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Q86TB3 (ALPK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-protein kinase 2

EC=2.7.11.-
Alternative name(s):
Heart alpha-protein kinase
Gene names
Name:ALPK2
Synonyms:HAK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2170 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Sequence similarities

Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.

Contains 1 alpha-type protein kinase domain.

Contains 2 Ig-like (immunoglobulin-like) domains.

Sequence caution

The sequence AAK95952.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAK95952.1 differs from that shown. Reason: Aberrant splicing.

The sequence BAC03812.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC03812.1 differs from that shown. Reason: Aberrant splicing.

The sequence BX647796 differs from that shown. Reason: Aberrant splicing.

The sequence CAD89922.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay. Source: HPA

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21702170Alpha-protein kinase 2
PRO_0000260030

Regions

Domain10 – 114105Ig-like 1
Domain1786 – 187489Ig-like 2
Domain1901 – 2133233Alpha-type protein kinase
Compositional bias1644 – 16496Poly-Ser

Amino acid modifications

Disulfide bond33 ↔ 98 By similarity
Disulfide bond1808 ↔ 1858 By similarity

Natural variations

Natural variant21K → T.
Corresponds to variant rs6566987 [ dbSNP | Ensembl ].
VAR_054914
Natural variant1361R → S.
Corresponds to variant rs9944810 [ dbSNP | Ensembl ].
VAR_054915
Natural variant7191H → Q. Ref.1 Ref.3 Ref.4
Corresponds to variant rs12103986 [ dbSNP | Ensembl ].
VAR_054916
Natural variant8101G → S. Ref.1 Ref.3 Ref.4
Corresponds to variant rs3809970 [ dbSNP | Ensembl ].
VAR_054917
Natural variant8251R → T. Ref.1 Ref.3 Ref.4
Corresponds to variant rs3809972 [ dbSNP | Ensembl ].
VAR_054918
Natural variant8291K → N.
Corresponds to variant rs3809973 [ dbSNP | Ensembl ].
VAR_054919
Natural variant8841S → L.
Corresponds to variant rs3809974 [ dbSNP | Ensembl ].
VAR_054920
Natural variant8911T → I. Ref.1 Ref.3 Ref.4
Corresponds to variant rs3826593 [ dbSNP | Ensembl ].
VAR_054921
Natural variant9161N → K. Ref.1 Ref.3 Ref.4
Corresponds to variant rs4940404 [ dbSNP | Ensembl ].
VAR_054922
Natural variant9421E → K in an ovarian undifferentiated carcinoma sample; somatic mutation. Ref.5
VAR_045591
Natural variant9771S → T.
Corresponds to variant rs3809975 [ dbSNP | Ensembl ].
VAR_054923
Natural variant10571L → V. Ref.1 Ref.3 Ref.4
Corresponds to variant rs3809976 [ dbSNP | Ensembl ].
VAR_054924
Natural variant10631G → V.
Corresponds to variant rs34347938 [ dbSNP | Ensembl ].
VAR_062168
Natural variant11341K → N.
Corresponds to variant rs35791514 [ dbSNP | Ensembl ].
VAR_054925
Natural variant11741H → P. Ref.1 Ref.3 Ref.4
Corresponds to variant rs3809977 [ dbSNP | Ensembl ].
VAR_054926
Natural variant12961L → V.
Corresponds to variant rs3809976 [ dbSNP | Ensembl ].
VAR_045593
Natural variant14491P → S. Ref.1 Ref.3 Ref.4
Corresponds to variant rs3809982 [ dbSNP | Ensembl ].
VAR_054927
Natural variant14761K → T in a melanoma metastatic sample; somatic mutation. Ref.5
VAR_045594
Natural variant15511A → S. Ref.1
Corresponds to variant rs3809983 [ dbSNP | Ensembl ].
VAR_054928
Natural variant15791Q → R.
Corresponds to variant rs33910491 [ dbSNP | Ensembl ].
VAR_054929
Natural variant17291K → E.
Corresponds to variant rs34409558 [ dbSNP | Ensembl ].
VAR_054930
Natural variant17301K → E.
Corresponds to variant rs17065127 [ dbSNP | Ensembl ].
VAR_054931
Natural variant17671H → Y.
Corresponds to variant rs7234999 [ dbSNP | Ensembl ].
VAR_054932
Natural variant18841R → C.
Corresponds to variant rs33969768 [ dbSNP | Ensembl ].
VAR_057742
Natural variant19691E → K.
Corresponds to variant rs17065127 [ dbSNP | Ensembl ].
VAR_045595
Natural variant21571I → V. Ref.1 Ref.3
Corresponds to variant rs7240666 [ dbSNP | Ensembl ].
VAR_054933

Experimental info

Sequence conflict5501N → S in BX647796. Ref.1
Sequence conflict8291K → S in CAD89922. Ref.1
Sequence conflict9121A → T in BX647796. Ref.1
Sequence conflict9591G → E in BAC03812. Ref.4
Sequence conflict10671K → E in CAD89922. Ref.1
Sequence conflict11651E → G in CAD89922. Ref.1
Sequence conflict12171I → T in BAC03812. Ref.4
Sequence conflict14021S → P in BX647796. Ref.1
Sequence conflict14281Q → R in BAC03812. Ref.4
Sequence conflict14431H → R in BX647796. Ref.1
Sequence conflict17841R → S in BX647639. Ref.1
Sequence conflict18141H → R in BX647796. Ref.1
Sequence conflict19391M → V in CAD89922. Ref.1
Sequence conflict20421I → V in CAD89922. Ref.1
Sequence conflict20921G → D in BX647796. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q86TB3 [UniParc].

Last modified April 14, 2009. Version 3.
Checksum: 5C257153F091B08E

FASTA2,170237,013
        10         20         30         40         50         60 
MKDSEGPQRP PLCFLSTLLS QKVPEKSDAV LRCIISGQPK PEVTWYKNGQ AIDGSGIISN 

        70         80         90        100        110        120 
YEFFENQYIH VLHLSCCTKN DAAVYQISAK NSFGMICCSA SVEVECSSEN PQLSPNLEDD 

       130        140        150        160        170        180 
RDRGWKHETG THEEERANQI DEKEHPYKEE ESISPGTPRS ADSSPSKSNH SLSLQSLGNL 

       190        200        210        220        230        240 
DISVSSSENP LGVKGTRHTG EAYDPSNTEE IANGLLFLNS SHIYEKQDRC CHKTVHSMAS 

       250        260        270        280        290        300 
KFTDGDLNND GPHDEGLRSS QQNPKVQKYI SFSLPLSEAT AHIYPGDSAV ANKQPSPQLS 

       310        320        330        340        350        360 
SEDSDSDYEL CPEITLTYTE EFSDDDLEYL ECSDVMTDYS NAVWQRNLLG TEHVFLLESD 

       370        380        390        400        410        420 
DEEMEFGEHC LGGCEHFLSG MGCGSRVSGD AGPMVATAGF CGHHSQPQEV GVRSSRVSKH 

       430        440        450        460        470        480 
GPSSPQTGMT LILGPHQDGT SSVTEQGRYK LPTAPEAAEN DYPGIQGETR DSHQAREEFA 

       490        500        510        520        530        540 
SDNLLNMDES VRETEMKLLS GESENSGMSQ CWETAADKRV GGKDLWSKRG SRKSARVRQP 

       550        560        570        580        590        600 
GMKGNPKKPN ANLRESTTEG TLHLCSAKES AEPPLTQSDK RETSHTTAAA TGRSSHADAR 

       610        620        630        640        650        660 
ECAISTQAEQ EAKTLQTSTD SVSKEGNTNC KGEGMQVNTL FETSQVPDWS DPPQVQVQET 

       670        680        690        700        710        720 
VRETISCSQM PAFSEPAGEE SPFTGTTTIS FSNLGGVHKE NASLAQHSEV KPCTCGPQHE 

       730        740        750        760        770        780 
EKQDRDGNIP DNFREDLKYE QSISEANDET MSPGVFSRHL PKDARADFRE PVAVSVASPE 

       790        800        810        820        830        840 
PTDTALTLEN VCDEPRDREA VCAMECFEAG DQGTCFDTID SLVGRPVDKY SPQEICSVDT 

       850        860        870        880        890        900 
ELAEGQNKVS DLCSSNDKTL EVFFQTQVSE TSVSTCKSSK DGNSVMSPLF TSTFTLNISH 

       910        920        930        940        950        960 
TASEGATGEN LAKVENSTYP LASTVHAGQE QPSPSNSGGL DETQLLSSEN NPLVQFKEGG 

       970        980        990       1000       1010       1020 
DKSPSPSAAD TTATPASYSS IVSFPWEKPT TLTANNECFQ ATRETEDTST VTIATEVHPA 

      1030       1040       1050       1060       1070       1080 
KYLAVSIPED KHAGGTEERF PRASHEKVSQ FPSQVQLDHI LSGATIKSTK ELLCRAPSVP 

      1090       1100       1110       1120       1130       1140 
GVPHHVLQLP EGEGFCSNSP LQVDNLSGDK SQTVDRADFR SYEENFQERG SETKQGVQQQ 

      1150       1160       1170       1180       1190       1200 
SLSQQGSLSA PDFQQSLPTT SAAQEERNLV PTAHSPASSR EGAGQRSGWG TRVSVVAETA 

      1210       1220       1230       1240       1250       1260 
GEEDSQALSN VPSLSDILLE ESKEYRPGNW EAGNKLKIIT LEASASEIWP PRQLTNSESK 

      1270       1280       1290       1300       1310       1320 
ASDGGLIIPD KVWAVPDSLK ADAVVPELAP SEIAALAHSP EDAESALADS RESHKGEEPT 

      1330       1340       1350       1360       1370       1380 
ISVHWRSLSS RGFSQPRLLE SSVDPVDEKE LSVTDSLSAA SETGGKENVN NVSQDQEEKQ 

      1390       1400       1410       1420       1430       1440 
LKMDHTAFFK KFLTCPKILE SSVDPIDEIS VIEYTRAGKP EPSETTPQGA REGGQSNDGN 

      1450       1460       1470       1480       1490       1500 
MGHEAEIQPA ILQVPCLQGT ILSENRISRS QEGSMKQEAE QIQPEEAKTA IWQVLQPSEG 

      1510       1520       1530       1540       1550       1560 
GERIPSGCSI GQIQESSDGS LGEAEQSKKD KAELISPTSP LSSCLPIMTH ASLGVDTHNS 

      1570       1580       1590       1600       1610       1620 
TGQIHDVPEN DIVEPRKRQY VFPVSQKRGT IENERGKPLP SSPDLTRFPC TSSPEGNVTD 

      1630       1640       1650       1660       1670       1680 
FLISHKMEEP KIEVLQIGET KPPSSSSSSA KTLAFISGER ELEKAPKLLQ DPCQKGTLGC 

      1690       1700       1710       1720       1730       1740 
AKKSREREKS LEARAGKSPG TLTAVTGSEE VKRKPEAPGS GHLAEGVKKK ILSRVAALRL 

      1750       1760       1770       1780       1790       1800 
KLEEKENIRK NSAFLKKMPK LETSLSHTEE KQDPKKPSCK REGRAPVLLK KIQAEMFPEH 

      1810       1820       1830       1840       1850       1860 
SGNVKLSCQF AEIHEDSTIC WTKDSKSIAQ VQRSAGDNST VSFAIVQASP KDQGLYYCCI 

      1870       1880       1890       1900       1910       1920 
KNSYGKVTAE FNLTAEVLKQ LSSRQDTKGC EEIEFSQLIF KEDFLHDSYF GGRLRGQIAT 

      1930       1940       1950       1960       1970       1980 
EELHFGEGVH RKAFRSTVMH GLMPVFKPGH ACVLKVHNAI AYGTRNNDEL IQRNYKLAAQ 

      1990       2000       2010       2020       2030       2040 
ECYVQNTARY YAKIYAAEAQ PLEGFGEVPE IIPIFLIHRP ENNIPYATVE EELIGEFVKY 

      2050       2060       2070       2080       2090       2100 
SIRDGKEINF LRRESEAGQK CCTFQHWVYQ KTSGCLLVTD MQGVGMKLTD VGIATLAKGY 

      2110       2120       2130       2140       2150       2160 
KGFKGNCSMT FIDQFKALHQ CNKYCKMLGL KSLQNNNQKQ KQPSIGKSKV QTNSMTIKKA 

      2170 
GPETPGEKKT 

« Hide

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449; SER-1551 AND VAL-2157.
Tissue: Skeletal muscle.
[2]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 552-1770, VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174; SER-1449 AND VAL-2157.
Tissue: Heart and Teratocarcinoma.
[4]"Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
Ryazanov A.G., Pavur K.S., Dorovkov M.V.
Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 569-2170, VARIANTS GLN-719; SER-810; THR-825; ILE-891; LYS-916; VAL-1057; PRO-1174 AND SER-1449.
[5]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-942 AND THR-1476.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL832018 mRNA. Translation: CAD89922.1. Different initiation.
BX647796 mRNA. No translation available.
BX647639 mRNA. No translation available.
AK092133 mRNA. Translation: BAC03812.1. Sequence problems.
AY044450 mRNA. Translation: AAK95952.1. Sequence problems.
RefSeqNP_443179.3. NM_052947.3.
UniGeneHs.628152.

3D structure databases

ProteinModelPortalQ86TB3.
SMRQ86TB3. Positions 14-109, 1802-2137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125447. 1 interaction.

PTM databases

PhosphoSiteQ86TB3.

Polymorphism databases

DMDM226694196.

Proteomic databases

PaxDbQ86TB3.
PRIDEQ86TB3.

Protocols and materials databases

DNASU115701.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361673; ENSP00000354991; ENSG00000198796.
GeneID115701.
KEGGhsa:115701.
UCSCuc002lhj.4. human.

Organism-specific databases

CTD115701.
GeneCardsGC18M056148.
H-InvDBHIX0014477.
HGNCHGNC:20565. ALPK2.
HPAHPA027377.
HPA027976.
HPA028084.
HPA029801.
neXtProtNX_Q86TB3.
PharmGKBPA134916108.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148552.
HOGENOMHOG000033907.
HOVERGENHBG100440.
InParanoidQ86TB3.
KOK08868.
OMAMICCSAS.
OrthoDBEOG7SN8CS.
PhylomeDBQ86TB3.
TreeFamTF332629.

Gene expression databases

BgeeQ86TB3.
CleanExHS_ALPK2.
GenevestigatorQ86TB3.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamPF02816. Alpha_kinase. 1 hit.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTSM00811. Alpha_kinase. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51158. ALPHA_KINASE. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi115701.
NextBio79646.
PROQ86TB3.

Entry information

Entry nameALPK2_HUMAN
AccessionPrimary (citable) accession number: Q86TB3
Secondary accession number(s): Q6ZUX0, Q8NAT5, Q96L95
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM