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Protein

Sarcalumenin

Gene

SRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of calcium transport.

Caution

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcalumenin
Gene namesi
Name:SRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000185739.13
HGNCiHGNC:11295 SRL
MIMi604992 gene
neXtProtiNX_Q86TD4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6345
OpenTargetsiENSG00000185739
PharmGKBiPA36119

Polymorphism and mutation databases

BioMutaiSRL
DMDMi85540609

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004542621 – 932SarcalumeninAdd BLAST912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi848N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86TD4
PeptideAtlasiQ86TD4
PRIDEiQ86TD4

PTM databases

iPTMnetiQ86TD4
PhosphoSitePlusiQ86TD4

Expressioni

Gene expression databases

BgeeiENSG00000185739
CleanExiHS_SRL
ExpressionAtlasiQ86TD4 baseline and differential
GenevisibleiQ86TD4 HS

Organism-specific databases

HPAiHPA041535
HPA045520

Interactioni

Protein-protein interaction databases

IntActiQ86TD4 3 interactors.
STRINGi9606.ENSP00000382518

Structurei

3D structure databases

ProteinModelPortaliQ86TD4
SMRiQ86TD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini549 – 790Dynamin-type GAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 481Acidic domain, probably binds calciumBy similarityAdd BLAST461

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1954 Eukaryota
ENOG410XYGB LUCA
GeneTreeiENSGT00760000118985
HOGENOMiHOG000290639
HOVERGENiHBG017848
InParanoidiQ86TD4
OrthoDBiEOG091G014W
PhylomeDBiQ86TD4
TreeFamiTF324008

Family and domain databases

InterProiView protein in InterPro
IPR022812 Dynamin_SF
IPR031692 EHD_N
IPR030381 G_DYNAMIN_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00350 Dynamin_N, 1 hit
PF16880 EHD_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51718 G_DYNAMIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86TD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALVLLGCL LASLLFSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE
60 70 80 90 100
KERALYADTA PQDKKLLLHY PDGREAESPK KTPASAASAG PDPEASLSNA
110 120 130 140 150
SATESPPPGE RDDRDAAGPG EEKNGPPVAS ALPPGGAKGP VEEEWPEPSS
160 170 180 190 200
GEGQGEEETG FGLPTEGTAS GEAGGQAGGH ELPEEVQEVQ GDSLVQGAVA
210 220 230 240 250
GTAEPKAEGA SPHSEGDGVG PLNAEAEGSP GPGEEPAVPE GAPDVAAVGG
260 270 280 290 300
ESEPDIDTQA SEGTEDQGEP GPAAEASAEP GGAQSVKAGD TEESQAPEMT
310 320 330 340 350
EEDADEASSE EESGDGSGSE EEGGVPSEEE SEEDSGDGAS SEEAEGASEE
360 370 380 390 400
ATEPQEAGEP QEAREPQEGG DLQEAEESQE GGDPQEAEEP QEGGAPQEGG
410 420 430 440 450
EPQEGGDPQE AREPQEAREP QEGAELPEAT GTTSHRDRGA QPGPEELNTE
460 470 480 490 500
SMGSETLDMK AEEPEEGHQG RESPIIVAQE ETEDANEEAP LRDRSHIEKT
510 520 530 540 550
LMLNEDKPSD DYSAVLQRLR KIYHSSIKPL EQSYKYNELR QHEITDGEIT
560 570 580 590 600
SKPMVLFLGP WSVGKSTMIN YLLGLENTRY QLYTGAEPTT SEFTVLMHGP
610 620 630 640 650
KLKTIEGIVM AADSARSFSP LEKFGQNFLE KLIGIEVPHK LLERVTFVDT
660 670 680 690 700
PGIIENRKQQ ERGYPFNDVC QWFIDRADLI FVVFDPTKLD VGLELEMLFR
710 720 730 740 750
QLKGRESQIR IILNKADNLA TQMLMRVYGA LFWSLAPLIN VTEPPRVYVS
760 770 780 790 800
SFWPQEYKPD THQELFLQEE ISLLEDLNQV IENRLENKIA FIRQHAIRVR
810 820 830 840 850
IHALLVDRYL QTYKDKMTFF SDGELVFKDI VEDPDKFYIF KTILAKTNVS
860 870 880 890 900
KFDLPNREAY KDFFGINPIS SFKLLSQQCS YMGGCFLEKI ERAITQELPG
910 920 930
LLGSLGLGKN PGALNCDKTG CSETPKNRYR KH
Note: No experimental confirmation available.
Length:932
Mass (Da):100,788
Last modified:January 10, 2006 - v2
Checksum:iBBCBFDBB13CC0EC1
GO
Isoform 2 (identifier: Q86TD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-480: Missing.

Show »
Length:473
Mass (Da):54,431
Checksum:i976721235C129CB7
GO
Isoform 3 (identifier: Q86TD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-501: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):49,807
Checksum:iE369EECCB12D137F
GO

Sequence cautioni

The sequence CAD89901 differs from that shown. Reason: Frameshift at position 927.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti875L → P in CAD89901 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0594181 – 501Missing in isoform 3. Add BLAST501
Alternative sequenceiVSP_01692122 – 480Missing in isoform 2. 1 PublicationAdd BLAST459

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831973 mRNA Translation: CAD89901.1 Frameshift.
AL832361 mRNA No translation available.
BX647476 mRNA No translation available.
AC009171 Genomic DNA No translation available.
AK302601 mRNA Translation: BAG63851.1
CCDSiCCDS42113.1 [Q86TD4-2]
RefSeqiNP_001092284.1, NM_001098814.1 [Q86TD4-2]
NP_001310596.1, NM_001323667.1
NP_001310597.1, NM_001323668.1
XP_016879017.1, XM_017023528.1
XP_016879018.1, XM_017023529.1
UniGeneiHs.10041

Genome annotation databases

EnsembliENST00000399609; ENSP00000382518; ENSG00000185739 [Q86TD4-2]
ENST00000537996; ENSP00000440350; ENSG00000185739 [Q86TD4-3]
GeneIDi6345
KEGGihsa:6345
UCSCiuc002cvz.4 human [Q86TD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRCA_HUMAN
AccessioniPrimary (citable) accession number: Q86TD4
Secondary accession number(s): B4DYT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: April 25, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome