Q86T75 (NBPFB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblastoma breakpoint family member 11

Gene names

Name:

NBPF11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	865 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Probable.
Tissue specificity	Expressed in spinal cord. Ref.5
Miscellaneous	Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
Sequence similarities	Belongs to the NBPF family. Contains 6 NBPF domains.
Sequence caution	The sequence CAD89962.1 differs from that shown. Reason: Frameshift at position 498. The sequence CAI17086.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI21822.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86T75-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86T75-2)

The sequence of this isoform differs from the canonical sequence as follows:
     575-598: LASYQSYSSTFHSLEEQQVCMAVD → TSVGSSEKGGPRGNRSQAQQGAAG
     599-865: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 865	865	Neuroblastoma breakpoint family member 11		PRO_0000288046
Regions
	Domain	165 – 259	95	NBPF 1
	Domain	436 – 528	93	NBPF 2
	Domain	529 – 617	89	NBPF 3
	Domain	620 – 675	56	NBPF 4
	Domain	676 – 767	92	NBPF 5
	Domain	770 – 865	96	NBPF 6
	Coiled coil	70 – 130	61	Potential
	Coiled coil	339 – 401	63	Potential
Natural variations
	Alternative sequence	575 – 598	24	LASYQ…CMAVD → TSVGSSEKGGPRGNRSQAQQ GAAG in isoform 2.		VSP_040663
	Alternative sequence	599 – 865	267	Missing in isoform 2.		VSP_040664

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 8, 2011. Version 3. Checksum: 7541A8714464D504	FASTA	865	99,433
	10 20 30 40 50 60 MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF LANRQKKYKY 70 80 90 100 110 120 EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS 130 140 150 160 170 180 RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE 190 200 210 220 230 240 KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSSL 250 260 270 280 290 300 VVDRESSHDG CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLCPQLA 310 320 330 340 350 360 EKKQQFRSLK EKCFVTQVAC FLAKQQNKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA 370 380 390 400 410 420 EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA 430 440 450 460 470 480 EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSSPR EMQKAEEKEV PEDSLEECAI 490 500 510 520 530 540 TCSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK 550 560 570 580 590 600 GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPERLASYQS YSSTFHSLEE QQVCMAVDIG 610 620 630 640 650 660 RHRWDQVKKE DQEATGPRLS RELLDEKEPE VLQDSLDRCY STPSVYLGLT DSCQPYRSAF 670 680 690 700 710 720 YVLEQQRIGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLA EKEPEVLQDS LDRCYSTPSG 730 740 750 760 770 780 YLELPDLGQP YRSAVYSLEE QYLGLALDVD RIKKDQEEEE DQGPPCPRLS RELLEVVEPE 790 800 810 820 830 840 VLQDSLDVIQ LLPVVLNSLT PASPTEVPFM HWRKNMLAFL LTWEKLKRRG RGRKEGEEDQ 850 860 RRKEEGEEKK GKKIKTHHAP GSAAC
	Isoform 2 [UniParc]. Checksum: 5406012A69E87785	FASTA	598	68,201
	10 20 30 40 50 60 MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF LANRQKKYKY 70 80 90 100 110 120 EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH SQERELTQLR EKLREGRDAS 130 140 150 160 170 180 RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE 190 200 210 220 230 240 KVLESSAPRE VQKAEESKVP EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSSL 250 260 270 280 290 300 VVDRESSHDG CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLCPQLA 310 320 330 340 350 360 EKKQQFRSLK EKCFVTQVAC FLAKQQNKYK YEECKDLIKS MLRNERQFKE EKLAEQLKQA 370 380 390 400 410 420 EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA LLTPDEPDKS QGQDLQEQLA 430 440 450 460 470 480 EGCRLAQHLV QKLSPENDND DDEDVQVEVA EKVQKSSSPR EMQKAEEKEV PEDSLEECAI 490 500 510 520 530 540 TCSNSHGPYD SNQPHRKTKI TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK 550 560 570 580 590 GPVSPRNLQE SEEEEVPQES WDEGYSTLSI PPERTSVGSS EKGGPRGNRS QAQQGAAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spinal cord.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution." Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F. Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK302413 mRNA. Translation: BAH13700.1. AL832622 mRNA. Translation: CAD89962.1. Frameshift. AL356004, AL049742 Genomic DNA. Translation: CAI17086.2. Sequence problems. AL049742, AL356004 Genomic DNA. Translation: CAI21822.2. Sequence problems. BC136292 mRNA. Translation: AAI36293.1.
IPI	IPI00937731. IPI00977512.
RefSeq	NP_001095133.2. NM_001101663.2. NP_899228.4. NM_183372.4.
UniGene	Hs.515947. Hs.534675. Hs.571820. Hs.721588. Hs.730358. Hs.740943.
3D structure databases
ProteinModelPortal	Q86T75.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47328N.
STRING	9606.ENSP00000358228.
PTM databases
PhosphoSite	Q86T75.
Polymorphism databases
DMDM	205371846.
Proteomic databases
PaxDb	Q86T75.
PRIDE	Q86T75.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369323; ENSP00000358329; ENSG00000152042. ENST00000479926; ENSP00000418802; ENSG00000152042.
GeneID	200030. 728912.
KEGG	hsa:200030. hsa:728912.
UCSC	uc010ozg.2. human.
Organism-specific databases
CTD	200030. 728912.
GeneCards	GC01M146040.
H-InvDB	HIX0199864.
HGNC	HGNC:31993. NBPF11.
MIM	614001. gene.
neXtProt	NX_Q86T75.
GenAtlas	Search...
Phylogenomic databases
eggNOG	biNOG22098.
HOGENOM	HOG000049041.
HOVERGEN	HBG058300.
OrthoDB	EOG4MSCZD.
Gene expression databases
ArrayExpress	Q86T75.
Bgee	Q86T75.
CleanEx	HS_NBPF11.
Genevestigator	Q86T75.
Family and domain databases
InterPro	IPR010630. NBPF_dom. [Graphical view]
Pfam	PF06758. DUF1220. 6 hits. [Graphical view]
PROSITE	PS51316. NBPF. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NBPF11. human.
NextBio	89813.
SOURCE	Search...

Entry information

Entry name

NBPFB_HUMAN

Accession

Primary (citable) accession number: Q86T75
Secondary accession number(s): B1AKG1, B7Z7R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 8, 2011
Last modified:	April 3, 2013
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.