000308022; ENSG00000173011. [Q86TJ2-1]
ENST00000512388; ENSP00000423947; ENSG00000173011. [Q86TJ2-2]
ENST00000515646; ENSP00000423181; ENSG00000173011. [Q86TJ2-3]
GeneIDi93624.
KEGGihsa:93624.
UCSCiuc003gjw.5. human. [Q86TJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093974 mRNA. Translation: BAG52792.1.
AK096655 mRNA. Translation: BAG53348.1.
AC097382 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82372.1.
BC047794 mRNA. Translation: AAH47794.1. Sequence problems.
BC101334 mRNA. Translation: AAI01335.1.
BC101335 mRNA. Translation: AAI01336.1.
BC101336 mRNA. Translation: AAI01337.1.
BC101337 mRNA. Translation: AAI01338.1. Different initiation.
BX641147 mRNA. Translation: CAE46064.1.
CCDSiCCDS47007.1. [Q86TJ2-1]
RefSeqiNP_689506.2. NM_152293.2. [Q86TJ2-1]
XP_011511897.1. XM_011513595.1. [Q86TJ2-3]
UniGeneiHs.518614.

3D structure databases

ProteinModelPortaliQ86TJ2.
SMRiQ86TJ2. Positions 70-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125041. 23 interactions.
IntActiQ86TJ2. 3 interactions.
STRINGi9606.ENSP00000308022.

PTM databases

iPTMnetiQ86TJ2.
PhosphoSiteiQ86TJ2.

Polymorphism and mutation databases

BioMutaiTADA2B.
DMDMi166225686.

Proteomic databases

EPDiQ86TJ2.
MaxQBiQ86TJ2.
PaxDbiQ86TJ2.
PeptideAtlasiQ86TJ2.
PRIDEiQ86TJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310074; ENSP00000308022; ENSG00000173011. [Q86TJ2-1]
ENST00000512388; ENSP00000423947; ENSG00000173011. [Q86TJ2-2]
ENST00000515646; ENSP00000423181; ENSG00000173011. [Q86TJ2-3]
GeneIDi93624.
KEGGihsa:93624.
UCSCiuc003gjw.5. human. [Q86TJ2-1]

Organism-specific databases

CTDi93624.
GeneCardsiTADA2B.
HGNCiHGNC:30781. TADA2B.
HPAiHPA035770.
HPA041452.
MIMi608790. gene.
neXtProtiNX_Q86TJ2.
PharmGKBiPA165664556.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0457. Eukaryota.
COG5114. LUCA.
GeneTreeiENSGT00530000063657.
HOGENOMiHOG000007843.
HOVERGENiHBG102016.
InParanoidiQ86TJ2.
KOiK15127.
OMAiNMHKERI.
OrthoDBiEOG091G0CQZ.
PhylomeDBiQ86TJ2.
TreeFamiTF313975.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiTADA2B. human.
GenomeRNAii93624.
PROiQ86TJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173011.
ExpressionAtlasiQ86TJ2. baseline and differential.
GenevisibleiQ86TJ2. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAD2B_HUMAN
AccessioniPrimary (citable) accession number: Q86TJ2
Secondary accession number(s): A0AUJ8
, A4QMR7, B3KSN0, B3KU86, Q6MZG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.