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Protein

MOB kinase activator 3B

Gene

MOB3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the activity of kinases.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi164 – 1641ZincBy similarity
Metal bindingi169 – 1691ZincBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 3B
Alternative name(s):
Mob1 homolog 2b
Mps one binder kinase activator-like 2B
Gene namesi
Name:MOB3B
Synonyms:MOBKL2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23825. MOB3B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886513.

Polymorphism and mutation databases

BioMutaiMOB3B.
DMDMi56749334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216MOB kinase activator 3BPRO_0000193572Add
BLAST

Proteomic databases

EPDiQ86TA1.
MaxQBiQ86TA1.
PaxDbiQ86TA1.
PeptideAtlasiQ86TA1.
PRIDEiQ86TA1.

PTM databases

iPTMnetiQ86TA1.
PhosphoSiteiQ86TA1.

Expressioni

Gene expression databases

BgeeiENSG00000120162.
CleanExiHS_MOBKL2B.
GenevisibleiQ86TA1. HS.

Organism-specific databases

HPAiHPA046866.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NT5C2P499023EBI-751703,EBI-742084

Protein-protein interaction databases

BioGridi122912. 7 interactions.
IntActiQ86TA1. 3 interactions.
MINTiMINT-1480138.
STRINGi9606.ENSP00000262244.

Structurei

3D structure databases

ProteinModelPortaliQ86TA1.
SMRiQ86TA1. Positions 13-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG1903. Eukaryota.
ENOG410XSM4. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ86TA1.
OMAiKFEYLWA.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ86TA1.
TreeFamiTF300789.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86TA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL
60 70 80 90 100
PSGEDQNDWV AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW
110 120 130 140 150
QDDLKYKKPT ALPAPQYMNL LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI
160 170 180 190 200
CKKILCRLFR VFVHVYIHHF DRVIVMGAEA HVNTCYKHFY YFVTEMNLID
210
RKELEPLKEM TSRMCH
Length:216
Mass (Da):25,464
Last modified:December 21, 2004 - v2
Checksum:i377F1FA8096103FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671F → L in CAD89934 (PubMed:17974005).Curated
Sequence conflicti152 – 1521K → M in AAH33027 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580636 mRNA. Translation: CAE45268.1.
AL832572 mRNA. Translation: CAD89934.1.
AK023266 mRNA. Translation: BAB14497.1.
CR457307 mRNA. Translation: CAG33588.1.
BC033027 mRNA. Translation: AAH33027.1.
CCDSiCCDS6520.1.
RefSeqiNP_079037.3. NM_024761.4.
UniGeneiHs.369022.
Hs.690014.
Hs.733701.

Genome annotation databases

EnsembliENST00000262244; ENSP00000262244; ENSG00000120162.
GeneIDi79817.
KEGGihsa:79817.
UCSCiuc003zqn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580636 mRNA. Translation: CAE45268.1.
AL832572 mRNA. Translation: CAD89934.1.
AK023266 mRNA. Translation: BAB14497.1.
CR457307 mRNA. Translation: CAG33588.1.
BC033027 mRNA. Translation: AAH33027.1.
CCDSiCCDS6520.1.
RefSeqiNP_079037.3. NM_024761.4.
UniGeneiHs.369022.
Hs.690014.
Hs.733701.

3D structure databases

ProteinModelPortaliQ86TA1.
SMRiQ86TA1. Positions 13-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122912. 7 interactions.
IntActiQ86TA1. 3 interactions.
MINTiMINT-1480138.
STRINGi9606.ENSP00000262244.

PTM databases

iPTMnetiQ86TA1.
PhosphoSiteiQ86TA1.

Polymorphism and mutation databases

BioMutaiMOB3B.
DMDMi56749334.

Proteomic databases

EPDiQ86TA1.
MaxQBiQ86TA1.
PaxDbiQ86TA1.
PeptideAtlasiQ86TA1.
PRIDEiQ86TA1.

Protocols and materials databases

DNASUi79817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262244; ENSP00000262244; ENSG00000120162.
GeneIDi79817.
KEGGihsa:79817.
UCSCiuc003zqn.4. human.

Organism-specific databases

CTDi79817.
GeneCardsiMOB3B.
HGNCiHGNC:23825. MOB3B.
HPAiHPA046866.
neXtProtiNX_Q86TA1.
PharmGKBiPA134886513.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1903. Eukaryota.
ENOG410XSM4. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ86TA1.
OMAiKFEYLWA.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ86TA1.
TreeFamiTF300789.

Miscellaneous databases

ChiTaRSiMOB3B. human.
GenomeRNAii79817.
PROiQ86TA1.

Gene expression databases

BgeeiENSG00000120162.
CleanExiHS_MOBKL2B.
GenevisibleiQ86TA1. HS.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOB3B_HUMAN
AccessioniPrimary (citable) accession number: Q86TA1
Secondary accession number(s): Q8NEB4, Q9H8V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.