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Protein

MOB kinase activator 3B

Gene

MOB3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the activity of kinases.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi164ZincBy similarity1
Metal bindingi169ZincBy similarity1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 3B
Alternative name(s):
Mob1 homolog 2b
Mps one binder kinase activator-like 2B
Gene namesi
Name:MOB3BImported
Synonyms:C9orf35Imported, MOBKL2BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120162.9.
HGNCiHGNC:23825. MOB3B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79817.
OpenTargetsiENSG00000120162.
PharmGKBiPA134886513.

Polymorphism and mutation databases

BioMutaiMOB3B.
DMDMi56749334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935721 – 216MOB kinase activator 3BAdd BLAST216

Proteomic databases

EPDiQ86TA1.
MaxQBiQ86TA1.
PaxDbiQ86TA1.
PeptideAtlasiQ86TA1.
PRIDEiQ86TA1.

PTM databases

iPTMnetiQ86TA1.
PhosphoSitePlusiQ86TA1.

Expressioni

Gene expression databases

BgeeiENSG00000120162.
CleanExiHS_MOBKL2B.
GenevisibleiQ86TA1. HS.

Organism-specific databases

HPAiHPA057744.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NT5C2P499023EBI-751703,EBI-742084

Protein-protein interaction databases

BioGridi122912. 8 interactors.
IntActiQ86TA1. 4 interactors.
MINTiMINT-1480138.
STRINGi9606.ENSP00000262244.

Structurei

3D structure databases

ProteinModelPortaliQ86TA1.
SMRiQ86TA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG1903. Eukaryota.
ENOG410XSM4. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ86TA1.
OMAiYKKPTPL.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ86TA1.
TreeFamiTF300789.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiView protein in InterPro
IPR005301. MOB_kinase_act_fam.
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiView protein in Pfam
PF03637. Mob1_phocein. 1 hit.
SMARTiView protein in SMART
SM01388. Mob1_phocein. 1 hit.
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86TA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL
60 70 80 90 100
PSGEDQNDWV AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW
110 120 130 140 150
QDDLKYKKPT ALPAPQYMNL LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI
160 170 180 190 200
CKKILCRLFR VFVHVYIHHF DRVIVMGAEA HVNTCYKHFY YFVTEMNLID
210
RKELEPLKEM TSRMCH
Length:216
Mass (Da):25,464
Last modified:December 21, 2004 - v2
Checksum:i377F1FA8096103FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67F → L in CAD89934 (PubMed:17974005).Curated1
Sequence conflicti152K → M in AAH33027 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580636 mRNA. Translation: CAE45268.1.
AL832572 mRNA. Translation: CAD89934.1.
AK023266 mRNA. Translation: BAB14497.1.
CR457307 mRNA. Translation: CAG33588.1.
BC033027 mRNA. Translation: AAH33027.1.
CCDSiCCDS6520.1.
RefSeqiNP_079037.3. NM_024761.4.
UniGeneiHs.369022.
Hs.690014.
Hs.733701.

Genome annotation databases

EnsembliENST00000262244; ENSP00000262244; ENSG00000120162.
GeneIDi79817.
KEGGihsa:79817.
UCSCiuc003zqn.4. human.

Similar proteinsi

Entry informationi

Entry nameiMOB3B_HUMAN
AccessioniPrimary (citable) accession number: Q86TA1
Secondary accession number(s): Q8NEB4, Q9H8V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 27, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families