Q86T65 (DAAM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disheveled-associated activator of morphogenesis 2

Gene names

Name:	DAAM2
Synonyms:	KIAA0381

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1068 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in most tissues examined.
Sequence similarities	Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Sequence caution	The sequence BAA20835.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Molecular function	Rho GTPase binding Inferred from electronic annotation. Source: InterPro actin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1068	1068	Disheveled-associated activator of morphogenesis 2		PRO_0000194909
Regions
	Domain	40 – 416	377	GBD/FH3
	Domain	518 – 594	77	FH1
	Domain	595 – 994	400	FH2
	Domain	1016 – 1048	33	DAD
	Coiled coil	434 – 516	83	Potential
	Compositional bias	518 – 604	87	Pro-rich
Natural variations
	Natural variant	105	1	R → H. Corresponds to variant rs6919807 [ dbSNP | Ensembl ].		VAR_055805
	Natural variant	617	1	R → H. Corresponds to variant rs34699846 [ dbSNP | Ensembl ].		VAR_055806
Experimental info
	Sequence conflict	414	1	R → W in CAD89973. Ref.3
	Sequence conflict	894	1	Missing in CAD89973. Ref.3
	Sequence conflict	901	1	Q → R in CAD89973. Ref.3
	Sequence conflict	1003	1	R → W in CAD89973. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q86T65 [UniParc]. Last modified April 26, 2005. Version 3. Checksum: 90B071DD1BC13F9A	FASTA	1,068	123,499
	10 20 30 40 50 60 MAPRKRSHHG LGFLCCFGGS DIPEINLRDN HPLQFMEFSS PIPNAEELNI RFAELVDELD 70 80 90 100 110 120 LTDKNREAMF ALPPEKKWQI YCSKKKEQED PNKLATSWPD YYIDRINSMA AMQSLYAFDE 130 140 150 160 170 180 EETEMRNQVV EDLKTALRTQ PMRFVTRFIE LEGLTCLLNF LRSMDHATCE SRIHTSLIGC 190 200 210 220 230 240 IKALMNNSQG RAHVLAQPEA ISTIAQSLRT ENSKTKVAVL EILGAVCLVP GGHKKVLQAM 250 260 270 280 290 300 LHYQVYAAER TRFQTLLNEL DRSLGRYRDE VNLKTAIMSF INAVLNAGAG EDNLEFRLHL 310 320 330 340 350 360 RYEFLMLGIQ PVIDKLRQHE NAILDKHLDF FEMVRNEDDL ELARRFDMVH IDTKSASQMF 370 380 390 400 410 420 ELIHKKLKYT EAYPCLLSVL HHCLQMPYKR NGGYFQQWQL LDRILQQIVL QDERGVDPDL 430 440 450 460 470 480 APLENFNVKN IVNMLINENE VKQWRDQAEK FRKEHMELVS RLERKERECE TKTLEKEEMM 490 500 510 520 530 540 RTLNKMKDKL ARESQELRQA RGQVAELVAQ LSELSTGPVS SPPPPGGPLT LSSSMTTNDL 550 560 570 580 590 600 PPPPPPLPFA CCPPPPPPPL PPGGPPTPPG APPCLGMGLP LPQDPYPSSD VPLRKKRVPQ 610 620 630 640 650 660 PSHPLKSFNW VKLNEERVPG TVWNEIDDMQ VFRILDLEDF EKMFSAYQRH QKELGSTEDI 670 680 690 700 710 720 YLASRKVKEL SVIDGRRAQN CIILLSKLKL SNEEIRQAIL KMDEQEDLAK DMLEQLLKFI 730 740 750 760 770 780 PEKSDIDLLE EHKHEIERMA RADRFLYEMS RIDHYQQRLQ ALFFKKKFQE RLAEAKPKVE 790 800 810 820 830 840 AILLASRELV RSKRLRQMLE VILAIGNFMN KGQRGGAYGF RVASLNKIAD TKSSIDRNIS 850 860 870 880 890 900 LLHYLIMILE KHFPDILNMP SELQHLPEAA KVNLAELEKE VGNLRRGLRA VEVELEYQRR 910 920 930 940 950 960 QVREPSDKFV PVMSDFITVS SFSFSELEDQ LNEARDKFAK ALMHFGEHDS KMQPDEFFGI 970 980 990 1000 1010 1020 FDTFLQAFSE ARQDLEAMRR RKEEEERRAR MEAMLKEQRE RERWQRQRKV LAAGSSLEEG 1030 1040 1050 1060 GEFDDLVSAL RSGEVFDKDL CKLKRSRKRS GSQALEVTRE RAINRLNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spinal cord.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB002379 mRNA. Translation: BAA20835.2. Different initiation. AL833083 mRNA. Translation: CAD89973.1. AL590999, AL136089, AL357412 Genomic DNA. Translation: CAI16176.2. AL136089, AL357412, AL590999 Genomic DNA. Translation: CAI20010.2. AL357412, AL136089, AL590999 Genomic DNA. Translation: CAI23288.2.
IPI	IPI00514893.
RefSeq	NP_001188356.1. NM_001201427.1. NP_056160.2. NM_015345.3.
UniGene	Hs.357128. Hs.718492.
3D structure databases
ProteinModelPortal	Q86T65.
SMR	Q86T65. Positions 48-420, 590-1038.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86T65. 1 interaction.
STRING	Q86T65.
PTM databases
PhosphoSite	Q86T65.
Polymorphism databases
DMDM	62906888.
Proteomic databases
PRIDE	Q86T65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274867; ENSP00000274867; ENSG00000146122. ENST00000398904; ENSP00000381876; ENSG00000146122.
GeneID	23500.
KEGG	hsa:23500.
UCSC	uc003oow.1. human.
Organism-specific databases
CTD	23500.
GeneCards	GC06P039807.
H-InvDB	HIX0005854.
HGNC	HGNC:18143. DAAM2.
MIM	606627. gene.
neXtProt	NX_Q86T65.
PharmGKB	PA27130.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05304.
GeneTree	ENSGT00600000084372.
HOGENOM	HBG357301.
HOVERGEN	HBG101333.
InParanoid	Q86T65.
OMA	IMILEKH.
OrthoDB	EOG4MKNFH.
PhylomeDB	Q86T65.
Gene expression databases
ArrayExpress	Q86T65.
Bgee	Q86T65.
CleanEx	HS_DAAM2.
Genevestigator	Q86T65.
GermOnline	ENSG00000146122. Homo sapiens.
Family and domain databases
InterPro	IPR003104. Actin-bd_FH2/DRF_autoreg. IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR014767. Diaphanous_autoregulatory. IPR010472. Drf_FH3. IPR010473. Drf_GTPase-bd. IPR015425. FH2_actin-bd. IPR014768. GTPase-bd/formin_homology_3. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 2 hits.
KO	K04512.
Pfam	PF06367. Drf_FH3. 1 hit. PF06371. Drf_GBD. 1 hit. PF02181. FH2. 1 hit. [Graphical view]
SMART	SM00498. FH2. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF101447. FH2_actin_bd. 1 hit.
PROSITE	PS51231. DAD. 1 hit. PS51444. FH2. 1 hit. PS51232. GBD_FH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	45877.
SOURCE	Search...

Entry information

Entry name

DAAM2_HUMAN

Accession

Primary (citable) accession number: Q86T65
Secondary accession number(s): Q5T4T8 , Q5T4U0, Q9NQI5, Q9Y4G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.