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Protein

Neuroblastoma breakpoint family member 11

Gene

NBPF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31463-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 11Curated
Alternative name(s):
Neuroblastoma breakpoint family member 24Imported
Gene namesi
Name:NBPF11Imported
Synonyms:NBPF24Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31993. NBPF11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000263956.
PharmGKBiPA165752039.

Polymorphism and mutation databases

BioMutaiNBPF11.
DMDMi325511389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880461 – 865Neuroblastoma breakpoint family member 11Add BLAST865

Proteomic databases

MaxQBiQ86T75.
PaxDbiQ86T75.
PeptideAtlasiQ86T75.
PRIDEiQ86T75.

PTM databases

iPTMnetiQ86T75.
PhosphoSitePlusiQ86T75.

Expressioni

Tissue specificityi

Expressed in spinal cord.1 Publication

Gene expression databases

BgeeiENSG00000203836.
CleanExiHS_NBPF11.
ExpressionAtlasiQ86T75. baseline and differential.
GenevisibleiQ86T75. HS.

Organism-specific databases

HPAiHPA038748.
HPA042595.
HPA044023.
HPA046888.
HPA046971.
HPA058050.

Interactioni

Protein-protein interaction databases

BioGridi128294. 2 interactors.
DIPiDIP-47328N.
IntActiQ86T75. 1 interactor.
STRINGi9606.ENSP00000418802.

Structurei

3D structure databases

ProteinModelPortaliQ86T75.
SMRiQ86T75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 259NBPF 1PROSITE-ProRule annotationAdd BLAST95
Domaini436 – 528NBPF 2PROSITE-ProRule annotationAdd BLAST93
Domaini529 – 617NBPF 3PROSITE-ProRule annotationAdd BLAST89
Domaini620 – 675NBPF 4PROSITE-ProRule annotationAdd BLAST56
Domaini676 – 767NBPF 5PROSITE-ProRule annotationAdd BLAST92
Domaini770 – 865NBPF 6PROSITE-ProRule annotationAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 130Sequence analysisAdd BLAST61
Coiled coili339 – 401Sequence analysisAdd BLAST63

Sequence similaritiesi

Belongs to the NBPF family.Curated
Contains 6 NBPF domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410KG3F. Eukaryota.
ENOG4110SQ7. LUCA.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ86T75.
OrthoDBiEOG091G03WI.
PhylomeDBiQ86T75.
TreeFamiTF341151.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 6 hits.
[Graphical view]
SMARTiSM01148. DUF1220. 6 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86T75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
SQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE KVLESSAPRE VQKAEESKVP
210 220 230 240 250
EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSSL VVDRESSHDG
260 270 280 290 300
CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLCPQLA
310 320 330 340 350
EKKQQFRSLK EKCFVTQVAC FLAKQQNKYK YEECKDLIKS MLRNERQFKE
360 370 380 390 400
EKLAEQLKQA EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA
410 420 430 440 450
LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DDEDVQVEVA
460 470 480 490 500
EKVQKSSSPR EMQKAEEKEV PEDSLEECAI TCSNSHGPYD SNQPHRKTKI
510 520 530 540 550
TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE
560 570 580 590 600
SEEEEVPQES WDEGYSTLSI PPERLASYQS YSSTFHSLEE QQVCMAVDIG
610 620 630 640 650
RHRWDQVKKE DQEATGPRLS RELLDEKEPE VLQDSLDRCY STPSVYLGLT
660 670 680 690 700
DSCQPYRSAF YVLEQQRIGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLA
710 720 730 740 750
EKEPEVLQDS LDRCYSTPSG YLELPDLGQP YRSAVYSLEE QYLGLALDVD
760 770 780 790 800
RIKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDVIQ LLPVVLNSLT
810 820 830 840 850
PASPTEVPFM HWRKNMLAFL LTWEKLKRRG RGRKEGEEDQ RRKEEGEEKK
860
GKKIKTHHAP GSAAC
Length:865
Mass (Da):99,433
Last modified:March 8, 2011 - v3
Checksum:i7541A8714464D504
GO
Isoform 2 (identifier: Q86T75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     575-598: LASYQSYSSTFHSLEEQQVCMAVD → TSVGSSEKGGPRGNRSQAQQGAAG
     599-865: Missing.

Show »
Length:598
Mass (Da):68,201
Checksum:i5406012A69E87785
GO

Sequence cautioni

The sequence CAD89962 differs from that shown. Reason: Frameshift at position 498.Curated
The sequence CAI17086 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21822 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI23637 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040663575 – 598LASYQ…CMAVD → TSVGSSEKGGPRGNRSQAQQ GAAG in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_040664599 – 865Missing in isoform 2. 1 PublicationAdd BLAST267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302413 mRNA. Translation: BAH13700.1.
AL832622 mRNA. Translation: CAD89962.1. Frameshift.
AL356004, AL049742 Genomic DNA. Translation: CAI17086.2. Sequence problems.
AL049742, AL356004 Genomic DNA. Translation: CAI21822.2. Sequence problems.
BX842679 Genomic DNA. Translation: CAI23637.1. Sequence problems.
BC136292 mRNA. Translation: AAI36293.1.
CCDSiCCDS41381.2. [Q86T75-1]
RefSeqiNP_001095133.3. NM_001101663.4. [Q86T75-1]
NP_899228.4. NM_183372.5.
UniGeneiHs.721588.
Hs.730358.
Hs.740943.
Hs.744018.

Genome annotation databases

EnsembliENST00000614015; ENSP00000484213; ENSG00000263956. [Q86T75-1]
ENST00000615281; ENSP00000477509; ENSG00000263956. [Q86T75-1]
GeneIDi200030.
KEGGihsa:200030.
UCSCiuc010ozx.3. human. [Q86T75-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302413 mRNA. Translation: BAH13700.1.
AL832622 mRNA. Translation: CAD89962.1. Frameshift.
AL356004, AL049742 Genomic DNA. Translation: CAI17086.2. Sequence problems.
AL049742, AL356004 Genomic DNA. Translation: CAI21822.2. Sequence problems.
BX842679 Genomic DNA. Translation: CAI23637.1. Sequence problems.
BC136292 mRNA. Translation: AAI36293.1.
CCDSiCCDS41381.2. [Q86T75-1]
RefSeqiNP_001095133.3. NM_001101663.4. [Q86T75-1]
NP_899228.4. NM_183372.5.
UniGeneiHs.721588.
Hs.730358.
Hs.740943.
Hs.744018.

3D structure databases

ProteinModelPortaliQ86T75.
SMRiQ86T75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128294. 2 interactors.
DIPiDIP-47328N.
IntActiQ86T75. 1 interactor.
STRINGi9606.ENSP00000418802.

PTM databases

iPTMnetiQ86T75.
PhosphoSitePlusiQ86T75.

Polymorphism and mutation databases

BioMutaiNBPF11.
DMDMi325511389.

Proteomic databases

MaxQBiQ86T75.
PaxDbiQ86T75.
PeptideAtlasiQ86T75.
PRIDEiQ86T75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614015; ENSP00000484213; ENSG00000263956. [Q86T75-1]
ENST00000615281; ENSP00000477509; ENSG00000263956. [Q86T75-1]
GeneIDi200030.
KEGGihsa:200030.
UCSCiuc010ozx.3. human. [Q86T75-1]

Organism-specific databases

CTDi200030.
GeneCardsiNBPF11.
H-InvDBHIX0199864.
HGNCiHGNC:31993. NBPF11.
HPAiHPA038748.
HPA042595.
HPA044023.
HPA046888.
HPA046971.
HPA058050.
MIMi614001. gene.
neXtProtiNX_Q86T75.
OpenTargetsiENSG00000263956.
PharmGKBiPA165752039.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KG3F. Eukaryota.
ENOG4110SQ7. LUCA.
GeneTreeiENSGT00420000029746.
HOGENOMiHOG000049041.
HOVERGENiHBG058300.
InParanoidiQ86T75.
OrthoDBiEOG091G03WI.
PhylomeDBiQ86T75.
TreeFamiTF341151.

Enzyme and pathway databases

BioCyciZFISH:G66-31463-MONOMER.

Miscellaneous databases

ChiTaRSiNBPF11. human.
GenomeRNAii200030.
PROiQ86T75.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000203836.
CleanExiHS_NBPF11.
ExpressionAtlasiQ86T75. baseline and differential.
GenevisibleiQ86T75. HS.

Family and domain databases

InterProiIPR010630. NBPF_dom.
[Graphical view]
PfamiPF06758. DUF1220. 6 hits.
[Graphical view]
SMARTiSM01148. DUF1220. 6 hits.
[Graphical view]
PROSITEiPS51316. NBPF. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNBPFB_HUMAN
AccessioniPrimary (citable) accession number: Q86T75
Secondary accession number(s): B1AKG1, B7Z7R4, Q5RGN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 8, 2011
Last modified: November 2, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.