Reviewed, UniProtKB/Swiss-Prot Q86TA1 (MOL2B_HUMAN)

Names and origin

Protein names

Recommended name:
    Mps one binder kinase activator-like 2B
Alternative name(s):
    Mob1 homolog 2b
    Protein Mob3B

Gene names

Name:	MOBKL2B
Synonyms:	MOB3B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May regulate the activity of kinases By similarity.
Sequence similarities	Belongs to the MOB1/phocein family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CNKSR2	Q8WXI2	1	EBI-751703,EBI-1045119
NT5C2	P49902	2	EBI-751703,EBI-742084

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Mps one binder kinase activator-like 2B		PRO_0000193572
Sites
	Metal binding	82	1	Zinc By similarity
	Metal binding	87	1	Zinc By similarity
	Metal binding	164	1	Zinc By similarity
	Metal binding	169	1	Zinc By similarity
Experimental info
	Sequence conflict	67	1	F → L in CAD89934. Ref.2
	Sequence conflict	152	1	K → M in AAH33027. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q86TA1-1 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: 377F1FA8096103FC	FASTA	216	25,464
	10 20 30 40 50 60 MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL PSGEDQNDWV 70 80 90 100 110 120 AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW QDDLKYKKPT ALPAPQYMNL 130 140 150 160 170 180 LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI CKKILCRLFR VFVHVYIHHF DRVIVMGAEA 190 200 210 HVNTCYKHFY YFVTEMNLID RKELEPLKEM TSRMCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human Mob-1 like proteins." Florindo C.S., Tavares A.A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The German cDNA consortium Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spinal cord.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ580636 mRNA. Translation: CAE45268.1. AL832572 mRNA. Translation: CAD89934.1. AK023266 mRNA. Translation: BAB14497.1. CR457307 mRNA. Translation: CAG33588.1. BC033027 mRNA. Translation: AAH33027.1.
IPI	IPI00335089.
RefSeq	NP_079037.3.
UniGene	Hs.369022 Hs.690014
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86TA1. 2 interactions.
STRING	Q86TA1.
Proteomic databases
PRIDE	Q86TA1.
Genome annotation databases
Ensembl	ENST00000262244; ENSP00000262244; ENSG00000120162; Homo sapiens. [Genome view]
GeneID	79817.
KEGG	hsa:79817.
UCSC	uc003zqn.1. human.
Organism-specific databases
CTD	79817.
GeneCards	GC09M027318.
HGNC	HGNC:23825. MOBKL2B.
PharmGKB	PA134886513.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q86TA1.
HOVERGEN	Q86TA1.
OMA	IGAEAHV
OrthoDB	EOG9PVRK2
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000000804-MON.
Gene expression databases
ArrayExpress	Q86TA1.
Bgee	Q86TA1.
CleanEx	HS_MOBKL2B.
Genevestigator	Q86TA1.
GermOnline	ENSG00000120162. Homo sapiens.
Family and domain databases
InterPro	IPR005301. Mob1_phocein. [Graphical view]
Gene3D	G3DSA:1.20.140.30. Mob1_phocein. 1 hit.
PANTHER	PTHR22599. Mob1_phocein. 1 hit.
Pfam	PF03637. Mob1_phocein. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69426.

Entry information

Entry name

MOL2B_HUMAN

Accession

Primary (citable) accession number: Q86TA1
Secondary accession number(s): Q8NEB4, Q9H8V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	November 24, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.