Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-protein kinase 2

Gene

ALPK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 2 (EC:2.7.11.-)
Alternative name(s):
Heart alpha-protein kinase
Gene namesi
Name:ALPK2
Synonyms:HAK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:20565. ALPK2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi115701.
OpenTargetsiENSG00000198796.
PharmGKBiPA134916108.

Polymorphism and mutation databases

BioMutaiALPK2.
DMDMi226694196.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600301 – 2170Alpha-protein kinase 2Add BLAST2170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 98PROSITE-ProRule annotation
Disulfide bondi1808 ↔ 1858PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ86TB3.
PaxDbiQ86TB3.
PeptideAtlasiQ86TB3.
PRIDEiQ86TB3.

PTM databases

iPTMnetiQ86TB3.
PhosphoSitePlusiQ86TB3.

Expressioni

Gene expression databases

BgeeiENSG00000198796.
CleanExiHS_ALPK2.
GenevisibleiQ86TB3. HS.

Organism-specific databases

HPAiHPA027377.
HPA027976.
HPA028084.
HPA029801.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354991.

Structurei

3D structure databases

ProteinModelPortaliQ86TB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 114Ig-like 1Add BLAST105
Domaini1786 – 1874Ig-like 2Add BLAST89
Domaini1901 – 2133Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST233

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1644 – 1649Poly-Ser6

Sequence similaritiesi

Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000033907.
HOVERGENiHBG100440.
InParanoidiQ86TB3.
KOiK08868.
OMAiMICCSAS.
OrthoDBiEOG091G008T.
PhylomeDBiQ86TB3.
TreeFamiTF332629.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86TB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSEGPQRP PLCFLSTLLS QKVPEKSDAV LRCIISGQPK PEVTWYKNGQ
60 70 80 90 100
AIDGSGIISN YEFFENQYIH VLHLSCCTKN DAAVYQISAK NSFGMICCSA
110 120 130 140 150
SVEVECSSEN PQLSPNLEDD RDRGWKHETG THEEERANQI DEKEHPYKEE
160 170 180 190 200
ESISPGTPRS ADSSPSKSNH SLSLQSLGNL DISVSSSENP LGVKGTRHTG
210 220 230 240 250
EAYDPSNTEE IANGLLFLNS SHIYEKQDRC CHKTVHSMAS KFTDGDLNND
260 270 280 290 300
GPHDEGLRSS QQNPKVQKYI SFSLPLSEAT AHIYPGDSAV ANKQPSPQLS
310 320 330 340 350
SEDSDSDYEL CPEITLTYTE EFSDDDLEYL ECSDVMTDYS NAVWQRNLLG
360 370 380 390 400
TEHVFLLESD DEEMEFGEHC LGGCEHFLSG MGCGSRVSGD AGPMVATAGF
410 420 430 440 450
CGHHSQPQEV GVRSSRVSKH GPSSPQTGMT LILGPHQDGT SSVTEQGRYK
460 470 480 490 500
LPTAPEAAEN DYPGIQGETR DSHQAREEFA SDNLLNMDES VRETEMKLLS
510 520 530 540 550
GESENSGMSQ CWETAADKRV GGKDLWSKRG SRKSARVRQP GMKGNPKKPN
560 570 580 590 600
ANLRESTTEG TLHLCSAKES AEPPLTQSDK RETSHTTAAA TGRSSHADAR
610 620 630 640 650
ECAISTQAEQ EAKTLQTSTD SVSKEGNTNC KGEGMQVNTL FETSQVPDWS
660 670 680 690 700
DPPQVQVQET VRETISCSQM PAFSEPAGEE SPFTGTTTIS FSNLGGVHKE
710 720 730 740 750
NASLAQHSEV KPCTCGPQHE EKQDRDGNIP DNFREDLKYE QSISEANDET
760 770 780 790 800
MSPGVFSRHL PKDARADFRE PVAVSVASPE PTDTALTLEN VCDEPRDREA
810 820 830 840 850
VCAMECFEAG DQGTCFDTID SLVGRPVDKY SPQEICSVDT ELAEGQNKVS
860 870 880 890 900
DLCSSNDKTL EVFFQTQVSE TSVSTCKSSK DGNSVMSPLF TSTFTLNISH
910 920 930 940 950
TASEGATGEN LAKVENSTYP LASTVHAGQE QPSPSNSGGL DETQLLSSEN
960 970 980 990 1000
NPLVQFKEGG DKSPSPSAAD TTATPASYSS IVSFPWEKPT TLTANNECFQ
1010 1020 1030 1040 1050
ATRETEDTST VTIATEVHPA KYLAVSIPED KHAGGTEERF PRASHEKVSQ
1060 1070 1080 1090 1100
FPSQVQLDHI LSGATIKSTK ELLCRAPSVP GVPHHVLQLP EGEGFCSNSP
1110 1120 1130 1140 1150
LQVDNLSGDK SQTVDRADFR SYEENFQERG SETKQGVQQQ SLSQQGSLSA
1160 1170 1180 1190 1200
PDFQQSLPTT SAAQEERNLV PTAHSPASSR EGAGQRSGWG TRVSVVAETA
1210 1220 1230 1240 1250
GEEDSQALSN VPSLSDILLE ESKEYRPGNW EAGNKLKIIT LEASASEIWP
1260 1270 1280 1290 1300
PRQLTNSESK ASDGGLIIPD KVWAVPDSLK ADAVVPELAP SEIAALAHSP
1310 1320 1330 1340 1350
EDAESALADS RESHKGEEPT ISVHWRSLSS RGFSQPRLLE SSVDPVDEKE
1360 1370 1380 1390 1400
LSVTDSLSAA SETGGKENVN NVSQDQEEKQ LKMDHTAFFK KFLTCPKILE
1410 1420 1430 1440 1450
SSVDPIDEIS VIEYTRAGKP EPSETTPQGA REGGQSNDGN MGHEAEIQPA
1460 1470 1480 1490 1500
ILQVPCLQGT ILSENRISRS QEGSMKQEAE QIQPEEAKTA IWQVLQPSEG
1510 1520 1530 1540 1550
GERIPSGCSI GQIQESSDGS LGEAEQSKKD KAELISPTSP LSSCLPIMTH
1560 1570 1580 1590 1600
ASLGVDTHNS TGQIHDVPEN DIVEPRKRQY VFPVSQKRGT IENERGKPLP
1610 1620 1630 1640 1650
SSPDLTRFPC TSSPEGNVTD FLISHKMEEP KIEVLQIGET KPPSSSSSSA
1660 1670 1680 1690 1700
KTLAFISGER ELEKAPKLLQ DPCQKGTLGC AKKSREREKS LEARAGKSPG
1710 1720 1730 1740 1750
TLTAVTGSEE VKRKPEAPGS GHLAEGVKKK ILSRVAALRL KLEEKENIRK
1760 1770 1780 1790 1800
NSAFLKKMPK LETSLSHTEE KQDPKKPSCK REGRAPVLLK KIQAEMFPEH
1810 1820 1830 1840 1850
SGNVKLSCQF AEIHEDSTIC WTKDSKSIAQ VQRSAGDNST VSFAIVQASP
1860 1870 1880 1890 1900
KDQGLYYCCI KNSYGKVTAE FNLTAEVLKQ LSSRQDTKGC EEIEFSQLIF
1910 1920 1930 1940 1950
KEDFLHDSYF GGRLRGQIAT EELHFGEGVH RKAFRSTVMH GLMPVFKPGH
1960 1970 1980 1990 2000
ACVLKVHNAI AYGTRNNDEL IQRNYKLAAQ ECYVQNTARY YAKIYAAEAQ
2010 2020 2030 2040 2050
PLEGFGEVPE IIPIFLIHRP ENNIPYATVE EELIGEFVKY SIRDGKEINF
2060 2070 2080 2090 2100
LRRESEAGQK CCTFQHWVYQ KTSGCLLVTD MQGVGMKLTD VGIATLAKGY
2110 2120 2130 2140 2150
KGFKGNCSMT FIDQFKALHQ CNKYCKMLGL KSLQNNNQKQ KQPSIGKSKV
2160 2170
QTNSMTIKKA GPETPGEKKT
Length:2,170
Mass (Da):237,013
Last modified:April 14, 2009 - v3
Checksum:i5C257153F091B08E
GO

Sequence cautioni

The sequence AAK95952 differs from that shown. Aberrant splicing.Curated
The sequence AAK95952 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03812 differs from that shown. Aberrant splicing.Curated
The sequence BAC03812 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BX647796 differs from that shown. Aberrant splicing.Curated
The sequence CAD89922 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti550N → S in BX647796 (PubMed:17974005).Curated1
Sequence conflicti829K → S in CAD89922 (PubMed:17974005).Curated1
Sequence conflicti912A → T in BX647796 (PubMed:17974005).Curated1
Sequence conflicti959G → E in BAC03812 (PubMed:10021370).Curated1
Sequence conflicti1067K → E in CAD89922 (PubMed:17974005).Curated1
Sequence conflicti1165E → G in CAD89922 (PubMed:17974005).Curated1
Sequence conflicti1217I → T in BAC03812 (PubMed:10021370).Curated1
Sequence conflicti1402S → P in BX647796 (PubMed:17974005).Curated1
Sequence conflicti1428Q → R in BAC03812 (PubMed:10021370).Curated1
Sequence conflicti1443H → R in BX647796 (PubMed:17974005).Curated1
Sequence conflicti1784R → S in BX647639 (PubMed:17974005).Curated1
Sequence conflicti1814H → R in BX647796 (PubMed:17974005).Curated1
Sequence conflicti1939M → V in CAD89922 (PubMed:17974005).Curated1
Sequence conflicti2042I → V in CAD89922 (PubMed:17974005).Curated1
Sequence conflicti2092G → D in BX647796 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0549142K → T.Corresponds to variant rs6566987dbSNPEnsembl.1
Natural variantiVAR_054915136R → S.Corresponds to variant rs9944810dbSNPEnsembl.1
Natural variantiVAR_054916719H → Q.3 PublicationsCorresponds to variant rs12103986dbSNPEnsembl.1
Natural variantiVAR_054917810G → S.3 PublicationsCorresponds to variant rs3809970dbSNPEnsembl.1
Natural variantiVAR_054918825R → T.3 PublicationsCorresponds to variant rs3809972dbSNPEnsembl.1
Natural variantiVAR_054919829K → N.Corresponds to variant rs3809973dbSNPEnsembl.1
Natural variantiVAR_054920884S → L.Corresponds to variant rs3809974dbSNPEnsembl.1
Natural variantiVAR_054921891T → I.3 PublicationsCorresponds to variant rs3826593dbSNPEnsembl.1
Natural variantiVAR_054922916N → K.3 PublicationsCorresponds to variant rs4940404dbSNPEnsembl.1
Natural variantiVAR_045591942E → K in an ovarian undifferentiated carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_054923977S → T.Corresponds to variant rs3809975dbSNPEnsembl.1
Natural variantiVAR_0549241057L → V.3 PublicationsCorresponds to variant rs3809976dbSNPEnsembl.1
Natural variantiVAR_0621681063G → V.Corresponds to variant rs34347938dbSNPEnsembl.1
Natural variantiVAR_0549251134K → N.Corresponds to variant rs35791514dbSNPEnsembl.1
Natural variantiVAR_0549261174H → P.3 PublicationsCorresponds to variant rs3809977dbSNPEnsembl.1
Natural variantiVAR_0455931296L → V.Corresponds to variant rs3809976dbSNPEnsembl.1
Natural variantiVAR_0549271449P → S.3 PublicationsCorresponds to variant rs3809982dbSNPEnsembl.1
Natural variantiVAR_0455941476K → T in a melanoma metastatic sample; somatic mutation. 1 Publication1
Natural variantiVAR_0549281551A → S.1 PublicationCorresponds to variant rs3809983dbSNPEnsembl.1
Natural variantiVAR_0549291579Q → R.Corresponds to variant rs33910491dbSNPEnsembl.1
Natural variantiVAR_0549301729K → E.Corresponds to variant rs34409558dbSNPEnsembl.1
Natural variantiVAR_0549311730K → E.Corresponds to variant rs17065127dbSNPEnsembl.1
Natural variantiVAR_0549321767H → Y.Corresponds to variant rs7234999dbSNPEnsembl.1
Natural variantiVAR_0577421884R → C.Corresponds to variant rs33969768dbSNPEnsembl.1
Natural variantiVAR_0455951969E → K.Corresponds to variant rs17065127dbSNPEnsembl.1
Natural variantiVAR_0549332157I → V.2 PublicationsCorresponds to variant rs7240666dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832018 mRNA. Translation: CAD89922.1. Different initiation.
BX647796 mRNA. No translation available.
BX647639 mRNA. No translation available.
AK092133 mRNA. Translation: BAC03812.1. Sequence problems.
AY044450 mRNA. Translation: AAK95952.1. Sequence problems.
CCDSiCCDS11966.2.
RefSeqiNP_443179.3. NM_052947.3.
UniGeneiHs.628152.

Genome annotation databases

EnsembliENST00000361673; ENSP00000354991; ENSG00000198796.
GeneIDi115701.
KEGGihsa:115701.
UCSCiuc002lhj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832018 mRNA. Translation: CAD89922.1. Different initiation.
BX647796 mRNA. No translation available.
BX647639 mRNA. No translation available.
AK092133 mRNA. Translation: BAC03812.1. Sequence problems.
AY044450 mRNA. Translation: AAK95952.1. Sequence problems.
CCDSiCCDS11966.2.
RefSeqiNP_443179.3. NM_052947.3.
UniGeneiHs.628152.

3D structure databases

ProteinModelPortaliQ86TB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354991.

PTM databases

iPTMnetiQ86TB3.
PhosphoSitePlusiQ86TB3.

Polymorphism and mutation databases

BioMutaiALPK2.
DMDMi226694196.

Proteomic databases

MaxQBiQ86TB3.
PaxDbiQ86TB3.
PeptideAtlasiQ86TB3.
PRIDEiQ86TB3.

Protocols and materials databases

DNASUi115701.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361673; ENSP00000354991; ENSG00000198796.
GeneIDi115701.
KEGGihsa:115701.
UCSCiuc002lhj.5. human.

Organism-specific databases

CTDi115701.
DisGeNETi115701.
GeneCardsiALPK2.
H-InvDBHIX0014477.
HGNCiHGNC:20565. ALPK2.
HPAiHPA027377.
HPA027976.
HPA028084.
HPA029801.
neXtProtiNX_Q86TB3.
OpenTargetsiENSG00000198796.
PharmGKBiPA134916108.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFU. Eukaryota.
ENOG410Y8B3. LUCA.
GeneTreeiENSGT00530000063799.
HOGENOMiHOG000033907.
HOVERGENiHBG100440.
InParanoidiQ86TB3.
KOiK08868.
OMAiMICCSAS.
OrthoDBiEOG091G008T.
PhylomeDBiQ86TB3.
TreeFamiTF332629.

Miscellaneous databases

GenomeRNAii115701.
PROiQ86TB3.

Gene expression databases

BgeeiENSG00000198796.
CleanExiHS_ALPK2.
GenevisibleiQ86TB3. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALPK2_HUMAN
AccessioniPrimary (citable) accession number: Q86TB3
Secondary accession number(s): Q6ZUX0, Q8NAT5, Q96L95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 14, 2009
Last modified: November 2, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.