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Q86TD4

- SRCA_HUMAN

UniProt

Q86TD4 - SRCA_HUMAN

Protein

Sarcalumenin

Gene

SRL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of calcium transport.

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sarcalumenin
    Gene namesi
    Name:SRL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11295. SRL.

    Subcellular locationi

    Sarcoplasmic reticulum lumen By similarity
    Note: Associated through calcium with the membrane.By similarity

    GO - Cellular componenti

    1. sarcoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Sarcoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36119.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 932912SarcalumeninPRO_0000045426Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi740 – 7401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ86TD4.
    PRIDEiQ86TD4.

    PTM databases

    PhosphoSiteiQ86TD4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86TD4.
    BgeeiQ86TD4.
    CleanExiHS_SRL.
    GenevestigatoriQ86TD4.

    Organism-specific databases

    HPAiHPA041535.
    HPA045520.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000382518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86TD4.
    SMRiQ86TD4. Positions 515-902.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini549 – 790242Dynamin-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 481461Acidic domain, probably binds calciumBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG136252.
    HOGENOMiHOG000290639.
    HOVERGENiHBG017848.
    InParanoidiQ86TD4.
    PhylomeDBiQ86TD4.
    TreeFamiTF324008.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR001401. Dynamin_GTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00350. Dynamin_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86TD4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRALVLLGCL LASLLFSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE    50
    KERALYADTA PQDKKLLLHY PDGREAESPK KTPASAASAG PDPEASLSNA 100
    SATESPPPGE RDDRDAAGPG EEKNGPPVAS ALPPGGAKGP VEEEWPEPSS 150
    GEGQGEEETG FGLPTEGTAS GEAGGQAGGH ELPEEVQEVQ GDSLVQGAVA 200
    GTAEPKAEGA SPHSEGDGVG PLNAEAEGSP GPGEEPAVPE GAPDVAAVGG 250
    ESEPDIDTQA SEGTEDQGEP GPAAEASAEP GGAQSVKAGD TEESQAPEMT 300
    EEDADEASSE EESGDGSGSE EEGGVPSEEE SEEDSGDGAS SEEAEGASEE 350
    ATEPQEAGEP QEAREPQEGG DLQEAEESQE GGDPQEAEEP QEGGAPQEGG 400
    EPQEGGDPQE AREPQEAREP QEGAELPEAT GTTSHRDRGA QPGPEELNTE 450
    SMGSETLDMK AEEPEEGHQG RESPIIVAQE ETEDANEEAP LRDRSHIEKT 500
    LMLNEDKPSD DYSAVLQRLR KIYHSSIKPL EQSYKYNELR QHEITDGEIT 550
    SKPMVLFLGP WSVGKSTMIN YLLGLENTRY QLYTGAEPTT SEFTVLMHGP 600
    KLKTIEGIVM AADSARSFSP LEKFGQNFLE KLIGIEVPHK LLERVTFVDT 650
    PGIIENRKQQ ERGYPFNDVC QWFIDRADLI FVVFDPTKLD VGLELEMLFR 700
    QLKGRESQIR IILNKADNLA TQMLMRVYGA LFWSLAPLIN VTEPPRVYVS 750
    SFWPQEYKPD THQELFLQEE ISLLEDLNQV IENRLENKIA FIRQHAIRVR 800
    IHALLVDRYL QTYKDKMTFF SDGELVFKDI VEDPDKFYIF KTILAKTNVS 850
    KFDLPNREAY KDFFGINPIS SFKLLSQQCS YMGGCFLEKI ERAITQELPG 900
    LLGSLGLGKN PGALNCDKTG CSETPKNRYR KH 932
    Length:932
    Mass (Da):100,788
    Last modified:January 10, 2006 - v2
    Checksum:iBBCBFDBB13CC0EC1
    GO
    Isoform 2 (identifier: Q86TD4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-480: Missing.

    Show »
    Length:473
    Mass (Da):54,431
    Checksum:i976721235C129CB7
    GO

    Sequence cautioni

    The sequence CAD89901.1 differs from that shown. Reason: Frameshift at position 927.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti875 – 8751L → P in CAD89901. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 480459Missing in isoform 2. 1 PublicationVSP_016921Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL831973 mRNA. Translation: CAD89901.1. Frameshift.
    AL832361 mRNA. No translation available.
    BX647476 mRNA. No translation available.
    CCDSiCCDS42113.1. [Q86TD4-2]
    RefSeqiNP_001092284.1. NM_001098814.1. [Q86TD4-2]
    UniGeneiHs.10041.

    Genome annotation databases

    EnsembliENST00000399609; ENSP00000382518; ENSG00000185739. [Q86TD4-2]
    GeneIDi6345.
    KEGGihsa:6345.
    UCSCiuc002cvz.4. human. [Q86TD4-2]

    Polymorphism databases

    DMDMi85540609.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL831973 mRNA. Translation: CAD89901.1 . Frameshift.
    AL832361 mRNA. No translation available.
    BX647476 mRNA. No translation available.
    CCDSi CCDS42113.1. [Q86TD4-2 ]
    RefSeqi NP_001092284.1. NM_001098814.1. [Q86TD4-2 ]
    UniGenei Hs.10041.

    3D structure databases

    ProteinModelPortali Q86TD4.
    SMRi Q86TD4. Positions 515-902.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000382518.

    PTM databases

    PhosphoSitei Q86TD4.

    Polymorphism databases

    DMDMi 85540609.

    Proteomic databases

    PaxDbi Q86TD4.
    PRIDEi Q86TD4.

    Protocols and materials databases

    DNASUi 6345.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399609 ; ENSP00000382518 ; ENSG00000185739 . [Q86TD4-2 ]
    GeneIDi 6345.
    KEGGi hsa:6345.
    UCSCi uc002cvz.4. human. [Q86TD4-2 ]

    Organism-specific databases

    CTDi 6345.
    GeneCardsi GC16M004239.
    H-InvDB HIX0012778.
    HGNCi HGNC:11295. SRL.
    HPAi HPA041535.
    HPA045520.
    MIMi 604992. gene.
    neXtProti NX_Q86TD4.
    PharmGKBi PA36119.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136252.
    HOGENOMi HOG000290639.
    HOVERGENi HBG017848.
    InParanoidi Q86TD4.
    PhylomeDBi Q86TD4.
    TreeFami TF324008.

    Miscellaneous databases

    GeneWikii Sarcalumenin.
    GenomeRNAii 6345.
    NextBioi 24648.
    PROi Q86TD4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86TD4.
    Bgeei Q86TD4.
    CleanExi HS_SRL.
    Genevestigatori Q86TD4.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR001401. Dynamin_GTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00350. Dynamin_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51718. G_DYNAMIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-932 (ISOFORM 2).
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiSRCA_HUMAN
    AccessioniPrimary (citable) accession number: Q86TD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3