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Protein

Retrotransposon-derived protein PEG10

Gene

PEG10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).By similarity4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri293 – 31018CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Differentiation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon-derived protein PEG10
Alternative name(s):
Embryonal carcinoma differentiation-regulated protein
Mammalian retrotransposon-derived protein 2
Myelin expression factor 3-like protein 1
Short name:
MEF3-like protein 1
Paternally expressed gene 10 protein
Retrotransposon gag domain-containing protein 3
Retrotransposon-derived gag-like polyprotein
Ty3/Gypsy-like protein
Gene namesi
Name:PEG10
Synonyms:EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14005. PEG10.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi370 – 3701D → A: Inhibits proteolytic cleavage. 1 Publication

Organism-specific databases

PharmGKBiPA33170.

Polymorphism and mutation databases

BioMutaiPEG10.
DMDMi172046699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Retrotransposon-derived protein PEG10PRO_0000323026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform RF1 (identifier: Q86TG7-2)
Modified residuei316 – 3161PhosphoserineCombined sources
Modified residuei321 – 3211PhosphoserineCombined sources

Post-translational modificationi

Isoform RF1/RF2 undergoes proteolytic cleavage.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86TG7.
MaxQBiQ86TG7.
PaxDbiQ86TG7.
PRIDEiQ86TG7.

PTM databases

iPTMnetiQ86TG7.

Expressioni

Tissue specificityi

Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).5 Publications

Developmental stagei

Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation.2 Publications

Inductioni

Up-regulated by MYC and dihydrotestosterone (DHT).2 Publications

Gene expression databases

BgeeiQ86TG7.
CleanExiHS_PEG10.
ExpressionAtlasiQ86TG7. baseline and differential.
GenevisibleiQ86TG7. HS.

Organism-specific databases

HPAiHPA051038.

Interactioni

Subunit structurei

Interacts with ALK1, SIAH1 and SIAH2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-2858265,EBI-739580
FAM127AA6ZKI33EBI-2858265,EBI-10174072
FAM127CQ17RB03EBI-2858265,EBI-10238588
LDOC1O957513EBI-2858265,EBI-740738
SIAH1Q8IUQ43EBI-2858265,EBI-747107
TOLLIPQ9H0E22EBI-2858265,EBI-74615

Protein-protein interaction databases

BioGridi116717. 36 interactions.
IntActiQ86TG7. 18 interactions.
MINTiMINT-1190281.
STRINGi9606.ENSP00000417587.

Structurei

3D structure databases

ProteinModelPortaliQ86TG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 275200Necessary for interaction with ALK1Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 5050Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi682 – 70322Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri293 – 31018CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J3P7. Eukaryota.
ENOG410Y6K0. LUCA.
GeneTreeiENSGT00840000129904.
HOGENOMiHOG000169580.
HOVERGENiHBG108242.
InParanoidiQ86TG7.
OrthoDBiEOG70KGNZ.
PhylomeDBiQ86TG7.
TreeFamiTF335133.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
IPR021109. Peptidase_aspartic_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Note: The ribosomal frameshifting efficiency yield up to 66% of protein RF1/RF2 compared to RF1.1 Publication

Isoform RF1/RF2 (identifier: Q86TG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTERRRDELS EEINNLREKV MKQSEENNNL QSQVQKLTEE NTTLREQVEP
60 70 80 90 100
TPEDEDDDIE LRGAAAAAAP PPPIEEECPE DLPEKFDGNP DMLAPFMAQC
110 120 130 140 150
QIFMEKSTRD FSVDRVRVCF VTSMMTGRAA RWASAKLERS HYLMHNYPAF
160 170 180 190 200
MMEMKHVFED PQRREVAKRK IRRLRQGMGS VIDYSNAFQM IAQDLDWNEP
210 220 230 240 250
ALIDQYHEGL SDHIQEELSH LEVAKSLSAL IGQCIHIERR LARAAAARKP
260 270 280 290 300
RSPPRALVLP HIASHHQVDP TEPVGGARMR LTQEEKERRR KLNLCLYCGT
310 320 330 340 350
GGHYADNCPA KASKSSPAGK LPGPAVEGPS ATGPEIIRSP QDDASSPHLQ
360 370 380 390 400
VMLQIHLPGR HTLFVRAMID SGASGNFIDH EYVAQNGIPL RIKDWPILVE
410 420 430 440 450
AIDGRPIASG PVVHETHDLI VDLGDHREVL SFDVTQSPFF PVVLGVRWLS
460 470 480 490 500
THDPNITWST RSIVFDSEYC RYHCRMYSPI PPSLPPPAPQ PPLYYPVDGY
510 520 530 540 550
RVYQPVRYYY VQNVYTPVDE HVYPDHRLVD PHIEMIPGAH SIPSGHVYSL
560 570 580 590 600
SEPEMAALRD FVARNVKDGL ITPTIAPNGA QVLQVKRGWK LQVSYDCRAP
610 620 630 640 650
NNFTIQNQYP RLSIPNLEDQ AHLATYTEFV PQIPGYQTYP TYAAYPTYPV
660 670 680 690 700
GFAWYPVGRD GQGRSLYVPV MITWNPHWYR QPPVPQYPPP QPPPPPPPPP

PPPSYSTL
Note: Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-319 and Lys-320.
Length:708
Mass (Da):80,173
Last modified:March 18, 2008 - v2
Checksum:iBFAA2FA24941D5D1
GO
Isoform RF1 (identifier: Q86TG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-325: KLPGPA → NSPAPL
     326-708: Missing.

Note: Produced by conventional translation.Combined sources
Show »
Length:325
Mass (Da):36,966
Checksum:i118E4CFAF97F2A76
GO

Sequence cautioni

The sequence BAA83003.2 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei320 – 3256KLPGPA → NSPAPL in isoform RF1. CuratedVSP_032007
Alternative sequencei326 – 708383Missing in isoform RF1. CuratedVSP_032008Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049834 mRNA. Translation: BAB43951.1.
AB028974 mRNA. Translation: BAA83003.2. Sequence problems.
AB049150 mRNA. Translation: BAB68387.1.
AC069292 Genomic DNA. Translation: AAS07484.1.
BC050659 mRNA. Translation: AAH50659.1.
CCDSiCCDS55126.1. [Q86TG7-2]
RefSeqiNP_001035242.1. NM_001040152.1. [Q86TG7-2]
NP_001171890.1. NM_001184961.1.
NP_001171891.1. NM_001184962.1.
NP_055883.2. NM_015068.3. [Q86TG7-1]
UniGeneiHs.147492.

Genome annotation databases

EnsembliENST00000482108; ENSP00000417587; ENSG00000242265. [Q86TG7-2]
GeneIDi23089.
KEGGihsa:23089.
UCSCiuc064flv.1. human. [Q86TG7-1]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049834 mRNA. Translation: BAB43951.1.
AB028974 mRNA. Translation: BAA83003.2. Sequence problems.
AB049150 mRNA. Translation: BAB68387.1.
AC069292 Genomic DNA. Translation: AAS07484.1.
BC050659 mRNA. Translation: AAH50659.1.
CCDSiCCDS55126.1. [Q86TG7-2]
RefSeqiNP_001035242.1. NM_001040152.1. [Q86TG7-2]
NP_001171890.1. NM_001184961.1.
NP_001171891.1. NM_001184962.1.
NP_055883.2. NM_015068.3. [Q86TG7-1]
UniGeneiHs.147492.

3D structure databases

ProteinModelPortaliQ86TG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116717. 36 interactions.
IntActiQ86TG7. 18 interactions.
MINTiMINT-1190281.
STRINGi9606.ENSP00000417587.

PTM databases

iPTMnetiQ86TG7.

Polymorphism and mutation databases

BioMutaiPEG10.
DMDMi172046699.

Proteomic databases

EPDiQ86TG7.
MaxQBiQ86TG7.
PaxDbiQ86TG7.
PRIDEiQ86TG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000482108; ENSP00000417587; ENSG00000242265. [Q86TG7-2]
GeneIDi23089.
KEGGihsa:23089.
UCSCiuc064flv.1. human. [Q86TG7-1]

Organism-specific databases

CTDi23089.
GeneCardsiPEG10.
HGNCiHGNC:14005. PEG10.
HPAiHPA051038.
MIMi609810. gene.
neXtProtiNX_Q86TG7.
PharmGKBiPA33170.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3P7. Eukaryota.
ENOG410Y6K0. LUCA.
GeneTreeiENSGT00840000129904.
HOGENOMiHOG000169580.
HOVERGENiHBG108242.
InParanoidiQ86TG7.
OrthoDBiEOG70KGNZ.
PhylomeDBiQ86TG7.
TreeFamiTF335133.

Miscellaneous databases

ChiTaRSiPEG10. human.
GeneWikiiPEG10.
GenomeRNAii23089.
PROiQ86TG7.
SOURCEiSearch...

Gene expression databases

BgeeiQ86TG7.
CleanExiHS_PEG10.
ExpressionAtlasiQ86TG7. baseline and differential.
GenevisibleiQ86TG7. HS.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
IPR021109. Peptidase_aspartic_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21."
    Ono R., Kobayashi S., Wagatsuma H., Aisaka K., Kohda T., Kaneko-Ishino T., Ishino F.
    Genomics 73:232-237(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Isolation of MEF3 like gene 1."
    Satoh S., Furukawa Y.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  7. "Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta."
    Smallwood A., Papageorghiou A., Nicolaides K., Alley M.K.R., Jim A., Nargund G., Ojha K., Campbell S., Banerjee S.
    Biol. Reprod. 69:286-293(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  8. "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1."
    Okabe H., Satoh S., Furukawa Y., Kato T., Hasegawa S., Nakajima Y., Yamaoka Y., Nakamura Y.
    Cancer Res. 63:3043-3048(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SIAH1 AND SIAH2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1."
    Lux A., Beil C., Majety M., Barron S., Gallione C.J., Kuhn H.-M., Berg J.N., Kioschis P., Marchuk D.A., Hafner M.
    J. Biol. Chem. 280:8482-8493(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ALK1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia."
    Kainz B., Shehata M., Bilban M., Kienle D., Heintel D., Kroemer-Holzinger E., Le T., Kroeber A., Heller G., Schwarzinger I., Demirtas D., Chott A., Doehner H., Zoechbauer-Mueller S., Fonatsch C., Zielinski C., Stilgenbauer S., Gaiger A., Wagner O., Jaeger U.
    Int. J. Cancer 121:1984-1993(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  12. "Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues."
    Clark M.B., Jaenicke M., Gottesbuehren U., Kleffmann T., Legge M., Poole E.S., Tate W.P.
    J. Biol. Chem. 282:37359-37369(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: RIBOSOMAL FRAMESHIFT, PROTEOLYTIC PROCESSING, MUTAGENESIS OF ASP-370, DEVELOPMENTAL STAGE.
  13. "Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells."
    Jie X., Lang C., Jian Q., Chaoqun L., Dehua Y., Yi S., Yanping J., Luokun X., Qiuping Z., Hui W., Feili G., Boquan J., Youxin J., Jinquan T.
    Oncogene 26:5741-5751(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316 AND SER-321 (ISOFORM RF1), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 (ISOFORM RF1), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEG10_HUMAN
AccessioniPrimary (citable) accession number: Q86TG7
Secondary accession number(s): Q96A68, Q9UPV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The PEG10 locus is imprinted, giving rise to paternally expressed proteins.

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.