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Q86TD4

- SRCA_HUMAN

UniProt

Q86TD4 - SRCA_HUMAN

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Protein

Sarcalumenin

Gene
SRL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of calcium transport.

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcalumenin
Gene namesi
Name:SRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11295. SRL.

Subcellular locationi

Sarcoplasmic reticulum lumen By similarity
Note: Associated through calcium with the membrane By similarity.

GO - Cellular componenti

  1. sarcoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 932912SarcalumeninPRO_0000045426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi740 – 7401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi848 – 8481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86TD4.
PRIDEiQ86TD4.

PTM databases

PhosphoSiteiQ86TD4.

Expressioni

Gene expression databases

ArrayExpressiQ86TD4.
BgeeiQ86TD4.
CleanExiHS_SRL.
GenevestigatoriQ86TD4.

Organism-specific databases

HPAiHPA041535.
HPA045520.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382518.

Structurei

3D structure databases

ProteinModelPortaliQ86TD4.
SMRiQ86TD4. Positions 515-902.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 790242Dynamin-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 481461Acidic domain, probably binds calcium By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG136252.
HOGENOMiHOG000290639.
HOVERGENiHBG017848.
InParanoidiQ86TD4.
PhylomeDBiQ86TD4.
TreeFamiTF324008.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR001401. Dynamin_GTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86TD4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRALVLLGCL LASLLFSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE    50
KERALYADTA PQDKKLLLHY PDGREAESPK KTPASAASAG PDPEASLSNA 100
SATESPPPGE RDDRDAAGPG EEKNGPPVAS ALPPGGAKGP VEEEWPEPSS 150
GEGQGEEETG FGLPTEGTAS GEAGGQAGGH ELPEEVQEVQ GDSLVQGAVA 200
GTAEPKAEGA SPHSEGDGVG PLNAEAEGSP GPGEEPAVPE GAPDVAAVGG 250
ESEPDIDTQA SEGTEDQGEP GPAAEASAEP GGAQSVKAGD TEESQAPEMT 300
EEDADEASSE EESGDGSGSE EEGGVPSEEE SEEDSGDGAS SEEAEGASEE 350
ATEPQEAGEP QEAREPQEGG DLQEAEESQE GGDPQEAEEP QEGGAPQEGG 400
EPQEGGDPQE AREPQEAREP QEGAELPEAT GTTSHRDRGA QPGPEELNTE 450
SMGSETLDMK AEEPEEGHQG RESPIIVAQE ETEDANEEAP LRDRSHIEKT 500
LMLNEDKPSD DYSAVLQRLR KIYHSSIKPL EQSYKYNELR QHEITDGEIT 550
SKPMVLFLGP WSVGKSTMIN YLLGLENTRY QLYTGAEPTT SEFTVLMHGP 600
KLKTIEGIVM AADSARSFSP LEKFGQNFLE KLIGIEVPHK LLERVTFVDT 650
PGIIENRKQQ ERGYPFNDVC QWFIDRADLI FVVFDPTKLD VGLELEMLFR 700
QLKGRESQIR IILNKADNLA TQMLMRVYGA LFWSLAPLIN VTEPPRVYVS 750
SFWPQEYKPD THQELFLQEE ISLLEDLNQV IENRLENKIA FIRQHAIRVR 800
IHALLVDRYL QTYKDKMTFF SDGELVFKDI VEDPDKFYIF KTILAKTNVS 850
KFDLPNREAY KDFFGINPIS SFKLLSQQCS YMGGCFLEKI ERAITQELPG 900
LLGSLGLGKN PGALNCDKTG CSETPKNRYR KH 932
Length:932
Mass (Da):100,788
Last modified:January 10, 2006 - v2
Checksum:iBBCBFDBB13CC0EC1
GO
Isoform 2 (identifier: Q86TD4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-480: Missing.

Show »
Length:473
Mass (Da):54,431
Checksum:i976721235C129CB7
GO

Sequence cautioni

The sequence CAD89901.1 differs from that shown. Reason: Frameshift at position 927.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 480459Missing in isoform 2. VSP_016921Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti875 – 8751L → P in CAD89901. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL831973 mRNA. Translation: CAD89901.1. Frameshift.
AL832361 mRNA. No translation available.
BX647476 mRNA. No translation available.
CCDSiCCDS42113.1. [Q86TD4-2]
RefSeqiNP_001092284.1. NM_001098814.1. [Q86TD4-2]
UniGeneiHs.10041.

Genome annotation databases

EnsembliENST00000399609; ENSP00000382518; ENSG00000185739. [Q86TD4-2]
GeneIDi6345.
KEGGihsa:6345.
UCSCiuc002cvz.4. human. [Q86TD4-2]

Polymorphism databases

DMDMi85540609.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL831973 mRNA. Translation: CAD89901.1 . Frameshift.
AL832361 mRNA. No translation available.
BX647476 mRNA. No translation available.
CCDSi CCDS42113.1. [Q86TD4-2 ]
RefSeqi NP_001092284.1. NM_001098814.1. [Q86TD4-2 ]
UniGenei Hs.10041.

3D structure databases

ProteinModelPortali Q86TD4.
SMRi Q86TD4. Positions 515-902.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000382518.

PTM databases

PhosphoSitei Q86TD4.

Polymorphism databases

DMDMi 85540609.

Proteomic databases

PaxDbi Q86TD4.
PRIDEi Q86TD4.

Protocols and materials databases

DNASUi 6345.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399609 ; ENSP00000382518 ; ENSG00000185739 . [Q86TD4-2 ]
GeneIDi 6345.
KEGGi hsa:6345.
UCSCi uc002cvz.4. human. [Q86TD4-2 ]

Organism-specific databases

CTDi 6345.
GeneCardsi GC16M004239.
H-InvDB HIX0012778.
HGNCi HGNC:11295. SRL.
HPAi HPA041535.
HPA045520.
MIMi 604992. gene.
neXtProti NX_Q86TD4.
PharmGKBi PA36119.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG136252.
HOGENOMi HOG000290639.
HOVERGENi HBG017848.
InParanoidi Q86TD4.
PhylomeDBi Q86TD4.
TreeFami TF324008.

Miscellaneous databases

GeneWikii Sarcalumenin.
GenomeRNAii 6345.
NextBioi 24648.
PROi Q86TD4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86TD4.
Bgeei Q86TD4.
CleanExi HS_SRL.
Genevestigatori Q86TD4.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR001401. Dynamin_GTPase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00350. Dynamin_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51718. G_DYNAMIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-932 (ISOFORM 2).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiSRCA_HUMAN
AccessioniPrimary (citable) accession number: Q86TD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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