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Q86T75

- NBPFB_HUMAN

UniProt

Q86T75 - NBPFB_HUMAN

Protein

Neuroblastoma breakpoint family member 11

Gene

NBPF11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (08 Mar 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroblastoma breakpoint family member 11
    Gene namesi
    Name:NBPF11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:31993. NBPF11.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 865865Neuroblastoma breakpoint family member 11PRO_0000288046Add
    BLAST

    Proteomic databases

    PaxDbiQ86T75.
    PRIDEiQ86T75.

    PTM databases

    PhosphoSiteiQ86T75.

    Expressioni

    Tissue specificityi

    Expressed in spinal cord.1 Publication

    Gene expression databases

    BgeeiQ86T75.
    CleanExiHS_NBPF11.
    GenevestigatoriQ86T75.

    Interactioni

    Protein-protein interaction databases

    BioGridi128294. 2 interactions.
    DIPiDIP-47328N.
    IntActiQ86T75. 1 interaction.
    STRINGi9606.ENSP00000358228.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86T75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 25995NBPF 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini436 – 52893NBPF 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini529 – 61789NBPF 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini620 – 67556NBPF 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini676 – 76792NBPF 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini770 – 86596NBPF 6PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili70 – 13061Sequence AnalysisAdd
    BLAST
    Coiled coili339 – 40163Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NBPF family.Curated
    Contains 6 NBPF domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGibiNOG22098.
    HOGENOMiHOG000049041.
    HOVERGENiHBG058300.
    OrthoDBiEOG7GBFWV.
    PhylomeDBiQ86T75.
    TreeFamiTF341151.

    Family and domain databases

    InterProiIPR010630. NBPF_dom.
    [Graphical view]
    PfamiPF06758. DUF1220. 6 hits.
    [Graphical view]
    PROSITEiPS51316. NBPF. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86T75-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFRNLKE RCFLTQLAGF    50
    LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH 100
    SQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE 150
    GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE KVLESSAPRE VQKAEESKVP 200
    EDSLEECAIT CSNSHGPCDS IQPHKNIKIT FEEDKVNSSL VVDRESSHDG 250
    CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLCPQLA 300
    EKKQQFRSLK EKCFVTQVAC FLAKQQNKYK YEECKDLIKS MLRNERQFKE 350
    EKLAEQLKQA EELRQYKVLV HSQERELTQL REKLREGRDA SRSLNEHLQA 400
    LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DDEDVQVEVA 450
    EKVQKSSSPR EMQKAEEKEV PEDSLEECAI TCSNSHGPYD SNQPHRKTKI 500
    TFEEDKVDST LIGSSSHVEW EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE 550
    SEEEEVPQES WDEGYSTLSI PPERLASYQS YSSTFHSLEE QQVCMAVDIG 600
    RHRWDQVKKE DQEATGPRLS RELLDEKEPE VLQDSLDRCY STPSVYLGLT 650
    DSCQPYRSAF YVLEQQRIGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLA 700
    EKEPEVLQDS LDRCYSTPSG YLELPDLGQP YRSAVYSLEE QYLGLALDVD 750
    RIKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDVIQ LLPVVLNSLT 800
    PASPTEVPFM HWRKNMLAFL LTWEKLKRRG RGRKEGEEDQ RRKEEGEEKK 850
    GKKIKTHHAP GSAAC 865
    Length:865
    Mass (Da):99,433
    Last modified:March 8, 2011 - v3
    Checksum:i7541A8714464D504
    GO
    Isoform 2 (identifier: Q86T75-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         575-598: LASYQSYSSTFHSLEEQQVCMAVD → TSVGSSEKGGPRGNRSQAQQGAAG
         599-865: Missing.

    Show »
    Length:598
    Mass (Da):68,201
    Checksum:i5406012A69E87785
    GO

    Sequence cautioni

    The sequence CAD89962.1 differs from that shown. Reason: Frameshift at position 498.
    The sequence CAI17086.2 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI21822.2 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei575 – 59824LASYQ…CMAVD → TSVGSSEKGGPRGNRSQAQQ GAAG in isoform 2. 1 PublicationVSP_040663Add
    BLAST
    Alternative sequencei599 – 865267Missing in isoform 2. 1 PublicationVSP_040664Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK302413 mRNA. Translation: BAH13700.1.
    AL832622 mRNA. Translation: CAD89962.1. Frameshift.
    AL356004, AL049742 Genomic DNA. Translation: CAI17086.2. Sequence problems.
    AL049742, AL356004 Genomic DNA. Translation: CAI21822.2. Sequence problems.
    BC136292 mRNA. Translation: AAI36293.1.
    CCDSiCCDS41381.2. [Q86T75-1]
    RefSeqiNP_001095133.3. NM_001101663.4. [Q86T75-1]
    NP_899228.4. NM_183372.5.
    UniGeneiHs.721588.
    Hs.730358.
    Hs.740943.
    Hs.744018.

    Genome annotation databases

    GeneIDi200030.
    KEGGihsa:200030.
    UCSCiuc010ozh.3. human. [Q86T75-1]

    Polymorphism databases

    DMDMi325511389.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK302413 mRNA. Translation: BAH13700.1 .
    AL832622 mRNA. Translation: CAD89962.1 . Frameshift.
    AL356004 , AL049742 Genomic DNA. Translation: CAI17086.2 . Sequence problems.
    AL049742 , AL356004 Genomic DNA. Translation: CAI21822.2 . Sequence problems.
    BC136292 mRNA. Translation: AAI36293.1 .
    CCDSi CCDS41381.2. [Q86T75-1 ]
    RefSeqi NP_001095133.3. NM_001101663.4. [Q86T75-1 ]
    NP_899228.4. NM_183372.5.
    UniGenei Hs.721588.
    Hs.730358.
    Hs.740943.
    Hs.744018.

    3D structure databases

    ProteinModelPortali Q86T75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128294. 2 interactions.
    DIPi DIP-47328N.
    IntActi Q86T75. 1 interaction.
    STRINGi 9606.ENSP00000358228.

    PTM databases

    PhosphoSitei Q86T75.

    Polymorphism databases

    DMDMi 325511389.

    Proteomic databases

    PaxDbi Q86T75.
    PRIDEi Q86T75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 200030.
    KEGGi hsa:200030.
    UCSCi uc010ozh.3. human. [Q86T75-1 ]

    Organism-specific databases

    CTDi 200030.
    GeneCardsi GC01M146040.
    H-InvDB HIX0199864.
    HGNCi HGNC:31993. NBPF11.
    MIMi 614001. gene.
    neXtProti NX_Q86T75.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi biNOG22098.
    HOGENOMi HOG000049041.
    HOVERGENi HBG058300.
    OrthoDBi EOG7GBFWV.
    PhylomeDBi Q86T75.
    TreeFami TF341151.

    Miscellaneous databases

    ChiTaRSi NBPF11. human.
    NextBioi 89813.
    PROi Q86T75.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86T75.
    CleanExi HS_NBPF11.
    Genevestigatori Q86T75.

    Family and domain databases

    InterProi IPR010630. NBPF_dom.
    [Graphical view ]
    Pfami PF06758. DUF1220. 6 hits.
    [Graphical view ]
    PROSITEi PS51316. NBPF. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spinal cord.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution."
      Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F.
      Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNBPFB_HUMAN
    AccessioniPrimary (citable) accession number: Q86T75
    Secondary accession number(s): B1AKG1, B7Z7R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3