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Protein

Sarcalumenin

Gene

SRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of calcium transport.

GO - Molecular functioni

  1. GTP binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcalumenin
Gene namesi
Name:SRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11295. SRL.

Subcellular locationi

Sarcoplasmic reticulum lumen By similarity
Note: Associated through calcium with the membrane.By similarity

GO - Cellular componenti

  1. sarcoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 932912SarcalumeninPRO_0000045426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi740 – 7401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86TD4.
PRIDEiQ86TD4.

PTM databases

PhosphoSiteiQ86TD4.

Expressioni

Gene expression databases

BgeeiQ86TD4.
CleanExiHS_SRL.
ExpressionAtlasiQ86TD4. baseline.
GenevestigatoriQ86TD4.

Organism-specific databases

HPAiHPA041535.
HPA045520.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382518.

Structurei

3D structure databases

ProteinModelPortaliQ86TD4.
SMRiQ86TD4. Positions 515-902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 790242Dynamin-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 481461Acidic domain, probably binds calciumBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG136252.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000290639.
HOVERGENiHBG017848.
InParanoidiQ86TD4.
PhylomeDBiQ86TD4.
TreeFamiTF324008.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030381. G_DYNAMIN_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALVLLGCL LASLLFSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE
60 70 80 90 100
KERALYADTA PQDKKLLLHY PDGREAESPK KTPASAASAG PDPEASLSNA
110 120 130 140 150
SATESPPPGE RDDRDAAGPG EEKNGPPVAS ALPPGGAKGP VEEEWPEPSS
160 170 180 190 200
GEGQGEEETG FGLPTEGTAS GEAGGQAGGH ELPEEVQEVQ GDSLVQGAVA
210 220 230 240 250
GTAEPKAEGA SPHSEGDGVG PLNAEAEGSP GPGEEPAVPE GAPDVAAVGG
260 270 280 290 300
ESEPDIDTQA SEGTEDQGEP GPAAEASAEP GGAQSVKAGD TEESQAPEMT
310 320 330 340 350
EEDADEASSE EESGDGSGSE EEGGVPSEEE SEEDSGDGAS SEEAEGASEE
360 370 380 390 400
ATEPQEAGEP QEAREPQEGG DLQEAEESQE GGDPQEAEEP QEGGAPQEGG
410 420 430 440 450
EPQEGGDPQE AREPQEAREP QEGAELPEAT GTTSHRDRGA QPGPEELNTE
460 470 480 490 500
SMGSETLDMK AEEPEEGHQG RESPIIVAQE ETEDANEEAP LRDRSHIEKT
510 520 530 540 550
LMLNEDKPSD DYSAVLQRLR KIYHSSIKPL EQSYKYNELR QHEITDGEIT
560 570 580 590 600
SKPMVLFLGP WSVGKSTMIN YLLGLENTRY QLYTGAEPTT SEFTVLMHGP
610 620 630 640 650
KLKTIEGIVM AADSARSFSP LEKFGQNFLE KLIGIEVPHK LLERVTFVDT
660 670 680 690 700
PGIIENRKQQ ERGYPFNDVC QWFIDRADLI FVVFDPTKLD VGLELEMLFR
710 720 730 740 750
QLKGRESQIR IILNKADNLA TQMLMRVYGA LFWSLAPLIN VTEPPRVYVS
760 770 780 790 800
SFWPQEYKPD THQELFLQEE ISLLEDLNQV IENRLENKIA FIRQHAIRVR
810 820 830 840 850
IHALLVDRYL QTYKDKMTFF SDGELVFKDI VEDPDKFYIF KTILAKTNVS
860 870 880 890 900
KFDLPNREAY KDFFGINPIS SFKLLSQQCS YMGGCFLEKI ERAITQELPG
910 920 930
LLGSLGLGKN PGALNCDKTG CSETPKNRYR KH
Length:932
Mass (Da):100,788
Last modified:January 10, 2006 - v2
Checksum:iBBCBFDBB13CC0EC1
GO
Isoform 2 (identifier: Q86TD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-480: Missing.

Show »
Length:473
Mass (Da):54,431
Checksum:i976721235C129CB7
GO

Sequence cautioni

The sequence CAD89901.1 differs from that shown. Reason: Frameshift at position 927. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti875 – 8751L → P in CAD89901 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 480459Missing in isoform 2. 1 PublicationVSP_016921Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831973 mRNA. Translation: CAD89901.1. Frameshift.
AL832361 mRNA. No translation available.
BX647476 mRNA. No translation available.
CCDSiCCDS42113.1. [Q86TD4-2]
RefSeqiNP_001092284.1. NM_001098814.1. [Q86TD4-2]
UniGeneiHs.10041.

Genome annotation databases

EnsembliENST00000399609; ENSP00000382518; ENSG00000185739. [Q86TD4-2]
GeneIDi6345.
KEGGihsa:6345.
UCSCiuc002cvz.4. human. [Q86TD4-2]

Polymorphism databases

DMDMi85540609.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831973 mRNA. Translation: CAD89901.1. Frameshift.
AL832361 mRNA. No translation available.
BX647476 mRNA. No translation available.
CCDSiCCDS42113.1. [Q86TD4-2]
RefSeqiNP_001092284.1. NM_001098814.1. [Q86TD4-2]
UniGeneiHs.10041.

3D structure databases

ProteinModelPortaliQ86TD4.
SMRiQ86TD4. Positions 515-902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000382518.

PTM databases

PhosphoSiteiQ86TD4.

Polymorphism databases

DMDMi85540609.

Proteomic databases

PaxDbiQ86TD4.
PRIDEiQ86TD4.

Protocols and materials databases

DNASUi6345.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399609; ENSP00000382518; ENSG00000185739. [Q86TD4-2]
GeneIDi6345.
KEGGihsa:6345.
UCSCiuc002cvz.4. human. [Q86TD4-2]

Organism-specific databases

CTDi6345.
GeneCardsiGC16M004239.
H-InvDBHIX0012778.
HGNCiHGNC:11295. SRL.
HPAiHPA041535.
HPA045520.
MIMi604992. gene.
neXtProtiNX_Q86TD4.
PharmGKBiPA36119.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG136252.
GeneTreeiENSGT00760000118985.
HOGENOMiHOG000290639.
HOVERGENiHBG017848.
InParanoidiQ86TD4.
PhylomeDBiQ86TD4.
TreeFamiTF324008.

Miscellaneous databases

GeneWikiiSarcalumenin.
GenomeRNAii6345.
NextBioi24648.
PROiQ86TD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ86TD4.
CleanExiHS_SRL.
ExpressionAtlasiQ86TD4. baseline.
GenevestigatoriQ86TD4.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030381. G_DYNAMIN_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-932 (ISOFORM 2).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiSRCA_HUMAN
AccessioniPrimary (citable) accession number: Q86TD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: March 4, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.