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Q86T96 (RN180_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase RNF180

EC=6.3.2.-
Alternative name(s):
RING finger protein 180
Gene names
Name:RNF180
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2 By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with ZIC2 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope By similarity.

Domain

The RING-type zinc finger domain mediates polyubiquitination of the interacting protein.

Sequence similarities

Contains 1 RING-type zinc finger.

Sequence caution

The sequence CAD89939.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86T96-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86T96-2)

The sequence of this isoform differs from the canonical sequence as follows:
     410-416: TLNNEMS → VSIYLLI
     417-592: Missing.
Isoform 3 (identifier: Q86T96-3)

The sequence of this isoform differs from the canonical sequence as follows:
     78-397: Missing.
     410-416: TLNNEMS → VSIYLLI
     417-592: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 592592E3 ubiquitin-protein ligase RNF180
PRO_0000261617

Regions

Topological domain1 – 564564Cytoplasmic Potential
Transmembrane565 – 58521Helical; Potential
Topological domain586 – 5927Extracellular Potential
Zinc finger432 – 47443RING-type
Region281 – 489209Interaction with ZIC2 By similarity

Natural variations

Alternative sequence78 – 397320Missing in isoform 3.
VSP_021738
Alternative sequence410 – 4167TLNNEMS → VSIYLLI in isoform 2 and isoform 3.
VSP_021739
Alternative sequence417 – 592176Missing in isoform 2 and isoform 3.
VSP_021740

Experimental info

Sequence conflict151E → G in CAD89939. Ref.2
Sequence conflict18 – 225SILRC → GETVFSL in CAD89939. Ref.2
Sequence conflict4581R → G in CAD89939. Ref.2
Sequence conflict5261G → A in CAD89939. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: 030AF3FD04ECA57B

FASTA59268,254
        10         20         30         40         50         60 
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW 

        70         80         90        100        110        120 
HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT 

       130        140        150        160        170        180 
DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE 

       190        200        210        220        230        240 
ALCLEVRPTY FEMKNEKLLS KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT 

       250        260        270        280        290        300 
LLPTLYEIHS KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH 

       310        320        330        340        350        360 
ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE HLSPLDFLHS 

       370        380        390        400        410        420 
ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY SGVGLLDHMT LNNEMSTDED 

       430        440        450        460        470        480 
NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH IFCEPCLRTL AKDNPSSTPC PLCRTIISRV 

       490        500        510        520        530        540 
FFQTELNNAT KTFFTKEYLK IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF 

       550        560        570        580        590 
PHGAHRMDYL HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF 

« Hide

Isoform 2 [UniParc].

Checksum: 9BA191F2271C6A0E
Show »

FASTA41647,286
Isoform 3 [UniParc].

Checksum: 86BDAC24D6C70469
Show »

FASTA9611,132

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Cerebellum.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spinal cord.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK090756 mRNA. Translation: BAC03514.1.
AL832580 mRNA. Translation: CAD89939.1. Different initiation.
BC101277 mRNA. Translation: AAI01278.1.
BC101278 mRNA. Translation: AAI01279.1.
BC101279 mRNA. Translation: AAI01280.1.
BC101397 mRNA. Translation: AAI01398.1.
RefSeqNP_001107033.1. NM_001113561.1.
NP_848627.1. NM_178532.3.
UniGeneHs.657843.

3D structure databases

ProteinModelPortalQ86T96.
SMRQ86T96. Positions 425-508.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130174. 3 interactions.
MINTMINT-4722695.
STRING9606.ENSP00000373752.

PTM databases

PhosphoSiteQ86T96.

Polymorphism databases

DMDM118573800.

Proteomic databases

PaxDbQ86T96.
PRIDEQ86T96.

Protocols and materials databases

DNASU285671.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296615; ENSP00000296615; ENSG00000164197. [Q86T96-2]
ENST00000381081; ENSP00000370471; ENSG00000164197. [Q86T96-3]
ENST00000389100; ENSP00000373752; ENSG00000164197. [Q86T96-1]
GeneID285671.
KEGGhsa:285671.
UCSCuc003jth.4. human. [Q86T96-2]
uc003jti.3. human. [Q86T96-1]
uc010iws.3. human. [Q86T96-3]

Organism-specific databases

CTD285671.
GeneCardsGC05P063498.
HGNCHGNC:27752. RNF180.
HPAHPA006897.
neXtProtNX_Q86T96.
PharmGKBPA134980027.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42632.
HOGENOMHOG000154158.
HOVERGENHBG093907.
InParanoidQ86T96.
KOK15708.
OMAPTLYEIH.
OrthoDBEOG790G06.
PhylomeDBQ86T96.
TreeFamTF328580.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ86T96.
BgeeQ86T96.
CleanExHS_RNF180.
GenevestigatorQ86T96.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
PROSITEPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRNF180. human.
GenomeRNAi285671.
NextBio95695.
PROQ86T96.

Entry information

Entry nameRN180_HUMAN
AccessionPrimary (citable) accession number: Q86T96
Secondary accession number(s): Q0JSU3, Q495A8, Q8NBD1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: April 16, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM