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Protein

E3 ubiquitin-protein ligase RNF180

Gene

RNF180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri432 – 474RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ86T96
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF180 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 180
RING-type E3 ubiquitin transferase RNF180Curated
Gene namesi
Name:RNF180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164197.11
HGNCiHGNC:27752 RNF180
MIMi616015 gene
neXtProtiNX_Q86T96

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 564CytoplasmicSequence analysisAdd BLAST564
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 592ExtracellularSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi285671
OpenTargetsiENSG00000164197
PharmGKBiPA134980027

Polymorphism and mutation databases

BioMutaiRNF180
DMDMi118573800

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002616171 – 592E3 ubiquitin-protein ligase RNF180Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ86T96
PeptideAtlasiQ86T96
PRIDEiQ86T96

PTM databases

iPTMnetiQ86T96
PhosphoSitePlusiQ86T96

Expressioni

Gene expression databases

BgeeiENSG00000164197
CleanExiHS_RNF180
ExpressionAtlasiQ86T96 baseline and differential
GenevisibleiQ86T96 HS

Organism-specific databases

HPAiHPA006897

Interactioni

Subunit structurei

Interacts with ZIC2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130174, 2 interactors
STRINGi9606.ENSP00000373752

Structurei

3D structure databases

ProteinModelPortaliQ86T96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 489Interaction with ZIC2By similarityAdd BLAST209

Domaini

The RING-type zinc finger domain mediates polyubiquitination of the interacting protein.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri432 – 474RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IN5N Eukaryota
ENOG410ZJ1M LUCA
GeneTreeiENSGT00390000012786
HOGENOMiHOG000154158
HOVERGENiHBG093907
InParanoidiQ86T96
KOiK15708
OMAiLRCWKCR
OrthoDBiEOG091G15SR
PhylomeDBiQ86T96
TreeFamiTF328580

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR033263 RNF180
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23327:SF18 PTHR23327:SF18, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86T96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS
60 70 80 90 100
VDAQNICHVW HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV
110 120 130 140 150
STPKCSCGQL AAVHLSKSRT DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE
160 170 180 190 200
ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE ALCLEVRPTY FEMKNEKLLS
210 220 230 240 250
KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT LLPTLYEIHS
260 270 280 290 300
KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH
310 320 330 340 350
ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE
360 370 380 390 400
HLSPLDFLHS ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY
410 420 430 440 450
SGVGLLDHMT LNNEMSTDED NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH
460 470 480 490 500
IFCEPCLRTL AKDNPSSTPC PLCRTIISRV FFQTELNNAT KTFFTKEYLK
510 520 530 540 550
IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF PHGAHRMDYL
560 570 580 590
HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF
Length:592
Mass (Da):68,254
Last modified:November 28, 2006 - v2
Checksum:i030AF3FD04ECA57B
GO
Isoform 2 (identifier: Q86T96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-416: TLNNEMS → VSIYLLI
     417-592: Missing.

Show »
Length:416
Mass (Da):47,286
Checksum:i9BA191F2271C6A0E
GO
Isoform 3 (identifier: Q86T96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-397: Missing.
     410-416: TLNNEMS → VSIYLLI
     417-592: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):11,132
Checksum:i86BDAC24D6C70469
GO

Sequence cautioni

The sequence CAD89939 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15E → G in CAD89939 (PubMed:17974005).Curated1
Sequence conflicti18 – 22SILRC → GETVFSL in CAD89939 (PubMed:17974005).Curated5
Sequence conflicti458R → G in CAD89939 (PubMed:17974005).Curated1
Sequence conflicti526G → A in CAD89939 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02173878 – 397Missing in isoform 3. 1 PublicationAdd BLAST320
Alternative sequenceiVSP_021739410 – 416TLNNEMS → VSIYLLI in isoform 2 and isoform 3. 2 Publications7
Alternative sequenceiVSP_021740417 – 592Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST176

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090756 mRNA Translation: BAC03514.1
AL832580 mRNA Translation: CAD89939.1 Different initiation.
BC101277 mRNA Translation: AAI01278.1
BC101278 mRNA Translation: AAI01279.1
BC101279 mRNA Translation: AAI01280.1
BC101397 mRNA Translation: AAI01398.1
CCDSiCCDS34169.1 [Q86T96-2]
CCDS47219.1 [Q86T96-1]
RefSeqiNP_001107033.1, NM_001113561.2 [Q86T96-1]
NP_001310220.1, NM_001323291.1 [Q86T96-3]
NP_001310221.1, NM_001323292.1
NP_848627.1, NM_178532.4 [Q86T96-2]
UniGeneiHs.657843

Genome annotation databases

EnsembliENST00000296615; ENSP00000296615; ENSG00000164197 [Q86T96-2]
ENST00000389100; ENSP00000373752; ENSG00000164197 [Q86T96-1]
GeneIDi285671
KEGGihsa:285671
UCSCiuc003jth.5 human [Q86T96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRN180_HUMAN
AccessioniPrimary (citable) accession number: Q86T96
Secondary accession number(s): Q0JSU3, Q495A8, Q8NBD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: April 25, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health