Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q86TD4 (SRCA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sarcalumenin
Gene names
Name:SRL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the regulation of calcium transport.

Subcellular location

Sarcoplasmic reticulum lumen By similarity. Note: Associated through calcium with the membrane By similarity.

Sequence similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Contains 1 dynamin-type G (guanine nucleotide-binding) domain.

Sequence caution

The sequence CAD89901.1 differs from that shown. Reason: Frameshift at position 927.

Ontologies

Keywords
   Cellular componentSarcoplasmic reticulum
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentsarcoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: InterPro

GTPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86TD4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86TD4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     22-480: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 932912Sarcalumenin
PRO_0000045426

Regions

Domain549 – 790242Dynamin-type G
Region21 – 481461Acidic domain, probably binds calcium By similarity

Amino acid modifications

Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation7401N-linked (GlcNAc...) Potential
Glycosylation8481N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence22 – 480459Missing in isoform 2.
VSP_016921

Experimental info

Sequence conflict8751L → P in CAD89901. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: BBCBFDBB13CC0EC1

FASTA932100,788
        10         20         30         40         50         60 
MRALVLLGCL LASLLFSGQA ELQVSASGGT EDVGNLLENH FSAGDASLEE KERALYADTA 

        70         80         90        100        110        120 
PQDKKLLLHY PDGREAESPK KTPASAASAG PDPEASLSNA SATESPPPGE RDDRDAAGPG 

       130        140        150        160        170        180 
EEKNGPPVAS ALPPGGAKGP VEEEWPEPSS GEGQGEEETG FGLPTEGTAS GEAGGQAGGH 

       190        200        210        220        230        240 
ELPEEVQEVQ GDSLVQGAVA GTAEPKAEGA SPHSEGDGVG PLNAEAEGSP GPGEEPAVPE 

       250        260        270        280        290        300 
GAPDVAAVGG ESEPDIDTQA SEGTEDQGEP GPAAEASAEP GGAQSVKAGD TEESQAPEMT 

       310        320        330        340        350        360 
EEDADEASSE EESGDGSGSE EEGGVPSEEE SEEDSGDGAS SEEAEGASEE ATEPQEAGEP 

       370        380        390        400        410        420 
QEAREPQEGG DLQEAEESQE GGDPQEAEEP QEGGAPQEGG EPQEGGDPQE AREPQEAREP 

       430        440        450        460        470        480 
QEGAELPEAT GTTSHRDRGA QPGPEELNTE SMGSETLDMK AEEPEEGHQG RESPIIVAQE 

       490        500        510        520        530        540 
ETEDANEEAP LRDRSHIEKT LMLNEDKPSD DYSAVLQRLR KIYHSSIKPL EQSYKYNELR 

       550        560        570        580        590        600 
QHEITDGEIT SKPMVLFLGP WSVGKSTMIN YLLGLENTRY QLYTGAEPTT SEFTVLMHGP 

       610        620        630        640        650        660 
KLKTIEGIVM AADSARSFSP LEKFGQNFLE KLIGIEVPHK LLERVTFVDT PGIIENRKQQ 

       670        680        690        700        710        720 
ERGYPFNDVC QWFIDRADLI FVVFDPTKLD VGLELEMLFR QLKGRESQIR IILNKADNLA 

       730        740        750        760        770        780 
TQMLMRVYGA LFWSLAPLIN VTEPPRVYVS SFWPQEYKPD THQELFLQEE ISLLEDLNQV 

       790        800        810        820        830        840 
IENRLENKIA FIRQHAIRVR IHALLVDRYL QTYKDKMTFF SDGELVFKDI VEDPDKFYIF 

       850        860        870        880        890        900 
KTILAKTNVS KFDLPNREAY KDFFGINPIS SFKLLSQQCS YMGGCFLEKI ERAITQELPG 

       910        920        930 
LLGSLGLGKN PGALNCDKTG CSETPKNRYR KH 

« Hide

Isoform 2 [UniParc].

Checksum: 976721235C129CB7
Show »

FASTA47354,431

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-932 (ISOFORM 2).
Tissue: Skeletal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL831973 mRNA. Translation: CAD89901.1. Frameshift.
AL832361 mRNA. No translation available.
BX647476 mRNA. No translation available.
CCDSCCDS42113.1. [Q86TD4-2]
RefSeqNP_001092284.1. NM_001098814.1. [Q86TD4-2]
UniGeneHs.10041.

3D structure databases

ProteinModelPortalQ86TD4.
SMRQ86TD4. Positions 515-902.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000382518.

PTM databases

PhosphoSiteQ86TD4.

Polymorphism databases

DMDM85540609.

Proteomic databases

PaxDbQ86TD4.
PRIDEQ86TD4.

Protocols and materials databases

DNASU6345.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399609; ENSP00000382518; ENSG00000185739. [Q86TD4-2]
GeneID6345.
KEGGhsa:6345.
UCSCuc002cvz.4. human. [Q86TD4-2]

Organism-specific databases

CTD6345.
GeneCardsGC16M004239.
H-InvDBHIX0012778.
HGNCHGNC:11295. SRL.
HPAHPA041535.
HPA045520.
MIM604992. gene.
neXtProtNX_Q86TD4.
PharmGKBPA36119.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG136252.
HOGENOMHOG000290639.
HOVERGENHBG017848.
InParanoidQ86TD4.
PhylomeDBQ86TD4.
TreeFamTF324008.

Gene expression databases

ArrayExpressQ86TD4.
BgeeQ86TD4.
CleanExHS_SRL.
GenevestigatorQ86TD4.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR001401. Dynamin_GTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00350. Dynamin_N. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSarcalumenin.
GenomeRNAi6345.
NextBio24648.
PROQ86TD4.
SOURCESearch...

Entry information

Entry nameSRCA_HUMAN
AccessionPrimary (citable) accession number: Q86TD4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM