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Q86TB3

- ALPK2_HUMAN

UniProt

Q86TB3 - ALPK2_HUMAN

Protein

Alpha-protein kinase 2

Gene

ALPK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-protein kinase 2 (EC:2.7.11.-)
    Alternative name(s):
    Heart alpha-protein kinase
    Gene namesi
    Name:ALPK2
    Synonyms:HAK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:20565. ALPK2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134916108.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21702170Alpha-protein kinase 2PRO_0000260030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi1808 ↔ 1858PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ86TB3.
    PaxDbiQ86TB3.
    PRIDEiQ86TB3.

    PTM databases

    PhosphoSiteiQ86TB3.

    Expressioni

    Gene expression databases

    BgeeiQ86TB3.
    CleanExiHS_ALPK2.
    GenevestigatoriQ86TB3.

    Organism-specific databases

    HPAiHPA027377.
    HPA027976.
    HPA028084.
    HPA029801.

    Interactioni

    Protein-protein interaction databases

    BioGridi125447. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86TB3.
    SMRiQ86TB3. Positions 14-109, 1801-1879, 2009-2137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 114105Ig-like 1Add
    BLAST
    Domaini1786 – 187489Ig-like 2Add
    BLAST
    Domaini1901 – 2133233Alpha-type protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1644 – 16496Poly-Ser

    Sequence similaritiesi

    Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiNOG148552.
    HOGENOMiHOG000033907.
    HOVERGENiHBG100440.
    InParanoidiQ86TB3.
    KOiK08868.
    OMAiMICCSAS.
    OrthoDBiEOG7SN8CS.
    PhylomeDBiQ86TB3.
    TreeFamiTF332629.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view]
    PfamiPF02816. Alpha_kinase. 1 hit.
    PF07679. I-set. 2 hits.
    [Graphical view]
    SMARTiSM00811. Alpha_kinase. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51158. ALPHA_KINASE. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86TB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDSEGPQRP PLCFLSTLLS QKVPEKSDAV LRCIISGQPK PEVTWYKNGQ     50
    AIDGSGIISN YEFFENQYIH VLHLSCCTKN DAAVYQISAK NSFGMICCSA 100
    SVEVECSSEN PQLSPNLEDD RDRGWKHETG THEEERANQI DEKEHPYKEE 150
    ESISPGTPRS ADSSPSKSNH SLSLQSLGNL DISVSSSENP LGVKGTRHTG 200
    EAYDPSNTEE IANGLLFLNS SHIYEKQDRC CHKTVHSMAS KFTDGDLNND 250
    GPHDEGLRSS QQNPKVQKYI SFSLPLSEAT AHIYPGDSAV ANKQPSPQLS 300
    SEDSDSDYEL CPEITLTYTE EFSDDDLEYL ECSDVMTDYS NAVWQRNLLG 350
    TEHVFLLESD DEEMEFGEHC LGGCEHFLSG MGCGSRVSGD AGPMVATAGF 400
    CGHHSQPQEV GVRSSRVSKH GPSSPQTGMT LILGPHQDGT SSVTEQGRYK 450
    LPTAPEAAEN DYPGIQGETR DSHQAREEFA SDNLLNMDES VRETEMKLLS 500
    GESENSGMSQ CWETAADKRV GGKDLWSKRG SRKSARVRQP GMKGNPKKPN 550
    ANLRESTTEG TLHLCSAKES AEPPLTQSDK RETSHTTAAA TGRSSHADAR 600
    ECAISTQAEQ EAKTLQTSTD SVSKEGNTNC KGEGMQVNTL FETSQVPDWS 650
    DPPQVQVQET VRETISCSQM PAFSEPAGEE SPFTGTTTIS FSNLGGVHKE 700
    NASLAQHSEV KPCTCGPQHE EKQDRDGNIP DNFREDLKYE QSISEANDET 750
    MSPGVFSRHL PKDARADFRE PVAVSVASPE PTDTALTLEN VCDEPRDREA 800
    VCAMECFEAG DQGTCFDTID SLVGRPVDKY SPQEICSVDT ELAEGQNKVS 850
    DLCSSNDKTL EVFFQTQVSE TSVSTCKSSK DGNSVMSPLF TSTFTLNISH 900
    TASEGATGEN LAKVENSTYP LASTVHAGQE QPSPSNSGGL DETQLLSSEN 950
    NPLVQFKEGG DKSPSPSAAD TTATPASYSS IVSFPWEKPT TLTANNECFQ 1000
    ATRETEDTST VTIATEVHPA KYLAVSIPED KHAGGTEERF PRASHEKVSQ 1050
    FPSQVQLDHI LSGATIKSTK ELLCRAPSVP GVPHHVLQLP EGEGFCSNSP 1100
    LQVDNLSGDK SQTVDRADFR SYEENFQERG SETKQGVQQQ SLSQQGSLSA 1150
    PDFQQSLPTT SAAQEERNLV PTAHSPASSR EGAGQRSGWG TRVSVVAETA 1200
    GEEDSQALSN VPSLSDILLE ESKEYRPGNW EAGNKLKIIT LEASASEIWP 1250
    PRQLTNSESK ASDGGLIIPD KVWAVPDSLK ADAVVPELAP SEIAALAHSP 1300
    EDAESALADS RESHKGEEPT ISVHWRSLSS RGFSQPRLLE SSVDPVDEKE 1350
    LSVTDSLSAA SETGGKENVN NVSQDQEEKQ LKMDHTAFFK KFLTCPKILE 1400
    SSVDPIDEIS VIEYTRAGKP EPSETTPQGA REGGQSNDGN MGHEAEIQPA 1450
    ILQVPCLQGT ILSENRISRS QEGSMKQEAE QIQPEEAKTA IWQVLQPSEG 1500
    GERIPSGCSI GQIQESSDGS LGEAEQSKKD KAELISPTSP LSSCLPIMTH 1550
    ASLGVDTHNS TGQIHDVPEN DIVEPRKRQY VFPVSQKRGT IENERGKPLP 1600
    SSPDLTRFPC TSSPEGNVTD FLISHKMEEP KIEVLQIGET KPPSSSSSSA 1650
    KTLAFISGER ELEKAPKLLQ DPCQKGTLGC AKKSREREKS LEARAGKSPG 1700
    TLTAVTGSEE VKRKPEAPGS GHLAEGVKKK ILSRVAALRL KLEEKENIRK 1750
    NSAFLKKMPK LETSLSHTEE KQDPKKPSCK REGRAPVLLK KIQAEMFPEH 1800
    SGNVKLSCQF AEIHEDSTIC WTKDSKSIAQ VQRSAGDNST VSFAIVQASP 1850
    KDQGLYYCCI KNSYGKVTAE FNLTAEVLKQ LSSRQDTKGC EEIEFSQLIF 1900
    KEDFLHDSYF GGRLRGQIAT EELHFGEGVH RKAFRSTVMH GLMPVFKPGH 1950
    ACVLKVHNAI AYGTRNNDEL IQRNYKLAAQ ECYVQNTARY YAKIYAAEAQ 2000
    PLEGFGEVPE IIPIFLIHRP ENNIPYATVE EELIGEFVKY SIRDGKEINF 2050
    LRRESEAGQK CCTFQHWVYQ KTSGCLLVTD MQGVGMKLTD VGIATLAKGY 2100
    KGFKGNCSMT FIDQFKALHQ CNKYCKMLGL KSLQNNNQKQ KQPSIGKSKV 2150
    QTNSMTIKKA GPETPGEKKT 2170
    Length:2,170
    Mass (Da):237,013
    Last modified:April 14, 2009 - v3
    Checksum:i5C257153F091B08E
    GO

    Sequence cautioni

    The sequence AAK95952.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAC03812.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BX647796 differs from that shown. Reason: Aberrant splicing.
    The sequence AAK95952.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC03812.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAD89922.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti550 – 5501N → S in BX647796. (PubMed:17974005)Curated
    Sequence conflicti829 – 8291K → S in CAD89922. (PubMed:17974005)Curated
    Sequence conflicti912 – 9121A → T in BX647796. (PubMed:17974005)Curated
    Sequence conflicti959 – 9591G → E in BAC03812. (PubMed:10021370)Curated
    Sequence conflicti1067 – 10671K → E in CAD89922. (PubMed:17974005)Curated
    Sequence conflicti1165 – 11651E → G in CAD89922. (PubMed:17974005)Curated
    Sequence conflicti1217 – 12171I → T in BAC03812. (PubMed:10021370)Curated
    Sequence conflicti1402 – 14021S → P in BX647796. (PubMed:17974005)Curated
    Sequence conflicti1428 – 14281Q → R in BAC03812. (PubMed:10021370)Curated
    Sequence conflicti1443 – 14431H → R in BX647796. (PubMed:17974005)Curated
    Sequence conflicti1784 – 17841R → S in BX647639. (PubMed:17974005)Curated
    Sequence conflicti1814 – 18141H → R in BX647796. (PubMed:17974005)Curated
    Sequence conflicti1939 – 19391M → V in CAD89922. (PubMed:17974005)Curated
    Sequence conflicti2042 – 20421I → V in CAD89922. (PubMed:17974005)Curated
    Sequence conflicti2092 – 20921G → D in BX647796. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21K → T.
    Corresponds to variant rs6566987 [ dbSNP | Ensembl ].
    VAR_054914
    Natural varianti136 – 1361R → S.
    Corresponds to variant rs9944810 [ dbSNP | Ensembl ].
    VAR_054915
    Natural varianti719 – 7191H → Q.3 Publications
    Corresponds to variant rs12103986 [ dbSNP | Ensembl ].
    VAR_054916
    Natural varianti810 – 8101G → S.3 Publications
    Corresponds to variant rs3809970 [ dbSNP | Ensembl ].
    VAR_054917
    Natural varianti825 – 8251R → T.3 Publications
    Corresponds to variant rs3809972 [ dbSNP | Ensembl ].
    VAR_054918
    Natural varianti829 – 8291K → N.
    Corresponds to variant rs3809973 [ dbSNP | Ensembl ].
    VAR_054919
    Natural varianti884 – 8841S → L.
    Corresponds to variant rs3809974 [ dbSNP | Ensembl ].
    VAR_054920
    Natural varianti891 – 8911T → I.3 Publications
    Corresponds to variant rs3826593 [ dbSNP | Ensembl ].
    VAR_054921
    Natural varianti916 – 9161N → K.3 Publications
    Corresponds to variant rs4940404 [ dbSNP | Ensembl ].
    VAR_054922
    Natural varianti942 – 9421E → K in an ovarian undifferentiated carcinoma sample; somatic mutation. 1 Publication
    VAR_045591
    Natural varianti977 – 9771S → T.
    Corresponds to variant rs3809975 [ dbSNP | Ensembl ].
    VAR_054923
    Natural varianti1057 – 10571L → V.3 Publications
    Corresponds to variant rs3809976 [ dbSNP | Ensembl ].
    VAR_054924
    Natural varianti1063 – 10631G → V.
    Corresponds to variant rs34347938 [ dbSNP | Ensembl ].
    VAR_062168
    Natural varianti1134 – 11341K → N.
    Corresponds to variant rs35791514 [ dbSNP | Ensembl ].
    VAR_054925
    Natural varianti1174 – 11741H → P.3 Publications
    Corresponds to variant rs3809977 [ dbSNP | Ensembl ].
    VAR_054926
    Natural varianti1296 – 12961L → V.
    Corresponds to variant rs3809976 [ dbSNP | Ensembl ].
    VAR_045593
    Natural varianti1449 – 14491P → S.3 Publications
    Corresponds to variant rs3809982 [ dbSNP | Ensembl ].
    VAR_054927
    Natural varianti1476 – 14761K → T in a melanoma metastatic sample; somatic mutation. 1 Publication
    VAR_045594
    Natural varianti1551 – 15511A → S.1 Publication
    Corresponds to variant rs3809983 [ dbSNP | Ensembl ].
    VAR_054928
    Natural varianti1579 – 15791Q → R.
    Corresponds to variant rs33910491 [ dbSNP | Ensembl ].
    VAR_054929
    Natural varianti1729 – 17291K → E.
    Corresponds to variant rs34409558 [ dbSNP | Ensembl ].
    VAR_054930
    Natural varianti1730 – 17301K → E.
    Corresponds to variant rs17065127 [ dbSNP | Ensembl ].
    VAR_054931
    Natural varianti1767 – 17671H → Y.
    Corresponds to variant rs7234999 [ dbSNP | Ensembl ].
    VAR_054932
    Natural varianti1884 – 18841R → C.
    Corresponds to variant rs33969768 [ dbSNP | Ensembl ].
    VAR_057742
    Natural varianti1969 – 19691E → K.
    Corresponds to variant rs17065127 [ dbSNP | Ensembl ].
    VAR_045595
    Natural varianti2157 – 21571I → V.2 Publications
    Corresponds to variant rs7240666 [ dbSNP | Ensembl ].
    VAR_054933

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832018 mRNA. Translation: CAD89922.1. Different initiation.
    BX647796 mRNA. No translation available.
    BX647639 mRNA. No translation available.
    AK092133 mRNA. Translation: BAC03812.1. Sequence problems.
    AY044450 mRNA. Translation: AAK95952.1. Sequence problems.
    CCDSiCCDS11966.2.
    RefSeqiNP_443179.3. NM_052947.3.
    UniGeneiHs.628152.

    Genome annotation databases

    EnsembliENST00000361673; ENSP00000354991; ENSG00000198796.
    GeneIDi115701.
    KEGGihsa:115701.
    UCSCiuc002lhj.4. human.

    Polymorphism databases

    DMDMi226694196.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832018 mRNA. Translation: CAD89922.1 . Different initiation.
    BX647796 mRNA. No translation available.
    BX647639 mRNA. No translation available.
    AK092133 mRNA. Translation: BAC03812.1 . Sequence problems.
    AY044450 mRNA. Translation: AAK95952.1 . Sequence problems.
    CCDSi CCDS11966.2.
    RefSeqi NP_443179.3. NM_052947.3.
    UniGenei Hs.628152.

    3D structure databases

    ProteinModelPortali Q86TB3.
    SMRi Q86TB3. Positions 14-109, 1801-1879, 2009-2137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125447. 1 interaction.

    PTM databases

    PhosphoSitei Q86TB3.

    Polymorphism databases

    DMDMi 226694196.

    Proteomic databases

    MaxQBi Q86TB3.
    PaxDbi Q86TB3.
    PRIDEi Q86TB3.

    Protocols and materials databases

    DNASUi 115701.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361673 ; ENSP00000354991 ; ENSG00000198796 .
    GeneIDi 115701.
    KEGGi hsa:115701.
    UCSCi uc002lhj.4. human.

    Organism-specific databases

    CTDi 115701.
    GeneCardsi GC18M056148.
    H-InvDB HIX0014477.
    HGNCi HGNC:20565. ALPK2.
    HPAi HPA027377.
    HPA027976.
    HPA028084.
    HPA029801.
    neXtProti NX_Q86TB3.
    PharmGKBi PA134916108.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148552.
    HOGENOMi HOG000033907.
    HOVERGENi HBG100440.
    InParanoidi Q86TB3.
    KOi K08868.
    OMAi MICCSAS.
    OrthoDBi EOG7SN8CS.
    PhylomeDBi Q86TB3.
    TreeFami TF332629.

    Miscellaneous databases

    GenomeRNAii 115701.
    NextBioi 79646.
    PROi Q86TB3.

    Gene expression databases

    Bgeei Q86TB3.
    CleanExi HS_ALPK2.
    Genevestigatori Q86TB3.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view ]
    Pfami PF02816. Alpha_kinase. 1 hit.
    PF07679. I-set. 2 hits.
    [Graphical view ]
    SMARTi SM00811. Alpha_kinase. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51158. ALPHA_KINASE. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449; SER-1551 AND VAL-2157.
      Tissue: Skeletal muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 552-1770, VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449 AND VAL-2157.
      Tissue: Heart and Teratocarcinoma.
    4. "Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
      Ryazanov A.G., Pavur K.S., Dorovkov M.V.
      Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 569-2170, VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174 AND SER-1449.
    5. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-942 AND THR-1476.

    Entry informationi

    Entry nameiALPK2_HUMAN
    AccessioniPrimary (citable) accession number: Q86TB3
    Secondary accession number(s): Q6ZUX0, Q8NAT5, Q96L95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3