Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q86TB3

- ALPK2_HUMAN

UniProt

Q86TB3 - ALPK2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alpha-protein kinase 2

Gene

ALPK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 2 (EC:2.7.11.-)
Alternative name(s):
Heart alpha-protein kinase
Gene namesi
Name:ALPK2
Synonyms:HAK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:20565. ALPK2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21702170Alpha-protein kinase 2PRO_0000260030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 98PROSITE-ProRule annotation
Disulfide bondi1808 ↔ 1858PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ86TB3.
PaxDbiQ86TB3.
PRIDEiQ86TB3.

PTM databases

PhosphoSiteiQ86TB3.

Expressioni

Gene expression databases

BgeeiQ86TB3.
CleanExiHS_ALPK2.
GenevestigatoriQ86TB3.

Organism-specific databases

HPAiHPA027377.
HPA027976.
HPA028084.
HPA029801.

Interactioni

Protein-protein interaction databases

BioGridi125447. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ86TB3.
SMRiQ86TB3. Positions 14-109, 1800-2137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 114105Ig-like 1Add
BLAST
Domaini1786 – 187489Ig-like 2Add
BLAST
Domaini1901 – 2133233Alpha-type protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1644 – 16496Poly-Ser

Sequence similaritiesi

Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG148552.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000033907.
HOVERGENiHBG100440.
InParanoidiQ86TB3.
KOiK08868.
OMAiMICCSAS.
OrthoDBiEOG7SN8CS.
PhylomeDBiQ86TB3.
TreeFamiTF332629.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86TB3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDSEGPQRP PLCFLSTLLS QKVPEKSDAV LRCIISGQPK PEVTWYKNGQ
60 70 80 90 100
AIDGSGIISN YEFFENQYIH VLHLSCCTKN DAAVYQISAK NSFGMICCSA
110 120 130 140 150
SVEVECSSEN PQLSPNLEDD RDRGWKHETG THEEERANQI DEKEHPYKEE
160 170 180 190 200
ESISPGTPRS ADSSPSKSNH SLSLQSLGNL DISVSSSENP LGVKGTRHTG
210 220 230 240 250
EAYDPSNTEE IANGLLFLNS SHIYEKQDRC CHKTVHSMAS KFTDGDLNND
260 270 280 290 300
GPHDEGLRSS QQNPKVQKYI SFSLPLSEAT AHIYPGDSAV ANKQPSPQLS
310 320 330 340 350
SEDSDSDYEL CPEITLTYTE EFSDDDLEYL ECSDVMTDYS NAVWQRNLLG
360 370 380 390 400
TEHVFLLESD DEEMEFGEHC LGGCEHFLSG MGCGSRVSGD AGPMVATAGF
410 420 430 440 450
CGHHSQPQEV GVRSSRVSKH GPSSPQTGMT LILGPHQDGT SSVTEQGRYK
460 470 480 490 500
LPTAPEAAEN DYPGIQGETR DSHQAREEFA SDNLLNMDES VRETEMKLLS
510 520 530 540 550
GESENSGMSQ CWETAADKRV GGKDLWSKRG SRKSARVRQP GMKGNPKKPN
560 570 580 590 600
ANLRESTTEG TLHLCSAKES AEPPLTQSDK RETSHTTAAA TGRSSHADAR
610 620 630 640 650
ECAISTQAEQ EAKTLQTSTD SVSKEGNTNC KGEGMQVNTL FETSQVPDWS
660 670 680 690 700
DPPQVQVQET VRETISCSQM PAFSEPAGEE SPFTGTTTIS FSNLGGVHKE
710 720 730 740 750
NASLAQHSEV KPCTCGPQHE EKQDRDGNIP DNFREDLKYE QSISEANDET
760 770 780 790 800
MSPGVFSRHL PKDARADFRE PVAVSVASPE PTDTALTLEN VCDEPRDREA
810 820 830 840 850
VCAMECFEAG DQGTCFDTID SLVGRPVDKY SPQEICSVDT ELAEGQNKVS
860 870 880 890 900
DLCSSNDKTL EVFFQTQVSE TSVSTCKSSK DGNSVMSPLF TSTFTLNISH
910 920 930 940 950
TASEGATGEN LAKVENSTYP LASTVHAGQE QPSPSNSGGL DETQLLSSEN
960 970 980 990 1000
NPLVQFKEGG DKSPSPSAAD TTATPASYSS IVSFPWEKPT TLTANNECFQ
1010 1020 1030 1040 1050
ATRETEDTST VTIATEVHPA KYLAVSIPED KHAGGTEERF PRASHEKVSQ
1060 1070 1080 1090 1100
FPSQVQLDHI LSGATIKSTK ELLCRAPSVP GVPHHVLQLP EGEGFCSNSP
1110 1120 1130 1140 1150
LQVDNLSGDK SQTVDRADFR SYEENFQERG SETKQGVQQQ SLSQQGSLSA
1160 1170 1180 1190 1200
PDFQQSLPTT SAAQEERNLV PTAHSPASSR EGAGQRSGWG TRVSVVAETA
1210 1220 1230 1240 1250
GEEDSQALSN VPSLSDILLE ESKEYRPGNW EAGNKLKIIT LEASASEIWP
1260 1270 1280 1290 1300
PRQLTNSESK ASDGGLIIPD KVWAVPDSLK ADAVVPELAP SEIAALAHSP
1310 1320 1330 1340 1350
EDAESALADS RESHKGEEPT ISVHWRSLSS RGFSQPRLLE SSVDPVDEKE
1360 1370 1380 1390 1400
LSVTDSLSAA SETGGKENVN NVSQDQEEKQ LKMDHTAFFK KFLTCPKILE
1410 1420 1430 1440 1450
SSVDPIDEIS VIEYTRAGKP EPSETTPQGA REGGQSNDGN MGHEAEIQPA
1460 1470 1480 1490 1500
ILQVPCLQGT ILSENRISRS QEGSMKQEAE QIQPEEAKTA IWQVLQPSEG
1510 1520 1530 1540 1550
GERIPSGCSI GQIQESSDGS LGEAEQSKKD KAELISPTSP LSSCLPIMTH
1560 1570 1580 1590 1600
ASLGVDTHNS TGQIHDVPEN DIVEPRKRQY VFPVSQKRGT IENERGKPLP
1610 1620 1630 1640 1650
SSPDLTRFPC TSSPEGNVTD FLISHKMEEP KIEVLQIGET KPPSSSSSSA
1660 1670 1680 1690 1700
KTLAFISGER ELEKAPKLLQ DPCQKGTLGC AKKSREREKS LEARAGKSPG
1710 1720 1730 1740 1750
TLTAVTGSEE VKRKPEAPGS GHLAEGVKKK ILSRVAALRL KLEEKENIRK
1760 1770 1780 1790 1800
NSAFLKKMPK LETSLSHTEE KQDPKKPSCK REGRAPVLLK KIQAEMFPEH
1810 1820 1830 1840 1850
SGNVKLSCQF AEIHEDSTIC WTKDSKSIAQ VQRSAGDNST VSFAIVQASP
1860 1870 1880 1890 1900
KDQGLYYCCI KNSYGKVTAE FNLTAEVLKQ LSSRQDTKGC EEIEFSQLIF
1910 1920 1930 1940 1950
KEDFLHDSYF GGRLRGQIAT EELHFGEGVH RKAFRSTVMH GLMPVFKPGH
1960 1970 1980 1990 2000
ACVLKVHNAI AYGTRNNDEL IQRNYKLAAQ ECYVQNTARY YAKIYAAEAQ
2010 2020 2030 2040 2050
PLEGFGEVPE IIPIFLIHRP ENNIPYATVE EELIGEFVKY SIRDGKEINF
2060 2070 2080 2090 2100
LRRESEAGQK CCTFQHWVYQ KTSGCLLVTD MQGVGMKLTD VGIATLAKGY
2110 2120 2130 2140 2150
KGFKGNCSMT FIDQFKALHQ CNKYCKMLGL KSLQNNNQKQ KQPSIGKSKV
2160 2170
QTNSMTIKKA GPETPGEKKT
Length:2,170
Mass (Da):237,013
Last modified:April 14, 2009 - v3
Checksum:i5C257153F091B08E
GO

Sequence cautioni

The sequence AAK95952.1 differs from that shown. Reason: Aberrant splicing.
The sequence BAC03812.1 differs from that shown. Reason: Aberrant splicing.
The sequence BX647796 differs from that shown. Reason: Aberrant splicing.
The sequence AAK95952.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC03812.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAD89922.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti550 – 5501N → S in BX647796. (PubMed:17974005)Curated
Sequence conflicti829 – 8291K → S in CAD89922. (PubMed:17974005)Curated
Sequence conflicti912 – 9121A → T in BX647796. (PubMed:17974005)Curated
Sequence conflicti959 – 9591G → E in BAC03812. (PubMed:10021370)Curated
Sequence conflicti1067 – 10671K → E in CAD89922. (PubMed:17974005)Curated
Sequence conflicti1165 – 11651E → G in CAD89922. (PubMed:17974005)Curated
Sequence conflicti1217 – 12171I → T in BAC03812. (PubMed:10021370)Curated
Sequence conflicti1402 – 14021S → P in BX647796. (PubMed:17974005)Curated
Sequence conflicti1428 – 14281Q → R in BAC03812. (PubMed:10021370)Curated
Sequence conflicti1443 – 14431H → R in BX647796. (PubMed:17974005)Curated
Sequence conflicti1784 – 17841R → S in BX647639. (PubMed:17974005)Curated
Sequence conflicti1814 – 18141H → R in BX647796. (PubMed:17974005)Curated
Sequence conflicti1939 – 19391M → V in CAD89922. (PubMed:17974005)Curated
Sequence conflicti2042 – 20421I → V in CAD89922. (PubMed:17974005)Curated
Sequence conflicti2092 – 20921G → D in BX647796. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21K → T.
Corresponds to variant rs6566987 [ dbSNP | Ensembl ].
VAR_054914
Natural varianti136 – 1361R → S.
Corresponds to variant rs9944810 [ dbSNP | Ensembl ].
VAR_054915
Natural varianti719 – 7191H → Q.3 Publications
Corresponds to variant rs12103986 [ dbSNP | Ensembl ].
VAR_054916
Natural varianti810 – 8101G → S.3 Publications
Corresponds to variant rs3809970 [ dbSNP | Ensembl ].
VAR_054917
Natural varianti825 – 8251R → T.3 Publications
Corresponds to variant rs3809972 [ dbSNP | Ensembl ].
VAR_054918
Natural varianti829 – 8291K → N.
Corresponds to variant rs3809973 [ dbSNP | Ensembl ].
VAR_054919
Natural varianti884 – 8841S → L.
Corresponds to variant rs3809974 [ dbSNP | Ensembl ].
VAR_054920
Natural varianti891 – 8911T → I.3 Publications
Corresponds to variant rs3826593 [ dbSNP | Ensembl ].
VAR_054921
Natural varianti916 – 9161N → K.3 Publications
Corresponds to variant rs4940404 [ dbSNP | Ensembl ].
VAR_054922
Natural varianti942 – 9421E → K in an ovarian undifferentiated carcinoma sample; somatic mutation. 1 Publication
VAR_045591
Natural varianti977 – 9771S → T.
Corresponds to variant rs3809975 [ dbSNP | Ensembl ].
VAR_054923
Natural varianti1057 – 10571L → V.3 Publications
Corresponds to variant rs3809976 [ dbSNP | Ensembl ].
VAR_054924
Natural varianti1063 – 10631G → V.
Corresponds to variant rs34347938 [ dbSNP | Ensembl ].
VAR_062168
Natural varianti1134 – 11341K → N.
Corresponds to variant rs35791514 [ dbSNP | Ensembl ].
VAR_054925
Natural varianti1174 – 11741H → P.3 Publications
Corresponds to variant rs3809977 [ dbSNP | Ensembl ].
VAR_054926
Natural varianti1296 – 12961L → V.
Corresponds to variant rs3809976 [ dbSNP | Ensembl ].
VAR_045593
Natural varianti1449 – 14491P → S.3 Publications
Corresponds to variant rs3809982 [ dbSNP | Ensembl ].
VAR_054927
Natural varianti1476 – 14761K → T in a melanoma metastatic sample; somatic mutation. 1 Publication
VAR_045594
Natural varianti1551 – 15511A → S.1 Publication
Corresponds to variant rs3809983 [ dbSNP | Ensembl ].
VAR_054928
Natural varianti1579 – 15791Q → R.
Corresponds to variant rs33910491 [ dbSNP | Ensembl ].
VAR_054929
Natural varianti1729 – 17291K → E.
Corresponds to variant rs34409558 [ dbSNP | Ensembl ].
VAR_054930
Natural varianti1730 – 17301K → E.
Corresponds to variant rs17065127 [ dbSNP | Ensembl ].
VAR_054931
Natural varianti1767 – 17671H → Y.
Corresponds to variant rs7234999 [ dbSNP | Ensembl ].
VAR_054932
Natural varianti1884 – 18841R → C.
Corresponds to variant rs33969768 [ dbSNP | Ensembl ].
VAR_057742
Natural varianti1969 – 19691E → K.
Corresponds to variant rs17065127 [ dbSNP | Ensembl ].
VAR_045595
Natural varianti2157 – 21571I → V.2 Publications
Corresponds to variant rs7240666 [ dbSNP | Ensembl ].
VAR_054933

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL832018 mRNA. Translation: CAD89922.1. Different initiation.
BX647796 mRNA. No translation available.
BX647639 mRNA. No translation available.
AK092133 mRNA. Translation: BAC03812.1. Sequence problems.
AY044450 mRNA. Translation: AAK95952.1. Sequence problems.
CCDSiCCDS11966.2.
RefSeqiNP_443179.3. NM_052947.3.
UniGeneiHs.628152.

Genome annotation databases

EnsembliENST00000361673; ENSP00000354991; ENSG00000198796.
GeneIDi115701.
KEGGihsa:115701.
UCSCiuc002lhj.4. human.

Polymorphism databases

DMDMi226694196.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL832018 mRNA. Translation: CAD89922.1 . Different initiation.
BX647796 mRNA. No translation available.
BX647639 mRNA. No translation available.
AK092133 mRNA. Translation: BAC03812.1 . Sequence problems.
AY044450 mRNA. Translation: AAK95952.1 . Sequence problems.
CCDSi CCDS11966.2.
RefSeqi NP_443179.3. NM_052947.3.
UniGenei Hs.628152.

3D structure databases

ProteinModelPortali Q86TB3.
SMRi Q86TB3. Positions 14-109, 1800-2137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125447. 1 interaction.

PTM databases

PhosphoSitei Q86TB3.

Polymorphism databases

DMDMi 226694196.

Proteomic databases

MaxQBi Q86TB3.
PaxDbi Q86TB3.
PRIDEi Q86TB3.

Protocols and materials databases

DNASUi 115701.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361673 ; ENSP00000354991 ; ENSG00000198796 .
GeneIDi 115701.
KEGGi hsa:115701.
UCSCi uc002lhj.4. human.

Organism-specific databases

CTDi 115701.
GeneCardsi GC18M056148.
H-InvDB HIX0014477.
HGNCi HGNC:20565. ALPK2.
HPAi HPA027377.
HPA027976.
HPA028084.
HPA029801.
neXtProti NX_Q86TB3.
PharmGKBi PA134916108.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148552.
GeneTreei ENSGT00530000063799.
HOGENOMi HOG000033907.
HOVERGENi HBG100440.
InParanoidi Q86TB3.
KOi K08868.
OMAi MICCSAS.
OrthoDBi EOG7SN8CS.
PhylomeDBi Q86TB3.
TreeFami TF332629.

Miscellaneous databases

GenomeRNAii 115701.
NextBioi 79646.
PROi Q86TB3.

Gene expression databases

Bgeei Q86TB3.
CleanExi HS_ALPK2.
Genevestigatori Q86TB3.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view ]
Pfami PF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 2 hits.
[Graphical view ]
SMARTi SM00811. Alpha_kinase. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449; SER-1551 AND VAL-2157.
    Tissue: Skeletal muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 552-1770, VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449 AND VAL-2157.
    Tissue: Heart and Teratocarcinoma.
  4. "Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
    Ryazanov A.G., Pavur K.S., Dorovkov M.V.
    Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 569-2170, VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174 AND SER-1449.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-942 AND THR-1476.

Entry informationi

Entry nameiALPK2_HUMAN
AccessioniPrimary (citable) accession number: Q86TB3
Secondary accession number(s): Q6ZUX0, Q8NAT5, Q96L95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3