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Q86T96

- RN180_HUMAN

UniProt

Q86T96 - RN180_HUMAN

Protein

E3 ubiquitin-protein ligase RNF180

Gene

RNF180

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri432 – 47443RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. ubiquitin-protein transferase activity Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase RNF180 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 180
    Gene namesi
    Name:RNF180
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:27752. RNF180.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intrinsic component of endoplasmic reticulum membrane Source: Ensembl
    3. nuclear envelope Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134980027.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 592592E3 ubiquitin-protein ligase RNF180PRO_0000261617Add
    BLAST

    Proteomic databases

    PaxDbiQ86T96.
    PRIDEiQ86T96.

    PTM databases

    PhosphoSiteiQ86T96.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86T96.
    BgeeiQ86T96.
    CleanExiHS_RNF180.
    GenevestigatoriQ86T96.

    Organism-specific databases

    HPAiHPA006897.

    Interactioni

    Subunit structurei

    Interacts with ZIC2.By similarity

    Protein-protein interaction databases

    BioGridi130174. 3 interactions.
    MINTiMINT-4722695.
    STRINGi9606.ENSP00000373752.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86T96.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 564564CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini586 – 5927ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei565 – 58521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni281 – 489209Interaction with ZIC2By similarityAdd
    BLAST

    Domaini

    The RING-type zinc finger domain mediates polyubiquitination of the interacting protein.

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri432 – 47443RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG42632.
    HOGENOMiHOG000154158.
    HOVERGENiHBG093907.
    InParanoidiQ86T96.
    KOiK15708.
    OMAiPTLYEIH.
    OrthoDBiEOG790G06.
    PhylomeDBiQ86T96.
    TreeFamiTF328580.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86T96-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS    50
    VDAQNICHVW HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV 100
    STPKCSCGQL AAVHLSKSRT DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE 150
    ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE ALCLEVRPTY FEMKNEKLLS 200
    KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT LLPTLYEIHS 250
    KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH 300
    ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE 350
    HLSPLDFLHS ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY 400
    SGVGLLDHMT LNNEMSTDED NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH 450
    IFCEPCLRTL AKDNPSSTPC PLCRTIISRV FFQTELNNAT KTFFTKEYLK 500
    IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF PHGAHRMDYL 550
    HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF 592
    Length:592
    Mass (Da):68,254
    Last modified:November 28, 2006 - v2
    Checksum:i030AF3FD04ECA57B
    GO
    Isoform 2 (identifier: Q86T96-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         410-416: TLNNEMS → VSIYLLI
         417-592: Missing.

    Show »
    Length:416
    Mass (Da):47,286
    Checksum:i9BA191F2271C6A0E
    GO
    Isoform 3 (identifier: Q86T96-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         78-397: Missing.
         410-416: TLNNEMS → VSIYLLI
         417-592: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:96
    Mass (Da):11,132
    Checksum:i86BDAC24D6C70469
    GO

    Sequence cautioni

    The sequence CAD89939.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151E → G in CAD89939. (PubMed:17974005)Curated
    Sequence conflicti18 – 225SILRC → GETVFSL in CAD89939. (PubMed:17974005)Curated
    Sequence conflicti458 – 4581R → G in CAD89939. (PubMed:17974005)Curated
    Sequence conflicti526 – 5261G → A in CAD89939. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei78 – 397320Missing in isoform 3. 1 PublicationVSP_021738Add
    BLAST
    Alternative sequencei410 – 4167TLNNEMS → VSIYLLI in isoform 2 and isoform 3. 2 PublicationsVSP_021739
    Alternative sequencei417 – 592176Missing in isoform 2 and isoform 3. 2 PublicationsVSP_021740Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090756 mRNA. Translation: BAC03514.1.
    AL832580 mRNA. Translation: CAD89939.1. Different initiation.
    BC101277 mRNA. Translation: AAI01278.1.
    BC101278 mRNA. Translation: AAI01279.1.
    BC101279 mRNA. Translation: AAI01280.1.
    BC101397 mRNA. Translation: AAI01398.1.
    CCDSiCCDS34169.1. [Q86T96-2]
    CCDS47219.1. [Q86T96-1]
    RefSeqiNP_001107033.1. NM_001113561.1. [Q86T96-1]
    NP_848627.1. NM_178532.3. [Q86T96-2]
    XP_006714652.1. XM_006714589.1. [Q86T96-1]
    XP_006714653.1. XM_006714590.1. [Q86T96-1]
    UniGeneiHs.657843.

    Genome annotation databases

    EnsembliENST00000296615; ENSP00000296615; ENSG00000164197. [Q86T96-2]
    ENST00000389100; ENSP00000373752; ENSG00000164197. [Q86T96-1]
    GeneIDi285671.
    KEGGihsa:285671.
    UCSCiuc003jth.4. human. [Q86T96-2]
    uc003jti.3. human. [Q86T96-1]
    uc010iws.3. human. [Q86T96-3]

    Polymorphism databases

    DMDMi118573800.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090756 mRNA. Translation: BAC03514.1 .
    AL832580 mRNA. Translation: CAD89939.1 . Different initiation.
    BC101277 mRNA. Translation: AAI01278.1 .
    BC101278 mRNA. Translation: AAI01279.1 .
    BC101279 mRNA. Translation: AAI01280.1 .
    BC101397 mRNA. Translation: AAI01398.1 .
    CCDSi CCDS34169.1. [Q86T96-2 ]
    CCDS47219.1. [Q86T96-1 ]
    RefSeqi NP_001107033.1. NM_001113561.1. [Q86T96-1 ]
    NP_848627.1. NM_178532.3. [Q86T96-2 ]
    XP_006714652.1. XM_006714589.1. [Q86T96-1 ]
    XP_006714653.1. XM_006714590.1. [Q86T96-1 ]
    UniGenei Hs.657843.

    3D structure databases

    ProteinModelPortali Q86T96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130174. 3 interactions.
    MINTi MINT-4722695.
    STRINGi 9606.ENSP00000373752.

    PTM databases

    PhosphoSitei Q86T96.

    Polymorphism databases

    DMDMi 118573800.

    Proteomic databases

    PaxDbi Q86T96.
    PRIDEi Q86T96.

    Protocols and materials databases

    DNASUi 285671.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296615 ; ENSP00000296615 ; ENSG00000164197 . [Q86T96-2 ]
    ENST00000389100 ; ENSP00000373752 ; ENSG00000164197 . [Q86T96-1 ]
    GeneIDi 285671.
    KEGGi hsa:285671.
    UCSCi uc003jth.4. human. [Q86T96-2 ]
    uc003jti.3. human. [Q86T96-1 ]
    uc010iws.3. human. [Q86T96-3 ]

    Organism-specific databases

    CTDi 285671.
    GeneCardsi GC05P063498.
    HGNCi HGNC:27752. RNF180.
    HPAi HPA006897.
    neXtProti NX_Q86T96.
    PharmGKBi PA134980027.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42632.
    HOGENOMi HOG000154158.
    HOVERGENi HBG093907.
    InParanoidi Q86T96.
    KOi K15708.
    OMAi PTLYEIH.
    OrthoDBi EOG790G06.
    PhylomeDBi Q86T96.
    TreeFami TF328580.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi RNF180. human.
    GenomeRNAii 285671.
    NextBioi 95695.
    PROi Q86T96.

    Gene expression databases

    ArrayExpressi Q86T96.
    Bgeei Q86T96.
    CleanExi HS_RNF180.
    Genevestigatori Q86T96.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spinal cord.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).

    Entry informationi

    Entry nameiRN180_HUMAN
    AccessioniPrimary (citable) accession number: Q86T96
    Secondary accession number(s): Q0JSU3, Q495A8, Q8NBD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3