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Q86T96

- RN180_HUMAN

UniProt

Q86T96 - RN180_HUMAN

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Protein

E3 ubiquitin-protein ligase RNF180

Gene

RNF180

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri432 – 47443RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. norepinephrine metabolic process Source: Ensembl
  3. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  4. positive regulation of protein ubiquitination Source: Ensembl
  5. protein polyubiquitination Source: Ensembl
  6. regulation of catalytic activity Source: Ensembl
  7. serotonin metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF180 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 180
Gene namesi
Name:RNF180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:27752. RNF180.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 564564CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei565 – 58521HelicalSequence AnalysisAdd
BLAST
Topological domaini586 – 5927ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intrinsic component of endoplasmic reticulum membrane Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592E3 ubiquitin-protein ligase RNF180PRO_0000261617Add
BLAST

Proteomic databases

PaxDbiQ86T96.
PRIDEiQ86T96.

PTM databases

PhosphoSiteiQ86T96.

Expressioni

Gene expression databases

BgeeiQ86T96.
CleanExiHS_RNF180.
ExpressionAtlasiQ86T96. baseline and differential.
GenevestigatoriQ86T96.

Organism-specific databases

HPAiHPA006897.

Interactioni

Subunit structurei

Interacts with ZIC2.By similarity

Protein-protein interaction databases

BioGridi130174. 3 interactions.
MINTiMINT-4722695.
STRINGi9606.ENSP00000373752.

Structurei

3D structure databases

ProteinModelPortaliQ86T96.
SMRiQ86T96. Positions 423-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 489209Interaction with ZIC2By similarityAdd
BLAST

Domaini

The RING-type zinc finger domain mediates polyubiquitination of the interacting protein.

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri432 – 47443RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG42632.
GeneTreeiENSGT00390000012786.
HOGENOMiHOG000154158.
HOVERGENiHBG093907.
InParanoidiQ86T96.
KOiK15708.
OMAiPTLYEIH.
OrthoDBiEOG790G06.
PhylomeDBiQ86T96.
TreeFamiTF328580.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86T96-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS
60 70 80 90 100
VDAQNICHVW HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV
110 120 130 140 150
STPKCSCGQL AAVHLSKSRT DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE
160 170 180 190 200
ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE ALCLEVRPTY FEMKNEKLLS
210 220 230 240 250
KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT LLPTLYEIHS
260 270 280 290 300
KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH
310 320 330 340 350
ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE
360 370 380 390 400
HLSPLDFLHS ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY
410 420 430 440 450
SGVGLLDHMT LNNEMSTDED NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH
460 470 480 490 500
IFCEPCLRTL AKDNPSSTPC PLCRTIISRV FFQTELNNAT KTFFTKEYLK
510 520 530 540 550
IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF PHGAHRMDYL
560 570 580 590
HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF
Length:592
Mass (Da):68,254
Last modified:November 28, 2006 - v2
Checksum:i030AF3FD04ECA57B
GO
Isoform 2 (identifier: Q86T96-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-416: TLNNEMS → VSIYLLI
     417-592: Missing.

Show »
Length:416
Mass (Da):47,286
Checksum:i9BA191F2271C6A0E
GO
Isoform 3 (identifier: Q86T96-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-397: Missing.
     410-416: TLNNEMS → VSIYLLI
     417-592: Missing.

Note: No experimental confirmation available.

Show »
Length:96
Mass (Da):11,132
Checksum:i86BDAC24D6C70469
GO

Sequence cautioni

The sequence CAD89939.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151E → G in CAD89939. (PubMed:17974005)Curated
Sequence conflicti18 – 225SILRC → GETVFSL in CAD89939. (PubMed:17974005)Curated
Sequence conflicti458 – 4581R → G in CAD89939. (PubMed:17974005)Curated
Sequence conflicti526 – 5261G → A in CAD89939. (PubMed:17974005)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei78 – 397320Missing in isoform 3. 1 PublicationVSP_021738Add
BLAST
Alternative sequencei410 – 4167TLNNEMS → VSIYLLI in isoform 2 and isoform 3. 2 PublicationsVSP_021739
Alternative sequencei417 – 592176Missing in isoform 2 and isoform 3. 2 PublicationsVSP_021740Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090756 mRNA. Translation: BAC03514.1.
AL832580 mRNA. Translation: CAD89939.1. Different initiation.
BC101277 mRNA. Translation: AAI01278.1.
BC101278 mRNA. Translation: AAI01279.1.
BC101279 mRNA. Translation: AAI01280.1.
BC101397 mRNA. Translation: AAI01398.1.
CCDSiCCDS34169.1. [Q86T96-2]
CCDS47219.1. [Q86T96-1]
RefSeqiNP_001107033.1. NM_001113561.1. [Q86T96-1]
NP_848627.1. NM_178532.3. [Q86T96-2]
XP_006714652.1. XM_006714589.1. [Q86T96-1]
XP_006714653.1. XM_006714590.1. [Q86T96-1]
UniGeneiHs.657843.

Genome annotation databases

EnsembliENST00000296615; ENSP00000296615; ENSG00000164197. [Q86T96-2]
ENST00000389100; ENSP00000373752; ENSG00000164197. [Q86T96-1]
GeneIDi285671.
KEGGihsa:285671.
UCSCiuc003jth.4. human. [Q86T96-2]
uc003jti.3. human. [Q86T96-1]
uc010iws.3. human. [Q86T96-3]

Polymorphism databases

DMDMi118573800.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090756 mRNA. Translation: BAC03514.1 .
AL832580 mRNA. Translation: CAD89939.1 . Different initiation.
BC101277 mRNA. Translation: AAI01278.1 .
BC101278 mRNA. Translation: AAI01279.1 .
BC101279 mRNA. Translation: AAI01280.1 .
BC101397 mRNA. Translation: AAI01398.1 .
CCDSi CCDS34169.1. [Q86T96-2 ]
CCDS47219.1. [Q86T96-1 ]
RefSeqi NP_001107033.1. NM_001113561.1. [Q86T96-1 ]
NP_848627.1. NM_178532.3. [Q86T96-2 ]
XP_006714652.1. XM_006714589.1. [Q86T96-1 ]
XP_006714653.1. XM_006714590.1. [Q86T96-1 ]
UniGenei Hs.657843.

3D structure databases

ProteinModelPortali Q86T96.
SMRi Q86T96. Positions 423-481.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130174. 3 interactions.
MINTi MINT-4722695.
STRINGi 9606.ENSP00000373752.

PTM databases

PhosphoSitei Q86T96.

Polymorphism databases

DMDMi 118573800.

Proteomic databases

PaxDbi Q86T96.
PRIDEi Q86T96.

Protocols and materials databases

DNASUi 285671.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296615 ; ENSP00000296615 ; ENSG00000164197 . [Q86T96-2 ]
ENST00000389100 ; ENSP00000373752 ; ENSG00000164197 . [Q86T96-1 ]
GeneIDi 285671.
KEGGi hsa:285671.
UCSCi uc003jth.4. human. [Q86T96-2 ]
uc003jti.3. human. [Q86T96-1 ]
uc010iws.3. human. [Q86T96-3 ]

Organism-specific databases

CTDi 285671.
GeneCardsi GC05P063498.
HGNCi HGNC:27752. RNF180.
HPAi HPA006897.
MIMi 616015. gene.
neXtProti NX_Q86T96.
PharmGKBi PA134980027.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42632.
GeneTreei ENSGT00390000012786.
HOGENOMi HOG000154158.
HOVERGENi HBG093907.
InParanoidi Q86T96.
KOi K15708.
OMAi PTLYEIH.
OrthoDBi EOG790G06.
PhylomeDBi Q86T96.
TreeFami TF328580.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi RNF180. human.
GenomeRNAii 285671.
NextBioi 95695.
PROi Q86T96.
SOURCEi Search...

Gene expression databases

Bgeei Q86T96.
CleanExi HS_RNF180.
ExpressionAtlasi Q86T96. baseline and differential.
Genevestigatori Q86T96.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).

Entry informationi

Entry nameiRN180_HUMAN
AccessioniPrimary (citable) accession number: Q86T96
Secondary accession number(s): Q0JSU3, Q495A8, Q8NBD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 26, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3