Q86TC9 (MYPN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myopalladin

Alternative name(s):
145 kDa sarcomeric protein

Gene names

Name:	MYPN
Synonyms:	MYOP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1320 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. Ref.1
Subunit structure	Interacts with TTN/titin, NEB, NEBL, ACTN2 and CARP. Ref.1 Ref.5
Subcellular location	Cytoplasm. Nucleus By similarity. Cytoplasm › myofibril › sarcomere. Note: Bound to sarcomere both at the Z-line periphery and in the central I-band region.
Tissue specificity	Expressed in adult skeletal muscle and fetal heart. Ref.1
Sequence similarities	Belongs to the myotilin/palladin family. Contains 5 Ig-like (immunoglobulin-like) domains.
Sequence caution	The sequence CAD38923.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Immunoglobulin domain Repeat
Ligand	Actin-binding
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sarcomere organization Inferred from mutant phenotype Ref.1. Source: BHF-UCL
Cellular_component	I band Inferred from direct assay Ref.1. Source: BHF-UCL Z disc Inferred from electronic annotation. Source: Compara microtubule cytoskeleton Inferred from direct assay. Source: HPA nucleus Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86TC9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86TC9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     276-301: RSREVPEGTRVQLDCIVVGIPPPQVR → MLTVQVKTSSAIELPDSLAFLWIIPM

Note: No experimental confirmation available.

Isoform 3 (identifier: Q86TC9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     495-507: EEICTLVIAEVFA → GKDDFNFNLLVYE
     508-1320: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1320	1320	Myopalladin		PRO_0000240489
Regions
	Domain	269 – 359	91	Ig-like 1
	Domain	435 – 531	97	Ig-like 2
	Domain	945 – 1029	85	Ig-like 3
	Domain	1073 – 1162	90	Ig-like 4
	Domain	1172 – 1262	91	Ig-like 5
	Region	1 – 522	522	Interaction with CARP
	Region	649 – 677	29	Interaction with NEB
	Region	945 – 1320	376	Interaction with ACTN
	Coiled coil	219 – 248	30	Potential
	Compositional bias	53 – 56	4	Poly-Gly
	Compositional bias	784 – 856	73	Pro-rich
Amino acid modifications
	Modified residue	101	1	Phosphoserine Ref.8
	Modified residue	251	1	Phosphothreonine Ref.7
	Modified residue	759	1	Phosphoserine Ref.7
	Modified residue	813	1	Phosphoserine Ref.7 Ref.8
	Modified residue	818	1	Phosphoserine Ref.7
	Modified residue	928	1	Phosphoserine Ref.6 Ref.7 Ref.8
	Disulfide bond	290 ↔ 341		By similarity
	Disulfide bond	456 ↔ 515		By similarity
	Disulfide bond	1094 ↔ 1146		By similarity
Natural variations
	Alternative sequence	1 – 275	275	Missing in isoform 2.		VSP_019384
	Alternative sequence	276 – 301	26	RSREV…PPQVR → MLTVQVKTSSAIELPDSLAF LWIIPM in isoform 2.		VSP_019385
	Alternative sequence	495 – 507	13	EEICT…AEVFA → GKDDFNFNLLVYE in isoform 3.		VSP_019386
	Alternative sequence	508 – 1320	813	Missing in isoform 3.		VSP_019387
	Natural variant	393	1	V → A. Corresponds to variant rs11596653 [ dbSNP | Ensembl ].		VAR_049911
	Natural variant	628	1	F → L. Corresponds to variant rs10823148 [ dbSNP | Ensembl ].		VAR_049912
	Natural variant	691	1	S → N. Ref.1 Corresponds to variant rs10997975 [ dbSNP | Ensembl ].		VAR_026727
	Natural variant	707	1	S → N. Ref.1 Corresponds to variant rs7916821 [ dbSNP | Ensembl ].		VAR_026728
	Natural variant	803	1	S → R. Ref.1 Corresponds to variant rs3814182 [ dbSNP | Ensembl ].		VAR_026729
	Natural variant	1135	1	P → T. Corresponds to variant rs7079481 [ dbSNP | Ensembl ].		VAR_049913
Experimental info
	Sequence conflict	139	1	Q → R in CAD89906. Ref.2
	Sequence conflict	484	1	L → S in CAD89906. Ref.2
	Sequence conflict	509	1	D → G in CAD89906. Ref.2
	Sequence conflict	601	1	N → D in CAD89906. Ref.2
	Sequence conflict	677	1	L → S in CAD89906. Ref.2
	Sequence conflict	908	1	F → L in CAD89906. Ref.2
	Sequence conflict	991	1	H → R in CAD38923. Ref.2
	Sequence conflict	1078	1	A → T in CAD91155. Ref.2
	Sequence conflict	1118	1	S → P in CAD38923. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: FD59508CB611A9A9	FASTA	1,320	145,257
	10 20 30 40 50 60 MQDDSIEAST SISQLLRESY LAETRHRGNN ERSRAEPSSN PCHFGSPSGA AEGGGGQDDL 70 80 90 100 110 120 PDLSAFLSQE ELDESVNLAR LAINYDPLEK ADETQARKRL SPDQMKHSPN LSFEPNFCQD 130 140 150 160 170 180 NPRSPTSSKE SPQEAKRPQY CSETQSKKVF LNKAADFIEE LSSLFKSHSS KRIRPRACKN 190 200 210 220 230 240 HKSKLESQNK VMQENSSSFS DLSERRERSS VPIPIPADTR DNEVNHALEQ QEAKRREAEQ 250 260 270 280 290 300 AASEAAGGDT TPGSSPSSLY YEEPLGQPPR FTQKLRSREV PEGTRVQLDC IVVGIPPPQV 310 320 330 340 350 360 RWYCEGKELE NSPDIHIVQA GNLHSLTIAE AFEEDTGRYS CFASNIYGTD STSAEIYIEG 370 380 390 400 410 420 VSSSDSEGDP NKEEMNRIQK PNEVSSPPTT SAVIPPAVPQ AQHLVAQPRV ATIQQCQSPT 430 440 450 460 470 480 NYLQGLDGKP IIAAPVFTKM LQNLSASEGQ LVVFECRVKG APSPKVEWYR EGTLIEDSPD 490 500 510 520 530 540 FRILQKKPRS MAEPEEICTL VIAEVFAEDS GCFTCTASNK YGTVSSIAQL HVRGNEDLSN 550 560 570 580 590 600 NGSLHSANST TNLAAIEPQP SPPHSEPPSV EQPPKPKLEG VLVNHNEPRS SSRIGLRVHF 610 620 630 640 650 660 NLPEDDKGSE ASSEAGVVTT RQTRPDSFQE RFNGQATKTP EPSSPVKEPP PVLAKPKLDS 670 680 690 700 710 720 TQLQQLHNQV LLEQHQLQNP PPSSPKEFPF SMTVLNSNAP PAVTTSSKQV KAPSSQTFSL 730 740 750 760 770 780 ARPKYFFPST NTTAATVAPS SSPVFTLSST PQTIQRTVSK ESLLVSHPSV QTKSPGGLSI 790 800 810 820 830 840 QNEPLPPGPT EPTPPPFTFS IPSGNQFQPR CVSPIPVSPT SRIQNPVAFL SSVLPSLPAI 850 860 870 880 890 900 PPTNAMGLPR SAPSMPSQGL AKKNTKSPQP VNDDNIRETK NAVIRDLGKK ITFSDVRPNQ 910 920 930 940 950 960 QEYKISSFEQ RLMNEIEFRL ERTPVDESDD EIQHDEIPTG KCIAPIFDKR LKHFRVTEGS 970 980 990 1000 1010 1020 PVTFTCKIVG IPVPKVYWFK DGKQISKRNE HCKMRREGDG TCSLHIESTT SDDDGNYTIM 1030 1040 1050 1060 1070 1080 AANPQGRISC SGHLMVQSLP IRSRLTSAGQ SHRGRSRVQE RDKEPLQERF FRPHFLQAPG 1090 1100 1110 1120 1130 1140 DMVAHEGRLC RLDCKVSGLP PPELTWLLNG QPVLPDASHK MLVRETGVHS LLIDPLTQRD 1150 1160 1170 1180 1190 1200 AGTYKCIATN KTGQNSFSLE LSVVAKEVKK APVILEKLQN CGVPEGHPVR LECRVIGMPP 1210 1220 1230 1240 1250 1260 PVFYWKKDNE TIPCTRERIS MHQDTTGYAC LLIQPAKKSD AGWYTLSAKN EAGIVSCTAR 1270 1280 1290 1300 1310 1320 LDIYAQWHHQ IPPPMSVRPS GSRYGSLTSK GLDIFSAFSS MESTMVYSCS SRSVVESDEL
	Isoform 2 [UniParc]. Checksum: DAA885A7A5ED7D46	FASTA	1,045	114,695
	10 20 30 40 50 60 MLTVQVKTSS AIELPDSLAF LWIIPMWYCE GKELENSPDI HIVQAGNLHS LTIAEAFEED 70 80 90 100 110 120 TGRYSCFASN IYGTDSTSAE IYIEGVSSSD SEGDPNKEEM NRIQKPNEVS SPPTTSAVIP 130 140 150 160 170 180 PAVPQAQHLV AQPRVATIQQ CQSPTNYLQG LDGKPIIAAP VFTKMLQNLS ASEGQLVVFE 190 200 210 220 230 240 CRVKGAPSPK VEWYREGTLI EDSPDFRILQ KKPRSMAEPE EICTLVIAEV FAEDSGCFTC 250 260 270 280 290 300 TASNKYGTVS SIAQLHVRGN EDLSNNGSLH SANSTTNLAA IEPQPSPPHS EPPSVEQPPK 310 320 330 340 350 360 PKLEGVLVNH NEPRSSSRIG LRVHFNLPED DKGSEASSEA GVVTTRQTRP DSFQERFNGQ 370 380 390 400 410 420 ATKTPEPSSP VKEPPPVLAK PKLDSTQLQQ LHNQVLLEQH QLQNPPPSSP KEFPFSMTVL 430 440 450 460 470 480 NSNAPPAVTT SSKQVKAPSS QTFSLARPKY FFPSTNTTAA TVAPSSSPVF TLSSTPQTIQ 490 500 510 520 530 540 RTVSKESLLV SHPSVQTKSP GGLSIQNEPL PPGPTEPTPP PFTFSIPSGN QFQPRCVSPI 550 560 570 580 590 600 PVSPTSRIQN PVAFLSSVLP SLPAIPPTNA MGLPRSAPSM PSQGLAKKNT KSPQPVNDDN 610 620 630 640 650 660 IRETKNAVIR DLGKKITFSD VRPNQQEYKI SSFEQRLMNE IEFRLERTPV DESDDEIQHD 670 680 690 700 710 720 EIPTGKCIAP IFDKRLKHFR VTEGSPVTFT CKIVGIPVPK VYWFKDGKQI SKRNEHCKMR 730 740 750 760 770 780 REGDGTCSLH IESTTSDDDG NYTIMAANPQ GRISCSGHLM VQSLPIRSRL TSAGQSHRGR 790 800 810 820 830 840 SRVQERDKEP LQERFFRPHF LQAPGDMVAH EGRLCRLDCK VSGLPPPELT WLLNGQPVLP 850 860 870 880 890 900 DASHKMLVRE TGVHSLLIDP LTQRDAGTYK CIATNKTGQN SFSLELSVVA KEVKKAPVIL 910 920 930 940 950 960 EKLQNCGVPE GHPVRLECRV IGMPPPVFYW KKDNETIPCT RERISMHQDT TGYACLLIQP 970 980 990 1000 1010 1020 AKKSDAGWYT LSAKNEAGIV SCTARLDIYA QWHHQIPPPM SVRPSGSRYG SLTSKGLDIF 1030 1040 SAFSSMESTM VYSCSSRSVV ESDEL
	Isoform 3 [UniParc]. Checksum: BD8488478845DF39	FASTA	507	56,185
	10 20 30 40 50 60 MQDDSIEAST SISQLLRESY LAETRHRGNN ERSRAEPSSN PCHFGSPSGA AEGGGGQDDL 70 80 90 100 110 120 PDLSAFLSQE ELDESVNLAR LAINYDPLEK ADETQARKRL SPDQMKHSPN LSFEPNFCQD 130 140 150 160 170 180 NPRSPTSSKE SPQEAKRPQY CSETQSKKVF LNKAADFIEE LSSLFKSHSS KRIRPRACKN 190 200 210 220 230 240 HKSKLESQNK VMQENSSSFS DLSERRERSS VPIPIPADTR DNEVNHALEQ QEAKRREAEQ 250 260 270 280 290 300 AASEAAGGDT TPGSSPSSLY YEEPLGQPPR FTQKLRSREV PEGTRVQLDC IVVGIPPPQV 310 320 330 340 350 360 RWYCEGKELE NSPDIHIVQA GNLHSLTIAE AFEEDTGRYS CFASNIYGTD STSAEIYIEG 370 380 390 400 410 420 VSSSDSEGDP NKEEMNRIQK PNEVSSPPTT SAVIPPAVPQ AQHLVAQPRV ATIQQCQSPT 430 440 450 460 470 480 NYLQGLDGKP IIAAPVFTKM LQNLSASEGQ LVVFECRVKG APSPKVEWYR EGTLIEDSPD 490 500 FRILQKKPRS MAEPGKDDFN FNLLVYE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies." Bang M.-L., Mudry R.E., McElhinny A.S., Trombitas K., Geach A.J., Yamasaki R., Sorimachi H., Granzier H., Gregorio C.C., Labeit S. J. Cell Biol. 153:413-427(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH NEB; NEBL; ACTN2 AND CARP, VARIANTS ASN-691; ASN-707 AND ARG-803. Tissue: Skeletal muscle.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Embryo.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Skeletal muscle.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin." Ma K., Wang K. FEBS Lett. 532:273-278(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TTN.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-928, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-251; SER-759; SER-813; SER-818 AND SER-928, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101; SER-813 AND SER-928, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF328296 mRNA. Translation: AAK50625.1. AK027343 mRNA. Translation: BAB55048.1. AL832002 mRNA. Translation: CAD89906.1. AL832379 mRNA. Translation: CAD91155.1. AL834247 mRNA. Translation: CAD38923.2. Different initiation. AL512429, AC016395, AC024258 Genomic DNA. Translation: CAH73747.1. AL512429, AC016395, AC024258 Genomic DNA. Translation: CAH73748.1.
IPI	IPI00477680. IPI00645179. IPI00871200.
RefSeq	NP_001243196.1. NM_001256267.1. NP_115967.2. NM_032578.3.
UniGene	Hs.55205.
3D structure databases
ProteinModelPortal	Q86TC9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86TC9. 2 interactions.
STRING	9606.ENSP00000351790.
PTM databases
PhosphoSite	Q86TC9.
Polymorphism databases
DMDM	109892761.
Proteomic databases
PaxDb	Q86TC9.
PRIDE	Q86TC9.
Protocols and materials databases
DNASU	84665.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354393; ENSP00000346369; ENSG00000138347. ENST00000358913; ENSP00000351790; ENSG00000138347. ENST00000373675; ENSP00000362779; ENSG00000138347.
GeneID	84665.
KEGG	hsa:84665.
UCSC	uc001jnm.4. human. uc001jnn.4. human. uc001jnp.1. human.
Organism-specific databases
CTD	84665.
GeneCards	GC10P069865.
H-InvDB	HIX0008869.
HGNC	HGNC:23246. MYPN.
HPA	HPA036298.
MIM	608517. gene.
neXtProt	NX_Q86TC9.
PharmGKB	PA134944534.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG136920.
HOVERGEN	HBG059166.
InParanoid	Q86TC9.
OMA	YWKKDNE.
Gene expression databases
ArrayExpress	Q86TC9.
Bgee	Q86TC9.
CleanEx	HS_MYPN.
Genevestigator	Q86TC9.
GermOnline	ENSG00000138347. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 5 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. [Graphical view]
Pfam	PF07679. I-set. 5 hits. [Graphical view]
SMART	SM00408. IGc2. 5 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84665.
NextBio	74653.
SOURCE	Search...

Entry information

Entry name

MYPN_HUMAN

Accession

Primary (citable) accession number: Q86TC9
Secondary accession number(s): Q5VV35 , Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.