ID   NBPFB_HUMAN             Reviewed;         865 AA.
AC   Q86T75; B1AKG1; B7Z7R4; Q5RGN0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 3.
DT   24-JAN-2024, entry version 137.
DE   RecName: Full=Neuroblastoma breakpoint family member 11 {ECO:0000305};
DE   AltName: Full=Neuroblastoma breakpoint family member 24 {ECO:0000312|HGNC:HGNC:31993};
GN   Name=NBPF11 {ECO:0000312|HGNC:HGNC:31993};
GN   Synonyms=NBPF24 {ECO:0000312|HGNC:HGNC:31993};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Spinal cord;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=16079250; DOI=10.1093/molbev/msi222;
RA   Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.;
RT   "A novel gene family NBPF: intricate structure generated by gene
RT   duplications during primate evolution.";
RL   Mol. Biol. Evol. 22:2265-2274(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q86T75-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q86T75-2; Sequence=VSP_040663, VSP_040664;
CC   -!- TISSUE SPECIFICITY: Expressed in spinal cord.
CC       {ECO:0000269|PubMed:16079250}.
CC   -!- MISCELLANEOUS: Encoded by one of the numerous copies of NBPF genes
CC       clustered in the p36, p12 and q21 region of the chromosome 1.
CC   -!- SIMILARITY: Belongs to the NBPF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD89962.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAI17086.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAI21822.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AK302413; BAH13700.1; -; mRNA.
DR   EMBL; AL832622; CAD89962.1; ALT_FRAME; mRNA.
DR   EMBL; AL356004; CAI17086.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL049742; CAI17086.2; JOINED; Genomic_DNA.
DR   EMBL; AL049742; CAI21822.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL356004; CAI21822.2; JOINED; Genomic_DNA.
DR   EMBL; BX842679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC136292; AAI36293.1; -; mRNA.
DR   CCDS; CCDS41381.2; -. [Q86T75-1]
DR   RefSeq; NP_001095133.3; NM_001101663.4. [Q86T75-1]
DR   RefSeq; NP_899228.4; NM_183372.5. [Q86T75-1]
DR   AlphaFoldDB; Q86T75; -.
DR   SMR; Q86T75; -.
DR   BioGRID; 128294; 4.
DR   DIP; DIP-47328N; -.
DR   IntAct; Q86T75; 2.
DR   MINT; Q86T75; -.
DR   STRING; 9606.ENSP00000477509; -.
DR   iPTMnet; Q86T75; -.
DR   PhosphoSitePlus; Q86T75; -.
DR   BioMuta; NBPF11; -.
DR   DMDM; 325511389; -.
DR   jPOST; Q86T75; -.
DR   MassIVE; Q86T75; -.
DR   MaxQB; Q86T75; -.
DR   PaxDb; 9606-ENSP00000477509; -.
DR   PeptideAtlas; Q86T75; -.
DR   Antibodypedia; 74099; 34 antibodies from 9 providers.
DR   DNASU; 200030; -.
DR   Ensembl; ENST00000614015.4; ENSP00000484213.1; ENSG00000263956.8. [Q86T75-1]
DR   Ensembl; ENST00000615281.4; ENSP00000477509.1; ENSG00000263956.8. [Q86T75-1]
DR   Ensembl; ENST00000682118.1; ENSP00000507808.1; ENSG00000263956.8. [Q86T75-1]
DR   GeneID; 200030; -.
DR   KEGG; hsa:200030; -.
DR   MANE-Select; ENST00000682118.1; ENSP00000507808.1; NM_001385469.3; NP_001372398.2.
DR   UCSC; uc010ozx.3; human. [Q86T75-1]
DR   AGR; HGNC:31993; -.
DR   CTD; 200030; -.
DR   GeneCards; NBPF11; -.
DR   HGNC; HGNC:31993; NBPF11.
DR   HPA; ENSG00000263956; Low tissue specificity.
DR   MIM; 614001; gene.
DR   neXtProt; NX_Q86T75; -.
DR   OpenTargets; ENSG00000263956; -.
DR   VEuPathDB; HostDB:ENSG00000263956; -.
DR   eggNOG; ENOG502RU1I; Eukaryota.
DR   GeneTree; ENSGT00420000029746; -.
DR   HOGENOM; CLU_004609_0_0_1; -.
DR   InParanoid; Q86T75; -.
DR   OrthoDB; 5219905at2759; -.
DR   PhylomeDB; Q86T75; -.
DR   TreeFam; TF341151; -.
DR   PathwayCommons; Q86T75; -.
DR   SignaLink; Q86T75; -.
DR   BioGRID-ORCS; 200030; 219 hits in 683 CRISPR screens.
DR   ChiTaRS; NBPF11; human.
DR   GenomeRNAi; 200030; -.
DR   Pharos; Q86T75; Tdark.
DR   PRO; PR:Q86T75; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q86T75; Protein.
DR   Bgee; ENSG00000263956; Expressed in granulocyte and 101 other cell types or tissues.
DR   ExpressionAtlas; Q86T75; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010630; Olduvai_dom.
DR   PANTHER; PTHR14199:SF35; NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 1-RELATED; 1.
DR   PANTHER; PTHR14199; UNCHARACTERIZED; 1.
DR   Pfam; PF06758; Olduvai; 6.
DR   SMART; SM01148; DUF1220; 6.
DR   PROSITE; PS51316; ODV; 6.
DR   Genevisible; Q86T75; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Reference proteome; Repeat.
FT   CHAIN           1..865
FT                   /note="Neuroblastoma breakpoint family member 11"
FT                   /id="PRO_0000288046"
FT   DOMAIN          165..259
FT                   /note="Olduvai 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          436..528
FT                   /note="Olduvai 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          529..617
FT                   /note="Olduvai 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          620..675
FT                   /note="Olduvai 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          676..767
FT                   /note="Olduvai 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   DOMAIN          770..865
FT                   /note="Olduvai 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00647"
FT   REGION          161..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          829..865
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          70..130
FT                   /evidence="ECO:0000255"
FT   COILED          339..401
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        165..179
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..553
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..854
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         575..598
FT                   /note="LASYQSYSSTFHSLEEQQVCMAVD -> TSVGSSEKGGPRGNRSQAQQGAAG
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_040663"
FT   VAR_SEQ         599..865
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_040664"
SQ   SEQUENCE   865 AA;  99433 MW;  7541A8714464D504 CRC64;
     MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF LANRQKKYKY
     EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS
     RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE
     KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSSL
     VVDRESSHDG CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLCPQLA
     EKKQQFRSLK EKCFVTQVAC FLAKQQNKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA
     EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA
     EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSSPR EMQKAEEKEV PEDSLEECAI
     TCSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK
     GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPERLASYQS YSSTFHSLEE QQVCMAVDIG
     RHRWDQVKKE DQEATGPRLS RELLDEKEPE VLQDSLDRCY STPSVYLGLT DSCQPYRSAF
     YVLEQQRIGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLA EKEPEVLQDS LDRCYSTPSG
     YLELPDLGQP YRSAVYSLEE QYLGLALDVD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE
     VLQDSLDVIQ LLPVVLNSLT PASPTEVPFM HWRKNMLAFL LTWEKLKRRG RGRKEGEEDQ
     RRKEEGEEKK GKKIKTHHAP GSAAC
//