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Protein

Leucine zipper protein 2

Gene

LUZP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper protein 2
Gene namesi
Name:LUZP2
ORF Names:UNQ2566/PRO6246
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23206. LUZP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28445.

Polymorphism and mutation databases

BioMutaiLUZP2.
DMDMi166232937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 346327Leucine zipper protein 2PRO_0000315274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ86TE4.
PaxDbiQ86TE4.
PeptideAtlasiQ86TE4.
PRIDEiQ86TE4.

PTM databases

iPTMnetiQ86TE4.
PhosphoSiteiQ86TE4.

Expressioni

Gene expression databases

BgeeiENSG00000187398.
CleanExiHS_LUZP2.
ExpressionAtlasiQ86TE4. baseline and differential.
GenevisibleiQ86TE4. HS.

Organism-specific databases

HPAiHPA046161.

Interactioni

Protein-protein interaction databases

IntActiQ86TE4. 2 interactions.
STRINGi9606.ENSP00000336817.

Structurei

3D structure databases

ProteinModelPortaliQ86TE4.
SMRiQ86TE4. Positions 38-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni164 – 19229Leucine-zipperAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili16 – 211196Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi222 – 2254Poly-Pro

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IFSA. Eukaryota.
ENOG4111GQ9. LUCA.
GeneTreeiENSGT00390000013180.
HOGENOMiHOG000294171.
HOVERGENiHBG108108.
InParanoidiQ86TE4.
OMAiCSMKHKE.
OrthoDBiEOG091G0D2O.
PhylomeDBiQ86TE4.
TreeFamiTF331644.

Family and domain databases

InterProiIPR026718. Luzp2.
[Graphical view]
PANTHERiPTHR22414. PTHR22414. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFSPAHYLL PLLPALVLST RQDYEELEKQ LKEVFKERST ILRQLTKTSR
60 70 80 90 100
ELDGIKVNLQ SLKNDEQSAK TDVQKLLELG QKQREEMKSL QEALQNQLKE
110 120 130 140 150
TSEKAEKHQA TINFLKTEVE RKSKMIRDLQ NENKSLKNKL LSGNKLCGIH
160 170 180 190 200
AEESKKIQAQ LKELRYGKKD LLFKAQQLTD LEQKLAVAKN ELEKAALDRE
210 220 230 240 250
SQMKAMKETV QLCLTSVFRD QPPPPLSLIT SNPTRMLLPP RNIASKLPDA
260 270 280 290 300
AAKSKPQQSA SGNNESSQVE STKEGNPSTT ACDSQDEGRP CSMKHKESPP
310 320 330 340
SNATAETEPI PQKLQMPPCS ECEVKKAPEK PLTSFEGMAA REEKIL
Length:346
Mass (Da):38,958
Last modified:January 15, 2008 - v2
Checksum:iAC29F2D885EC3278
GO
Isoform 2 (identifier: Q86TE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-159: NKSLKNKLLSGNKLCGIHAEESKKIQA → DSRKRPRDLQWKIVSMRTMSIYLLMYL
     160-346: Missing.

Show »
Length:159
Mass (Da):18,865
Checksum:i0B8E2C31DCBB474F
GO
Isoform 3 (identifier: Q86TE4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-136: NKSL → VIQI
     137-346: Missing.

Show »
Length:136
Mass (Da):15,935
Checksum:iAB3E102F3030F9C5
GO
Isoform 4 (identifier: Q86TE4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Note: No experimental confirmation available.
Show »
Length:260
Mass (Da):28,921
Checksum:i3EA052C3CB38799B
GO

Sequence cautioni

The sequence CAD90000 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti308 – 3081E → Q.
Corresponds to variant rs7930185 [ dbSNP | Ensembl ].
VAR_038165

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8686Missing in isoform 4. 1 PublicationVSP_044970Add
BLAST
Alternative sequencei133 – 15927NKSLK…KKIQA → DSRKRPRDLQWKIVSMRTMS IYLLMYL in isoform 2. 1 PublicationVSP_030520Add
BLAST
Alternative sequencei133 – 1364NKSL → VIQI in isoform 3. 1 PublicationVSP_030521
Alternative sequencei137 – 346210Missing in isoform 3. 1 PublicationVSP_030522Add
BLAST
Alternative sequencei160 – 346187Missing in isoform 2. 1 PublicationVSP_030523Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358386 mRNA. Translation: AAQ88752.1.
AK127695 mRNA. Translation: BAC87089.1.
AL832641 mRNA. Translation: CAD90000.1. Different initiation.
AC023869 Genomic DNA. No translation available.
AC040968 Genomic DNA. No translation available.
AC067902 Genomic DNA. No translation available.
AC087373 Genomic DNA. No translation available.
AC115990 Genomic DNA. No translation available.
AC135168 Genomic DNA. No translation available.
BC132829 mRNA. Translation: AAI32830.1.
BC151234 mRNA. No translation available.
CCDSiCCDS31446.1. [Q86TE4-1]
CCDS58128.1. [Q86TE4-4]
RefSeqiNP_001009909.2. NM_001009909.3. [Q86TE4-1]
NP_001238937.1. NM_001252008.1. [Q86TE4-4]
NP_001238939.1. NM_001252010.1.
UniGeneiHs.144138.
Hs.655032.

Genome annotation databases

EnsembliENST00000336930; ENSP00000336817; ENSG00000187398. [Q86TE4-1]
ENST00000533227; ENSP00000432952; ENSG00000187398. [Q86TE4-4]
ENST00000620308; ENSP00000480441; ENSG00000187398. [Q86TE4-4]
GeneIDi338645.
KEGGihsa:338645.
UCSCiuc001mqs.4. human. [Q86TE4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358386 mRNA. Translation: AAQ88752.1.
AK127695 mRNA. Translation: BAC87089.1.
AL832641 mRNA. Translation: CAD90000.1. Different initiation.
AC023869 Genomic DNA. No translation available.
AC040968 Genomic DNA. No translation available.
AC067902 Genomic DNA. No translation available.
AC087373 Genomic DNA. No translation available.
AC115990 Genomic DNA. No translation available.
AC135168 Genomic DNA. No translation available.
BC132829 mRNA. Translation: AAI32830.1.
BC151234 mRNA. No translation available.
CCDSiCCDS31446.1. [Q86TE4-1]
CCDS58128.1. [Q86TE4-4]
RefSeqiNP_001009909.2. NM_001009909.3. [Q86TE4-1]
NP_001238937.1. NM_001252008.1. [Q86TE4-4]
NP_001238939.1. NM_001252010.1.
UniGeneiHs.144138.
Hs.655032.

3D structure databases

ProteinModelPortaliQ86TE4.
SMRiQ86TE4. Positions 38-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86TE4. 2 interactions.
STRINGi9606.ENSP00000336817.

PTM databases

iPTMnetiQ86TE4.
PhosphoSiteiQ86TE4.

Polymorphism and mutation databases

BioMutaiLUZP2.
DMDMi166232937.

Proteomic databases

MaxQBiQ86TE4.
PaxDbiQ86TE4.
PeptideAtlasiQ86TE4.
PRIDEiQ86TE4.

Protocols and materials databases

DNASUi338645.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336930; ENSP00000336817; ENSG00000187398. [Q86TE4-1]
ENST00000533227; ENSP00000432952; ENSG00000187398. [Q86TE4-4]
ENST00000620308; ENSP00000480441; ENSG00000187398. [Q86TE4-4]
GeneIDi338645.
KEGGihsa:338645.
UCSCiuc001mqs.4. human. [Q86TE4-1]

Organism-specific databases

CTDi338645.
GeneCardsiLUZP2.
HGNCiHGNC:23206. LUZP2.
HPAiHPA046161.
MIMi608178. gene.
neXtProtiNX_Q86TE4.
PharmGKBiPA28445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFSA. Eukaryota.
ENOG4111GQ9. LUCA.
GeneTreeiENSGT00390000013180.
HOGENOMiHOG000294171.
HOVERGENiHBG108108.
InParanoidiQ86TE4.
OMAiCSMKHKE.
OrthoDBiEOG091G0D2O.
PhylomeDBiQ86TE4.
TreeFamiTF331644.

Miscellaneous databases

ChiTaRSiLUZP2. human.
GenomeRNAii338645.
PROiQ86TE4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187398.
CleanExiHS_LUZP2.
ExpressionAtlasiQ86TE4. baseline and differential.
GenevisibleiQ86TE4. HS.

Family and domain databases

InterProiIPR026718. Luzp2.
[Graphical view]
PANTHERiPTHR22414. PTHR22414. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLUZP2_HUMAN
AccessioniPrimary (citable) accession number: Q86TE4
Secondary accession number(s): A2RUB8
, E9PN53, Q6UXE7, Q6ZS65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.