Reviewed,
UniProtKB/Swiss-Prot Q86TB3 (ALPK2_HUMAN)
Last modified
November 24, 2009.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alpha-protein kinase 2 EC=2.7.11.- Alternative name(s): Heart alpha-protein kinase | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 2170 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. |
| Sequence similarities | Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. Contains 1 alpha-type protein kinase domain. Contains 1 Ig-like (immunoglobulin-like) domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Immunoglobulin domain |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Disulfide bond Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q86TB3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q86TB3-2) The sequence of this isoform differs from the canonical sequence as follows: 1006-1010: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2170 | 2170 | Alpha-protein kinase 2 | PRO_0000260030 | |||||||
Regions | |||||||||||
| Domain | 1786 – 1874 | 89 | Ig-like | ||||||||
| Domain | 1901 – 2133 | 233 | Alpha-type protein kinase | ||||||||
| Compositional bias | 1644 – 1649 | 6 | Poly-Ser | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 1602 | 1 | Phosphoserine Ref.5 | ||||||||
| Disulfide bond | 1808 ↔ 1858 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 1006 – 1010 | 5 | Missing in isoform 2. | VSP_036887 | |||||||
| Natural variant | 2 | 1 | K → T: dbSNP rs6566987. | VAR_054914 | |||||||
| Natural variant | 136 | 1 | R → S: dbSNP rs9944810. | VAR_054915 | |||||||
| Natural variant | 719 | 1 | H → Q: dbSNP rs12103986. Ref.1 Ref.3 Ref.4 | VAR_054916 | |||||||
| Natural variant | 810 | 1 | G → S: dbSNP rs3809970. Ref.1 Ref.3 Ref.4 | VAR_054917 | |||||||
| Natural variant | 825 | 1 | R → T: dbSNP rs3809972. Ref.1 Ref.3 Ref.4 | VAR_054918 | |||||||
| Natural variant | 829 | 1 | K → N: dbSNP rs3809973. | VAR_054919 | |||||||
| Natural variant | 884 | 1 | S → L: dbSNP rs3809974. | VAR_054920 | |||||||
| Natural variant | 891 | 1 | T → I: dbSNP rs3826593. Ref.1 Ref.3 | VAR_054921 | |||||||
| Natural variant | 916 | 1 | N → K: dbSNP rs4940404. Ref.1 Ref.3 Ref.4 | VAR_054922 | |||||||
| Natural variant | 942 | 1 | E → K in an ovarian undifferentiated carcinoma sample; somatic mutation. Ref.6 | VAR_045591 | |||||||
| Natural variant | 977 | 1 | S → T: dbSNP rs3809975. | VAR_054923 | |||||||
| Natural variant | 1057 | 1 | L → V: dbSNP rs3809976. Ref.1 Ref.3 Ref.4 | VAR_054924 | |||||||
| Natural variant | 1133 | 1 | T → I: dbSNP rs3826593. Ref.4 | VAR_045592 | |||||||
| Natural variant | 1134 | 1 | K → N: dbSNP rs35791514. | VAR_054925 | |||||||
| Natural variant | 1174 | 1 | H → P: dbSNP rs3809977. Ref.1 Ref.3 Ref.4 | VAR_054926 | |||||||
| Natural variant | 1296 | 1 | L → V: dbSNP rs3809976. | VAR_045593 | |||||||
| Natural variant | 1449 | 1 | P → S: dbSNP rs3809982. Ref.1 Ref.3 Ref.4 | VAR_054927 | |||||||
| Natural variant | 1476 | 1 | K → T in a melanoma metastatic sample; somatic mutation. Ref.6 | VAR_045594 | |||||||
| Natural variant | 1551 | 1 | A → S: dbSNP rs3809983. Ref.1 | VAR_054928 | |||||||
| Natural variant | 1579 | 1 | Q → R: dbSNP rs33910491. | VAR_054929 | |||||||
| Natural variant | 1729 | 1 | K → E: dbSNP rs34409558. | VAR_054930 | |||||||
| Natural variant | 1730 | 1 | K → E: dbSNP rs17065127. | VAR_054931 | |||||||
| Natural variant | 1767 | 1 | H → Y: dbSNP rs7234999. | VAR_054932 | |||||||
| Natural variant | 1884 | 1 | R → C: dbSNP rs33969768. | VAR_057742 | |||||||
| Natural variant | 1969 | 1 | E → K: dbSNP rs17065127. | VAR_045595 | |||||||
| Natural variant | 2157 | 1 | I → V: dbSNP rs7240666. Ref.1 Ref.3 | VAR_054933 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 550 | 1 | N → S in BX647796. Ref.1 | ||||||||
| Sequence conflict | 829 | 1 | K → S in CAD89922. Ref.1 | ||||||||
| Sequence conflict | 912 | 1 | A → T in BX647796. Ref.1 | ||||||||
| Sequence conflict | 959 | 1 | G → E in BAC03812. Ref.4 | ||||||||
| Sequence conflict | 1067 | 1 | K → E in CAD89922. Ref.1 | ||||||||
| Sequence conflict | 1165 | 1 | E → G in CAD89922. Ref.1 | ||||||||
| Sequence conflict | 1217 | 1 | I → T in BAC03812. Ref.4 | ||||||||
| Sequence conflict | 1402 | 1 | S → P in BX647796. Ref.1 | ||||||||
| Sequence conflict | 1428 | 1 | Q → R in BAC03812. Ref.4 | ||||||||
| Sequence conflict | 1443 | 1 | H → R in BX647796. Ref.1 | ||||||||
| Sequence conflict | 1784 | 1 | R → S in BX647639. Ref.1 | ||||||||
| Sequence conflict | 1814 | 1 | H → R in BX647796. Ref.1 | ||||||||
| Sequence conflict | 1939 | 1 | M → V in CAD89922. Ref.1 | ||||||||
| Sequence conflict | 2042 | 1 | I → V in CAD89922. Ref.1 | ||||||||
| Sequence conflict | 2092 | 1 | G → D in BX647796. Ref.1 | ||||||||
Sequences
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References
| [1] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 308-2170 (ISOFORM 1), VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449; SER-1551 AND VAL-2157. Tissue: Skeletal muscle. |
| [2] | "DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. Lander E.S.Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 552-1770 (ISOFORM 2), VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449 AND VAL-2157. Tissue: Heart and Teratocarcinoma. |
| [4] | "Alpha-kinases: a new class of protein kinases with a novel catalytic domain." Ryazanov A.G., Pavur K.S., Dorovkov M.V. Curr. Biol. 9:R43-R45(1999) [PubMed: 10021370] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 569-2170 (ISOFORM 2), VARIANTS GLN-719; SER-810; THR-825; LYS-916; VAL-1057; ILE-1133; PRO-1174 AND SER-1449. |
| [5] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1602, MASS SPECTROMETRY. |
| [6] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-942 AND THR-1476. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AL832018 mRNA. Translation: CAD89922.1. Different initiation. BX647796 mRNA. No translation available. BX647639 mRNA. No translation available. AK092133 mRNA. Translation: BAC03812.1. Different initiation. AY044450 mRNA. Translation: AAK95952.1. Different initiation. | |
| IPI | IPI00646010. IPI00792557. |
| RefSeq | NP_443179.3. |
| UniGene | Hs.656805 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAJ based on UniProtKB Q923J1. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q86TB3. |
PTM databases | |
| PhosphoSite | Q86TB3. |
Proteomic databases | |
| PRIDE | Q86TB3. |
Genome annotation databases | |
| Ensembl | ENST00000361673; ENSP00000354991; ENSG00000198796; Homo sapiens. [Genome view] |
| GeneID | 115701. |
| KEGG | hsa:115701. |
| UCSC | uc002lhj.2. human. |
Organism-specific databases | |
| CTD | 115701. |
| GeneCards | GC18M054300. |
| HGNC | HGNC:20565. ALPK2. |
| PharmGKB | PA134916108. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q86TB3. |
| OMA | YLPQEIC |
| OrthoDB | EOG9BCH6J |
Gene expression databases | |
| ArrayExpress | Q86TB3. |
| Bgee | Q86TB3. |
| CleanEx | HS_ALPK2. |
| Genevestigator | Q86TB3. |
| GermOnline | ENSG00000198796. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR004166. MHCK_EF2_kinase. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 2 hits. |
| Pfam | PF02816. Alpha_kinase. 1 hit. PF07679. I-set. 2 hits. [Graphical view] |
| SMART | SM00811. Alpha_kinase. 1 hit. SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. [Graphical view] |
| PROSITE | PS51158. ALPHA_KINASE. 1 hit. PS50835. IG_LIKE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALPK2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q86TB3 Secondary accession number(s): Q6ZUX0, Q8NAT5, Q96L95 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 18 Human chromosome 18: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


