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Protein

WD repeat-containing protein 86

Gene

WDR86

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ86TI4.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 86
Gene namesi
Name:WDR86
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:28020. WDR86.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147619.

Polymorphism and mutation databases

BioMutaiWDR86.
DMDMi308153536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376WD repeat-containing protein 86PRO_0000320674Add
BLAST

Proteomic databases

PaxDbiQ86TI4.
PRIDEiQ86TI4.

PTM databases

iPTMnetiQ86TI4.
PhosphoSiteiQ86TI4.

Expressioni

Gene expression databases

BgeeiQ86TI4.
CleanExiHS_WDR86.
ExpressionAtlasiQ86TI4. baseline and differential.
GenevisibleiQ86TI4. HS.

Organism-specific databases

HPAiHPA021086.

Interactioni

Protein-protein interaction databases

BioGridi131548. 13 interactions.
STRINGi9606.ENSP00000335522.

Structurei

3D structure databases

ProteinModelPortaliQ86TI4.
SMRiQ86TI4. Positions 14-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati13 – 5240WD 1Add
BLAST
Repeati55 – 9440WD 2Add
BLAST
Repeati95 – 13238WD 3Add
BLAST
Repeati135 – 18854WD 4Add
BLAST
Repeati191 – 23242WD 5Add
BLAST
Repeati234 – 27239WD 6Add
BLAST
Repeati274 – 31037WD 7Add
BLAST
Repeati313 – 35038WD 8Add
BLAST

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQCU. Eukaryota.
ENOG410Z3TA. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000171556.
InParanoidiQ86TI4.
OMAiGPQTQRE.
OrthoDBiEOG7HXCVB.
PhylomeDBiQ86TI4.
TreeFamiTF338411.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q86TI4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGGGSALRV CADHRGGINW LSLSPDGQRL LTGSEDGTAR LWSTADGQCC
60 70 80 90 100
ALLQGHESYV TFCQLEDEAA FTCSADCTIR RWDVLTGQCL QVYRGHTSIV
110 120 130 140 150
NRILVANNQL FSSSYDRTAR VWSVDKGQMS REFRGHRNCV LTLAYSAPWD
160 170 180 190 200
LPSTPCAEEA AAGGLLVTGS TDGTAKVWQV ASGCCHQTLR GHTGAVLCLV
210 220 230 240 250
LDTPGHTAFT GSTDATIRAW DILSGEQLRV FREHRGSVIC LELVNRLVYS
260 270 280 290 300
GSADRTVKCW LADTGECVRT FTAHRRNVSA LKYHAGTLFT GSGDACARAF
310 320 330 340 350
DAQSGELRRV FRGHTFIINC IQVHGQVLYT ASHDGALRLW DVRGLRGAPR
360 370
PPPPMRSLSR LFSNKVGCAA APLQPA
Length:376
Mass (Da):40,731
Last modified:October 5, 2010 - v3
Checksum:i1911439E465CAB15
GO
Isoform 1 (identifier: Q86TI4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: Q → QGRPSHSLPD...PTYRRGNRLG

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:491
Mass (Da):53,068
Checksum:iD98E26A38D8DADBD
GO
Isoform 2 (identifier: Q86TI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     243-376: LVNRLVYSGS...GCAAAPLQPA → CSRAAGTLAP...SPWGPPPFPF

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):29,044
Checksum:i8075771DA5DD9CC0
GO
Isoform 4 (identifier: Q86TI4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-376: LVNRLVYSGS...GCAAAPLQPA → RERSGGLQSC...RVAPVLPPHP

Note: No experimental confirmation available.Curated
Show »
Length:482
Mass (Da):52,228
Checksum:i5AD731C71EB033EA
GO

Sequence cautioni

The sequence AAI07126.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541Q → E in AAI07126 (PubMed:15489334).Curated
Isoform 4 (identifier: Q86TI4-4)
Sequence conflicti182 – 1821S → R in BAC86140 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti355 – 3551M → T.1 Publication
Corresponds to variant rs4141455 [ dbSNP | Ensembl ].
VAR_063633

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 128128Missing in isoform 2. 1 PublicationVSP_031725Add
BLAST
Alternative sequencei54 – 541Q → QGRPSHSLPDLFAAAHRPQT ADPSSCARRPLSRSPAPAHP GTLAEERLSGPSIWLLSARQ GRVPCGLFVANCALLLAFPV DDSHSNNRRLLRASGAEKCA VVTLCYPTYRRGNRLG in isoform 1. 1 PublicationVSP_039818
Alternative sequencei243 – 376134LVNRL…PLQPA → CSRAAGTLAPGPSTRSLESC GGCSGATHSSSTASRCTARC STPPRTTAPCASGTCAGSEV PRGPLRPCAASRGSSATRWA APPRPCSRPDPAGPLQTPAQ TPSGSQSAPPCYPRWWRPMA GEGRGARKPGREESPSQASG FSLVARRRWERECSPWGPPP FPF in isoform 2. 1 PublicationVSP_031726Add
BLAST
Alternative sequencei243 – 376134LVNRL…PLQPA → RERSGGLQSCPSCRPSLLLL AAGEPTRVLWQRGQDRQVLA GRHRGVCAHVHGPQTQRERP QVPRGHLVHGQRGRLRPGLR RAVWRAAEGVPGPHIHHQLH PGARPGALHRLARRRPAPLG RARAPRCPAAPSAHAQPLAA LQQQGGLRRRAPAAGLIPRG PCRRQPRHPAAPRAPRPATR GGGARWPARGEERGSPGGRR ARRRRLVFLWWPGGAGSGSA RPGDRPLFPFRVAPVLPPHP in isoform 4. 1 PublicationVSP_054908Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125347 mRNA. Translation: BAC86140.1.
AK296049 mRNA. Translation: BAG58813.1.
AC005486 Genomic DNA. No translation available.
AC005996 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW53997.1.
BC047921 mRNA. No translation available.
BC107125 mRNA. Translation: AAI07126.1. Different initiation.
CCDSiCCDS5925.2. [Q86TI4-3]
CCDS64805.1. [Q86TI4-2]
CCDS64806.1. [Q86TI4-4]
RefSeqiNP_001271189.1. NM_001284260.1. [Q86TI4-4]
NP_001271190.1. NM_001284261.1. [Q86TI4-2]
NP_001271191.1. NM_001284262.1.
NP_938026.2. NM_198285.2. [Q86TI4-3]
XP_011514455.1. XM_011516153.1.
XP_011514456.1. XM_011516154.1.
UniGeneiHs.647083.
Hs.659458.

Genome annotation databases

EnsembliENST00000334493; ENSP00000335522; ENSG00000187260. [Q86TI4-3]
ENST00000469830; ENSP00000419162; ENSG00000187260. [Q86TI4-4]
ENST00000477459; ENSP00000417512; ENSG00000187260. [Q86TI4-2]
ENST00000628331; ENSP00000486705; ENSG00000187260. [Q86TI4-2]
GeneIDi349136.
KEGGihsa:349136.
UCSCiuc003wkb.3. human. [Q86TI4-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125347 mRNA. Translation: BAC86140.1.
AK296049 mRNA. Translation: BAG58813.1.
AC005486 Genomic DNA. No translation available.
AC005996 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW53997.1.
BC047921 mRNA. No translation available.
BC107125 mRNA. Translation: AAI07126.1. Different initiation.
CCDSiCCDS5925.2. [Q86TI4-3]
CCDS64805.1. [Q86TI4-2]
CCDS64806.1. [Q86TI4-4]
RefSeqiNP_001271189.1. NM_001284260.1. [Q86TI4-4]
NP_001271190.1. NM_001284261.1. [Q86TI4-2]
NP_001271191.1. NM_001284262.1.
NP_938026.2. NM_198285.2. [Q86TI4-3]
XP_011514455.1. XM_011516153.1.
XP_011514456.1. XM_011516154.1.
UniGeneiHs.647083.
Hs.659458.

3D structure databases

ProteinModelPortaliQ86TI4.
SMRiQ86TI4. Positions 14-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131548. 13 interactions.
STRINGi9606.ENSP00000335522.

PTM databases

iPTMnetiQ86TI4.
PhosphoSiteiQ86TI4.

Polymorphism and mutation databases

BioMutaiWDR86.
DMDMi308153536.

Proteomic databases

PaxDbiQ86TI4.
PRIDEiQ86TI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334493; ENSP00000335522; ENSG00000187260. [Q86TI4-3]
ENST00000469830; ENSP00000419162; ENSG00000187260. [Q86TI4-4]
ENST00000477459; ENSP00000417512; ENSG00000187260. [Q86TI4-2]
ENST00000628331; ENSP00000486705; ENSG00000187260. [Q86TI4-2]
GeneIDi349136.
KEGGihsa:349136.
UCSCiuc003wkb.3. human. [Q86TI4-3]

Organism-specific databases

CTDi349136.
GeneCardsiWDR86.
HGNCiHGNC:28020. WDR86.
HPAiHPA021086.
neXtProtiNX_Q86TI4.
PharmGKBiPA145147619.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQCU. Eukaryota.
ENOG410Z3TA. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000171556.
InParanoidiQ86TI4.
OMAiGPQTQRE.
OrthoDBiEOG7HXCVB.
PhylomeDBiQ86TI4.
TreeFamiTF338411.

Enzyme and pathway databases

SignaLinkiQ86TI4.

Miscellaneous databases

GenomeRNAii349136.
PROiQ86TI4.

Gene expression databases

BgeeiQ86TI4.
CleanExiHS_WDR86.
ExpressionAtlasiQ86TI4. baseline and differential.
GenevisibleiQ86TI4. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Subthalamic nucleus and Teratocarcinoma.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-376 (ISOFORM 3), VARIANT THR-355.
    Tissue: PNS.

Entry informationi

Entry nameiWDR86_HUMAN
AccessioniPrimary (citable) accession number: Q86TI4
Secondary accession number(s): B4DJF1
, C9JAJ5, C9JXE3, Q3KNT1, Q6ZUS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.